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Protein

Homeobox protein DLX-3

Gene

Dlx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • blood vessel development Source: MGI
  • odontoblast differentiation Source: CACAO
  • odontogenesis of dentin-containing tooth Source: MGI
  • placenta development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-3
Gene namesi
Name:Dlx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94903 Dlx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490271 – 287Homeobox protein DLX-3Add BLAST287

Proteomic databases

PaxDbiQ64205
PRIDEiQ64205

PTM databases

iPTMnetiQ64205
PhosphoSitePlusiQ64205

Expressioni

Tissue specificityi

Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.

Gene expression databases

BgeeiENSMUSG00000001510 Expressed in 183 organ(s), highest expression level in skin of back
CleanExiMM_DLX3
ExpressionAtlasiQ64205 baseline and differential
GenevisibleiQ64205 MM

Interactioni

Subunit structurei

Heterodimer with MEIS1.By similarity

Protein-protein interaction databases

IntActiQ64205, 1 interactor
MINTiQ64205
STRINGi10090.ENSMUSP00000090443

Structurei

3D structure databases

ProteinModelPortaliQ64205
SMRiQ64205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 181Interaction with DNABy similarityAdd BLAST51

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231940
HOVERGENiHBG005493
InParanoidiQ64205
KOiK09315
OMAiSWYHTQN
OrthoDBiEOG091G0P17
PhylomeDBiQ64205
TreeFamiTF350606

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR022135 Distal-less_N
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF12413 DLL_N, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY
60 70 80 90 100
YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE
110 120 130 140 150
QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK
160 170 180 190 200
AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN
210 220 230 240 250
NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS PNYLDDPTNS
260 270 280
WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
Length:287
Mass (Da):31,791
Last modified:November 1, 1996 - v1
Checksum:i1F7DB917FC4C2158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA Translation: AAB33879.1
BC058852 mRNA Translation: AAH58852.1
CCDSiCCDS25272.1
RefSeqiNP_034185.1, NM_010055.3
UniGeneiMm.5194

Genome annotation databases

EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510
GeneIDi13393
KEGGimmu:13393
UCSCiuc007kzy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA Translation: AAB33879.1
BC058852 mRNA Translation: AAH58852.1
CCDSiCCDS25272.1
RefSeqiNP_034185.1, NM_010055.3
UniGeneiMm.5194

3D structure databases

ProteinModelPortaliQ64205
SMRiQ64205
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64205, 1 interactor
MINTiQ64205
STRINGi10090.ENSMUSP00000090443

PTM databases

iPTMnetiQ64205
PhosphoSitePlusiQ64205

Proteomic databases

PaxDbiQ64205
PRIDEiQ64205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510
GeneIDi13393
KEGGimmu:13393
UCSCiuc007kzy.2 mouse

Organism-specific databases

CTDi1747
MGIiMGI:94903 Dlx3

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231940
HOVERGENiHBG005493
InParanoidiQ64205
KOiK09315
OMAiSWYHTQN
OrthoDBiEOG091G0P17
PhylomeDBiQ64205
TreeFamiTF350606

Miscellaneous databases

PROiPR:Q64205
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001510 Expressed in 183 organ(s), highest expression level in skin of back
CleanExiMM_DLX3
ExpressionAtlasiQ64205 baseline and differential
GenevisibleiQ64205 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR022135 Distal-less_N
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF12413 DLL_N, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLX3_MOUSE
AccessioniPrimary (citable) accession number: Q64205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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