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Protein

Coiled-coil domain-containing protein 18

Gene

Ccdc18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 18
Gene namesi
Name:Ccdc18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1922974 Ccdc18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847761 – 1455Coiled-coil domain-containing protein 18Add BLAST1455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineCombined sources1
Modified residuei1356PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ640L5
PaxDbiQ640L5
PRIDEiQ640L5

PTM databases

iPTMnetiQ640L5
PhosphoSitePlusiQ640L5

Expressioni

Gene expression databases

BgeeiENSMUSG00000056531 Expressed in 123 organ(s), highest expression level in embryonic stem cell
CleanExiMM_CCDC18
GenevisibleiQ640L5 MM

Interactioni

Protein-protein interaction databases

BioGridi215867, 1 interactor
STRINGi10090.ENSMUSP00000036507

Structurei

3D structure databases

ProteinModelPortaliQ640L5
SMRiQ640L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 405Sequence analysisAdd BLAST298
Coiled coili441 – 473Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi785 – 831Gln-richAdd BLAST47

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJJN Eukaryota
ENOG4111YKF LUCA
GeneTreeiENSGT00710000106794
HOGENOMiHOG000111405
HOVERGENiHBG095601
InParanoidiQ640L5
OMAiEMEKENM
OrthoDBiEOG091G00RE
PhylomeDBiQ640L5
TreeFamiTF335610

Family and domain databases

InterProiView protein in InterPro
IPR029613 Ccdc18/Sojo
PANTHERiPTHR18875:SF8 PTHR18875:SF8, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q640L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFISSDYCT KDNDNEEESL LANVASLRHE LKITEWSLHN LGEELSSVSP
60 70 80 90 100
SENSEYVCSP SRSERLILEE LTQPSHLGRL IYPPYKKVCK TSDSTDYQKK
110 120 130 140 150
SRDQVSFSSV SMDQEVKNLR EKLHKLRQQN ACLVTQNHSL MTKIESVHFE
160 170 180 190 200
LTQSKAKIAM LESAQEQAAN IPILEEQIIN LEAEVSAQDK VLREAEDKLE
210 220 230 240 250
QSQKMVIEKE HSLQEAKEEC IKLKVDLLEQ SKQGKRAERQ RNEALYNAEE
260 270 280 290 300
LSKAFQLYKE KVAEKLEKVQ DEEEILERNL SNCEKENKRL QEKCNLYKSE
310 320 330 340 350
LEILKEKFRE LKEEHYSGKE KLMIMAMKNS EVMSQLTESR QCILKLEREL
360 370 380 390 400
EDKDEIVREK FSLLNENREL KVRVATQNER LELCQQDIDN SRVELKSLEK
410 420 430 440 450
LITQIPLKRE IVGFRSSLCK HQRSSVSDKE DKCIGCCEAN KLMISELRIK
460 470 480 490 500
LAIREAEIQK LHANLTVNQL SQNVANDSQE CGKVNTLETE PVKLGGSQVE
510 520 530 540 550
SIKDGDQQTV NKQYEREKQR LATGIEELRA KLTQIEAENS DLKVNMAHRT
560 570 580 590 600
SQFQLIQEEL LEKASNASKL ENEMTKKCSQ LLILEKQLEE KIIAYSSIAA
610 620 630 640 650
KNAELEQELM EKNEKIRSLE SNINTEHEKI CFAFEKAKKI HLEQHKEMEK
660 670 680 690 700
QIEQLETQLE KRDQQFKEQE KTMSILQQDI LCKQHHLESL DRLLTESKVE
710 720 730 740 750
MEKENMKKDE ALKALQIHVS EETIKVRQLD SALEICKEEL ALHLNQLERN
760 770 780 790 800
KEKFERQLKK KSEEVYCLQK ELKIKTHNLE ETSEQNAILQ HTLQQQQQML
810 820 830 840 850
QQETMRNGEL EDTQSKLEKQ VSKQEQELQK QRESSTEKLR KMEEKYETAI
860 870 880 890 900
REVDLKRQKI IELTGTARQA KLEMDQYKEE LSKMEKEIIH LKRDGENKSM
910 920 930 940 950
QLSQLDMVLD QTKTELEKTT NSVKELERLQ HHTETELTET MQKREALENE
960 970 980 990 1000
LQNAHGELKS TLRQLQELRD VLQKAQLSLE EKYTTIKDLT AELRECKMEI
1010 1020 1030 1040 1050
EDKKQELIEM DQALKERNWE LKQRAAQVTH LDMTIREHRG EMEQKIIKLE
1060 1070 1080 1090 1100
GTLEKSELEL KECNKQVESL NEKLQNAKEQ LREKEFIMLQ NEQEISQLKK
1110 1120 1130 1140 1150
EIERTQQRMK EMESVIKEQE DYIATQYKEV IDLGQELRLT QEQMQNTHSE
1160 1170 1180 1190 1200
LVEARRQEVQ AQREIERLAG ELEDIKQLSK EKEAHGNRLA EELGASQVRE
1210 1220 1230 1240 1250
AHLEARMQAE IKKLSSEVDS LKEAYQIEMI SHQENHAKWK LSAESQKTSV
1260 1270 1280 1290 1300
QQLNEQLEKA KQELEEAQDT VSNLHQQVQD RNEVIEAANE ALLIKESELT
1310 1320 1330 1340 1350
RLQAKISGHE KTEDTKYLPA PFTTLTEIIP DSQHPNFAKH SQISLFKCRK
1360 1370 1380 1390 1400
LRRSISASDL SFKSHGNDDL SEELLQDLKK MQFEQTSAIE SGHKDLPLTH
1410 1420 1430 1440 1450
SESFKPLPYN LEDDSSESND FSTLSGMLRY INKEVRLLKK SSLQTATGLS

QGGKL
Length:1,455
Mass (Da):169,741
Last modified:October 25, 2004 - v1
Checksum:iEF04ACB9E4AA2472
GO
Isoform 2 (identifier: Q640L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-407: L → D
     408-1455: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):47,556
Checksum:i695377698CB439A3
GO
Isoform 3 (identifier: Q640L5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-1455: Missing.

Show »
Length:193
Mass (Da):22,027
Checksum:i4E16E636522D76FD
GO
Isoform 4 (identifier: Q640L5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     36-37: WS → ME
     158-171: IAMLESAQEQAANI → VCLLMGEENICNIL
     172-1455: Missing.

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,572
Checksum:i3C3C16E91F07FF10
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246371 – 35Missing in isoform 4. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_02463836 – 37WS → ME in isoform 4. 1 Publication2
Alternative sequenceiVSP_024639158 – 171IAMLE…QAANI → VCLLMGEENICNIL in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_024640172 – 1455Missing in isoform 4. 1 PublicationAdd BLAST1284
Alternative sequenceiVSP_024641194 – 1455Missing in isoform 3. 1 PublicationAdd BLAST1262
Alternative sequenceiVSP_024642407L → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_024643408 – 1455Missing in isoform 2. 1 PublicationAdd BLAST1048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040158 mRNA Translation: BAC30527.1
AK040607 mRNA Translation: BAC30642.1
AK006197 mRNA Translation: BAB24453.1
BC082598 mRNA Translation: AAH82598.1
CCDSiCCDS39202.1 [Q640L5-1]
RefSeqiNP_082757.1, NM_028481.1 [Q640L5-1]
UniGeneiMm.441231

Genome annotation databases

EnsembliENSMUST00000047677; ENSMUSP00000036507; ENSMUSG00000056531 [Q640L5-1]
ENSMUST00000197718; ENSMUSP00000142963; ENSMUSG00000056531 [Q640L5-3]
GeneIDi73254
KEGGimmu:73254
UCSCiuc008ynr.1 mouse [Q640L5-1]
uc008yns.2 mouse [Q640L5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040158 mRNA Translation: BAC30527.1
AK040607 mRNA Translation: BAC30642.1
AK006197 mRNA Translation: BAB24453.1
BC082598 mRNA Translation: AAH82598.1
CCDSiCCDS39202.1 [Q640L5-1]
RefSeqiNP_082757.1, NM_028481.1 [Q640L5-1]
UniGeneiMm.441231

3D structure databases

ProteinModelPortaliQ640L5
SMRiQ640L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215867, 1 interactor
STRINGi10090.ENSMUSP00000036507

PTM databases

iPTMnetiQ640L5
PhosphoSitePlusiQ640L5

Proteomic databases

EPDiQ640L5
PaxDbiQ640L5
PRIDEiQ640L5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047677; ENSMUSP00000036507; ENSMUSG00000056531 [Q640L5-1]
ENSMUST00000197718; ENSMUSP00000142963; ENSMUSG00000056531 [Q640L5-3]
GeneIDi73254
KEGGimmu:73254
UCSCiuc008ynr.1 mouse [Q640L5-1]
uc008yns.2 mouse [Q640L5-3]

Organism-specific databases

CTDi343099
MGIiMGI:1922974 Ccdc18

Phylogenomic databases

eggNOGiENOG410IJJN Eukaryota
ENOG4111YKF LUCA
GeneTreeiENSGT00710000106794
HOGENOMiHOG000111405
HOVERGENiHBG095601
InParanoidiQ640L5
OMAiEMEKENM
OrthoDBiEOG091G00RE
PhylomeDBiQ640L5
TreeFamiTF335610

Miscellaneous databases

ChiTaRSiCcdc18 mouse
PROiPR:Q640L5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056531 Expressed in 123 organ(s), highest expression level in embryonic stem cell
CleanExiMM_CCDC18
GenevisibleiQ640L5 MM

Family and domain databases

InterProiView protein in InterPro
IPR029613 Ccdc18/Sojo
PANTHERiPTHR18875:SF8 PTHR18875:SF8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCD18_MOUSE
AccessioniPrimary (citable) accession number: Q640L5
Secondary accession number(s): Q8BIM9, Q8BIN1, Q9DA43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 25, 2004
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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