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UniProtKB - Q641Z7 (ASM3A_RAT)
Protein
Acid sphingomyelinase-like phosphodiesterase 3a
Gene
Smpdl3a
Organism
Rattus norvegicus (Rat)
Status
Functioni
Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.
By similarityCofactori
Zn2+By similarityNote: Binds 2 Zn2+ per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 42 | Zinc 1By similarity | 1 | |
Metal bindingi | 44 | Zinc 1By similarity | 1 | |
Metal bindingi | 107 | Zinc 1By similarity | 1 | |
Metal bindingi | 107 | Zinc 2By similarity | 1 | |
Binding sitei | 111 | SubstrateBy similarity | 1 | |
Metal bindingi | 148 | Zinc 2By similarity | 1 | |
Binding sitei | 148 | SubstrateBy similarity | 1 | |
Binding sitei | 149 | SubstrateBy similarity | 1 | |
Metal bindingi | 249 | Zinc 2By similarity | 1 | |
Metal bindingi | 290 | Zinc 2By similarity | 1 | |
Metal bindingi | 292 | Zinc 1By similarity | 1 |
GO - Molecular functioni
- phosphoric diester hydrolase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- nucleoside triphosphate catabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Acid sphingomyelinase-like phosphodiesterase 3a (EC:3.1.4.-)Short name: ASM-like phosphodiesterase 3a |
Gene namesi | Name:Smpdl3a Synonyms:Asml3a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359277, Smpdl3a |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000002330 | 23 – 445 | Acid sphingomyelinase-like phosphodiesterase 3aAdd BLAST | 423 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 59 ↔ 78 | By similarity | ||
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 219 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 235 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 353 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 364 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 417 ↔ 421 | Sequence analysis | ||
Disulfide bondi | 427 ↔ 440 | By similarity |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q641Z7 |
PTM databases
GlyGeni | Q641Z7, 6 sites |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000000815, Expressed in liver and 21 other tissues |
Genevisiblei | Q641Z7, RN |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000001081 |
Family & Domainsi
Sequence similaritiesi
Belongs to the acid sphingomyelinase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3770, Eukaryota |
GeneTreei | ENSGT00950000183182 |
HOGENOMi | CLU_014743_0_0_1 |
InParanoidi | Q641Z7 |
OMAi | SCHAPLE |
OrthoDBi | 1142100at2759 |
PhylomeDBi | Q641Z7 |
TreeFami | TF313674 |
Family and domain databases
CDDi | cd00842, MPP_ASMase, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR017064, ASM-like_Pdiesterase_prd IPR045473, ASM_C IPR041805, ASMase/PPN1_MPP IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like |
Pfami | View protein in Pfam PF19272, ASMase_C, 1 hit PF00149, Metallophos, 1 hit |
PIRSFi | PIRSF036767, ASM-like_PDE, 1 hit |
SUPFAMi | SSF56300, SSF56300, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q641Z7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPGNFLCC LLVAWLCDPG LGVPLAPAYG APAVGQFWHV TDLHLDPTYH
60 70 80 90 100
ITDDHTKVCA SSKGANVSNP GPFGDVLCDS PYQLILSAFD FIKNSGQEAS
110 120 130 140 150
FMIWTGDSPP HVPVRELSTG SVIEVITNMT VTVQNLFPNL QVFPALGNHD
160 170 180 190 200
YWPQDQLPIA TSKVYSAVSD LWKPWLDEEA ISTLRKGGFY SQKVASNPDL
210 220 230 240 250
RIISLNTNLY YGPNIMTLNK TDPANQFEWL ENTLNSSLRN KEKVYVIAHV
260 270 280 290 300
PVGYLPYATK TPAMRQYYNE KLVDIFRRYS SVIAGQFYGH THRDSLMVLS
310 320 330 340 350
DKNGNPINSV FVAPAVTPVK GVLEKETNNP GVRLFQYKPG DYTLLDMLQY
360 370 380 390 400
YLNLTEANLK GESNWTLEYT LTQAYGVADL QPKSLHGLAQ QLATIDSKQF
410 420 430 440
LKYYHYFFVS YDSSAPCDQR CKTLQICAIM NLDLVSYEDC LKRHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC082029 mRNA Translation: AAH82029.1 |
RefSeqi | NP_001005539.1, NM_001005539.1 |
Genome annotation databases
Ensembli | ENSRNOT00000001081; ENSRNOP00000001081; ENSRNOG00000000815 |
GeneIDi | 294422 |
KEGGi | rno:294422 |
UCSCi | RGD:1359277, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC082029 mRNA Translation: AAH82029.1 |
RefSeqi | NP_001005539.1, NM_001005539.1 |
3D structure databases
SMRi | Q641Z7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000001081 |
PTM databases
GlyGeni | Q641Z7, 6 sites |
Proteomic databases
PaxDbi | Q641Z7 |
Genome annotation databases
Ensembli | ENSRNOT00000001081; ENSRNOP00000001081; ENSRNOG00000000815 |
GeneIDi | 294422 |
KEGGi | rno:294422 |
UCSCi | RGD:1359277, rat |
Organism-specific databases
CTDi | 10924 |
RGDi | 1359277, Smpdl3a |
Phylogenomic databases
eggNOGi | KOG3770, Eukaryota |
GeneTreei | ENSGT00950000183182 |
HOGENOMi | CLU_014743_0_0_1 |
InParanoidi | Q641Z7 |
OMAi | SCHAPLE |
OrthoDBi | 1142100at2759 |
PhylomeDBi | Q641Z7 |
TreeFami | TF313674 |
Miscellaneous databases
PROi | PR:Q641Z7 |
Gene expression databases
Bgeei | ENSRNOG00000000815, Expressed in liver and 21 other tissues |
Genevisiblei | Q641Z7, RN |
Family and domain databases
CDDi | cd00842, MPP_ASMase, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR017064, ASM-like_Pdiesterase_prd IPR045473, ASM_C IPR041805, ASMase/PPN1_MPP IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like |
Pfami | View protein in Pfam PF19272, ASMase_C, 1 hit PF00149, Metallophos, 1 hit |
PIRSFi | PIRSF036767, ASM-like_PDE, 1 hit |
SUPFAMi | SSF56300, SSF56300, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASM3A_RAT | |
Accessioni | Q641Z7Primary (citable) accession number: Q641Z7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | October 25, 2004 | |
Last modified: | February 23, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families