UniProtKB - Q64127 (TIF1A_MOUSE)
Transcription intermediary factor 1-alpha
Trim24
Functioni
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity).
Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
By similarity7 PublicationsTranscriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (By similarity).
Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway. Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (By similarity).
By similarity7 PublicationsCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 163 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 166 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 187 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 200 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 223 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 226 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 246 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 251 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 77 | RING-typePROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 158 – 211 | B box-type 1PROSITE-ProRule annotationAdd BLAST | 54 | |
Zinc fingeri | 218 – 259 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 827 – 874 | PHD-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- chromatin binding Source: MGI
- estrogen response element binding Source: UniProtKB
- lysine-acetylated histone binding Source: UniProtKB
- nuclear receptor binding Source: MGI
- p53 binding Source: UniProtKB
- protein kinase activity Source: MGI
- sequence-specific DNA binding Source: MGI
- transcription coactivator activity Source: UniProtKB
- ubiquitin protein ligase activity Source: MGI
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- calcium ion homeostasis Source: MGI
- cellular response to estrogen stimulus Source: UniProtKB
- negative regulation of cell population proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- protein autophosphorylation Source: MGI
- protein catabolic process Source: UniProtKB
- protein phosphorylation Source: MGI
- protein ubiquitination Source: UniProtKB
- regulation of apoptotic process Source: MGI
- regulation of protein stability Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: MGI
- regulation of vitamin D receptor signaling pathway Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor, Transferase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription intermediary factor 1-alpha (EC:2.3.2.27)Short name: TIF1-alpha Alternative name(s): E3 ubiquitin-protein ligase Trim24 RING-type E3 ubiquitin transferase TIF1-alphaCurated Tripartite motif-containing protein 24 |
Gene namesi | Name:Trim24 Synonyms:Tif1, Tif1a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109275, Trim24 |
VEuPathDBi | HostDB:ENSMUSG00000029833 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- perichromatin fibrils Source: MGI
Other locations
- cytoplasm Source: MGI
- euchromatin Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 724 | K → R: Loss of sumoylation; when associated with R-742. 1 Publication | 1 | |
Mutagenesisi | 742 | K → R: Loss of sumoylation; when associated with R-724. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 332 – 333 | Breakpoint for translocation to form TRIM24-BRAF oncogene | 2 |
Keywords - Diseasei
Proto-oncogene, Tumor suppressorPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056391 | 1 – 1051 | Transcription intermediary factor 1-alphaAdd BLAST | 1051 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 7 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 97 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 110 | PhosphoserineBy similarity | 1 | |
Cross-linki | 205 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 276 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 436 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 458 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 469 | Omega-N-methylarginineCombined sources | 1 | |
Cross-linki | 553 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 642 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 655 | PhosphoserineBy similarity | 1 | |
Modified residuei | 661 | PhosphoserineCombined sources | 1 | |
Modified residuei | 668 | PhosphoserineCombined sources | 1 | |
Cross-linki | 703 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 712 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 724 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateCurated | ||
Cross-linki | 724 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 724 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 742 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateCurated | ||
Cross-linki | 742 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 745 | PhosphoserineBy similarity | 1 | |
Modified residuei | 769 | PhosphoserineBy similarity | 1 | |
Cross-linki | 802 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 809 | PhosphoserineBy similarity | 1 | |
Cross-linki | 811 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 812 | PhosphoserineCombined sources | 1 | |
Modified residuei | 819 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 876 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 950 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 993 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1026 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1029 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1042 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1043 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q64127 |
jPOSTi | Q64127 |
MaxQBi | Q64127 |
PaxDbi | Q64127 |
PeptideAtlasi | Q64127 |
PRIDEi | Q64127 |
ProteomicsDBi | 262780 [Q64127-1] 262781 [Q64127-2] |
PTM databases
iPTMneti | Q64127 |
PhosphoSitePlusi | Q64127 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000029833, Expressed in testis and 330 other tissues |
ExpressionAtlasi | Q64127, baseline and differential |
Genevisiblei | Q64127, MM |
Interactioni
Subunit structurei
Interacts (via bromo domain) with histone H3 (via N-terminus), provided that it is not methylated at 'Lys-4' (H3K4me0). Does not interact with histone H3 that is methylated at 'Lys-4' (H3K4me1, H3K4me2 or H3K4me3).
Interacts (via bromo domain) with histone H3 (via N-terminus) that is acetylated at 'Lys-23' (H3K23ac). Has the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has very low affinity for histone H3 that is methylated at 'Lys-9' (H3K9me), or acetylated at both 'Lys-9' (H3K9ac) and 'Lys-14' (H3K14ac), or acetylated at 'Lys-27' (H3K27ac) (in vitro).
Interacts with TRIM16.
Interacts with NR3C2/MCR (By similarity).
Interacts with the ligand-binding domain of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires the presence of estradiol (By similarity).
Interacts with AR, CARM1, KAT5/TIP60, NCOA2/GRIP1, BRD7, CBX1, CBX3 and CBX5.
Part of a coactivator complex containing TRIM24, NCOA2/GRIP1 and CARM1.
Interacts with p53/TP53 and PML.
By similarity7 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 828 | Interaction with histone H3 that is not methylated at 'Lys-4' (H3K4me0)By similarity | 1 |
Binary interactionsi
Q64127
With | #Exp. | IntAct |
---|---|---|
Cbx1 [P83917] | 4 | EBI-307947,EBI-78119 |
Cbx5 [Q61686] | 4 | EBI-307947,EBI-307973 |
Tp53 [P02340] | 2 | EBI-307947,EBI-474016 |
Trim33 [Q99PP7] | 2 | EBI-307947,EBI-3043980 |
GO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
- nuclear receptor binding Source: MGI
- p53 binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 204196, 17 interactors |
DIPi | DIP-31476N |
IntActi | Q64127, 12 interactors |
STRINGi | 10090.ENSMUSP00000031859 |
Miscellaneous databases
RNActi | Q64127, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 933 – 988 | BromoPROSITE-ProRule annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 94 – 115 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 429 – 457 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 479 – 551 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 644 – 713 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 755 – 780 | Nuclear receptor binding site (NRBS)Add BLAST | 26 | |
Regioni | 771 – 827 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 835 – 841 | Interaction with histone H3 that is not methylated at 'Lys-4' (H3K4me0)By similarity | 7 | |
Regioni | 1024 – 1051 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 289 – 359 | Sequence analysisAdd BLAST | 71 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 892 – 908 | Nuclear localization signalSequence analysisAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 113 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 431 – 457 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 499 – 525 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 537 – 551 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 651 – 672 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 681 – 707 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 771 – 813 | Polar residuesSequence analysisAdd BLAST | 43 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 77 | RING-typePROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 158 – 211 | B box-type 1PROSITE-ProRule annotationAdd BLAST | 54 | |
Zinc fingeri | 218 – 259 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 827 – 874 | PHD-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Bromodomain, Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000159863 |
HOGENOMi | CLU_005817_0_1_1 |
InParanoidi | Q64127 |
OMAi | WIGPSHT |
OrthoDBi | 756911at2759 |
PhylomeDBi | Q64127 |
TreeFami | TF106455 |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR003649, Bbox_C IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR019786, Zinc_finger_PHD-type_CS IPR000315, Znf_B-box IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF00628, PHD, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 2 hits SM00297, BROMO, 1 hit SM00249, PHD, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 1 hit PS50119, ZF_BBOX, 2 hits PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVAVEKAAA AAAPAGGPAA AAPSGENEAE SRQGPDSESG GEASRLNLLD
60 70 80 90 100
TCAVCHQNIQ SRVPKLLPCL HSFCQRCLPA PQRYLMLTAP ALGSAETPPP
110 120 130 140 150
APAPAPAPGS PAGGPSPFAT QVGVIRCPVC SQECAERHII DNFFVKDTTE
160 170 180 190 200
VPSSTVEKSN QVCTSCEDNA EANGFCVECV EWLCKTCIRA HQRVKFTKDH
210 220 230 240 250
TVRQKEEVSP EAVGVTSQRP VFCPFHKKEQ LKLYCETCDK LTCRDCQLLE
260 270 280 290 300
HKEHRYQFIE EAFQNQKVII DTLITKLMEK TKYIKYTGNQ IQNRIIEINQ
310 320 330 340 350
NQKQVEQDIK VAIFTLMVEI NKKGKALLHQ LESLAKDHRM KLMQQQQEVA
360 370 380 390 400
GLSKQLEHVM HFSKWAVSSG SSTALLYSKR LITYRLRHLL RARCDASPVT
410 420 430 440 450
NTTIQFHCDP SFWAQNIINL GSLVIEDKES QPQMPKQNPV VEQSSQPPGG
460 470 480 490 500
LPSNQLSKFP TQISLAQLRL QHIQQQVMAQ RQQVQRRPAP VGLPNPRMQG
510 520 530 540 550
PIQQPSISHQ HPPPRLINFQ NHSPKPNGPV LPPYPQQLRY SPSQNVPRQT
560 570 580 590 600
TIKPNPLQMA FLAQQAIKQW QISSVQAPPT TASSSSSTPS SPTITSAAGY
610 620 630 640 650
DGKAFSSPMI DLSAPVGGSY NLPSLPDIDC SSTIMLDNIA RKDTGVDHAQ
660 670 680 690 700
PRPPSNRTVQ SPNSSVPSPG LAGPVTMTSV HPPIRSPSAS SVGSRGSSGS
710 720 730 740 750
SSKPAGADST HKVPVVMLEP IRIKQENSGP PENYDFPVVI VKQESDEESR
760 770 780 790 800
PQNTNYPRSI LTSLLLNSSQ SSASEETVLR SDAPDSTGDQ PGLHQENSSN
810 820 830 840 850
GKSEWSDASQ KSPVHVGETR KEDDPNEDWC AVCQNGGELL CCEKCPKVFH
860 870 880 890 900
LTCHVPTLTN FPSGEWICTF CRDLSKPEVD YDCDVPSHHS EKRKSEGLTK
910 920 930 940 950
LTPIDKRKCE RLLLFLYCHE MSLAFQDPVP LTVPDYYKII KNPMDLSTIK
960 970 980 990 1000
KRLQEDYCMY TKPEDFVADF RLIFQNCAEF NEPDSEVANA GIKLESYFEE
1010 1020 1030 1040 1050
LLKNLYPEKR FPKVEFRHEA EDCKFSDDSD DDFVQPRKKR LKSTEDRQLL
K
The sequence of this isoform differs from the canonical sequence as follows:
477-510: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q1U8 | E9Q1U8_MOUSE | Transcription intermediary factor 1... | Trim24 | 981 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005773 | 477 – 510 | Missing in isoform Short. CuratedAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S78221 mRNA Translation: AAB34290.1 S78219 mRNA Translation: AAB34289.1 BC056959 mRNA Translation: AAH56959.1 |
CCDSi | CCDS20008.1 [Q64127-1] CCDS71751.1 [Q64127-2] |
PIRi | S55259 |
RefSeqi | NP_001258993.1, NM_001272064.1 [Q64127-2] NP_001259005.1, NM_001272076.1 NP_659542.3, NM_145076.4 [Q64127-1] |
Genome annotation databases
Ensembli | ENSMUST00000031859; ENSMUSP00000031859; ENSMUSG00000029833 [Q64127-1] ENSMUST00000120428; ENSMUSP00000113063; ENSMUSG00000029833 [Q64127-2] |
GeneIDi | 21848 |
KEGGi | mmu:21848 |
UCSCi | uc009bjk.2, mouse [Q64127-1] uc009bjl.2, mouse [Q64127-2] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S78221 mRNA Translation: AAB34290.1 S78219 mRNA Translation: AAB34289.1 BC056959 mRNA Translation: AAH56959.1 |
CCDSi | CCDS20008.1 [Q64127-1] CCDS71751.1 [Q64127-2] |
PIRi | S55259 |
RefSeqi | NP_001258993.1, NM_001272064.1 [Q64127-2] NP_001259005.1, NM_001272076.1 NP_659542.3, NM_145076.4 [Q64127-1] |
3D structure databases
AlphaFoldDBi | Q64127 |
SMRi | Q64127 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204196, 17 interactors |
DIPi | DIP-31476N |
IntActi | Q64127, 12 interactors |
STRINGi | 10090.ENSMUSP00000031859 |
PTM databases
iPTMneti | Q64127 |
PhosphoSitePlusi | Q64127 |
Proteomic databases
EPDi | Q64127 |
jPOSTi | Q64127 |
MaxQBi | Q64127 |
PaxDbi | Q64127 |
PeptideAtlasi | Q64127 |
PRIDEi | Q64127 |
ProteomicsDBi | 262780 [Q64127-1] 262781 [Q64127-2] |
Protocols and materials databases
Antibodypediai | 32326, 536 antibodies from 39 providers |
DNASUi | 21848 |
Genome annotation databases
Ensembli | ENSMUST00000031859; ENSMUSP00000031859; ENSMUSG00000029833 [Q64127-1] ENSMUST00000120428; ENSMUSP00000113063; ENSMUSG00000029833 [Q64127-2] |
GeneIDi | 21848 |
KEGGi | mmu:21848 |
UCSCi | uc009bjk.2, mouse [Q64127-1] uc009bjl.2, mouse [Q64127-2] |
Organism-specific databases
CTDi | 8805 |
MGIi | MGI:109275, Trim24 |
VEuPathDBi | HostDB:ENSMUSG00000029833 |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000159863 |
HOGENOMi | CLU_005817_0_1_1 |
InParanoidi | Q64127 |
OMAi | WIGPSHT |
OrthoDBi | 756911at2759 |
PhylomeDBi | Q64127 |
TreeFami | TF106455 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
BioGRID-ORCSi | 21848, 13 hits in 80 CRISPR screens |
ChiTaRSi | Trim24, mouse |
PROi | PR:Q64127 |
RNActi | Q64127, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029833, Expressed in testis and 330 other tissues |
ExpressionAtlasi | Q64127, baseline and differential |
Genevisiblei | Q64127, MM |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR003649, Bbox_C IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR019786, Zinc_finger_PHD-type_CS IPR000315, Znf_B-box IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF00628, PHD, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 2 hits SM00297, BROMO, 1 hit SM00249, PHD, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 1 hit PS50119, ZF_BBOX, 2 hits PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TIF1A_MOUSE | |
Accessioni | Q64127Primary (citable) accession number: Q64127 Secondary accession number(s): Q64126 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 195 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways