UniProtKB - Q64176 (EST1E_MOUSE)
Protein
Carboxylesterase 1E
Gene
Ces1e
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 222 | Acyl-ester intermediatePROSITE-ProRule annotation | 1 | |
Active sitei | 354 | Charge relay systemBy similarity | 1 | |
Active sitei | 467 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: MGI
- methyl indole-3-acetate esterase activity Source: UniProtKB-EC
- palmitoyl-CoA hydrolase activity Source: MGI
- sterol esterase activity Source: GO_Central
- triglyceride lipase activity Source: GO_Central
GO - Biological processi
- lipid catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Serine esterase |
Protein family/group databases
ESTHERi | mouse-Ces1e, Carb_B_Chordata |
Names & Taxonomyi
Protein namesi | Recommended name: Carboxylesterase 1ECurated (EC:3.1.1.1PROSITE-ProRule annotation)Alternative name(s): Egasyn Liver carboxylesterase 22 Short name: Es-22 Short name: Esterase-22 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95432, Ces1e |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen By similarity
- Microsome membrane By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: MGI
- organelle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
ChainiPRO_0000008576 | 20 – 562 | Carboxylesterase 1EAdd BLAST | 543 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 88 ↔ 117 | By similarity | ||
Disulfide bondi | 274 ↔ 285 | By similarity | ||
Glycosylationi | 276 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 490 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q64176 |
MaxQBi | Q64176 |
PaxDbi | Q64176 |
PRIDEi | Q64176 |
PTM databases
GlyGeni | Q64176, 3 sites |
iPTMneti | Q64176 |
PhosphoSitePlusi | Q64176 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000061959, Expressed in liver and 110 other tissues |
ExpressionAtlasi | Q64176, baseline and differential |
Genevisiblei | Q64176, MM |
Interactioni
Protein-protein interaction databases
CORUMi | Q64176 |
IntActi | Q64176, 4 interactors |
MINTi | Q64176 |
STRINGi | 10090.ENSMUSP00000034173 |
Miscellaneous databases
RNActi | Q64176, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 559 – 562 | Prevents secretion from ERSequence analysis | 4 |
Sequence similaritiesi
Belongs to the type-B carboxylesterase/lipase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000158564 |
InParanoidi | Q64176 |
OMAi | NIANTVC |
OrthoDBi | 754103at2759 |
PhylomeDBi | Q64176 |
TreeFami | TF315470 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q64176-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCLSALILVS LAAFTAGAGH PSSPPMVDTV QGKVLGKYIS LEGFTQPVAV
60 70 80 90 100
FLGVPFAKPP LGSLRFAPPQ PAEPWSSVKN ATSYPPMCFQ DPVTGQIVND
110 120 130 140 150
LLTNRKEKIP LQFSEDCLYL NIYTPADLTK SDRLPVMVWI HGGGLVLGGA
160 170 180 190 200
STYDGLVLST HENVVVVVIQ YRLGIWGFFS TGDEHSRGNW GHLDQVAALH
210 220 230 240 250
WVQDNIAKFG GDPGSVTIFG ESAGGESVSV LVLSPLAKNL FQRAISESGV
260 270 280 290 300
ALTAGLVKKN TRPLAEKIAV ISGCKNTTSA AMVHCLRQKT EEELLGTTLK
310 320 330 340 350
LNLFKLDLHG DSRQSHPFVP TVLDGVLLPK MPEEILAEKN FNTVPYIVGI
360 370 380 390 400
NKQEFGWILP TMMNYPPSDV KLDQMTAMSL LKKSSFLLNL PEDAIAVAIE
410 420 430 440 450
KYLRDKDYTG RNKDQLLELI GDVVFGVPSV IVSRGHRDAG APTYMYEFQY
460 470 480 490 500
SPSFSSEMKP DTVVGDHGDE IYSVFGAPIL RGGTSEEEIN LSKMMMKFWA
510 520 530 540 550
NFARNGNPNG QGLPHWPEYD QKEGYLQIGA TTQQAQKLKE KEVAFWTELL
560
AKKQLPTEHT EL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BL34 | H3BL34_MOUSE | Carboxylic ester hydrolase | Ces1e | 561 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S80191 mRNA Translation: AAB21335.1 BC019208 mRNA Translation: AAH19208.1 |
CCDSi | CCDS22529.1 |
PIRi | A55281 |
RefSeqi | NP_598421.1, NM_133660.3 |
Genome annotation databases
Ensembli | ENSMUST00000034173; ENSMUSP00000034173; ENSMUSG00000061959 |
GeneIDi | 13897 |
KEGGi | mmu:13897 |
UCSCi | uc009muo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S80191 mRNA Translation: AAB21335.1 BC019208 mRNA Translation: AAH19208.1 |
CCDSi | CCDS22529.1 |
PIRi | A55281 |
RefSeqi | NP_598421.1, NM_133660.3 |
3D structure databases
SMRi | Q64176 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | Q64176 |
IntActi | Q64176, 4 interactors |
MINTi | Q64176 |
STRINGi | 10090.ENSMUSP00000034173 |
Protein family/group databases
ESTHERi | mouse-Ces1e, Carb_B_Chordata |
PTM databases
GlyGeni | Q64176, 3 sites |
iPTMneti | Q64176 |
PhosphoSitePlusi | Q64176 |
Proteomic databases
jPOSTi | Q64176 |
MaxQBi | Q64176 |
PaxDbi | Q64176 |
PRIDEi | Q64176 |
Genome annotation databases
Ensembli | ENSMUST00000034173; ENSMUSP00000034173; ENSMUSG00000061959 |
GeneIDi | 13897 |
KEGGi | mmu:13897 |
UCSCi | uc009muo.2, mouse |
Organism-specific databases
CTDi | 13897 |
MGIi | MGI:95432, Ces1e |
Phylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000158564 |
InParanoidi | Q64176 |
OMAi | NIANTVC |
OrthoDBi | 754103at2759 |
PhylomeDBi | Q64176 |
TreeFami | TF315470 |
Miscellaneous databases
BioGRID-ORCSi | 13897, 0 hits in 17 CRISPR screens |
ChiTaRSi | Ces1e, mouse |
PROi | PR:Q64176 |
RNActi | Q64176, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000061959, Expressed in liver and 110 other tissues |
ExpressionAtlasi | Q64176, baseline and differential |
Genevisiblei | Q64176, MM |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EST1E_MOUSE | |
Accessioni | Q64176Primary (citable) accession number: Q64176 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families