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Protein

Helix-loop-helix protein 2

Gene

Nhlh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • mating behavior Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • ovulation cycle Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Helix-loop-helix protein 2
Short name:
HEN-2
Alternative name(s):
Nescient helix loop helix 2
Short name:
NSCL-2
Gene namesi
Name:Nhlh2
Synonyms:Hen2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:97324 Nhlh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272001 – 135Helix-loop-helix protein 2Add BLAST135

Proteomic databases

PaxDbiQ64221
PRIDEiQ64221

PTM databases

PhosphoSitePlusiQ64221

Expressioni

Tissue specificityi

In developing neurons.

Developmental stagei

Markedly restricted pattern of expression predominantly confined to murine embryos at days 11-13 of development, although low level expression can be detected in murine embryos flanking this time point.

Gene expression databases

BgeeiENSMUSG00000048540
CleanExiMM_NHLH2
GenevisibleiQ64221 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Binary interactionsi

WithEntry#Exp.IntActNotes
Sirt1Q923E42EBI-5378529,EBI-1802585

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ64221, 1 interactor
STRINGi10090.ENSMUSP00000064355

Structurei

3D structure databases

ProteinModelPortaliQ64221
SMRiQ64221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 129bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 73Poly-Arg5

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000016617
HOVERGENiHBG016345
InParanoidiQ64221
KOiK09075
OMAiATLYPHP
OrthoDBiEOG091G0RR2

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q64221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSPDQAAD SDHPSSTHSD PESLGGADTK VLGSVSDLEP VEEADGDGKG
60 70 80 90 100
GSRAALYPHP QQLSREEKRR RRRATAKYRS AHATRERIRV EAFNLAFAEL
110 120 130
RKLLPTLPPD KKLSKIEILR LAICYISYLN HVLDV
Length:135
Mass (Da):15,004
Last modified:October 3, 2012 - v2
Checksum:iE7872BF22A601405
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → V in AAB22580 (PubMed:1633105).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40532 mRNA Translation: AAB22580.1
AK031747 mRNA Translation: BAC27535.1
AK053837 mRNA Translation: BAC35549.1
AK079121 mRNA Translation: BAC37549.1
AK082728 mRNA Translation: BAC38590.1
AK084160 mRNA Translation: BAC39129.1
AK140559 mRNA Translation: BAE24423.1
AC166072 Genomic DNA No translation available.
CH466608 Genomic DNA Translation: EDL07620.1
CH466608 Genomic DNA Translation: EDL07621.1
CH466608 Genomic DNA Translation: EDL07622.1
BC058413 mRNA Translation: AAH58413.1
CCDSiCCDS17685.1
PIRiA49005
RefSeqiNP_848892.1, NM_178777.3
XP_006501175.1, XM_006501112.2
UniGeneiMm.137286

Genome annotation databases

EnsembliENSMUST00000066187; ENSMUSP00000064355; ENSMUSG00000048540
ENSMUST00000196324; ENSMUSP00000142746; ENSMUSG00000048540
ENSMUST00000198675; ENSMUSP00000143362; ENSMUSG00000048540
GeneIDi18072
KEGGimmu:18072
UCSCiuc008qro.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHEN2_MOUSE
AccessioniPrimary (citable) accession number: Q64221
Secondary accession number(s): Q8BFV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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