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Protein

Semaphorin-4C

Gene

Sema4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.4 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4C
Alternative name(s):
M-Sema F
Semaphorin-C-like 1
Short name:
Sema I
Short name:
Semaphorin I
Gene namesi
Name:Sema4c
Synonyms:S4c, Semacl1, Semai
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109252 Sema4c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 664ExtracellularSequence analysisAdd BLAST644
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21
Topological domaini686 – 834CytoplasmicSequence analysisAdd BLAST149

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Partial neonate lethality, due to defects in brain and neural tube development. In about one third of the embryos cranial neural folds fail to converge, leading to an open neural tube and exencephaly. Mice without exencephaly are viable and fertile.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi832S → A: Loss of the effect on myogenic differentiation; when associated with A-834. Loss of interaction with DLG4; when associated with A-833 and A-834. 2 Publications1
Mutagenesisi833S → A: Loss of interaction with DLG4; when associated with A-832 and A-834. 1 Publication1
Mutagenesisi834V → A: Loss of the effect on myogenic differentiation; when associated with A-832. Loss of interaction with DLG4; when associated with A-832 and A-833. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003232621 – 834Semaphorin-4CAdd BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 110By similarity
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 137By similarity
Disulfide bondi261 ↔ 370By similarity
Disulfide bondi285 ↔ 330By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 517By similarity
Disulfide bondi509 ↔ 526By similarity
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi578 ↔ 628By similarity
Modified residuei743PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ64151
PaxDbiQ64151
PeptideAtlasiQ64151
PRIDEiQ64151

PTM databases

iPTMnetiQ64151
PhosphoSitePlusiQ64151

Expressioni

Tissue specificityi

Predominantly expressed in brain (at protein level).1 Publication

Developmental stagei

First detected at E14, levels increase by birth and remain strong in the adult brain (at protein level). Expressed widely in the nervous tissues during development.1 Publication

Inductioni

Up-regulated in differentiating myoblasts and upon muscle regeneration (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000026121 Expressed in 212 organ(s), highest expression level in metanephros
ExpressionAtlasiQ64151 baseline and differential
GenevisibleiQ64151 MM

Interactioni

Subunit structurei

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain). Interacts with NCDN. Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ64151, 2 interactors
MINTiQ64151
STRINGi10090.ENSMUSP00000027295

Structurei

3D structure databases

ProteinModelPortaliQ64151
SMRiQ64151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 497SemaPROSITE-ProRule annotationAdd BLAST468
Domaini499 – 552PSIAdd BLAST54
Domaini557 – 645Ig-like C2-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 489Dominant negative effect on myogenic differentiationAdd BLAST444

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi831 – 834PDZ-binding4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi678 – 687Poly-Leu10
Compositional biasi709 – 774Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ64151
KOiK06521
OMAiCINNWHR
OrthoDBiEOG091G01W0
PhylomeDBiQ64151
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q64151-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPHWAVWLL AAGLWGLGIG AEMWWNLVPR KTVSSGELVT VVRRFSQTGI
60 70 80 90 100
QDFLTLTLTE HSGLLYVGAR EALFAFSVEA LELQGAISWE APAEKKIECT
110 120 130 140 150
QKGKSNQTEC FNFIRFLQPY NSSHLYVCGT YAFQPKCTYI NMLTFTLDRA
160 170 180 190 200
EFEDGKGKCP YDPAKGHTGL LVDGELYSAT LNNFLGTEPV ILRYMGTHHS
210 220 230 240 250
IKTEYLAFWL NEPHFVGSAF VPESVGSFTG DDDKIYFFFS ERAVEYDCYS
260 270 280 290 300
EQVVARVARV CKGDMGGART LQKKWTTFLK ARLVCSAPDW KVYFNQLKAV
310 320 330 340 350
HTLRGASWHN TTFFGVFQAR WGDMDLSAVC EYQLEQIQQV FEGPYKEYSE
360 370 380 390 400
QAQKWARYTD PVPSPRPGSC INNWHRDNGY TSSLELPDNT LNFIKKHPLM
410 420 430 440 450
EDQVKPRLGR PLLVKKNTNF THVVADRVPG LDGATYTVLF IGTGDGWLLK
460 470 480 490 500
AVSLGPWIHM VEELQVFDQE PVESLVLSQS KKVLFAGSRS QLVQLSLADC
510 520 530 540 550
TKYRFCVDCV LARDPYCAWN VNTSRCVATT SGRSGSFLVQ HVANLDTSKM
560 570 580 590 600
CNQYGIKKVR SIPKNITVVS GTDLVLPCHL SSNLAHAHWT FGSQDLPAEQ
610 620 630 640 650
PGSFLYDTGL QALVVMAAQS RHSGPYRCYS EEQGTRLAAE SYLVAVVAGS
660 670 680 690 700
SVTLEARAPL ENLGLVWLAV VALGAVCLVL LLLVLSLRRR LREELEKGAK
710 720 730 740 750
ASERTLVYPL ELPKEPASPP FRPGPETDEK LWDPVGYYYS DGSLKIVPGH
760 770 780 790 800
ARCQPGGGPP SPPPGIPGQP LPSPTRLHLG GGRNSNANGY VRLQLGGEDR
810 820 830
GGSGHPLPEL ADELRRKLQQ RQPLPDSNPE ESSV
Length:834
Mass (Da):92,557
Last modified:November 1, 1996 - v1
Checksum:i6868BB5BF571482D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YX48A0A0A6YX48_MOUSE
Semaphorin-4C
Sema4c
36Annotation score:
A0A0A6YXK9A0A0A6YXK9_MOUSE
Semaphorin-4C
Sema4c
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79463 mRNA Translation: AAB35184.1
CCDSiCCDS48240.1
PIRiS66498
RefSeqiNP_001119519.1, NM_001126047.3
NP_001291258.1, NM_001304329.1
NP_001291259.1, NM_001304330.1
XP_006495868.1, XM_006495805.2
XP_006495870.1, XM_006495807.1
XP_006495871.1, XM_006495808.2
XP_006495872.1, XM_006495809.3
XP_006495873.1, XM_006495810.3
UniGeneiMm.29558

Genome annotation databases

EnsembliENSMUST00000114991; ENSMUSP00000110643; ENSMUSG00000026121
ENSMUST00000191642; ENSMUSP00000142284; ENSMUSG00000026121
ENSMUST00000191677; ENSMUSP00000141263; ENSMUSG00000026121
ENSMUST00000195620; ENSMUSP00000141527; ENSMUSG00000026121
GeneIDi20353
KEGGimmu:20353
UCSCiuc007aqq.4 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79463 mRNA Translation: AAB35184.1
CCDSiCCDS48240.1
PIRiS66498
RefSeqiNP_001119519.1, NM_001126047.3
NP_001291258.1, NM_001304329.1
NP_001291259.1, NM_001304330.1
XP_006495868.1, XM_006495805.2
XP_006495870.1, XM_006495807.1
XP_006495871.1, XM_006495808.2
XP_006495872.1, XM_006495809.3
XP_006495873.1, XM_006495810.3
UniGeneiMm.29558

3D structure databases

ProteinModelPortaliQ64151
SMRiQ64151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64151, 2 interactors
MINTiQ64151
STRINGi10090.ENSMUSP00000027295

PTM databases

iPTMnetiQ64151
PhosphoSitePlusiQ64151

Proteomic databases

MaxQBiQ64151
PaxDbiQ64151
PeptideAtlasiQ64151
PRIDEiQ64151

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114991; ENSMUSP00000110643; ENSMUSG00000026121
ENSMUST00000191642; ENSMUSP00000142284; ENSMUSG00000026121
ENSMUST00000191677; ENSMUSP00000141263; ENSMUSG00000026121
ENSMUST00000195620; ENSMUSP00000141527; ENSMUSG00000026121
GeneIDi20353
KEGGimmu:20353
UCSCiuc007aqq.4 mouse

Organism-specific databases

CTDi54910
MGIiMGI:109252 Sema4c

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ64151
KOiK06521
OMAiCINNWHR
OrthoDBiEOG091G01W0
PhylomeDBiQ64151
TreeFamiTF316102

Miscellaneous databases

ChiTaRSiSema4c mouse
PROiPR:Q64151
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026121 Expressed in 212 organ(s), highest expression level in metanephros
ExpressionAtlasiQ64151 baseline and differential
GenevisibleiQ64151 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4C_MOUSE
AccessioniPrimary (citable) accession number: Q64151
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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