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Entry version 136 (13 Nov 2019)
Sequence version 1 (25 Oct 2004)
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Protein

Adipocyte enhancer-binding protein 1

Gene

Aebp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.By similarity
Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.9 Publications

Caution

Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M14.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adipocyte enhancer-binding protein 1
Short name:
AE-binding protein 1
Alternative name(s):
Aortic carboxypeptidase-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aebp1
Synonyms:Aclp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1197012 Aebp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Two independent knockout mice have been generated for the gene encoding this protein, and these exhibit different phenotypes. Mice lacking exons 7-12 exhibit reduced growth rate and body weight and resistance to dietary-induced obesity. Individual adipocytes from these animals are hypoproliferative while the adipose tissue is prone to apoptosis. Mice lacking exons 7-16 die perinatally from gastroschisis, in which abdominal viscera are extruded through the ventral body wall. Surviving mice exhibit deficient wound healing, having dermal fibroblasts with reduced proliferative capacity. Mice lacking exons 7-16 may exhibit phenotypes arising from effects on the locus encoding Pold2, which lies immediately downstream of this locus.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1003T → A: Impairs DNA-binding and phosphorylation by MAPK1. 1 Publication1
Mutagenesisi1003T → D: Impairs DNA-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033319026 – 1128Adipocyte enhancer-binding protein 1Add BLAST1103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK1 in vitro.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3446

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q640N1

PeptideAtlas

More...
PeptideAtlasi
Q640N1

PRoteomics IDEntifications database

More...
PRIDEi
Q640N1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q640N1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q640N1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in adipose tissue, brain, heart, kidney, liver, lung, skeletal muscle, small intestine, spleen and testis. Isoform 2 is expressed in macrophages. Expressed in aorta, preadipocytes, adipocyte tissue, brain, heart, liver, lung, skeletal muscle, skin and spleen (at protein level).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the somites and dorsa from 9.5 dpc and in the yolk sac and embryonic vasculature from 10.5 dpc. Expression within the large and small blood vessels increases at 11.5 dpc and 13.5 dpc, with high expression in the vascular smooth muscle at 16.5 dpc. Also expressed later in development in mesenchymal cells in the dermal layer, the developing skeleton, connective tissue and the umbilical ring and vessels. Up-regulated during vascular smooth muscle cell differentiation and down-regulated during adipocyte differentiation and osteoblast differentiation.9 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TGF-beta. Expression is also induced by a high fat diet.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020473 Expressed in 290 organ(s), highest expression level in ascending aorta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q640N1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1:

Interacts with different types of collagen, including collagens I, III, and V (By similarity). Isoform 2:

Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. Interaction with MAPK1 may stimulate DNA-binding. May interact with calmodulin. Binds to DNA in vitro.

By similarity5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198013, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099987

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q640N1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini374 – 531F5/8 type CPROSITE-ProRule annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni381 – 546Required for DNA-binding and interaction with NFKBIA1 PublicationAdd BLAST166
Regioni412 – 615Interaction with MAPK1 and MAPK31 PublicationAdd BLAST204
Regioni546 – 976Interaction with PTEN1 PublicationAdd BLAST431
Regioni932 – 1128Required for transcriptional repressionAdd BLAST197
Regioni997 – 1128Interaction with MAPK1 and MAPK31 PublicationAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 166Lys-richAdd BLAST97
Compositional biasi625 – 629Poly-Leu5
Compositional biasi1069 – 1106Glu-richAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Isoform 1: The F5/8 type C domain binds to different types of collagen, including collagens I, III, and V.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2649 Eukaryota
ENOG410XX0H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158323

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q640N1

KEGG Orthology (KO)

More...
KOi
K21392

Database of Orthologous Groups

More...
OrthoDBi
101221at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q640N1

TreeFam database of animal gene trees

More...
TreeFami
TF315592

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000834 Peptidase_M14

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF00246 Peptidase_M14, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00765 CRBOXYPTASEA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00231 FA58C, 1 hit
SM00631 Zn_pept, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464 SSF49464, 1 hit
SSF49785 SSF49785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q640N1-1) [UniParc]FASTAAdd to basket
Also known as: Aclp

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPVRTASLL CGLLALLTLC PEGNPQTVLT DDEIEEFLEG FLSELETQSP
60 70 80 90 100
PREDDVEVQP LPEPTQRPRK SKAGGKQRAD VEVPPEKNKD KEKKGKKDKG
110 120 130 140 150
PKATKPLEGS TRPTKKPKEK PPKATKKPKE KPPKATKKPK EKPPKATKKP
160 170 180 190 200
KEKPPKATKR PSAGKKFSTV APLETLDRLL PSPSNPSAQE LPQKRDTPFP
210 220 230 240 250
NAWQGQGEET QVEAKQPRPE PEEETEMPTL DYNDQIEKED YEDFEYIRRQ
260 270 280 290 300
KQPRPTPSRR RLWPERPEEK TEEPEERKEV EPPLKPLLPP DYGDSYVIPN
310 320 330 340 350
YDDLDYYFPH PPPQKPDVGQ EVDEEKEEMK KPKKEGSSPK EDTEDKWTVE
360 370 380 390 400
KNKDHKGPRK GEELEEEWAP VEKIKCPPIG MESHRIEDNQ IRASSMLRHG
410 420 430 440 450
LGAQRGRLNM QAGANEDDYY DGAWCAEDES QTQWIEVDTR RTTRFTGVIT
460 470 480 490 500
QGRDSSIHDD FVTTFFVGFS NDSQTWVMYT NGYEEMTFYG NVDKDTPVLS
510 520 530 540 550
ELPEPVVARF IRIYPLTWNG SLCMRLEVLG CPVTPVYSYY AQNEVVTTDS
560 570 580 590 600
LDFRHHSYKD MRQLMKAVNE ECPTITRTYS LGKSSRGLKI YAMEISDNPG
610 620 630 640 650
DHELGEPEFR YTAGIHGNEV LGRELLLLLM QYLCQEYRDG NPRVRNLVQD
660 670 680 690 700
TRIHLVPSLN PDGYEVAAQM GSEFGNWALG LWTEEGFDIF EDFPDLNSVL
710 720 730 740 750
WAAEEKKWVP YRVPNNNLPI PERYLSPDAT VSTEVRAIIS WMEKNPFVLG
760 770 780 790 800
ANLNGGERLV SYPYDMARTP SQEQLLAEAL AAARGEDDDG VSEAQETPDH
810 820 830 840 850
AIFRWLAISF ASAHLTMTEP YRGGCQAQDY TSGMGIVNGA KWNPRSGTFN
860 870 880 890 900
DFSYLHTNCL ELSVYLGCDK FPHESELPRE WENNKEALLT FMEQVHRGIK
910 920 930 940 950
GVVTDEQGIP IANATISVSG INHGVKTASG GDYWRILNPG EYRVTAHAEG
960 970 980 990 1000
YTSSAKICNV DYDIGATQCN FILARSNWKR IREILAMNGN RPILRVDPSR
1010 1020 1030 1040 1050
PMTPQQRRMQ QRRLQYRLRM REQMRLRRLN STAGPATSPT PALMPPPSPT
1060 1070 1080 1090 1100
PAITLRPWEV LPTTTAGWEE SETETYTEVV TEFETEYGTD LEVEEIEEEE
1110 1120
EEEEEEMDTG LTFPLTTVET YTVNFGDF
Length:1,128
Mass (Da):128,365
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC24F46B893C02DC9
GO
Isoform 2 (identifier: Q640N1-2) [UniParc]FASTAAdd to basket
Also known as: Aebp1

The sequence of this isoform differs from the canonical sequence as follows:
     1-380: Missing.

Note: No experimental confirmation available.
Show »
Length:748
Mass (Da):84,983
Checksum:iD27B68FD02F72A2E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA56648 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti333K → E in BAE34995 (PubMed:16141072).Curated1
Sequence conflicti333K → E in BAE35004 (PubMed:16141072).Curated1
Sequence conflicti356K → KA in BAE35359 (PubMed:16141072).Curated1
Sequence conflicti356K → KA in BAE35513 (PubMed:16141072).Curated1
Sequence conflicti356K → KA in BAE34995 (PubMed:16141072).Curated1
Sequence conflicti356K → KA in BAE35004 (PubMed:16141072).Curated1
Sequence conflicti356K → KA in BAE35033 (PubMed:16141072).Curated1
Sequence conflicti356K → KA in BAE35060 (PubMed:16141072).Curated1
Sequence conflicti792S → F in BAE35359 (PubMed:16141072).Curated1
Sequence conflicti792S → F in BAE35513 (PubMed:16141072).Curated1
Sequence conflicti917S → C in BAE35359 (PubMed:16141072).Curated1
Sequence conflicti995R → G in AAC25584 (PubMed:9624159).Curated1
Sequence conflicti1096I → IEE in BAE35359 (PubMed:16141072).Curated1
Sequence conflicti1096I → IEE in BAE35513 (PubMed:16141072).Curated1
Sequence conflicti1096I → IEE in BAE34995 (PubMed:16141072).Curated1
Sequence conflicti1096I → IEE in BAE35004 (PubMed:16141072).Curated1
Sequence conflicti1096I → IEE in BAE35033 (PubMed:16141072).Curated1
Sequence conflicti1096I → IEE in BAE35060 (PubMed:16141072).Curated1
Sequence conflicti1115L → F in BAE35359 (PubMed:16141072).Curated1
Sequence conflicti1115L → F in BAE35513 (PubMed:16141072).Curated1
Sequence conflicti1115L → F in BAE34995 (PubMed:16141072).Curated1
Sequence conflicti1115L → F in BAE35004 (PubMed:16141072).Curated1
Sequence conflicti1115L → F in BAE35033 (PubMed:16141072).Curated1
Sequence conflicti1115L → F in BAE35060 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0334701 – 380Missing in isoform 2. 1 PublicationAdd BLAST380

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X80478 mRNA Translation: CAA56648.1 Frameshift.
AF053943 mRNA Translation: AAC25584.1
AK159330 mRNA Translation: BAE34995.1
AK159342 mRNA Translation: BAE35004.1
AK159377 mRNA Translation: BAE35033.1
AK159409 mRNA Translation: BAE35060.1
AK159774 mRNA Translation: BAE35359.1
AK159957 mRNA Translation: BAE35513.1
AL627069 Genomic DNA No translation available.
BC082577 mRNA Translation: AAH82577.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24406.1 [Q640N1-1]

Protein sequence database of the Protein Information Resource

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PIRi
S60227 S51739

NCBI Reference Sequences

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RefSeqi
NP_001278786.1, NM_001291857.2
NP_033766.2, NM_009636.3 [Q640N1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000102923; ENSMUSP00000099987; ENSMUSG00000020473 [Q640N1-1]
ENSMUST00000109829; ENSMUSP00000105454; ENSMUSG00000020473 [Q640N1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11568

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:11568

UCSC genome browser

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UCSCi
uc007hxg.3 mouse [Q640N1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80478 mRNA Translation: CAA56648.1 Frameshift.
AF053943 mRNA Translation: AAC25584.1
AK159330 mRNA Translation: BAE34995.1
AK159342 mRNA Translation: BAE35004.1
AK159377 mRNA Translation: BAE35033.1
AK159409 mRNA Translation: BAE35060.1
AK159774 mRNA Translation: BAE35359.1
AK159957 mRNA Translation: BAE35513.1
AL627069 Genomic DNA No translation available.
BC082577 mRNA Translation: AAH82577.1
CCDSiCCDS24406.1 [Q640N1-1]
PIRiS60227 S51739
RefSeqiNP_001278786.1, NM_001291857.2
NP_033766.2, NM_009636.3 [Q640N1-1]

3D structure databases

SMRiQ640N1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198013, 3 interactors
STRINGi10090.ENSMUSP00000099987

Protein family/group databases

MEROPSiM14.951

PTM databases

iPTMnetiQ640N1
PhosphoSitePlusiQ640N1

Proteomic databases

CPTACinon-CPTAC-3446
PaxDbiQ640N1
PeptideAtlasiQ640N1
PRIDEiQ640N1

Genome annotation databases

EnsembliENSMUST00000102923; ENSMUSP00000099987; ENSMUSG00000020473 [Q640N1-1]
ENSMUST00000109829; ENSMUSP00000105454; ENSMUSG00000020473 [Q640N1-2]
GeneIDi11568
KEGGimmu:11568
UCSCiuc007hxg.3 mouse [Q640N1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
165
MGIiMGI:1197012 Aebp1

Phylogenomic databases

eggNOGiKOG2649 Eukaryota
ENOG410XX0H LUCA
GeneTreeiENSGT00940000158323
InParanoidiQ640N1
KOiK21392
OrthoDBi101221at2759
PhylomeDBiQ640N1
TreeFamiTF315592

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Aebp1 mouse

Protein Ontology

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PROi
PR:Q640N1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020473 Expressed in 290 organ(s), highest expression level in ascending aorta
GenevisibleiQ640N1 MM

Family and domain databases

CDDicd00057 FA58C, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF00246 Peptidase_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00231 FA58C, 1 hit
SM00631 Zn_pept, 1 hit
SUPFAMiSSF49464 SSF49464, 1 hit
SSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAEBP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q640N1
Secondary accession number(s): O88442
, Q3TVV5, Q3TWA7, Q3TX56, Q3TXB2, Q5NCI9, Q61281
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 25, 2004
Last modified: November 13, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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