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UniProtKB - Q641G3 (CCAR1_XENLA)

Entry version 74 (12 Aug 2020)
Sequence version 1 (25 Oct 2004)
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Protein

Cell division cycle and apoptosis regulator protein 1

Gene

ccar1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for nuclear receptors which may play an important role in regulating cell growth and apoptosis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processCell cycle, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle and apoptosis regulator protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccar1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-989032, ccar1.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331501 – 1157Cell division cycle and apoptosis regulator protein 1Add BLAST1157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1157PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q641G3

PRoteomics IDEntifications database

More...PRIDEi		Q641G3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		607867, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q641G3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q641G3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini643 – 677SAPPROSITE-ProRule annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili601 – 625Sequence analysisAdd BLAST25
Coiled coili1043 – 1128Sequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi48 – 84Ala-richAdd BLAST37
Compositional biasi300 – 368Arg-richAdd BLAST69
Compositional biasi680 – 725Glu-richAdd BLAST46
Compositional biasi824 – 908Asp-richAdd BLAST85

Keywords - Domaini

Coiled coil

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		614048at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025224, CCAR1/CCAR2
IPR025954, DBC1/CARP1_inactive_NUDIX_dom
IPR011992, EF-hand-dom_pair
IPR025223, S1-like_RNA-bd_dom
IPR003034, SAP_dom
IPR036361, SAP_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14304, PTHR14304, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14443, DBC1, 1 hit
PF14444, S1-like, 1 hit
PF02037, SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01122, DBC1, 1 hit
SM00513, SAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF68906, SSF68906, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50800, SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q641G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQFGGQKNP PPWATQFTAT AVSQPGPLAV QQSSLLGASP TIYTQQSALA 
        60         70         80         90        100
AAGLASPSPA NYQLSQTAAL QQQAAAAAAA AAAALQQQYT QPQQTIYSVQ 
       110        120        130        140        150
QQLQPPPQAI LTQPAVALPT SLALSTPQQA AQITVSYPTP RSNQQQTQPQ 
       160        170        180        190        200
KQRVFTGVVT KLHETFGFVD EDVFFQLTAV KGKSPQAGDR VLVEATYNPN 
       210        220        230        240        250
MPFKWNAQRI QTLPNQNPAS AQSLIKNPAA VMQPVAQPTA YAVQTQPPPQ 
       260        270        280        290        300
AQTLLQAQIS AATLTPLLQT QTSPLLQQPQ QKAGLLQTPV RIVSQPQPVR 
       310        320        330        340        350
RIEPPSRFSV RNDRGDSILS RKDDRNRERE RERRRSRDRS PQRKRSRERS 
       360        370        380        390        400
PRRERERSPR RPRRVVPRYT VQISKFCLDC PGCDTMELRR RYQNLYIPSD 
       410        420        430        440        450
FFDAQFTWVD AFPISRPFQL GNYSNFYIMH KEVDPLEKNT AIVDPPDADH 
       460        470        480        490        500
TYSAKVMLLA SPSLEELYHK SCALAEDPIE VREGFQHPAR LIKFLVGMKG 
       510        520        530        540        550
KDEAMAIGGH WSPSLDGPNP DKDPSVLIRT AVRCCKALTG IELSLCTQWY 
       560        570        580        590        600
RFAEIRYHRP EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWENLCHGY 
       610        620        630        640        650
KQQLVDKLQG DRKEADGEQE EEDKEDGDAK EISTPTHWSK LDPKIMKVND 
       660        670        680        690        700
LRKELESRTL SSKGLKSQLI ARLTKQLRIE EQKEEQKELE KCEKEEEEEE 
       710        720        730        740        750
ERKSEDDKEE EERKRQEELE RQRREKRYML PDEPAIIVHP NWSAKNGKFD 
       760        770        780        790        800
CSIMSLSVLL DYRIEDNKEH SFEVSLFAEL FNEMLQRDFG VRIYRELLAL 
       810        820        830        840        850
PEKEEKKDKE KKCKKEDKRE RKEDKDDDDE PKPKRRKSSD DKIKLEEKEE 
       860        870        880        890        900
RKRDDRRKED YREEDDPDYE NQDDYEPIAA EEDDGDYDDR EDDDDDSSSK 
       910        920        930        940        950
DKREDKRDGN RYSKERQSKD KEKDKKQMVT VNRDLLMAFV YFDQSHCGYL 
       960        970        980        990       1000
LEKDLEEILY TLGLHLSRAQ VKKLFTKILL KESLLYRKLT DTATEDGSHE 
      1010       1020       1030       1040       1050
ETDPLHNDIL GNCSLLPSKA VRTGLSTVED KGGLIVYKGA MVDVGSLLQK 
      1060       1070       1080       1090       1100
LEKSEKTRTE LEHRLQTLES KTEEDEKTIS QLEASNRNLS EELKQTKDDV 
      1110       1120       1130       1140       1150
GHLKDSLKAA EDTRSLYEDQ LTNTIKNLSA AMGEIQVVLN KNPSTTEDQK 

SKENGSS
Length:1,157
Mass (Da):132,502
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E6ED4AA8D39C3FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC082374 mRNA Translation: AAH82374.1

NCBI Reference Sequences

More...RefSeqi		NP_001090254.1, NM_001096785.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		779160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:779160

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082374 mRNA Translation: AAH82374.1
RefSeqiNP_001090254.1, NM_001096785.1

3D structure databases

SMRiQ641G3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi607867, 1 interactor
IntActiQ641G3, 1 interactor

Proteomic databases

MaxQBiQ641G3
PRIDEiQ641G3

Genome annotation databases

GeneIDi779160
KEGGixla:779160

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		779160
XenbaseiXB-GENE-989032, ccar1.L

Phylogenomic databases

OrthoDBi614048at2759

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR025224, CCAR1/CCAR2
IPR025954, DBC1/CARP1_inactive_NUDIX_dom
IPR011992, EF-hand-dom_pair
IPR025223, S1-like_RNA-bd_dom
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
PANTHERiPTHR14304, PTHR14304, 1 hit
PfamiView protein in Pfam
PF14443, DBC1, 1 hit
PF14444, S1-like, 1 hit
PF02037, SAP, 1 hit
SMARTiView protein in SMART
SM01122, DBC1, 1 hit
SM00513, SAP, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF68906, SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800, SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCAR1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q641G3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 25, 2004
Last modified: August 12, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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