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UniProtKB - Q63ZY3 (KANK2_HUMAN)

Entry version 161 (25 May 2022)
Sequence version 1 (25 Oct 2004)
Previous versions | rss
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Protein

KN motif and ankyrin repeat domain-containing protein 2

Gene

KANK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305).

Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500).

Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500).

Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081).

Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457).

May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457).

Through the Rho signaling pathway may also regulate cell proliferation (By similarity).

By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q63ZY3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q63ZY3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 2
Alternative name(s):
Ankyrin repeat domain-containing protein 25
Matrix-remodeling-associated protein 3
SRC-1-interacting protein
Short name:
SIP
Short name:
SRC-interacting protein
Short name:
SRC1-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KANK2
Synonyms:ANKRD25, KIAA1518, MXRA3, SIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29300, KANK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614610, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q63ZY3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197256

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Palmoplantar keratoderma and woolly hair (PPKWH)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormal thickening of the skin on the palms and soles, in association with woolly scalp hair. Affected individuals manifest a variable degree of striate palmoplantar keratoderma, generally more severe on the soles. Leukonychia is more pronounced on the fingernails than toenails. Scalp hair, body hair, eyebrows, and eyelashes are sparse. The fifth toes show variable degrees of pseudoainhum, ranging from external rotation to a deep sulcus at the digitoplantar fold, accompanied by a bulbous appearance of the distal toe.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072431670A → V in PPKWH. 1 PublicationCorresponds to variant dbSNP:rs606231303EnsemblClinVar.1
Nephrotic syndrome 16 (NPHS16)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form that progresses to end-stage renal failure. NPHS16 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080959181S → G in NPHS16; increased interaction with ARHGDIA; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; loss of function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555820663EnsemblClinVar.1
Natural variantiVAR_080960676S → F in NPHS16; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; decreased function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555816634EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi510 – 512SSS → AAA: Impairs phosphorylation; when associated with A-515. 1 Publication3
Mutagenesisi515S → A: Impairs phosphorylation; when associated with 510-A--A-512. 1 Publication1
Mutagenesisi702Y → A: 4-fold decrease in binding to KIF21A. 1 Publication1
Mutagenesisi702Y → L: 33-fold decrease in binding to KIF21A. 1 Publication1
Mutagenesisi803D → A: 26-fold decrease in binding to KIF21A. 1 Publication1
Mutagenesisi805D → A: 20-fold decrease in binding to KIF21A. 1 Publication1

Keywords - Diseasei

Disease variant, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		25959

MalaCards human disease database

More...MalaCardsi		KANK2
MIMi616099, phenotype
617783, phenotype

Open Targets

More...OpenTargetsi		ENSG00000197256

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		420686, Woolly hair-palmoplantar keratoderma syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162392581

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q63ZY3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KANK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74757262

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408401 – 851KN motif and ankyrin repeat domain-containing protein 2Add BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei92PhosphoserineCombined sources1
Modified residuei105Omega-N-methylarginineCombined sources1
Modified residuei168PhosphothreonineBy similarity1
Modified residuei323PhosphoserineCombined sources1
Modified residuei329PhosphothreonineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei472PhosphothreonineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei552PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by casein kinase II upon estrogen stimulation (PubMed:17476305). Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription (PubMed:17476305).1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q63ZY3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q63ZY3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q63ZY3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q63ZY3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q63ZY3

PeptideAtlas

More...PeptideAtlasi		Q63ZY3

PRoteomics IDEntifications database

More...PRIDEi		Q63ZY3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65901 [Q63ZY3-1]
65902 [Q63ZY3-2]
65903 [Q63ZY3-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q63ZY3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q63ZY3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q63ZY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q63ZY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197256, Expressed in lower esophagus and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q63ZY3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q63ZY3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197256, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (non-phosphorylated form) with NCOA1; NCOA2 AND NCOA3 (PubMed:17476305).

Interacts with AIFM1 (PubMed:22371500).

Interacts with ARHGDIA; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (PubMed:25961457).

Interacts (via ANK repeats 1-5) with KIF21A (via residues 1146-1167) (PubMed:29183992).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q63ZY3
With#Exp.IntAct
ABI3 [Q9P2A4]6EBI-2556193,EBI-742038
ABT1 [Q9ULW3]3EBI-2556193,EBI-2602396
AEN - isoform 2 [Q8WTP8-2]3EBI-2556193,EBI-12119298
AIFM1 [O95831]2EBI-2556193,EBI-356440
ANKRD11 [X5D778]3EBI-2556193,EBI-17183751
AP2B1 - isoform 2 [P63010-2]3EBI-2556193,EBI-11529439
ARL14EP [Q8N8R7]3EBI-2556193,EBI-2807994
ASB15 [Q8WXK1]3EBI-2556193,EBI-12809012
BEND7 - isoform 2 [Q8N7W2-2]3EBI-2556193,EBI-10181188
BIRC7 [Q96CA5]3EBI-2556193,EBI-517623
BLZF1 [Q9H2G9]3EBI-2556193,EBI-2548012
BORCS6 [Q96GS4]3EBI-2556193,EBI-10193358
C11orf1 [Q9H5F2]3EBI-2556193,EBI-718615
C2orf68 [Q2NKX9]3EBI-2556193,EBI-11603468
CADPS [A2RRN7]3EBI-2556193,EBI-10179719
CAMK2G - isoform 5 [Q13555-5]3EBI-2556193,EBI-12020154
CAPN3 - isoform IV [P20807-4]3EBI-2556193,EBI-11532021
CARD10 [Q9BWT7]3EBI-2556193,EBI-3866279
CARD9 - isoform 2 [Q9H257-2]3EBI-2556193,EBI-11530605
CBX8 [Q9HC52]3EBI-2556193,EBI-712912
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-2556193,EBI-10961624
CCDC88B [A6NC98]3EBI-2556193,EBI-347573
CDC20B - isoform 5 [Q86Y33-5]3EBI-2556193,EBI-11983537
CDC5L [Q99459]3EBI-2556193,EBI-374880
CDK18 [Q07002]3EBI-2556193,EBI-746238
CDKL3 [Q8IVW4]3EBI-2556193,EBI-3919850
CEACAM6 [P40199]3EBI-2556193,EBI-4314501
CEP55 [Q53EZ4]3EBI-2556193,EBI-747776
CEP63 - isoform 3 [Q96MT8-3]3EBI-2556193,EBI-11522539
CEP70 [Q8NHQ1]6EBI-2556193,EBI-739624
CHCHD3 [Q9NX63]3EBI-2556193,EBI-743375
CHIC2 [Q9UKJ5]3EBI-2556193,EBI-741528
CINP [Q9BW66]3EBI-2556193,EBI-739784
COG6 [Q9Y2V7]3EBI-2556193,EBI-3866319
CRX [O43186]3EBI-2556193,EBI-748171
CUTC [Q9NTM9]3EBI-2556193,EBI-714918
CWF19L2 [Q2TBE0]3EBI-2556193,EBI-5453285
CYTH4 [Q9UIA0]3EBI-2556193,EBI-11521003
DDIT4L [Q96D03]3EBI-2556193,EBI-742054
DLGAP3 [O95886]3EBI-2556193,EBI-1752541
DPEP2NB [A0A0U1RQF7]3EBI-2556193,EBI-18398199
DTX2 [Q86UW9]3EBI-2556193,EBI-740376
DYNLL1 [P63167]6EBI-2556193,EBI-349105
DYNLL2 [Q96FJ2]3EBI-2556193,EBI-742371
EFHC2 [Q5JST6]3EBI-2556193,EBI-2349927
EIF4E [P06730]7EBI-2556193,EBI-73440
ELOA [Q14241]3EBI-2556193,EBI-742350
EXOSC8 [Q96B26]3EBI-2556193,EBI-371922
FAM161A [Q3B820]3EBI-2556193,EBI-719941
FAM90A1 [Q86YD7]3EBI-2556193,EBI-6658203
FHL2 [Q14192]6EBI-2556193,EBI-701903
FHL3 [Q13643]3EBI-2556193,EBI-741101
FKBP6 [O75344]3EBI-2556193,EBI-744771
GADD45GIP1 [Q8TAE8]3EBI-2556193,EBI-372506
GAS2L2 [Q8NHY3]3EBI-2556193,EBI-7960826
GATA1 - isoform 2 [P15976-2]3EBI-2556193,EBI-9090198
GEMIN4 [P57678]3EBI-2556193,EBI-356700
GKAP1 [Q5VSY0]5EBI-2556193,EBI-743722
GMCL1 [Q96IK5]3EBI-2556193,EBI-2548508
GMNN [O75496]3EBI-2556193,EBI-371669
GNL3L [Q9NVN8]3EBI-2556193,EBI-746682
GOLGA2 [Q08379]7EBI-2556193,EBI-618309
GOLGA6A [Q9NYA3]3EBI-2556193,EBI-11163335
GOLGA6L9 [A6NEM1]3EBI-2556193,EBI-5916454
GPANK1 [O95872]3EBI-2556193,EBI-751540
GPKOW [Q92917]3EBI-2556193,EBI-746309
GPSM1 - isoform 3 [Q86YR5-3]3EBI-2556193,EBI-10261098
GRB10 - isoform 4 [Q13322-4]3EBI-2556193,EBI-12353035
HAND2 - isoform 2 [P61296-2]3EBI-2556193,EBI-13086076
HOMER3 [Q9NSC5]3EBI-2556193,EBI-748420
HSF2BP [O75031]3EBI-2556193,EBI-7116203
HSPB2 [Q16082]3EBI-2556193,EBI-739395
IHO1 [Q8IYA8]6EBI-2556193,EBI-8638439
IKZF3 [Q9UKT9]3EBI-2556193,EBI-747204
IL16 - isoform 2 [Q14005-2]6EBI-2556193,EBI-17178971
INO80B [Q9C086]3EBI-2556193,EBI-715611
KIF9 [Q9HAQ2]3EBI-2556193,EBI-8472129
KIFAP3 [Q92845]3EBI-2556193,EBI-954040
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-2556193,EBI-14069005
KRT27 [Q7Z3Y8]3EBI-2556193,EBI-3044087
KRT34 [O76011]3EBI-2556193,EBI-1047093
KRT40 [Q6A162]3EBI-2556193,EBI-10171697
KRT75 [O95678]3EBI-2556193,EBI-2949715
KRT86 [O43790]3EBI-2556193,EBI-9996498
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-2556193,EBI-11985629
LBX1 [P52954]3EBI-2556193,EBI-20141748
LENG1 [Q96BZ8]3EBI-2556193,EBI-726510
LHX1 [P48742]3EBI-2556193,EBI-11990598
LHX3 - isoform B [Q9UBR4-2]3EBI-2556193,EBI-12039345
LMO1 [P25800]9EBI-2556193,EBI-8639312
LMO2 [P25791]3EBI-2556193,EBI-739696
LMO2 - isoform 3 [P25791-3]3EBI-2556193,EBI-11959475
LMO3 - isoform 4 [Q8TAP4-4]3EBI-2556193,EBI-11742507
LMO4 [P61968]6EBI-2556193,EBI-2798728
LZTS1 [Q9Y250]3EBI-2556193,EBI-1216080
MAGEB4 [O15481]6EBI-2556193,EBI-751857
MCCD1 [P59942]3EBI-2556193,EBI-11987923
MCRS1 [Q96EZ8]3EBI-2556193,EBI-348259
MED19 - isoform 2 [A0JLT2-2]3EBI-2556193,EBI-13288755
MEOX1 [P50221]3EBI-2556193,EBI-2864512
MEOX2 [Q6FHY5]3EBI-2556193,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-2556193,EBI-10172526
MITD1 [Q8WV92]3EBI-2556193,EBI-2691489
MKRN3 [Q13064]3EBI-2556193,EBI-2340269
MNS1 [Q8NEH6]3EBI-2556193,EBI-743811
MOB1A [Q9H8S9]6EBI-2556193,EBI-748229
MOB3C [Q70IA8]3EBI-2556193,EBI-9679267
MORN3 [Q6PF18]3EBI-2556193,EBI-9675802
MSS51 [Q4VC12]3EBI-2556193,EBI-11599933
MTUS2 - isoform 2 [Q5JR59-3]3EBI-2556193,EBI-11522433
MYOZ3 [Q8TDC0]3EBI-2556193,EBI-5662487
NCOA1 [Q15788]4EBI-2556193,EBI-455189
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-2556193,EBI-10172876
NELFE [P18615]3EBI-2556193,EBI-348444
OIP5 [O43482]3EBI-2556193,EBI-536879
PAX6 [P26367]3EBI-2556193,EBI-747278
PCBD1 [P61457]3EBI-2556193,EBI-740475
PDE9A - isoform PDE9A2 [O76083-2]3EBI-2556193,EBI-11524542
PDLIM7 [Q9NR12]3EBI-2556193,EBI-350517
PFDN6 [O15212]3EBI-2556193,EBI-356973
PIBF1 [Q4G0R1]3EBI-2556193,EBI-14066006
PLAGL1 [Q9UM63]3EBI-2556193,EBI-7233410
PLAGL2 [Q9UPG8]3EBI-2556193,EBI-2876622
PLEKHA2 [Q9HB19]3EBI-2556193,EBI-4401947
PNKP [Q96T60]3EBI-2556193,EBI-1045072
PPP1CB [P62140]3EBI-2556193,EBI-352350
PRDM14 [Q9GZV8]3EBI-2556193,EBI-3957793
PRDM6 [Q9NQX0]3EBI-2556193,EBI-11320284
PRKAR1B [P31321]3EBI-2556193,EBI-2805516
PRMT5 [O14744]3EBI-2556193,EBI-351098
PRPF18 [Q99633]3EBI-2556193,EBI-2798416
PRPF31 [Q8WWY3]3EBI-2556193,EBI-1567797
PRR5L [Q6MZQ0]3EBI-2556193,EBI-1567866
PSMB4 [P28070]3EBI-2556193,EBI-603350
PSTPIP1 [O43586]3EBI-2556193,EBI-1050964
RAB11FIP2 [Q7L804]3EBI-2556193,EBI-1049676
RALBP1 [Q15311]3EBI-2556193,EBI-749285
RBCK1 [Q9BYM8]3EBI-2556193,EBI-2340624
RHOH [Q15669]3EBI-2556193,EBI-1244971
RNF8 [O76064]3EBI-2556193,EBI-373337
SCARA5 - isoform 2 [Q6ZMJ2-2]3EBI-2556193,EBI-12823227
SCNM1 [Q9BWG6]6EBI-2556193,EBI-748391
SERTAD3 [Q9UJW9]3EBI-2556193,EBI-748621
SNAPIN [O95295]3EBI-2556193,EBI-296723
SNW1 [Q13573]3EBI-2556193,EBI-632715
SORBS3 [O60504]3EBI-2556193,EBI-741237
STAC [Q8WUK8]3EBI-2556193,EBI-10276615
STAC [Q99469]3EBI-2556193,EBI-2652799
SYT6 - isoform 2 [Q5T7P8-2]6EBI-2556193,EBI-10246152
TAX1BP1 [Q86VP1]3EBI-2556193,EBI-529518
TEX11 - isoform 3 [Q8IYF3-3]3EBI-2556193,EBI-11523345
TFIP11 [Q9UBB9]3EBI-2556193,EBI-1105213
TGM5 [O43548]3EBI-2556193,EBI-12027348
THAP1 [Q9NVV9]3EBI-2556193,EBI-741515
THAP6 [Q8TBB0]3EBI-2556193,EBI-3925505
TIFA [Q96CG3]3EBI-2556193,EBI-740711
TLE5 [Q08117]3EBI-2556193,EBI-717810
TLE5 - isoform 2 [Q08117-2]6EBI-2556193,EBI-11741437
TOP3B [O95985]3EBI-2556193,EBI-373403
TRAF1 [Q13077]3EBI-2556193,EBI-359224
TRAF2 [Q12933]3EBI-2556193,EBI-355744
TRAF4 [Q9BUZ4]3EBI-2556193,EBI-3650647
TRIB3 [Q96RU7]5EBI-2556193,EBI-492476
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-2556193,EBI-17716262
TRIM54 [Q9BYV2]3EBI-2556193,EBI-2130429
TSGA10 [Q9BZW7]3EBI-2556193,EBI-744794
TSGA10IP [Q3SY00]3EBI-2556193,EBI-10241197
TSPYL6 [Q8N831]3EBI-2556193,EBI-12023322
TXLNA [P40222]6EBI-2556193,EBI-359793
UBAP2 [Q5T6F2]3EBI-2556193,EBI-2514383
USHBP1 [Q8N6Y0]3EBI-2556193,EBI-739895
UTP14C [Q5TAP6]3EBI-2556193,EBI-11737646
VMAC [Q2NL98]3EBI-2556193,EBI-2803134
VPS52 [Q8N1B4]3EBI-2556193,EBI-2799833
VWC2 [Q2TAL6]3EBI-2556193,EBI-11957238
WASF3 - isoform 2 [Q9UPY6-2]3EBI-2556193,EBI-12026286
ZBTB42 [B2RXF5]3EBI-2556193,EBI-12287587
ZFP57 - isoform 3 [Q9NU63-3]3EBI-2556193,EBI-12879708
ZMAT2 [Q96NC0]3EBI-2556193,EBI-2682299
ZMYND12 [Q9H0C1]3EBI-2556193,EBI-12030590
ZNF212 [Q9UDV6]3EBI-2556193,EBI-1640204
ZNF414 [Q96IQ9]3EBI-2556193,EBI-744257
ZNF417 [Q8TAU3]3EBI-2556193,EBI-740727
ZNF512 [Q96ME7]3EBI-2556193,EBI-10986895
ZNF648 [Q5T619]3EBI-2556193,EBI-11985915
ZNF774 [Q6NX45]3EBI-2556193,EBI-10251462
ZNF784 [Q8NCA9]3EBI-2556193,EBI-7138303
ZNHIT1 [O43257]3EBI-2556193,EBI-347522
ZRANB1 [Q9UGI0]3EBI-2556193,EBI-527853
Isoform 2 [Q63ZY3-2]
With#Exp.IntAct
AIFM1 [O95831]4EBI-6244894,EBI-356440

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117449, 287 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q63ZY3

Protein interaction database and analysis system

More...IntActi		Q63ZY3, 237 interactors

Molecular INTeraction database

More...MINTi		Q63ZY3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000468002

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q63ZY3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1851
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q63ZY3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q63ZY3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati614 – 651ANK 0; degenerate1 PublicationAdd BLAST38
Repeati666 – 696ANK 1Sequence analysisAdd BLAST31
Repeati700 – 733ANK 2Sequence analysisAdd BLAST34
Repeati738 – 767ANK 3Sequence analysisAdd BLAST30
Repeati771 – 801ANK 4Sequence analysisAdd BLAST31
Repeati805 – 835ANK 5Sequence analysisAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 72Interaction with AIFM11 PublicationAdd BLAST72
Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni139 – 182DisorderedSequence analysisAdd BLAST44
Regioni304 – 325DisorderedSequence analysisAdd BLAST22
Regioni416 – 584DisorderedSequence analysisAdd BLAST169
Regioni669 – 835Interaction with NCOA11 PublicationAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili183 – 234Sequence analysisAdd BLAST52
Coiled coili282 – 312Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 30Pro residuesSequence analysisAdd BLAST21
Compositional biasi142 – 156Polar residuesSequence analysisAdd BLAST15
Compositional biasi425 – 447Polar residuesSequence analysisAdd BLAST23
Compositional biasi448 – 462Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi504 – 527Polar residuesSequence analysisAdd BLAST24
Compositional biasi556 – 580Polar residuesSequence analysisAdd BLAST25

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0514, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004269_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q63ZY3

Identification of Orthologs from Complete Genome Data

More...OMAi		HQRSLQF

Database of Orthologous Groups

More...OrthoDBi		98668at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q63ZY3

TreeFam database of animal gene trees

More...TreeFami		TF324499

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR021939, KN_motif

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF12075, KN_motif, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q63ZY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV 
        60         70         80         90        100
DDIEKGHTLR RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY 
       110        120        130        140        150
SYCGRGFYPQ YGALETRGGF NPRVERTLLD ARRRLEDQAA TPTGLGSLTP 
       160        170        180        190        200
SAAGSTASLV GVGLPPPTPR SSGLSTPVPP SAGHLAHVRE QMAGALRKLR 
       210        220        230        240        250
QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT AGRGRSELCL 
       260        270        280        290        300
DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 
       310        320        330        340        350
QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP 
       360        370        380        390        400
AQRAQSLEPY GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH 
       410        420        430        440        450
MVKKISITER SCDGAAGLPE VPAESSSSPP GSEVASLTQP EKSTGRVPTQ 
       460        470        480        490        500
EPTHREPTRQ AASQESEEAG GTGGPPAGVR SIMKRKEEVA DPTAHRRSLQ 
       510        520        530        540        550
FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS VAEAPQLRPA 
       560        570        580        590        600
GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA 
       610        620        630        640        650
LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA 
       660        670        680        690        700
MSARLLDYVV NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA 
       710        720        730        740        750
GYSPIMLTAL ATLKTQDDIE TVLQLFRLGN INAKASQAGQ TALMLAVSHG 
       760        770        780        790        800
RVDVVKALLA CEADVNVQDD DGSTALMCAC EHGHKEIAGL LLAVPSCDIS 
       810        820        830        840        850
LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSFAPMSD DESPTSSSAE 

E
Length:851
Mass (Da):91,174
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC14CD8B937A7B6E8
GO
Isoform 2 (identifier: Q63ZY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-472: T → TAPPLSSPP

Show »
Length:859
Mass (Da):91,921
Checksum:i0629BE4E0E29FCEE
GO
Isoform 3 (identifier: Q63ZY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     835-841: FAPMSDD → VSLNPAG
     842-851: Missing.

Show »
Length:841
Mass (Da):90,044
Checksum:iD82155CD26E514F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES05K7ES05_HUMAN
KN motif and ankyrin repeat domain-...
KANK2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL48K7EL48_HUMAN
KN motif and ankyrin repeat domain-...
KANK2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIU4K7EIU4_HUMAN
KN motif and ankyrin repeat domain-...
KANK2
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERU2K7ERU2_HUMAN
KN motif and ankyrin repeat domain-...
KANK2
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92081 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA96042 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14531 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti525D → N in BAA96042 (PubMed:10819331).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048304118G → S. Corresponds to variant dbSNP:rs755237Ensembl.1
Natural variantiVAR_080959181S → G in NPHS16; increased interaction with ARHGDIA; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; loss of function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555820663EnsemblClinVar.1
Natural variantiVAR_048305401M → T. Corresponds to variant dbSNP:rs17616661Ensembl.1
Natural variantiVAR_072431670A → V in PPKWH. 1 PublicationCorresponds to variant dbSNP:rs606231303EnsemblClinVar.1
Natural variantiVAR_080960676S → F in NPHS16; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; decreased function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555816634EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019427472T → TAPPLSSPP in isoform 2. 1 Publication1
Alternative sequenceiVSP_019428835 – 841FAPMSDD → VSLNPAG in isoform 3. 1 Publication7
Alternative sequenceiVSP_019429842 – 851Missing in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY639929 mRNA Translation: AAT57879.1
AB284125 mRNA Translation: BAG06864.1
AB040951 mRNA Translation: BAA96042.2 Different initiation.
CH471106 Genomic DNA Translation: EAW84177.1
BC082762 mRNA Translation: AAH82762.1
BC098105 mRNA Translation: AAH98105.1
BC098286 mRNA Translation: AAH98286.1
BC098312 mRNA Translation: AAH98312.1
BC105989 mRNA Translation: AAI05990.1
AK002094 mRNA Translation: BAA92081.1 Different initiation.
AK023332 mRNA Translation: BAB14531.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12255.1 [Q63ZY3-1]
CCDS54219.1 [Q63ZY3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001129663.1, NM_001136191.2 [Q63ZY3-1]
NP_001316380.1, NM_001329451.1 [Q63ZY3-1]
NP_056308.3, NM_015493.6 [Q63ZY3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000586659.6; ENSP00000465650.1; ENSG00000197256.11
ENST00000589359.5; ENSP00000468002.1; ENSG00000197256.11 [Q63ZY3-2]
ENST00000589894.1; ENSP00000467029.1; ENSG00000197256.11 [Q63ZY3-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25959

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25959

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000586659.6; ENSP00000465650.1; NM_001136191.3; NP_001129663.1

UCSC genome browser

More...UCSCi		uc002mqo.5, human [Q63ZY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY639929 mRNA Translation: AAT57879.1
AB284125 mRNA Translation: BAG06864.1
AB040951 mRNA Translation: BAA96042.2 Different initiation.
CH471106 Genomic DNA Translation: EAW84177.1
BC082762 mRNA Translation: AAH82762.1
BC098105 mRNA Translation: AAH98105.1
BC098286 mRNA Translation: AAH98286.1
BC098312 mRNA Translation: AAH98312.1
BC105989 mRNA Translation: AAI05990.1
AK002094 mRNA Translation: BAA92081.1 Different initiation.
AK023332 mRNA Translation: BAB14531.1 Different initiation.
CCDSiCCDS12255.1 [Q63ZY3-1]
CCDS54219.1 [Q63ZY3-2]
RefSeqiNP_001129663.1, NM_001136191.2 [Q63ZY3-1]
NP_001316380.1, NM_001329451.1 [Q63ZY3-1]
NP_056308.3, NM_015493.6 [Q63ZY3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HBDX-ray1.72A578-832[»]
5YBVX-ray2.12A/B578-832[»]
6TMDX-ray1.50A583-832[»]
AlphaFoldDBiQ63ZY3
SMRiQ63ZY3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117449, 287 interactors
ELMiQ63ZY3
IntActiQ63ZY3, 237 interactors
MINTiQ63ZY3
STRINGi9606.ENSP00000468002

PTM databases

GlyGeniQ63ZY3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ63ZY3
MetOSiteiQ63ZY3
PhosphoSitePlusiQ63ZY3

Genetic variation databases

BioMutaiKANK2
DMDMi74757262

Proteomic databases

EPDiQ63ZY3
jPOSTiQ63ZY3
MassIVEiQ63ZY3
MaxQBiQ63ZY3
PaxDbiQ63ZY3
PeptideAtlasiQ63ZY3
PRIDEiQ63ZY3
ProteomicsDBi65901 [Q63ZY3-1]
65902 [Q63ZY3-2]
65903 [Q63ZY3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2885, 189 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		25959

Genome annotation databases

EnsembliENST00000586659.6; ENSP00000465650.1; ENSG00000197256.11
ENST00000589359.5; ENSP00000468002.1; ENSG00000197256.11 [Q63ZY3-2]
ENST00000589894.1; ENSP00000467029.1; ENSG00000197256.11 [Q63ZY3-3]
GeneIDi25959
KEGGihsa:25959
MANE-SelectiENST00000586659.6; ENSP00000465650.1; NM_001136191.3; NP_001129663.1
UCSCiuc002mqo.5, human [Q63ZY3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25959
DisGeNETi25959

GeneCards: human genes, protein and diseases

More...GeneCardsi		KANK2
HGNCiHGNC:29300, KANK2
HPAiENSG00000197256, Low tissue specificity
MalaCardsiKANK2
MIMi614610, gene
616099, phenotype
617783, phenotype
neXtProtiNX_Q63ZY3
OpenTargetsiENSG00000197256
Orphaneti420686, Woolly hair-palmoplantar keratoderma syndrome
PharmGKBiPA162392581
VEuPathDBiHostDB:ENSG00000197256

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0514, Eukaryota
GeneTreeiENSGT00940000161012
HOGENOMiCLU_004269_2_0_1
InParanoidiQ63ZY3
OMAiHQRSLQF
OrthoDBi98668at2759
PhylomeDBiQ63ZY3
TreeFamiTF324499

Enzyme and pathway databases

PathwayCommonsiQ63ZY3
SignaLinkiQ63ZY3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25959, 14 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KANK2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ANKRD25

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25959
PharosiQ63ZY3, Tbio

Protein Ontology

More...PROi		PR:Q63ZY3
RNActiQ63ZY3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197256, Expressed in lower esophagus and 238 other tissues
ExpressionAtlasiQ63ZY3, baseline and differential
GenevisibleiQ63ZY3, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR021939, KN_motif
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF12075, KN_motif, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKANK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63ZY3
Secondary accession number(s): B0I1P4
, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 25, 2004
Last modified: May 25, 2022
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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