UniProtKB - Q63ZY3 (KANK2_HUMAN)
KN motif and ankyrin repeat domain-containing protein 2
KANK2
Functioni
Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305).
Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500).
Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500).
Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081).
Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457).
May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457).
Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
By similarity5 PublicationsGO - Biological processi
- apoptotic process Source: UniProtKB-KW
- glomerular visceral epithelial cell migration Source: UniProtKB
- kidney epithelium development Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- negative regulation of programmed cell death Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of vitamin D receptor signaling pathway Source: UniProtKB
- regulation of Rho protein signal transduction Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q63ZY3 |
SignaLinki | Q63ZY3 |
Names & Taxonomyi
Protein namesi | Recommended name: KN motif and ankyrin repeat domain-containing protein 2Alternative name(s): Ankyrin repeat domain-containing protein 25 Matrix-remodeling-associated protein 3 SRC-1-interacting protein Short name: SIP Short name: SRC-interacting protein Short name: SRC1-interacting protein |
Gene namesi | Name:KANK2 Synonyms:ANKRD25, KIAA1518, MXRA3, SIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29300, KANK2 |
MIMi | 614610, gene |
neXtProti | NX_Q63ZY3 |
VEuPathDBi | HostDB:ENSG00000197256 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 4 Publications
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MitochondrionPathology & Biotechi
Involvement in diseasei
Palmoplantar keratoderma and woolly hair (PPKWH)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072431 | 670 | A → V in PPKWH. 1 PublicationCorresponds to variant dbSNP:rs606231303EnsemblClinVar. | 1 |
Nephrotic syndrome 16 (NPHS16)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080959 | 181 | S → G in NPHS16; increased interaction with ARHGDIA; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; loss of function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555820663EnsemblClinVar. | 1 | |
Natural variantiVAR_080960 | 676 | S → F in NPHS16; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; decreased function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555816634EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 510 – 512 | SSS → AAA: Impairs phosphorylation; when associated with A-515. 1 Publication | 3 | |
Mutagenesisi | 515 | S → A: Impairs phosphorylation; when associated with 510-A--A-512. 1 Publication | 1 | |
Mutagenesisi | 702 | Y → A: 4-fold decrease in binding to KIF21A. 1 Publication | 1 | |
Mutagenesisi | 702 | Y → L: 33-fold decrease in binding to KIF21A. 1 Publication | 1 | |
Mutagenesisi | 803 | D → A: 26-fold decrease in binding to KIF21A. 1 Publication | 1 | |
Mutagenesisi | 805 | D → A: 20-fold decrease in binding to KIF21A. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Palmoplantar keratodermaOrganism-specific databases
DisGeNETi | 25959 |
MalaCardsi | KANK2 |
MIMi | 616099, phenotype 617783, phenotype |
OpenTargetsi | ENSG00000197256 |
Orphaneti | 420686, Woolly hair-palmoplantar keratoderma syndrome |
PharmGKBi | PA162392581 |
Miscellaneous databases
Pharosi | Q63ZY3, Tbio |
Genetic variation databases
BioMutai | KANK2 |
DMDMi | 74757262 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240840 | 1 – 851 | KN motif and ankyrin repeat domain-containing protein 2Add BLAST | 851 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 83 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphoserineBy similarity | 1 | |
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 168 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineCombined sources | 1 | |
Modified residuei | 375 | PhosphoserineCombined sources | 1 | |
Modified residuei | 472 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 540 | PhosphoserineCombined sources | 1 | |
Modified residuei | 552 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q63ZY3 |
jPOSTi | Q63ZY3 |
MassIVEi | Q63ZY3 |
MaxQBi | Q63ZY3 |
PaxDbi | Q63ZY3 |
PeptideAtlasi | Q63ZY3 |
PRIDEi | Q63ZY3 |
ProteomicsDBi | 65901 [Q63ZY3-1] 65902 [Q63ZY3-2] 65903 [Q63ZY3-3] |
PTM databases
GlyGeni | Q63ZY3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q63ZY3 |
MetOSitei | Q63ZY3 |
PhosphoSitePlusi | Q63ZY3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000197256, Expressed in lower esophagus and 238 other tissues |
ExpressionAtlasi | Q63ZY3, baseline and differential |
Genevisiblei | Q63ZY3, HS |
Organism-specific databases
HPAi | ENSG00000197256, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (non-phosphorylated form) with NCOA1; NCOA2 AND NCOA3 (PubMed:17476305).
Interacts with AIFM1 (PubMed:22371500).
Interacts with ARHGDIA; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (PubMed:25961457).
Interacts (via ANK repeats 1-5) with KIF21A (via residues 1146-1167) (PubMed:29183992).
4 PublicationsBinary interactionsi
Q63ZY3
Isoform 2 [Q63ZY3-2]
With | #Exp. | IntAct |
---|---|---|
AIFM1 [O95831] | 4 | EBI-6244894,EBI-356440 |
Protein-protein interaction databases
BioGRIDi | 117449, 287 interactors |
ELMi | Q63ZY3 |
IntActi | Q63ZY3, 237 interactors |
MINTi | Q63ZY3 |
STRINGi | 9606.ENSP00000468002 |
Miscellaneous databases
RNActi | Q63ZY3, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q63ZY3 |
SMRi | Q63ZY3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 614 – 651 | ANK 0; degenerate1 PublicationAdd BLAST | 38 | |
Repeati | 666 – 696 | ANK 1Sequence analysisAdd BLAST | 31 | |
Repeati | 700 – 733 | ANK 2Sequence analysisAdd BLAST | 34 | |
Repeati | 738 – 767 | ANK 3Sequence analysisAdd BLAST | 30 | |
Repeati | 771 – 801 | ANK 4Sequence analysisAdd BLAST | 31 | |
Repeati | 805 – 835 | ANK 5Sequence analysisAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | Interaction with AIFM11 PublicationAdd BLAST | 72 | |
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 139 – 182 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 304 – 325 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 416 – 584 | DisorderedSequence analysisAdd BLAST | 169 | |
Regioni | 669 – 835 | Interaction with NCOA11 PublicationAdd BLAST | 167 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 183 – 234 | Sequence analysisAdd BLAST | 52 | |
Coiled coili | 282 – 312 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 30 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 142 – 156 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 425 – 447 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 448 – 462 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 504 – 527 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 556 – 580 | Polar residuesSequence analysisAdd BLAST | 25 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000161012 |
HOGENOMi | CLU_004269_2_0_1 |
InParanoidi | Q63ZY3 |
OMAi | HQRSLQF |
OrthoDBi | 98668at2759 |
PhylomeDBi | Q63ZY3 |
TreeFami | TF324499 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF12075, KN_motif, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV
60 70 80 90 100
DDIEKGHTLR RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY
110 120 130 140 150
SYCGRGFYPQ YGALETRGGF NPRVERTLLD ARRRLEDQAA TPTGLGSLTP
160 170 180 190 200
SAAGSTASLV GVGLPPPTPR SSGLSTPVPP SAGHLAHVRE QMAGALRKLR
210 220 230 240 250
QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT AGRGRSELCL
260 270 280 290 300
DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL
310 320 330 340 350
QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP
360 370 380 390 400
AQRAQSLEPY GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH
410 420 430 440 450
MVKKISITER SCDGAAGLPE VPAESSSSPP GSEVASLTQP EKSTGRVPTQ
460 470 480 490 500
EPTHREPTRQ AASQESEEAG GTGGPPAGVR SIMKRKEEVA DPTAHRRSLQ
510 520 530 540 550
FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS VAEAPQLRPA
560 570 580 590 600
GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA
610 620 630 640 650
LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA
660 670 680 690 700
MSARLLDYVV NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA
710 720 730 740 750
GYSPIMLTAL ATLKTQDDIE TVLQLFRLGN INAKASQAGQ TALMLAVSHG
760 770 780 790 800
RVDVVKALLA CEADVNVQDD DGSTALMCAC EHGHKEIAGL LLAVPSCDIS
810 820 830 840 850
LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSFAPMSD DESPTSSSAE
E
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ES05 | K7ES05_HUMAN | KN motif and ankyrin repeat domain-... | KANK2 | 147 | Annotation score: | ||
K7EL48 | K7EL48_HUMAN | KN motif and ankyrin repeat domain-... | KANK2 | 44 | Annotation score: | ||
K7EIU4 | K7EIU4_HUMAN | KN motif and ankyrin repeat domain-... | KANK2 | 221 | Annotation score: | ||
K7ERU2 | K7ERU2_HUMAN | KN motif and ankyrin repeat domain-... | KANK2 | 122 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 525 | D → N in BAA96042 (PubMed:10819331).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048304 | 118 | G → S. Corresponds to variant dbSNP:rs755237Ensembl. | 1 | |
Natural variantiVAR_080959 | 181 | S → G in NPHS16; increased interaction with ARHGDIA; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; loss of function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555820663EnsemblClinVar. | 1 | |
Natural variantiVAR_048305 | 401 | M → T. Corresponds to variant dbSNP:rs17616661Ensembl. | 1 | |
Natural variantiVAR_072431 | 670 | A → V in PPKWH. 1 PublicationCorresponds to variant dbSNP:rs606231303EnsemblClinVar. | 1 | |
Natural variantiVAR_080960 | 676 | S → F in NPHS16; loss of function in regulation of the Rho signaling pathway; no effect on cytoplasmic localization; decreased function in podocytes migration. 1 PublicationCorresponds to variant dbSNP:rs1555816634EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019427 | 472 | T → TAPPLSSPP in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_019428 | 835 – 841 | FAPMSDD → VSLNPAG in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_019429 | 842 – 851 | Missing in isoform 3. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY639929 mRNA Translation: AAT57879.1 AB284125 mRNA Translation: BAG06864.1 AB040951 mRNA Translation: BAA96042.2 Different initiation. CH471106 Genomic DNA Translation: EAW84177.1 BC082762 mRNA Translation: AAH82762.1 BC098105 mRNA Translation: AAH98105.1 BC098286 mRNA Translation: AAH98286.1 BC098312 mRNA Translation: AAH98312.1 BC105989 mRNA Translation: AAI05990.1 AK002094 mRNA Translation: BAA92081.1 Different initiation. AK023332 mRNA Translation: BAB14531.1 Different initiation. |
CCDSi | CCDS12255.1 [Q63ZY3-1] CCDS54219.1 [Q63ZY3-2] |
RefSeqi | NP_001129663.1, NM_001136191.2 [Q63ZY3-1] NP_001316380.1, NM_001329451.1 [Q63ZY3-1] NP_056308.3, NM_015493.6 [Q63ZY3-2] |
Genome annotation databases
Ensembli | ENST00000586659.6; ENSP00000465650.1; ENSG00000197256.11 ENST00000589359.5; ENSP00000468002.1; ENSG00000197256.11 [Q63ZY3-2] ENST00000589894.1; ENSP00000467029.1; ENSG00000197256.11 [Q63ZY3-3] |
GeneIDi | 25959 |
KEGGi | hsa:25959 |
MANE-Selecti | ENST00000586659.6; ENSP00000465650.1; NM_001136191.3; NP_001129663.1 |
UCSCi | uc002mqo.5, human [Q63ZY3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY639929 mRNA Translation: AAT57879.1 AB284125 mRNA Translation: BAG06864.1 AB040951 mRNA Translation: BAA96042.2 Different initiation. CH471106 Genomic DNA Translation: EAW84177.1 BC082762 mRNA Translation: AAH82762.1 BC098105 mRNA Translation: AAH98105.1 BC098286 mRNA Translation: AAH98286.1 BC098312 mRNA Translation: AAH98312.1 BC105989 mRNA Translation: AAI05990.1 AK002094 mRNA Translation: BAA92081.1 Different initiation. AK023332 mRNA Translation: BAB14531.1 Different initiation. |
CCDSi | CCDS12255.1 [Q63ZY3-1] CCDS54219.1 [Q63ZY3-2] |
RefSeqi | NP_001129663.1, NM_001136191.2 [Q63ZY3-1] NP_001316380.1, NM_001329451.1 [Q63ZY3-1] NP_056308.3, NM_015493.6 [Q63ZY3-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HBD | X-ray | 1.72 | A | 578-832 | [»] | |
5YBV | X-ray | 2.12 | A/B | 578-832 | [»] | |
6TMD | X-ray | 1.50 | A | 583-832 | [»] | |
AlphaFoldDBi | Q63ZY3 | |||||
SMRi | Q63ZY3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117449, 287 interactors |
ELMi | Q63ZY3 |
IntActi | Q63ZY3, 237 interactors |
MINTi | Q63ZY3 |
STRINGi | 9606.ENSP00000468002 |
PTM databases
GlyGeni | Q63ZY3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q63ZY3 |
MetOSitei | Q63ZY3 |
PhosphoSitePlusi | Q63ZY3 |
Genetic variation databases
BioMutai | KANK2 |
DMDMi | 74757262 |
Proteomic databases
EPDi | Q63ZY3 |
jPOSTi | Q63ZY3 |
MassIVEi | Q63ZY3 |
MaxQBi | Q63ZY3 |
PaxDbi | Q63ZY3 |
PeptideAtlasi | Q63ZY3 |
PRIDEi | Q63ZY3 |
ProteomicsDBi | 65901 [Q63ZY3-1] 65902 [Q63ZY3-2] 65903 [Q63ZY3-3] |
Protocols and materials databases
Antibodypediai | 2885, 189 antibodies from 28 providers |
DNASUi | 25959 |
Genome annotation databases
Ensembli | ENST00000586659.6; ENSP00000465650.1; ENSG00000197256.11 ENST00000589359.5; ENSP00000468002.1; ENSG00000197256.11 [Q63ZY3-2] ENST00000589894.1; ENSP00000467029.1; ENSG00000197256.11 [Q63ZY3-3] |
GeneIDi | 25959 |
KEGGi | hsa:25959 |
MANE-Selecti | ENST00000586659.6; ENSP00000465650.1; NM_001136191.3; NP_001129663.1 |
UCSCi | uc002mqo.5, human [Q63ZY3-1] |
Organism-specific databases
CTDi | 25959 |
DisGeNETi | 25959 |
GeneCardsi | KANK2 |
HGNCi | HGNC:29300, KANK2 |
HPAi | ENSG00000197256, Low tissue specificity |
MalaCardsi | KANK2 |
MIMi | 614610, gene 616099, phenotype 617783, phenotype |
neXtProti | NX_Q63ZY3 |
OpenTargetsi | ENSG00000197256 |
Orphaneti | 420686, Woolly hair-palmoplantar keratoderma syndrome |
PharmGKBi | PA162392581 |
VEuPathDBi | HostDB:ENSG00000197256 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000161012 |
HOGENOMi | CLU_004269_2_0_1 |
InParanoidi | Q63ZY3 |
OMAi | HQRSLQF |
OrthoDBi | 98668at2759 |
PhylomeDBi | Q63ZY3 |
TreeFami | TF324499 |
Enzyme and pathway databases
PathwayCommonsi | Q63ZY3 |
SignaLinki | Q63ZY3 |
Miscellaneous databases
BioGRID-ORCSi | 25959, 14 hits in 1079 CRISPR screens |
ChiTaRSi | KANK2, human |
GeneWikii | ANKRD25 |
GenomeRNAii | 25959 |
Pharosi | Q63ZY3, Tbio |
PROi | PR:Q63ZY3 |
RNActi | Q63ZY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197256, Expressed in lower esophagus and 238 other tissues |
ExpressionAtlasi | Q63ZY3, baseline and differential |
Genevisiblei | Q63ZY3, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF12075, KN_motif, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KANK2_HUMAN | |
Accessioni | Q63ZY3Primary (citable) accession number: Q63ZY3 Secondary accession number(s): B0I1P4 Q9P210 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | October 25, 2004 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references