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Protein

Lymphocyte antigen 6E

Gene

Ly6e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in T-cell development (PubMed:8258699). Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394).1 Publication1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6E
Short name:
Ly-6E
Alternative name(s):
Stem cell antigen 2
Thymic shared antigen 1
Short name:
TSA-1
Gene namesi
Name:Ly6e
Synonyms:Ly67, Sca-2, Tsa-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106651 Ly6e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003614021 – 102Lymphocyte antigen 6EAdd BLAST82
PropeptideiPRO_0000036141103 – 130Removed in mature formBy similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 48By similarity
Disulfide bondi26 ↔ 35By similarity
Disulfide bondi41 ↔ 70By similarity
Disulfide bondi74 ↔ 92By similarity
Disulfide bondi93 ↔ 98By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi102GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ64253
MaxQBiQ64253
PaxDbiQ64253
PeptideAtlasiQ64253
PRIDEiQ64253

PTM databases

PhosphoSitePlusiQ64253
SwissPalmiQ64253

Expressioni

Gene expression databases

CleanExiMM_LY6E

Interactioni

Subunit structurei

Interacts with CHRNA4.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201242, 1 interactor
IntActiQ64253, 1 interactor
STRINGi10090.ENSMUSP00000056703

Structurei

3D structure databases

ProteinModelPortaliQ64253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 101UPAR/Ly6Add BLAST81

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYXK Eukaryota
ENOG4111AYX LUCA
HOVERGENiHBG001732
InParanoidiQ64253
KOiK06846
PhylomeDBiQ64253

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q64253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVFLPVLLA ALLGMEQVHS LMCFSCTDQK NNINCLWPVS CQEKDHYCIT
60 70 80 90 100
LSAAAGFGNV NLGYTLNKGC SPICPSENVN LNLGVASVNS YCCQSSFCNF
110 120 130
SAAGLGLRAS IPLLGLGLLL SLLALLQLSP
Length:130
Mass (Da):13,800
Last modified:December 1, 2000 - v2
Checksum:i0D1C25505F61DEB2
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99JA5Q99JA5_MOUSE
Ly6e protein
Ly6e mCG_2785
136Annotation score:
A0A087WPY4A0A087WPY4_MOUSE
Lymphocyte antigen 6E
Ly6e
119Annotation score:
A0A087WNT2A0A087WNT2_MOUSE
Lymphocyte antigen 6E
Ly6e
117Annotation score:
A0A087WRZ2A0A087WRZ2_MOUSE
Lymphocyte antigen 6E
Ly6e
117Annotation score:
A0A087WNS9A0A087WNS9_MOUSE
Lymphocyte antigen 6E
Ly6e
63Annotation score:
A0A087WQ65A0A087WQ65_MOUSE
Lymphocyte antigen 6E
Ly6e
113Annotation score:

Sequence cautioni

The sequence AAA19121 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB03366 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09192 mRNA Translation: AAB03366.1 Different initiation.
U04268 mRNA Translation: AAA19121.1 Different initiation.
U47737 Genomic DNA Translation: AAB17698.1
RefSeqiNP_001157508.1, NM_001164036.1
NP_001157509.1, NM_001164037.1
NP_001157510.1, NM_001164038.1
NP_001157511.1, NM_001164039.1
NP_001157512.1, NM_001164040.1
NP_032555.1, NM_008529.3
UniGeneiMm.788

Genome annotation databases

GeneIDi17069
KEGGimmu:17069

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09192 mRNA Translation: AAB03366.1 Different initiation.
U04268 mRNA Translation: AAA19121.1 Different initiation.
U47737 Genomic DNA Translation: AAB17698.1
RefSeqiNP_001157508.1, NM_001164036.1
NP_001157509.1, NM_001164037.1
NP_001157510.1, NM_001164038.1
NP_001157511.1, NM_001164039.1
NP_001157512.1, NM_001164040.1
NP_032555.1, NM_008529.3
UniGeneiMm.788

3D structure databases

ProteinModelPortaliQ64253
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201242, 1 interactor
IntActiQ64253, 1 interactor
STRINGi10090.ENSMUSP00000056703

PTM databases

PhosphoSitePlusiQ64253
SwissPalmiQ64253

Proteomic databases

EPDiQ64253
MaxQBiQ64253
PaxDbiQ64253
PeptideAtlasiQ64253
PRIDEiQ64253

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17069
KEGGimmu:17069

Organism-specific databases

CTDi4061
MGIiMGI:106651 Ly6e

Phylogenomic databases

eggNOGiENOG410IYXK Eukaryota
ENOG4111AYX LUCA
HOVERGENiHBG001732
InParanoidiQ64253
KOiK06846
PhylomeDBiQ64253

Miscellaneous databases

ChiTaRSiLy6e mouse
PROiPR:Q64253
SOURCEiSearch...

Gene expression databases

CleanExiMM_LY6E

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLY6E_MOUSE
AccessioniPrimary (citable) accession number: Q64253
Secondary accession number(s): Q61128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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