UniProtKB - Q64133 (AOFA_MOUSE)
Protein
Amine oxidase [flavin-containing] A
Gene
Maoa
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).By similarity
Catalytic activityi
- EC:1.4.3.4
Cofactori
FADBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 335 | Important for substrate specificityBy similarity | 1 | |
Sitei | 374 | Important for catalytic activityBy similarity | 1 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: MGI
- primary amine oxidase activity Source: MGI
- serotonin binding Source: MGI
GO - Biological processi
- dopamine catabolic process Source: MGI
- neurotransmitter catabolic process Source: UniProtKB-KW
- phenylethylamine metabolic process Source: MGI
- positive regulation of signal transduction Source: MGI
- serotonin metabolic process Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Catecholamine metabolism, Neurotransmitter degradation |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BRENDAi | 1.4.3.4, 3474 |
Reactomei | R-MMU-141333, Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-MMU-181430, Norepinephrine Neurotransmitter Release Cycle R-MMU-379397, Enzymatic degradation of dopamine by COMT R-MMU-379398, Enzymatic degradation of Dopamine by monoamine oxidase R-MMU-380612, Metabolism of serotonin |
Names & Taxonomyi
Protein namesi | Recommended name: Amine oxidase [flavin-containing] A (EC:1.4.3.4)Alternative name(s): Monoamine oxidase type A Short name: MAO-A |
Gene namesi | Name:Maoa |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96915, Maoa |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 497 | CytoplasmicBy similarityAdd BLAST | 497 | |
Transmembranei | 498 – 518 | Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST | 21 | |
Topological domaini | 519 – 526 | Mitochondrial intermembraneBy similarity | 8 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099851 | 1 – 526 | Amine oxidase [flavin-containing] AAdd BLAST | 526 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 383 | PhosphoserineBy similarity | 1 | |
Modified residuei | 406 | S-8alpha-FAD cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q64133 |
jPOSTi | Q64133 |
MaxQBi | Q64133 |
PaxDbi | Q64133 |
PRIDEi | Q64133 |
TopDownProteomicsi | Q64133 |
PTM databases
iPTMneti | Q64133 |
PhosphoSitePlusi | Q64133 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025037, Expressed in colon and 336 other tissues |
Genevisiblei | Q64133, MM |
Interactioni
Subunit structurei
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 201307, 4 interactors |
IntActi | Q64133, 3 interactors |
STRINGi | 10090.ENSMUSP00000026013 |
Chemistry databases
BindingDBi | Q64133 |
Miscellaneous databases
RNActi | Q64133, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 520 – 522 | Interaction with membrane phospholipid headgroupsBy similarity | 3 |
Sequence similaritiesi
Belongs to the flavin monoamine oxidase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0029, Eukaryota |
GeneTreei | ENSGT00940000160514 |
HOGENOMi | CLU_004498_0_1_1 |
InParanoidi | Q64133 |
OMAi | EWTRGAY |
OrthoDBi | 1034142at2759 |
TreeFami | TF313314 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR001613, Flavin_amine_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 1 hit |
PRINTSi | PR00757, AMINEOXDASEF |
SUPFAMi | SSF51905, SSF51905, 1 hit |
i Sequence
Sequence statusi: Complete.
Q64133-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDDMGKEIPV DAPWQARHAE
160 170 180 190 200
EWDKITMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ
210 220 230 240 250
CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL SSPVTYIDQT
260 270 280 290 300
DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM
310 320 330 340 350
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM
360 370 380 390 400
GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTLYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKVAKKD IWVQEPESKD VPALEITHTF LERNLPSVPG
510 520
LLKITGFSTS VALLCFVLYK FKQPQS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 83 | E → D in AAH29100 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL805907 Genomic DNA No translation available. AL831729 Genomic DNA No translation available. CH466584 Genomic DNA Translation: EDL35717.1 BC029100 mRNA Translation: AAH29100.1 S78615, S78606 Genomic DNA Translation: AAB34677.1 |
CCDSi | CCDS30033.1 |
RefSeqi | NP_776101.3, NM_173740.3 |
Genome annotation databases
Ensembli | ENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037 |
GeneIDi | 17161 |
KEGGi | mmu:17161 |
UCSCi | uc009ssa.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL805907 Genomic DNA No translation available. AL831729 Genomic DNA No translation available. CH466584 Genomic DNA Translation: EDL35717.1 BC029100 mRNA Translation: AAH29100.1 S78615, S78606 Genomic DNA Translation: AAB34677.1 |
CCDSi | CCDS30033.1 |
RefSeqi | NP_776101.3, NM_173740.3 |
3D structure databases
SMRi | Q64133 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201307, 4 interactors |
IntActi | Q64133, 3 interactors |
STRINGi | 10090.ENSMUSP00000026013 |
Chemistry databases
BindingDBi | Q64133 |
ChEMBLi | CHEMBL3681 |
PTM databases
iPTMneti | Q64133 |
PhosphoSitePlusi | Q64133 |
Proteomic databases
EPDi | Q64133 |
jPOSTi | Q64133 |
MaxQBi | Q64133 |
PaxDbi | Q64133 |
PRIDEi | Q64133 |
TopDownProteomicsi | Q64133 |
Protocols and materials databases
Antibodypediai | 10933, 445 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026013; ENSMUSP00000026013; ENSMUSG00000025037 |
GeneIDi | 17161 |
KEGGi | mmu:17161 |
UCSCi | uc009ssa.2, mouse |
Organism-specific databases
CTDi | 4128 |
MGIi | MGI:96915, Maoa |
Phylogenomic databases
eggNOGi | KOG0029, Eukaryota |
GeneTreei | ENSGT00940000160514 |
HOGENOMi | CLU_004498_0_1_1 |
InParanoidi | Q64133 |
OMAi | EWTRGAY |
OrthoDBi | 1034142at2759 |
TreeFami | TF313314 |
Enzyme and pathway databases
BRENDAi | 1.4.3.4, 3474 |
Reactomei | R-MMU-141333, Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-MMU-181430, Norepinephrine Neurotransmitter Release Cycle R-MMU-379397, Enzymatic degradation of dopamine by COMT R-MMU-379398, Enzymatic degradation of Dopamine by monoamine oxidase R-MMU-380612, Metabolism of serotonin |
Miscellaneous databases
BioGRID-ORCSi | 17161, 1 hit in 17 CRISPR screens |
ChiTaRSi | Maoa, mouse |
PROi | PR:Q64133 |
RNActi | Q64133, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025037, Expressed in colon and 336 other tissues |
Genevisiblei | Q64133, MM |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR001613, Flavin_amine_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 1 hit |
PRINTSi | PR00757, AMINEOXDASEF |
SUPFAMi | SSF51905, SSF51905, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AOFA_MOUSE | |
Accessioni | Q64133Primary (citable) accession number: Q64133 Secondary accession number(s): B1AX52, Q8K0Z8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families