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UniProtKB - Q64057 (AL7A1_RAT)
Protein
Alpha-aminoadipic semialdehyde dehydrogenase
Gene
Aldh7a1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity).
By similarityCatalytic activityi
: betaine biosynthesis via choline pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde. This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 195 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 296 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 330 | NucleophilePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 274 – 279 | NADBy similarity | 6 |
GO - Molecular functioni
- betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
- L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-RNO-6798163, Choline catabolism R-RNO-71064, Lysine catabolism |
UniPathwayi | UPA00529;UER00386 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)Short name: Alpha-AASA dehydrogenase Alternative name(s): |
Gene namesi | Name:Aldh7a1 Synonyms:Ald7a1 |
Organismi | Rattus norvegicus (Rat)Curated |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308614, Aldh7a1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- Mitochondrion By similarity
Cytoplasm and Cytosol
- cytosol By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 26 | MitochondrionSequence analysisAdd BLAST | 26 | |
ChainiPRO_0000056492 | 27 – 539 | Alpha-aminoadipic semialdehyde dehydrogenaseAdd BLAST | 513 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 86 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 94 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 94 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 97 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 97 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 462 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 500 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 537 | N6-succinyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | Q64057 |
PaxDbi | Q64057 |
PRIDEi | Q64057 |
PTM databases
iPTMneti | Q64057 |
PhosphoSitePlusi | Q64057 |
Expressioni
Tissue specificityi
Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas.2 Publications
Gene expression databases
Bgeei | ENSRNOG00000014645, Expressed in adult mammalian kidney and 21 other tissues |
Genevisiblei | Q64057, RN |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
BioGRIDi | 253522, 1 interactor |
STRINGi | 10116.ENSRNOP00000020325 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2453, Eukaryota |
GeneTreei | ENSGT00940000154938 |
HOGENOMi | CLU_005391_1_2_1 |
InParanoidi | Q64057 |
OMAi | DAWKVYM |
OrthoDBi | 692580at2759 |
PhylomeDBi | Q64057 |
TreeFami | TF300388 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR044638, ALDH7A1-like |
PANTHERi | PTHR43521, PTHR43521, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q64057-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLARPLCV QTVKASKLSR LWSRPAALMS TLLIHHPQYA WLQDLGLRED
60 70 80 90 100
NEGVFNGSWG GRGEVITTYC PANNEPIARV RQASMKDYEE TIGKAKKAWN
110 120 130 140 150
IWADIPAPKR GEIVRKIGDA LREKIQLLGR LVSLEMGKIL VEGIGEVQEY
160 170 180 190 200
VDVCDYAAGL SRMIGGPTLP SERPGHALME QWNPLGLVGI ITAFNFPVAV
210 220 230 240 250
FGWNNAIALI TGNVCLWKGA PTTSLVSIAV TKIIAKVLED NLLPGAICSL
260 270 280 290 300
TCGGADMGTA MARDERVNLL SFTGSTQVGK QVALMVQERF GKSLLELGGN
310 320 330 340 350
NAIIAFEDAD LSLVLPSALF AAVGTAGQRC TTVRRLFLHE SIHDEVVDRL
360 370 380 390 400
KNAYSQIRVG NPWDPNILYG PLHTKQAVSM FVQAVEEAKK EGGTVVYGGK
410 420 430 440 450
VMDHPGNYVE PTIVTGLVHD APIVHKETFA PILYVFKFKN EEEVFEWNNE
460 470 480 490 500
VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK
510 520 530
HTGGGRESGS DAWKQYMRRS TCTINYSTAL PLAQGIKFQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03109709 Genomic DNA No translation available. S75019 mRNA Translation: AAB31967.2 |
PIRi | B54676 |
RefSeqi | NP_001258034.1, NM_001271105.1 |
Genome annotation databases
Ensembli | ENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645 |
GeneIDi | 291450 |
KEGGi | rno:291450 |
UCSCi | RGD:1308614, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03109709 Genomic DNA No translation available. S75019 mRNA Translation: AAB31967.2 |
PIRi | B54676 |
RefSeqi | NP_001258034.1, NM_001271105.1 |
3D structure databases
SMRi | Q64057 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 253522, 1 interactor |
STRINGi | 10116.ENSRNOP00000020325 |
PTM databases
iPTMneti | Q64057 |
PhosphoSitePlusi | Q64057 |
Proteomic databases
jPOSTi | Q64057 |
PaxDbi | Q64057 |
PRIDEi | Q64057 |
Genome annotation databases
Ensembli | ENSRNOT00000020325; ENSRNOP00000020325; ENSRNOG00000014645 |
GeneIDi | 291450 |
KEGGi | rno:291450 |
UCSCi | RGD:1308614, rat |
Organism-specific databases
CTDi | 501 |
RGDi | 1308614, Aldh7a1 |
Phylogenomic databases
eggNOGi | KOG2453, Eukaryota |
GeneTreei | ENSGT00940000154938 |
HOGENOMi | CLU_005391_1_2_1 |
InParanoidi | Q64057 |
OMAi | DAWKVYM |
OrthoDBi | 692580at2759 |
PhylomeDBi | Q64057 |
TreeFami | TF300388 |
Enzyme and pathway databases
UniPathwayi | UPA00529;UER00386 |
Reactomei | R-RNO-6798163, Choline catabolism R-RNO-71064, Lysine catabolism |
Miscellaneous databases
PROi | PR:Q64057 |
Gene expression databases
Bgeei | ENSRNOG00000014645, Expressed in adult mammalian kidney and 21 other tissues |
Genevisiblei | Q64057, RN |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR044638, ALDH7A1-like |
PANTHERi | PTHR43521, PTHR43521, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AL7A1_RAT | |
Accessioni | Q64057Primary (citable) accession number: Q64057 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | April 20, 2010 | |
Last modified: | June 2, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families