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Entry version 120 (26 Feb 2020)
Sequence version 3 (05 Feb 2008)
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Protein

WASH complex subunit 2A

Gene

WASHC2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-4P), phosphatidylinositol 5-phosphate (PtdIns-5P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L.2 Publications

Miscellaneous

In human, WASHC2 has undergone evolutionary duplication, with 4 highly homologous family members existing, including WASHC2A, WASHC2C, and an N-terminally truncated WASHC2D form.

Caution

A WASHC2C construct with WASHC2A-specific sequence insertions has been used in a number of experiments; the results are included in the WASHC2C entry.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.3.1.2 the sorting nexin27 (snx27)-retromer assembly apparatus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WASH complex subunit 2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WASHC2AImported
Synonyms:FAM21AImported, FAM21BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23416 WASHC2A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q641Q2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134902481

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q641Q2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WASHC2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166971555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172991 – 1341WASH complex subunit 2AAdd BLAST1341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei539PhosphoserineCombined sources1
Modified residuei1054PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1114PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q641Q2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q641Q2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q641Q2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q641Q2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q641Q2

PeptideAtlas

More...
PeptideAtlasi
Q641Q2

PRoteomics IDEntifications database

More...
PRIDEi
Q641Q2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63762
65910 [Q641Q2-1]
65911 [Q641Q2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q641Q2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q641Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099290 Expressed in frontal cortex and 94 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q641Q2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q641Q2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047844
HPA060975
HPA061022

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5; in the complex interacts (via N-terminus) directly with WASHC1. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex.

Interacts with VPS35; mediates the association with the retromer CSC complex.

Interacts with FKBP15.

Interacts with CCDC93, CCDC22, VPS35L; indicative for an association of the WASH core complex with the CCC and retriever complexes (PubMed:25355947). Directly interacts with TBC1D23 (PubMed:29084197).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132390, 45 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1172 WASH complex, variant WASHC1/WASHC2A
CPX-1173 WASH complex, variant WASH2P/WASHC2A
CPX-1174 WASH complex, variant WASH3P/WASHC2A
CPX-1175 WASH complex, variant WASH4P/WASHC2A
CPX-1176 WASH complex, variant WASH6P/WASHC2A

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q641Q2

Protein interaction database and analysis system

More...
IntActi
Q641Q2, 34 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282633

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q641Q2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q641Q2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 220Sufficient for interaction with WASHC3, WASHC4 and WASHC5; required for interaction with WASHC1By similarityAdd BLAST220
Regioni356 – 742Required for interaction with CCDC22 and VPS35L1 PublicationAdd BLAST387
Regioni356 – 600Sufficient for interaction with CCDC931 PublicationAdd BLAST245
Regioni357 – 1341Interaction with VPS35By similarityAdd BLAST985
Regioni937 – 1341Interaction with phospholipidsBy similarityAdd BLAST405
Regioni1029 – 1047Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3)By similarityAdd BLAST19

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi367 – 378LFa 1By similarityAdd BLAST12
Motifi411 – 419LFa 2By similarity9
Motifi450 – 463LFa 3By similarityAdd BLAST14
Motifi482 – 491LFa 4By similarity10
Motifi537 – 548LFa 5By similarityAdd BLAST12
Motifi572 – 583LFa 6By similarityAdd BLAST12
Motifi617 – 629LFa 7By similarityAdd BLAST13
Motifi664 – 674LFa 8By similarityAdd BLAST11
Motifi690 – 702LFa 9By similarityAdd BLAST13
Motifi726 – 738LFa 10By similarityAdd BLAST13
Motifi803 – 817LFa 11By similarityAdd BLAST15
Motifi839 – 847LFa 12By similarity9
Motifi856 – 862LFa 13By similarity7
Motifi878 – 888LFa 14By similarityAdd BLAST11
Motifi1129 – 1136LFa 15By similarity8
Motifi1171 – 1185LFa 16By similarityAdd BLAST15
Motifi1201 – 1209LFa 17By similarity9
Motifi1234 – 1240LFa 18By similarity7
Motifi1262 – 1270LFa 19By similarity9
Motifi1290 – 1299LFa 20By similarity10
Motifi1330 – 1338LFa 21By similarity9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LFa (leucine-phenylalanine-acidic) motif bind directly to VPS35 of retromer CSC; adjacent motifs can act cooperatively to bind multiple CSCs, although there is significant variability in the affinities of different motifs for retromer.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEJH Eukaryota
ENOG4110AMY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153997

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q641Q2

KEGG Orthology (KO)

More...
KOi
K18462

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIHTIFY

Database of Orthologous Groups

More...
OrthoDBi
131637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q641Q2

TreeFam database of animal gene trees

More...
TreeFami
TF329309

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029341 FAM21/CAPZIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15255 CAP-ZIP_m, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q641Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNRTTPDQE LAPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF
60 70 80 90 100
SQQTISRTHE IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY
110 120 130 140 150
DEEVEEPVLK AEAEKTEQEK TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ
160 170 180 190 200
LDIKAGNSDS EEDDANGRVE LILEPKDLYI DRPLPYLIGS KLFMEQEDVG
210 220 230 240 250
LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN EQNRHTTQMS
260 270 280 290 300
DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD
310 320 330 340 350
AVGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED
360 370 380 390 400
FSPFGSGGGL FSGGKGLFDD EDEESDLFTE APQDRQAGAS VKEESSSSKP
410 420 430 440 450
GKKIPAGAVS VFLGDTDVFG AASVPSMKEP QKPEQPTPRK SPYGPPPTGL
460 470 480 490 500
FDDDDGDDDD DFFSAPHSKP SKTGKVQSTA DIFGDEEGDL FKEKAVASPE
510 520 530 540 550
ATVSQTDENK ARAEKKVTLS SSKNLKPSSE TKTQKGLFSD EEDSEDLFSS
560 570 580 590 600
QSASKLKGAS LLPGKLPTLV SLFDDEDEED NLFGGTAAKK QTLCLQAQRE
610 620 630 640 650
EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT
660 670 680 690 700
LQSQEAKAVK KTSLFEEDEE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS
710 720 730 740 750
LFGSPPTSVP PATKKKETVS EAPPLLFSDE EEKEAQLGVK SVDKKVESAK
760 770 780 790 800
ESLKFGRTDV AESEKEGLLT RSAQETVKHS DLFSSSSPWD KGTKPRTKTV
810 820 830 840 850
LSLFDEEEDK MEDQNIIQAP QKEVGKGRDP DAHPKSTGVF QDEELLFSHK
860 870 880 890 900
LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK
910 920 930 940 950
KRVVKKDHSV DSFKNQKHPE SIQGSKEKGI WKPETPQDSS GLAPFKTKEP
960 970 980 990 1000
STRIGKIQAN LAINPAALLP TAASQISEVK PVLPELAFPS SEHRRSHGLE
1010 1020 1030 1040 1050
SVPVLPGSGE AGVSFDLPAQ ADTLHSANKS RVKMRGKRRP QTRAARRLAA
1060 1070 1080 1090 1100
QESSETEDMS VPRGPIAQWA DGAISPNGHR PQLRAASGED STEEALAAAA
1110 1120 1130 1140 1150
APWEGGPVPG VDRSPFAKSL GHSRGEADLF DSGDIFSTGT GSQSVERTKP
1160 1170 1180 1190 1200
KAKIAENPAN PPVGGKAKSP MFPALGEASS DDDLFQSAKP KPAKKTNPFP
1210 1220 1230 1240 1250
LLEDEDDLFT DQKVKKNETK SNSQQDVILT TQDIFEDDIF ATEAIKPSQK
1260 1270 1280 1290 1300
TREKEKTLES NLFDDNIDIF ADLTVKPKEK SKKKVEAKSI FDDDMDDIFS
1310 1320 1330 1340
SGIQAKTTKP KSRSAQAAPE PRFEHKVSNI FDDPLNAFGG Q
Length:1,341
Mass (Da):147,184
Last modified:February 5, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F0F755EB1493EA7
GO
Isoform 2 (identifier: Q641Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     938-958: Missing.

Show »
Length:1,320
Mass (Da):144,941
Checksum:i64417D36898CFFBF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESD2E7ESD2_HUMAN
WASH complex subunit 2A
WASHC2A
1,279Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYF6A0A087WYF6_HUMAN
WASH complex subunit 2A
WASHC2A
1,245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7U3F8W7U3_HUMAN
WASH complex subunit 2A
WASHC2A
1,253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AP61B1AP61_HUMAN
WASH complex subunit 2A
WASHC2A
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T1D7Q5T1D7_HUMAN
WASH complex subunit 2A
WASHC2A
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI17187 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti342A → T in CAI17187 (PubMed:15164054).Curated1
Sequence conflicti444G → E in AAH75815 (PubMed:15489334).Curated1
Sequence conflicti569L → S in CAI17187 (PubMed:15164054).Curated1
Sequence conflicti698G → R in CAI17187 (PubMed:15164054).Curated1
Sequence conflicti816I → T in AAH75815 (PubMed:15489334).Curated1
Sequence conflicti997H → Y in AAH82258 (PubMed:15489334).Curated1
Sequence conflicti1198P → T in CAI17187 (PubMed:15164054).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030948938 – 958Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL442003 Genomic DNA No translation available.
AL450382 Genomic DNA No translation available.
AL954360 Genomic DNA Translation: CAI17187.1 Sequence problems.
BC075815 mRNA Translation: AAH75815.1
BC082258 mRNA Translation: AAH82258.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS41527.1 [Q641Q2-1]
CCDS76303.1 [Q641Q2-2]

NCBI Reference Sequences

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RefSeqi
NP_001005751.1, NM_001005751.2 [Q641Q2-1]
NP_001278327.1, NM_001291398.1 [Q641Q2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000282633; ENSP00000282633; ENSG00000099290 [Q641Q2-1]
ENST00000351071; ENSP00000344037; ENSG00000099290 [Q641Q2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
387680

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:387680

UCSC genome browser

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UCSCi
uc001jjb.4 human [Q641Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442003 Genomic DNA No translation available.
AL450382 Genomic DNA No translation available.
AL954360 Genomic DNA Translation: CAI17187.1 Sequence problems.
BC075815 mRNA Translation: AAH75815.1
BC082258 mRNA Translation: AAH82258.2
CCDSiCCDS41527.1 [Q641Q2-1]
CCDS76303.1 [Q641Q2-2]
RefSeqiNP_001005751.1, NM_001005751.2 [Q641Q2-1]
NP_001278327.1, NM_001291398.1 [Q641Q2-2]

3D structure databases

SMRiQ641Q2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi132390, 45 interactors
ComplexPortaliCPX-1172 WASH complex, variant WASHC1/WASHC2A
CPX-1173 WASH complex, variant WASH2P/WASHC2A
CPX-1174 WASH complex, variant WASH3P/WASHC2A
CPX-1175 WASH complex, variant WASH4P/WASHC2A
CPX-1176 WASH complex, variant WASH6P/WASHC2A
CORUMiQ641Q2
IntActiQ641Q2, 34 interactors
STRINGi9606.ENSP00000282633

Protein family/group databases

TCDBi9.A.3.1.2 the sorting nexin27 (snx27)-retromer assembly apparatus

PTM databases

iPTMnetiQ641Q2
PhosphoSitePlusiQ641Q2

Polymorphism and mutation databases

BioMutaiWASHC2A
DMDMi166971555

Proteomic databases

EPDiQ641Q2
jPOSTiQ641Q2
MassIVEiQ641Q2
MaxQBiQ641Q2
PaxDbiQ641Q2
PeptideAtlasiQ641Q2
PRIDEiQ641Q2
ProteomicsDBi63762
65910 [Q641Q2-1]
65911 [Q641Q2-2]

Genome annotation databases

EnsembliENST00000282633; ENSP00000282633; ENSG00000099290 [Q641Q2-1]
ENST00000351071; ENSP00000344037; ENSG00000099290 [Q641Q2-2]
GeneIDi387680
KEGGihsa:387680
UCSCiuc001jjb.4 human [Q641Q2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
387680

GeneCards: human genes, protein and diseases

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GeneCardsi
WASHC2A
HGNCiHGNC:23416 WASHC2A
HPAiHPA047844
HPA060975
HPA061022
neXtProtiNX_Q641Q2
PharmGKBiPA134902481

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEJH Eukaryota
ENOG4110AMY LUCA
GeneTreeiENSGT00940000153997
InParanoidiQ641Q2
KOiK18462
OMAiRIHTIFY
OrthoDBi131637at2759
PhylomeDBiQ641Q2
TreeFamiTF329309

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WASHC2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
387680
PharosiQ641Q2 Tdark

Protein Ontology

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PROi
PR:Q641Q2
RNActiQ641Q2 protein

Gene expression databases

BgeeiENSG00000099290 Expressed in frontal cortex and 94 other tissues
ExpressionAtlasiQ641Q2 baseline and differential
GenevisibleiQ641Q2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029341 FAM21/CAPZIP
PfamiView protein in Pfam
PF15255 CAP-ZIP_m, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWAC2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q641Q2
Secondary accession number(s): A2A3S2
, A2A3U6, Q5SNT6, Q6DHY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 26, 2020
This is version 120 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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