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Entry version 121 (12 Aug 2020)
Sequence version 2 (23 Oct 2007)
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Protein

Cytosolic carboxypeptidase 1

Gene

Agtpbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins (PubMed:30420557). Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell differentiation, accumulation of tubulin polyglutamylation causing neurodegeneration.3 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi912ZincCurated1
Metal bindingi915ZincCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei962NucleophileBy similarity1
Metal bindingi1009ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic carboxypeptidase 1 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein 1
Nervous system nuclear protein induced by axotomy protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Agtpbp1
Synonyms:Ccp1, Nna1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2159437, Agtpbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Agtpbp1 are the cause of Purkinje cell degeneration (pcd). Pcd is a spontaneous mutation that results in adult-onset degeneration of cerebellar Purkinje neurons, retinal photoreceptors, olfactory bulb mitral neurons and selected thalamic neurons, and causes defective spermatogenesis. Pcd mice also manifest cerebellar atrophy and a peripheral nerve degeneration resulting in pure motor or motor-predominant neuropathy. Motoric femoral quadriceps nerves are characterized by reduced total calibers, a loss of myelinated axons, perturbed axon morphology, and macrophage activation. The amount of motor neurons in the ventral horns of lumbar spinal cords is reduced. These anomalies are accompanied by dysregulated tubulin polyglutamylation (PubMed:30420557). Defects in mitochondrial metabolic functions are also observed. The molecular causes of neurodegeneration are probably due to an accumulation of glutamylation, either tubulin hyperglutamylation or another hyperglutamylated target proteins. An increase of intranuclear localization of lysyl oxidase (Lox) propeptide, which interferes with NF-kappa-B Rela signaling and microtubule-associated protein regulation of microtubule stability is also observed, possibly leading to underdevelopment of Purkinje cell dendrites.9 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi686Y → D: Decreased tubulin deglutamylation. 1 Publication1
Mutagenesisi843T → M: Decreased tubulin deglutamylation. 1 Publication1
Mutagenesisi910R → W: Decreased tubulin deglutamylation. 1 Publication1
Mutagenesisi912H → A: Abolishes ability to rescue Purkinje cell degeneration in pcd mice when expressed in a transgene. 3 Publications1
Mutagenesisi912H → S: Abolishes deglutamylase activity; when associated with Q-915. 3 Publications1
Mutagenesisi915E → A: Abolishes ability to rescue Purkinje cell degeneration in pcd mice when expressed in a transgene. 3 Publications1
Mutagenesisi915E → Q: Abolishes deglutamylase activity; when associated with S-912. 3 Publications1
Mutagenesisi971 – 972NR → AA: Abolishes ability to rescue Purkinje cell degeneration in pcd mice when expressed in a transgene. 1 Publication2
Mutagenesisi982H → L: Decreased tubulin deglutamylation. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003086911 – 1218Cytosolic carboxypeptidase 1Add BLAST1218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1160PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q641K1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q641K1

PRoteomics IDEntifications database

More...
PRIDEi
Q641K1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q641K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q641K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in the cerebellum and cortex of adult mouse brain. Expressed at similar levels in both the cerebellum and the cortex throughout all developmental stages. Also expressed in sciatic nerve transection, spinal motor neurons undergoing axon regeneration, testis, heart and in developing brain. Expression in cranial motor nuclei is the same as that observed in uninjured primary motor neurons. Expression is prevalent in sensory neurons and hippocampal CA3 neurons in addition to regenerating motor neurons.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in differentiating neurons. From 16.5 dpc, expression is widespread in brain, spinal cord, and peripheral nervous tissue. Within the developing CNS, expression is restricted to regions of brain and spinal cord containing differentiating neurons.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By axonal regeneration.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021557, Expressed in spermatid and 305 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q641K1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYLK.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212061, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022040

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q641K1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3641, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157707

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007391_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q641K1

KEGG Orthology (KO)

More...
KOi
K23435

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVATCGN

Database of Orthologous Groups

More...
OrthoDBi
481670at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q641K1

TreeFam database of animal gene trees

More...
TreeFami
TF313794

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q641K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKLKVVGEK SLTNSSRVVG LLAQLEKINT DSTESDTARY VTSKILHLAQ
60 70 80 90 100
SQEKTRREMT TKGSTGMEVL LSTLENTKDL QTVLNILSIL IELVSSGGGR
110 120 130 140 150
RASFLVAKGG SQILLQLLMN ASKDSPPHEE VMVQTHSILA KIGPKDKKFG
160 170 180 190 200
VKARVNGALT VTLNLVKQHF QNYRLVLPCL QLLRVYSTNS VNSVSLGKNG
210 220 230 240 250
VVELMFKIIG PFSKKNSGLM KVALDTLAAL LKSKTNARRA VDRGYVQVLL
260 270 280 290 300
TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN
310 320 330 340 350
TSQECLAVRT LDPLVNTSSL IMRKCFPKNR LPLPTIKSSF HFQLPIIPVT
360 370 380 390 400
GPVAQLYSLP PEVDDVVDES DDNDDIDLEV ENELENEDDL DQSFKNDDIE
410 420 430 440 450
TDINKLRPQQ VPGRTIEELK MYEHLFPELV DDFQDYELIS KEPKPFVFEG
460 470 480 490 500
KARGPIVVPT AGEEVPGNSG SVKKGVVMKE RASPKGEEAK EDPKGHDRTL
510 520 530 540 550
PQQLGGQSRV APSAHSFNND LVKALDRITL QNVPSQVASG LNAGMRKDFG
560 570 580 590 600
LPLTVLSCTK ACPHVAKCGS TLFEGRTVHL GKLCCTGVET EDDEDTESHS
610 620 630 640 650
STEQAPSVEA SDGPTLHDPD LYIEIVKNTK SVPEYSEVAY PDYFGHIPPP
660 670 680 690 700
FKEPILERPY GVQRTKIAQD IERLIHQNDI IDRVVYDLDN PTYTTPEEGD
710 720 730 740 750
TLKFNSKFES GNLRKVIQIR KSEYDLILNS DINSNHYHQW FYFEVSGMRP
760 770 780 790 800
GVAYRFNIIN CEKSNSQFNY GMQPLMYSVQ EALNARPWWI RMGTDICYYK
810 820 830 840 850
NHFSRSSVAA GGQKGKSYYT ITFTVNFPHK DDVCYFAYHY PYTYSTLQMH
860 870 880 890 900
LQKLESAHNP QQIYFRKDVL CETLSGNICP LVTITAMPES NYYEHICQFR
910 920 930 940 950
TRPYIFLSAR VHPGETNASW VMKGTLEYLM SNSPTAQSLR ESYIFKIVPM
960 970 980 990 1000
LNPDGVINGN HRCSLSGEDL NRQWQSPNPE LHPTIYHAKG LLQYLAAVKR
1010 1020 1030 1040 1050
LPLVYCDYHG HSRKKNVFMY GCSIKETVWH THDNSASCDI VEDMGYRTLP
1060 1070 1080 1090 1100
KILSHIAPAF CMSSCSFVVE KSKESTARVV VWREIGVQRS YTMESTLCGC
1110 1120 1130 1140 1150
DQGRYKGLQI GTRELEEMGA KFCVGLLRLK RLTSSLEYNL PSNLLDFEND
1160 1170 1180 1190 1200
LIESSCKVTS PTTYVLDEDE PRFLEEVDYS AESNDELDVE LAENTGDYEP
1210
SAQEEALSDS EVSRTHLI
Length:1,218
Mass (Da):137,197
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89917C6897AD9DD5
GO
Isoform 2 (identifier: Q641K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1160-1174: SPTTYVLDEDEPRFL → RTRGSSELQLFPAVL
     1175-1218: Missing.

Show »
Length:1,174
Mass (Da):132,220
Checksum:iD1C7D2CFAFB5D0EA
GO
Isoform 3 (identifier: Q641K1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-795: GMQPLMYSVQEALNARPWWIRMGTD → EITSHEAQLPQADRRASPTTPSPSP
     796-1218: Missing.

Note: Apparent retained intron. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:795
Mass (Da):88,657
Checksum:iDE3C127579DC21F3
GO
Isoform 4 (identifier: Q641K1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-789: GMQPLMYSVQEALNARPWW → DGEETCYKMIVVSTICCKD
     790-1218: Missing.

Show »
Length:789
Mass (Da):88,120
Checksum:iF765D2CD582ABE31
GO
Isoform 5 (identifier: Q641K1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     689-1218: Missing.

Show »
Length:688
Mass (Da):76,297
Checksum:iB1779CDF33BDDE52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZCF0F6ZCF0_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PYF9E9PYF9_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PXA7E9PXA7_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C1R2Q8C1R2_MOUSE
Agtpbp1 protein
Agtpbp1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PX07E9PX07_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q352E9Q352_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2R5E9Q2R5_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q3T5E9Q3T5_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q878E9Q878_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCK8A0A286YCK8_MOUSE
Cytosolic carboxypeptidase 1
Agtpbp1
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG37102 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237A → V in AAG37102 (PubMed:11083920).Curated1
Sequence conflicti274Q → R in AAG37102 (PubMed:11083920).Curated1
Sequence conflicti380V → A in BC060633 (PubMed:15489334).Curated1
Sequence conflicti542 – 548NAGMRKD → ERRNEEG in AAG37102 (PubMed:11083920).Curated7
Sequence conflicti644F → S in AAG37102 (PubMed:11083920).Curated1
Sequence conflicti969D → G in AAG37102 (PubMed:11083920).Curated1
Sequence conflicti1043D → G in AAG37102 (PubMed:11083920).Curated1
Sequence conflicti1121K → Q in AAG37102 (PubMed:11083920).Curated1
Sequence conflicti1126L → I in BAC25412 (PubMed:16141072).Curated1
Sequence conflicti1167D → G in BAB24963 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti832D → DD in pcd; pcd(5J) mutant. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038804689 – 1218Missing in isoform 5. 1 PublicationAdd BLAST530
Alternative sequenceiVSP_029045771 – 795GMQPL…RMGTD → EITSHEAQLPQADRRASPTT PSPSP in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_038803771 – 789GMQPL…ARPWW → DGEETCYKMIVVSTICCKD in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_038805790 – 1218Missing in isoform 4. 1 PublicationAdd BLAST429
Alternative sequenceiVSP_029046796 – 1218Missing in isoform 3. 1 PublicationAdd BLAST423
Alternative sequenceiVSP_0290471160 – 1174SPTTY…EPRFL → RTRGSSELQLFPAVL in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0290481175 – 1218Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF219141 mRNA Translation: AAG37102.1 Different initiation.
AK007328 mRNA Translation: BAB24963.2
AK013688 mRNA Translation: BAC25412.1
AK132695 mRNA Translation: BAE21306.1
AK170046 mRNA Translation: BAE41530.1
BC082335 mRNA Translation: AAH82335.1
BC060633 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36686.1 [Q641K1-1]
CCDS36687.1 [Q641K1-4]
CCDS70470.1 [Q641K1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001041473.1, NM_001048008.2 [Q641K1-4]
NP_001271147.1, NM_001284218.1 [Q641K1-4]
NP_001271148.1, NM_001284219.1
NP_001271150.1, NM_001284221.1 [Q641K1-2]
NP_075817.2, NM_023328.3 [Q641K1-1]
XP_006517398.1, XM_006517335.2
XP_006517399.1, XM_006517336.3 [Q641K1-1]
XP_006517400.1, XM_006517337.3 [Q641K1-1]
XP_006517401.1, XM_006517338.3 [Q641K1-1]
XP_011242857.1, XM_011244555.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022040; ENSMUSP00000022040; ENSMUSG00000021557 [Q641K1-1]
ENSMUST00000109830; ENSMUSP00000105456; ENSMUSG00000021557 [Q641K1-4]
ENSMUST00000164215; ENSMUSP00000130939; ENSMUSG00000021557 [Q641K1-2]
ENSMUST00000170555; ENSMUSP00000128589; ENSMUSG00000021557 [Q641K1-3]
ENSMUST00000171606; ENSMUSP00000132697; ENSMUSG00000021557 [Q641K1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67269

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67269

UCSC genome browser

More...
UCSCi
uc007qum.1, mouse [Q641K1-1]
uc007quq.2, mouse [Q641K1-4]
uc033gmf.1, mouse [Q641K1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219141 mRNA Translation: AAG37102.1 Different initiation.
AK007328 mRNA Translation: BAB24963.2
AK013688 mRNA Translation: BAC25412.1
AK132695 mRNA Translation: BAE21306.1
AK170046 mRNA Translation: BAE41530.1
BC082335 mRNA Translation: AAH82335.1
BC060633 mRNA No translation available.
CCDSiCCDS36686.1 [Q641K1-1]
CCDS36687.1 [Q641K1-4]
CCDS70470.1 [Q641K1-2]
RefSeqiNP_001041473.1, NM_001048008.2 [Q641K1-4]
NP_001271147.1, NM_001284218.1 [Q641K1-4]
NP_001271148.1, NM_001284219.1
NP_001271150.1, NM_001284221.1 [Q641K1-2]
NP_075817.2, NM_023328.3 [Q641K1-1]
XP_006517398.1, XM_006517335.2
XP_006517399.1, XM_006517336.3 [Q641K1-1]
XP_006517400.1, XM_006517337.3 [Q641K1-1]
XP_006517401.1, XM_006517338.3 [Q641K1-1]
XP_011242857.1, XM_011244555.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi212061, 2 interactors
STRINGi10090.ENSMUSP00000022040

PTM databases

iPTMnetiQ641K1
PhosphoSitePlusiQ641K1

Proteomic databases

EPDiQ641K1
PaxDbiQ641K1
PRIDEiQ641K1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27717, 328 antibodies

Genome annotation databases

EnsembliENSMUST00000022040; ENSMUSP00000022040; ENSMUSG00000021557 [Q641K1-1]
ENSMUST00000109830; ENSMUSP00000105456; ENSMUSG00000021557 [Q641K1-4]
ENSMUST00000164215; ENSMUSP00000130939; ENSMUSG00000021557 [Q641K1-2]
ENSMUST00000170555; ENSMUSP00000128589; ENSMUSG00000021557 [Q641K1-3]
ENSMUST00000171606; ENSMUSP00000132697; ENSMUSG00000021557 [Q641K1-4]
GeneIDi67269
KEGGimmu:67269
UCSCiuc007qum.1, mouse [Q641K1-1]
uc007quq.2, mouse [Q641K1-4]
uc033gmf.1, mouse [Q641K1-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23287
MGIiMGI:2159437, Agtpbp1

Phylogenomic databases

eggNOGiKOG3641, Eukaryota
GeneTreeiENSGT00940000157707
HOGENOMiCLU_007391_0_0_1
InParanoidiQ641K1
KOiK23435
OMAiHVATCGN
OrthoDBi481670at2759
PhylomeDBiQ641K1
TreeFamiTF313794

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67269, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Agtpbp1, mouse

Protein Ontology

More...
PROi
PR:Q641K1
RNActiQ641K1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021557, Expressed in spermatid and 305 other tissues
GenevisibleiQ641K1, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14
PfamiView protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q641K1
Secondary accession number(s): Q3TDS0
, Q3V147, Q6P9R9, Q8C1K8, Q9D962, Q9EQI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: August 12, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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