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Protein

Interferon-induced protein with tetratricopeptide repeats 2

Gene

Ifit2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.2 Publications

GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to interferon-alpha Source: MGI
  • defense response to virus Source: GO_Central
  • innate immune response Source: UniProtKB-KW
  • negative regulation of protein binding Source: MGI
  • positive regulation of apoptotic process Source: UniProtKB
  • response to virus Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processAntiviral defense, Apoptosis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 2
Short name:
IFIT-2
Alternative name(s):
Glucocorticoid-attenuated response gene 39 protein
Short name:
GARG-39
Interferon-induced 54 kDa protein
Short name:
IFI-54K
Short name:
P54
Gene namesi
Name:Ifit2
Synonyms:Garg39, Ifi54, Isg54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99449 Ifit2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001063482 – 472Interferon-induced protein with tetratricopeptide repeats 2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64112
PaxDbiQ64112
PeptideAtlasiQ64112
PRIDEiQ64112

PTM databases

PhosphoSitePlusiQ64112

Expressioni

Inductioni

By type I interferons, dsRNAs and viruses.1 Publication

Interactioni

Subunit structurei

Domain-swapped homodimer. Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT3. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1 (By similarity). Interacts with EIF3C.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099890

Structurei

3D structure databases

ProteinModelPortaliQ64112
SMRiQ64112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 89TPR 1Add BLAST39
Repeati90 – 135TPR 2Add BLAST46
Repeati136 – 171TPR 3Add BLAST36
Repeati172 – 208TPR 4Add BLAST37
Repeati244 – 277TPR 5Add BLAST34
Repeati278 – 333TPR 6Add BLAST56
Repeati334 – 364TPR 7Add BLAST31
Repeati365 – 403TPR 8Add BLAST39
Repeati404 – 445TPR 9Add BLAST42

Domaini

The C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface.By similarity

Sequence similaritiesi

Belongs to the IFIT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
HOGENOMiHOG000001558
HOVERGENiHBG066330
InParanoidiQ64112
PhylomeDBiQ64112

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR024124 Interferon-induced_IFIT2
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10271:SF4 PTHR10271:SF4, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q64112-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTSKESLV CNLRQLKCHF TWNLIAEDES LDEFEDRVFN KDEFQNSEFK
60 70 80 90 100
ATMCNILAYV KHCRGLNEAA LQCLGEAEGF IQQQHPDQVE IRSLVTWGNY
110 120 130 140 150
AWVYYHMGQF SKAQAYLDKV KQVCKKFSSP YRIENPALDC EEGWARLKCT
160 170 180 190 200
KNQNERVKVC FQKALEKDPK NPEFTSGWAI AFYRLDDWPA RNYCIDSLEQ
210 220 230 240 250
AIQLSPDNTY VKVLLALKLD AVHVHKNQAM ALVEEALKKD PSAIDTLLRA
260 270 280 290 300
ARFYCKVYDT DRAIQLLRKA LEKLPNNAYV HYYMGCCYRS KVHHMLNRRE
310 320 330 340 350
MVFSGDRKKL EELIQLAVNH LRKAEEIKEM LEYSCSFLAD LYIIAKKYDE
360 370 380 390 400
ADYYFQKELS KDLPPGPKQL LHLRYGNFQF FQMKRQDKAI YHYMEGVKIK
410 420 430 440 450
KKTIPQKKMR EKLQRIALRR LHEDESDSEA LHILAFLQEN GGGQQADKDS
460 470
ERGVDSANQV PSASLDEDGA EY
Length:472
Mass (Da):55,021
Last modified:November 1, 1996 - v1
Checksum:i0C76034B1C0B2C41
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6GTM0Q6GTM0_MOUSE
Ifit2 protein
Ifit2 mCG_21468
470Annotation score:
D3YZ80D3YZ80_MOUSE
Interferon-induced protein with tet...
Ifit2
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 11VC → ES in AAC52626 (PubMed:8660659).Curated2
Sequence conflicti182F → N in AAC52626 (PubMed:8660659).Curated1
Sequence conflicti223 – 224Missing in AAC52626 (PubMed:8660659).Curated2
Sequence conflicti468D → A in AAC52626 (PubMed:8660659).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77713, S77710 Genomic DNA Translation: AAB33830.1
U43085 mRNA Translation: AAC52626.1
PIRiA55508
S71355
RefSeqiNP_032358.1, NM_008332.3
XP_006526768.1, XM_006526705.2
XP_006526769.1, XM_006526706.3
UniGeneiMm.2036

Genome annotation databases

GeneIDi15958
KEGGimmu:15958

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77713, S77710 Genomic DNA Translation: AAB33830.1
U43085 mRNA Translation: AAC52626.1
PIRiA55508
S71355
RefSeqiNP_032358.1, NM_008332.3
XP_006526768.1, XM_006526705.2
XP_006526769.1, XM_006526706.3
UniGeneiMm.2036

3D structure databases

ProteinModelPortaliQ64112
SMRiQ64112
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099890

PTM databases

PhosphoSitePlusiQ64112

Proteomic databases

MaxQBiQ64112
PaxDbiQ64112
PeptideAtlasiQ64112
PRIDEiQ64112

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15958
KEGGimmu:15958

Organism-specific databases

CTDi3433
MGIiMGI:99449 Ifit2

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
HOGENOMiHOG000001558
HOVERGENiHBG066330
InParanoidiQ64112
PhylomeDBiQ64112

Miscellaneous databases

ChiTaRSiIfit2 mouse
PROiPR:Q64112
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR024124 Interferon-induced_IFIT2
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10271:SF4 PTHR10271:SF4, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFIT2_MOUSE
AccessioniPrimary (citable) accession number: Q64112
Secondary accession number(s): Q62385
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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