UniProtKB - Q64092 (TFE3_MOUSE)

BLAST

>sp|Q64092|TFE3_MOUSE Transcription factor E3 OS=Mus musculus OX=10090 GN=Tfe3 PE=1 SV=2
MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLLPESGIVADIELENILD
PDSFYELKSQPLFLRSSLPISLQATPTTPATLSASSSAGGSRTPAMSSSSSRVLLRQQLM
RAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQT
HLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTG
SAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGN
LLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFN
INDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANR
SLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEEEGRPSTTFHVSGG
PAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSP
LRAASDPLLSSVSPAVSKASSRRSSFSMEEES

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History
Entry version 132 (07 Nov 2018)
Sequence version 2 (09 Jan 2007)
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Protein

Transcription factor E3

Gene

Tfe3

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4⁺ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.1 Publication

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15994295
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16936731
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16936731
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16936731

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
humoral immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16936731
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 23885019
positive regulation of cell adhesion Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 15994295
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 16936731
regulation of osteoclast differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 11930005

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Adaptive immunity, Immunity, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor E3
Gene namesⁱ	Name:Tfe3 Synonyms:Tcfe3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:98511 Tfe3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127472	1 – 572	Transcription factor E3Add BLAST		572

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	187	Asymmetric dimethylarginineCombined sources	1
Cross-linkⁱ	338	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	539	PhosphoserineBy similarity	1
Modified residueⁱ	545	PhosphoserineCombined sources	1
Modified residueⁱ	551	PhosphoserineCombined sources	1
Modified residueⁱ	553	PhosphoserineCombined sources	1
Modified residueⁱ	557	PhosphoserineCombined sources	1
Modified residueⁱ	565	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Sumoylated; does not affect dimerization with MITF.By similarity

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q64092
PRIDEⁱ	Q64092

PTM databases

iPTMnetⁱ	Q64092
PhosphoSitePlusⁱ	Q64092

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000000134 Expressed in 255 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	MM_TCFE3
ExpressionAtlasⁱ	Q64092 baseline and differential
Genevisibleⁱ	Q64092 MM

Interactionⁱ

Subunit structureⁱ

Homodimer and heterodimer; with TFEB or MITF.By similarity

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16936731

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	229078, 1 interactor
IntActⁱ	Q64092, 1 interactor
STRINGⁱ	10090.ENSMUSP00000076864

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q64092
SMRⁱ	Q64092
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	345 – 398	bHLHPROSITE-ProRule annotationAdd BLAST		54

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	259 – 270	Strong transcription activation domainSequence analysisAdd BLAST		12
Regionⁱ	408 – 429	Leucine-zipperAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG410ZYYV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004402
HOVERGENⁱ	HBG006768
InParanoidⁱ	Q64092
KEGG Orthology (KO) More...KOⁱ	K09105
OMAⁱ	PGTATFH

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR031867 MiT/TFE_N IPR024100 TFE3
PANTHERⁱ	PTHR12565 PTHR12565, 1 hit PTHR12565:SF163 PTHR12565:SF163, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q64092-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHAAEPARD AVEASAEGPR AVFLLLEERR PAESAQLLSL NSLLPESGIV 
        60         70         80         90        100
ADIELENILD PDSFYELKSQ PLFLRSSLPI SLQATPTTPA TLSASSSAGG 
       110        120        130        140        150
SRTPAMSSSS SRVLLRQQLM RAQAQEQERR ERREQAAAAP FPSPAPASPA 
       160        170        180        190        200
ISVIGVSAGG HTLSRPPPAQ VPREVLKVQT HLENPTRYHL QQARRQQVKQ 
       210        220        230        240        250
YLSTTLGPKL ASQALTPPPG PSSAQPLPAP ETAHATGPTG SAPNSPMALL 
       260        270        280        290        300
TIGSSSEKEI DDVIDEIISL ESSYNDEMLS YLPGGTAGLQ LPSTLPVSGN 
       310        320        330        340        350
LLDVYSSQGV ATPAITVSNS CPAELPNIKR EISETEAKAL LKERQKKDNH 
       360        370        380        390        400
NLIERRRRFN INDRIKELGT LIPKSNDPEM RWNKGTILKA SVDYIRKLQK 
       410        420        430        440        450
EQQRSKDLES RQRSLEQANR SLQLRIQELE LQAQIHGLPV PPNPGLLSLT 
       460        470        480        490        500
TSSVSDSLKP EQLDIEEEGR PSTTFHVSGG PAQNAPPQQP PAPPSDALLD 
       510        520        530        540        550
LHFPSDHLGD LGDPFHLGLE DILMEEEGMV GGLSGGALSP LRAASDPLLS 
       560        570 
SVSPAVSKAS SRRSSFSMEE ES

Length:572

Mass (Da):61,536

Last modified:January 9, 2007 - v2

Checksum:ⁱDAB0487EC0F6E92D

Isoform 2 (identifier: Q64092-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-105: Missing.

« Hide

        10         20         30         40         50
MSSSSSRVLL RQQLMRAQAQ EQERRERREQ AAAAPFPSPA PASPAISVIG 
        60         70         80         90        100
VSAGGHTLSR PPPAQVPREV LKVQTHLENP TRYHLQQARR QQVKQYLSTT 
       110        120        130        140        150
LGPKLASQAL TPPPGPSSAQ PLPAPETAHA TGPTGSAPNS PMALLTIGSS 
       160        170        180        190        200
SEKEIDDVID EIISLESSYN DEMLSYLPGG TAGLQLPSTL PVSGNLLDVY 
       210        220        230        240        250
SSQGVATPAI TVSNSCPAEL PNIKREISET EAKALLKERQ KKDNHNLIER 
       260        270        280        290        300
RRRFNINDRI KELGTLIPKS NDPEMRWNKG TILKASVDYI RKLQKEQQRS 
       310        320        330        340        350
KDLESRQRSL EQANRSLQLR IQELELQAQI HGLPVPPNPG LLSLTTSSVS 
       360        370        380        390        400
DSLKPEQLDI EEEGRPSTTF HVSGGPAQNA PPQQPPAPPS DALLDLHFPS 
       410        420        430        440        450
DHLGDLGDPF HLGLEDILME EEGMVGGLSG GALSPLRAAS DPLLSSVSPA 
       460 
VSKASSRRSS FSMEEES

Note: No experimental confirmation available.

Show »

Length:467

Mass (Da):50,509

Checksum:ⁱ2353472086F2A3A0

Isoform 3 (identifier: Q64092-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-105: Missing.
260-294: Missing.

« Hide

        10         20         30         40         50
MSSSSSRVLL RQQLMRAQAQ EQERRERREQ AAAAPFPSPA PASPAISVIG 
        60         70         80         90        100
VSAGGHTLSR PPPAQVPREV LKVQTHLENP TRYHLQQARR QQVKQYLSTT 
       110        120        130        140        150
LGPKLASQAL TPPPGPSSAQ PLPAPETAHA TGPTGSAPNS PMALLTIGSS 
       160        170        180        190        200
SEKELPVSGN LLDVYSSQGV ATPAITVSNS CPAELPNIKR EISETEAKAL 
       210        220        230        240        250
LKERQKKDNH NLIERRRRFN INDRIKELGT LIPKSNDPEM RWNKGTILKA 
       260        270        280        290        300
SVDYIRKLQK EQQRSKDLES RQRSLEQANR SLQLRIQELE LQAQIHGLPV 
       310        320        330        340        350
PPNPGLLSLT TSSVSDSLKP EQLDIEEEGR PSTTFHVSGG PAQNAPPQQP 
       360        370        380        390        400
PAPPSDALLD LHFPSDHLGD LGDPFHLGLE DILMEEEGMV GGLSGGALSP 
       410        420        430 
LRAASDPLLS SVSPAVSKAS SRRSSFSMEE ES

Note: No experimental confirmation available.

Show »

Length:432

Mass (Da):46,770

Checksum:ⁱ24EE10757C31E2CC

Isoform 4 (identifier: Q64092-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
260-294: Missing.

« Hide

        10         20         30         40         50
MSHAAEPARD AVEASAEGPR AVFLLLEERR PAESAQLLSL NSLLPESGIV 
        60         70         80         90        100
ADIELENILD PDSFYELKSQ PLFLRSSLPI SLQATPTTPA TLSASSSAGG 
       110        120        130        140        150
SRTPAMSSSS SRVLLRQQLM RAQAQEQERR ERREQAAAAP FPSPAPASPA 
       160        170        180        190        200
ISVIGVSAGG HTLSRPPPAQ VPREVLKVQT HLENPTRYHL QQARRQQVKQ 
       210        220        230        240        250
YLSTTLGPKL ASQALTPPPG PSSAQPLPAP ETAHATGPTG SAPNSPMALL 
       260        270        280        290        300
TIGSSSEKEL PVSGNLLDVY SSQGVATPAI TVSNSCPAEL PNIKREISET 
       310        320        330        340        350
EAKALLKERQ KKDNHNLIER RRRFNINDRI KELGTLIPKS NDPEMRWNKG 
       360        370        380        390        400
TILKASVDYI RKLQKEQQRS KDLESRQRSL EQANRSLQLR IQELELQAQI 
       410        420        430        440        450
HGLPVPPNPG LLSLTTSSVS DSLKPEQLDI EEEGRPSTTF HVSGGPAQNA 
       460        470        480        490        500
PPQQPPAPPS DALLDLHFPS DHLGDLGDPF HLGLEDILME EEGMVGGLSG 
       510        520        530 
GALSPLRAAS DPLLSSVSPA VSKASSRRSS FSMEEES

Note: No experimental confirmation available.

Show »

Length:537

Mass (Da):57,797

Checksum:ⁱ8E063275FBFC4F7A

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2AEW1	A2AEW1_MOUSE	Transcription factor E3 Transcription factor E3	Tfe3	572	Annotation score:
A2AEW0	A2AEW0_MOUSE	Transcription factor E3 Transcription factor E3	Tfe3	537	Annotation score:
A2AEW2	A2AEW2_MOUSE	Transcription factor E3 Transcription factor E3	Tfe3	136	Annotation score:
Z4YLF7	Z4YLF7_MOUSE	Transcription factor E3 Transcription factor E3	Tfe3	108	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	73	F → S in BAE24128 (PubMed:16141072).Curated	1
Sequence conflictⁱ	73	F → S in BAE25994 (PubMed:16141072).Curated	1
Sequence conflictⁱ	127 – 131	QERRE → TSGTR in AAB21130 (PubMed:1732746).Curated	5
Sequence conflictⁱ	143	S → G in BAE25994 (PubMed:16141072).Curated	1
Sequence conflictⁱ	558	K → N in AAB21130 (PubMed:1732746).Curated	1
Sequence conflictⁱ	568	M → I in AAB21130 (PubMed:1732746).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_022143	1 – 105	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST		105
Alternative sequenceⁱVSP_022144	260 – 294	Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST		35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK089762 mRNA Translation: BAC40955.1 AK139756 mRNA Translation: BAE24128.1 AK144657 mRNA Translation: BAE25994.1 AK152221 mRNA Translation: BAE31048.1 AL671995 Genomic DNA No translation available. BC056358 mRNA Translation: AAH56358.1 BC063047 mRNA Translation: AAH63047.1 S76673 mRNA Translation: AAB21130.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52984.1 [Q64092-1] CCDS52985.1 [Q64092-4] CCDS72332.1 [Q64092-2] CCDS72333.1 [Q64092-3]
PIRⁱ	A42029
NCBI Reference Sequences More...RefSeqⁱ	NP_001098666.1, NM_001105196.1 NP_001098667.1, NM_001105197.1 [Q64092-2] NP_001258418.1, NM_001271489.1 [Q64092-2] NP_001258419.1, NM_001271490.1 [Q64092-2] NP_001258420.1, NM_001271491.1 [Q64092-3] NP_766060.2, NM_172472.3 XP_006527641.1, XM_006527578.2 [Q64092-2] XP_017173942.1, XM_017318453.1 [Q64092-2] XP_017173943.1, XM_017318454.1 [Q64092-3]
UniGeneⁱ	Mm.249142

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q64092-3	Uncharacterized protein (Fragment)		MOUSE		539	UniRef100_Q64092-3

Protein	Similar proteins		Species	Score	Length	Source
Q64092	Transcription factor E3		HUMAN		575	UniRef90_P19532
Transcription factor E3		BOVIN		573
Transcription factor binding to IGHM enhancer 3		GORGO		575
Uncharacterized protein		PONAB		297
Transcription factor binding to IGHM enhancer 3		RABIT		680
+153
Q64092-3	Uncharacterized protein (Fragment)		MOUSE		539	UniRef90_Q64092-3
Q64092-4	Transcription factor binding to IGHM enhancer 3		SAIBB		540	UniRef90_Q64092-4
Uncharacterized protein		Cebus capucinus imitator		540
Uncharacterized protein		MACMU		540
Uncharacterized protein		CERAT		540
Uncharacterized protein		MANLE		540
+24

Protein	Similar proteins		Species	Score	Length	Source
Q64092	Transcription factor E3		HUMAN		575	UniRef50_P19532
Transcription factor E3		BOVIN		573
Transcription factor binding to IGHM enhancer 3		GORGO		575
Uncharacterized protein		PONAB		297
Transcription factor binding to IGHM enhancer 3		RABIT		680
+210
Q64092-3	Uncharacterized protein (Fragment)		MOUSE		539	UniRef50_Q64092-3
Transcription factor binding to IGHM enhancer 3		MONDO		556
Transcription factor E3		HETGA		454
Uncharacterized protein		SARHA		533
Uncharacterized protein		MACMU		540
+32
Q64092-4	Isoform 3 of Transcription factor E3		MOUSE		432	UniRef50_Q64092-3
Transcription factor binding to IGHM enhancer 3		MONDO		556
Transcription factor E3		HETGA		454
Uncharacterized protein		SARHA		533
Uncharacterized protein		MACMU		540
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK089762 mRNA Translation: BAC40955.1 AK139756 mRNA Translation: BAE24128.1 AK144657 mRNA Translation: BAE25994.1 AK152221 mRNA Translation: BAE31048.1 AL671995 Genomic DNA No translation available. BC056358 mRNA Translation: AAH56358.1 BC063047 mRNA Translation: AAH63047.1 S76673 mRNA Translation: AAB21130.1
CCDSⁱ	CCDS52984.1 [Q64092-1] CCDS52985.1 [Q64092-4] CCDS72332.1 [Q64092-2] CCDS72333.1 [Q64092-3]
PIRⁱ	A42029
RefSeqⁱ	NP_001098666.1, NM_001105196.1 NP_001098667.1, NM_001105197.1 [Q64092-2] NP_001258418.1, NM_001271489.1 [Q64092-2] NP_001258419.1, NM_001271490.1 [Q64092-2] NP_001258420.1, NM_001271491.1 [Q64092-3] NP_766060.2, NM_172472.3 XP_006527641.1, XM_006527578.2 [Q64092-2] XP_017173942.1, XM_017318453.1 [Q64092-2] XP_017173943.1, XM_017318454.1 [Q64092-3]
UniGeneⁱ	Mm.249142

3D structure databases

ProteinModelPortalⁱ	Q64092
SMRⁱ	Q64092
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229078, 1 interactor
IntActⁱ	Q64092, 1 interactor
STRINGⁱ	10090.ENSMUSP00000076864

PTM databases

iPTMnetⁱ	Q64092
PhosphoSitePlusⁱ	Q64092

Proteomic databases

PaxDbⁱ	Q64092
PRIDEⁱ	Q64092

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000101695; ENSMUSP00000099219; ENSMUSG00000000134 [Q64092-2] ENSMUST00000115677; ENSMUSP00000111341; ENSMUSG00000000134 [Q64092-2] ENSMUST00000115678; ENSMUSP00000111342; ENSMUSG00000000134 [Q64092-3] ENSMUST00000115679; ENSMUSP00000111343; ENSMUSG00000000134 [Q64092-2] ENSMUST00000137467; ENSMUSP00000134125; ENSMUSG00000000134 [Q64092-2]
GeneIDⁱ	209446
KEGGⁱ	mmu:209446
UCSCⁱ	uc009smg.2 mouse [Q64092-1] uc009smk.2 mouse [Q64092-3]

Organism-specific databases

CTDⁱ	7030
MGIⁱ	MGI:98511 Tfe3

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG410ZYYV LUCA
GeneTreeⁱ	ENSGT00390000004402
HOVERGENⁱ	HBG006768
InParanoidⁱ	Q64092
KOⁱ	K09105
OMAⁱ	PGTATFH

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q64092
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000134 Expressed in 255 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	MM_TCFE3
ExpressionAtlasⁱ	Q64092 baseline and differential
Genevisibleⁱ	Q64092 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR031867 MiT/TFE_N IPR024100 TFE3
PANTHERⁱ	PTHR12565 PTHR12565, 1 hit PTHR12565:SF163 PTHR12565:SF163, 1 hit
Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFE3_MOUSE
Accessionⁱ	Q64092Primary (citable) accession number: Q64092 Secondary accession number(s): A2AEW3 Q8BN29
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 9, 2007
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q64092 (TFE3_MOUSE)

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Transcription factor E3

Tfe3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ