Insm1

Functionⁱ

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.5 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	272 – 292	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	300 – 322	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	373 – 395	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	452 – 475	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	480 – 503	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin DNA binding Source: UniProtKB
cyclin binding Source: MGI
DNA-binding transcription factor activity Source: UniProtKB
histone deacetylase binding Source: MGI
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adrenal chromaffin cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
cell cycle Source: UniProtKB-KW
cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16511571
endocrine pancreas development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16511571
endocrine system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16951258
negative regulation of cell proliferation Source: UniProtKB
negative regulation of protein phosphorylation Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: UniProtKB
noradrenergic neuron development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
norepinephrine biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
pancreatic A cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 16511571
positive regulation of cell cycle arrest Source: UniProtKB
positive regulation of cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
positive regulation of cell migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 25053427
positive regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 25053427
positive regulation of neural precursor cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
regulation of protein complex assembly Source: UniProtKB
sympathetic ganglion development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18094025
transdifferentiation Source: UniProtKB
type B pancreatic cell development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16951258
type B pancreatic cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 16511571

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Cell cycle, Differentiation, Neurogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulinoma-associated protein 1 Alternative name(s): Zinc finger protein IA-1
Gene namesⁱ	Name:Insm1 Synonyms:Ia1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1859980 Insm1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice die during the second half of gestation; lethality is caused by heart failure due to insufficient catecholamine synthesis. Display pancreatic, intestinal and sympatho-adrenal endocrine cell development impairment. Exhibits fewer terminally dividing neuronogenic basal progenitor cells (BPs) in the neocortex.3 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047269	1 – 521	Insulinoma-associated protein 1Add BLAST		521

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q63ZV0
PaxDbⁱ	Q63ZV0
PRIDEⁱ	Q63ZV0

PTM databases

iPTMnetⁱ	Q63ZV0
PhosphoSitePlusⁱ	Q63ZV0

Expressionⁱ

Tissue specificityⁱ

Expressed in adrenal gland. Expressed in the dentate gyrus of the hippocampus and the wall of the lateral ventricle. Expressed in pancreatic and intestinal endocrine cells.3 Publications

Developmental stageⁱ

Expressed in differentiating endocrine cells of the anterior pituitary gland between 11.5 and 17.5 dpc. Expressed in all hormone-secreting cell types of the pituitary gland. Expressed in primary sympathetic ganglion chain, spinal chord and in neurons of the dorsal root ganglia at 9.5 dpc. Expressed in chromaffin cells of the adrenal medulla at 13.5 dpc (at protein level). Expressed in the developing central nervous system (CNS). Expressed in midbrain-hindbrain region at 9.5 dpc, in the spinal cord and telencephalon at 11 dpc. Expressed in the forebrain, midbrain, hind brain, spinal cord, cerebellum, olfactory bulb and retina between 11.5 and 14.5 dpc. Expressed in neural stem and progenitor cells of the developing neocortex in both the ventricular zone (VZ) and in the adjacent subventricular zone (SVZ), and in the external granule cell layer of the developing cerebellum between 11 and 16.5 dpc. Expressed in neural progenitor cells at the apical side of the VZ, collectively referred to as apical basal cells (APs; neuroepithelial cells, radial glial cells and short neural precursors) between 10.5 and 16.5 dpc. Expressed in neural progenitor cells in the basal region of the VZ between 10.5 and 16.5 dpc and at later stages in basal progenitor cells (BPs) of the SVZ. Expressed in the cerebellum and pineal gland at 18.5 dpc. Expressed in islet progenitor cells at 10.5 dpc. Expressed in endocrine pancreatic cells, enteric nervous system, duodenum, stomach, thymus, thyroid, adrenal glands at 15.5 dpc.7 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000068154 Expressed in 186 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_INSM1
ExpressionAtlasⁱ	Q63ZV0 baseline and differential
Genevisibleⁱ	Q63ZV0 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via the N-terminal region) with CCND1 (via cyclin N-terminal domain); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and increases its transcriptional repressor activity. Interacts with HDAC3; the interaction increases its transcriptional repressor activity (By similarity). Interacts (via the SNAG domain) with HDAC1. Interacts (via the SNAG domain) with HDAC2. Interacts (via the SNAG domain) with KDM1A. Interacts (via the SNAG domain) with RCOR1. Interacts with SORBS1.By similarity2 Publications

GO - Molecular functionⁱ

cyclin binding Source: MGI
histone deacetylase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000092048

STRINGⁱ

10090.ENSMUSP00000092048

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63ZV0
SMRⁱ	Q63ZV0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20
Regionⁱ	43 – 56	Necessary for interaction with CCND1By similarityAdd BLAST		14

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1 – 250	Gly/Pro-richAdd BLAST		250
Compositional biasⁱ	405 – 414	Pro-rich		10

Domainⁱ

The C-terminal region is necessary for NEUROD1 promoter DNA-binding and transcriptional repressor activity.By similarity

Sequence similaritiesⁱ

Belongs to the INSM1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	272 – 292	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	300 – 322	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	373 – 395	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	452 – 475	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	480 – 503	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3993 Eukaryota ENOG4111MVC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064190
HOGENOMⁱ	HOG000113079
HOVERGENⁱ	HBG052137
InParanoidⁱ	Q63ZV0
OMAⁱ	APAELKM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BI3
PhylomeDBⁱ	Q63ZV0
TreeFamⁱ	TF320538

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q63ZV0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRGFLVKRS KKSTPVSYRV RGGEDSDRAL LLSPGCGGAR AEPPVPSPGP 
        60         70         80         90        100
LPPPPPPALA ERAHAALAAA LACAPGPPPP PPPGPRAAHF GNPEAAHPAP 
       110        120        130        140        150
LYSPTRPVSR EHEKHKYFER SFNLGSPVSA ESFPTPAALL AGGGSGANGA 
       160        170        180        190        200
GGGGGGTCGG DALLFAPAEL KMGTAFSAGA EAARGPGTGP PLSPAAALRP 
       210        220        230        240        250
PGKRPAPPAA VATEPPAKAA KAPSAKKPKA IRKLHFEDEV TTSPVLGLKI 
       260        270        280        290        300
KEGPVEAPRG RAGGATRPLG EFICQLCKEE YADPFALAQH KCSRIVRVEY 
       310        320        330        340        350
RCPECAKVFS CPANLASHRR WHKPRPVPAA ARAPEPEAAT RAEAREAAGG 
       360        370        380        390        400
GSSDRDTPSP GGVSESGSED GLYECHHCAK KFRRQAYLRK HLLAHHQALQ 
       410        420        430        440        450
AKGAPPPPPP PPPPAEDILA FYAGPDEKAP QEASGDGEAA GVLGLSATAQ 
       460        470        480        490        500
CHLCPVCGET FPSKGAQERH LRLLHAAQVF PCKYCPATFY SSPGLTRHIN 
       510        520 
KCHPSENRQV ILLQVPVRPA C

Length:521

Mass (Da):54,050

Last modified:October 25, 2004 - v1

Checksum:ⁱ84D0D8E64504D351

GO

Sequence cautionⁱ

The sequence AAD15718 differs from that shown. Reason: Frameshift at positions 329 and 369.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	59	L → R in AAD15718 (PubMed:12079283).Curated	1
Sequence conflictⁱ	255	V → L in AAD15718 (PubMed:12079283).Curated	1
Sequence conflictⁱ	266	T → A in AAD15718 (PubMed:12079283).Curated	1
Sequence conflictⁱ	332	R → G (PubMed:12079283).Curated	1
Sequence conflictⁱ	353	S → T (PubMed:12079283).Curated	1
Sequence conflictⁱ	371	G → R (PubMed:12079283).Curated	1
Sequence conflictⁱ	431	Q → H in AAD15718 (PubMed:12079283).Curated	1
Sequence conflictⁱ	437	G → S in AAD15718 (PubMed:12079283).Curated	1
Sequence conflictⁱ	446	S → N in AAD15718 (PubMed:12079283).Curated	1
Sequence conflictⁱ	454 – 456	CPV → FPL in AAD15718 (PubMed:12079283).Curated	3
Sequence conflictⁱ	463	S → T in AAD15718 (PubMed:12079283).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044669 mRNA Translation: AAD15718.1 Frameshift. BC082809 mRNA Translation: AAH82809.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16830.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058585.2, NM_016889.3
UniGeneⁱ	Mm.379070

Genome annotation databases

Ensemblⁱ	ENSMUST00000089257; ENSMUSP00000092048; ENSMUSG00000068154
GeneIDⁱ	53626
KEGGⁱ	mmu:53626
UCSC genome browser More...UCSCⁱ	uc008msh.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q63ZV0	Insm1 protein		MOUSE		521	UniRef100_Q63ZV0

Protein	Similar proteins		Species	Score	Length	Source
Q63ZV0	Insulinoma-associated protein 1		BOVIN		522	UniRef90_Q63ZV0
Insulinoma-associated protein 1	)	HUMAN		510
Insm1 protein		MOUSE		521
LOW QUALITY PROTEIN: insulinoma-associated protein 1		DELLE		524
insulinoma-associated protein 1		MESAU		517
+37

Protein	Similar proteins		Species	Score	Length	Source
Q63ZV0	Insulinoma-associated protein 1		BOVIN		522	UniRef50_Q63ZV0
Insulinoma-associated protein 1	)	HUMAN		510
Insm1 protein		MOUSE		521
LOW QUALITY PROTEIN: insulinoma-associated protein 1		DELLE		524
insulinoma-associated protein 1		MESAU		517
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044669 mRNA Translation: AAD15718.1 Frameshift. BC082809 mRNA Translation: AAH82809.1
CCDSⁱ	CCDS16830.1
RefSeqⁱ	NP_058585.2, NM_016889.3
UniGeneⁱ	Mm.379070

3D structure databases

ProteinModelPortalⁱ	Q63ZV0
SMRⁱ	Q63ZV0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000092048

STRINGⁱ

10090.ENSMUSP00000092048

PTM databases

iPTMnetⁱ	Q63ZV0
PhosphoSitePlusⁱ	Q63ZV0

Proteomic databases

MaxQBⁱ	Q63ZV0
PaxDbⁱ	Q63ZV0
PRIDEⁱ	Q63ZV0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000089257; ENSMUSP00000092048; ENSMUSG00000068154
GeneIDⁱ	53626
KEGGⁱ	mmu:53626
UCSCⁱ	uc008msh.2 mouse

Organism-specific databases

CTDⁱ	3642
MGIⁱ	MGI:1859980 Insm1

Phylogenomic databases

eggNOGⁱ	KOG3993 Eukaryota ENOG4111MVC LUCA
GeneTreeⁱ	ENSGT00530000064190
HOGENOMⁱ	HOG000113079
HOVERGENⁱ	HBG052137
InParanoidⁱ	Q63ZV0
OMAⁱ	APAELKM
OrthoDBⁱ	EOG091G0BI3
PhylomeDBⁱ	Q63ZV0
TreeFamⁱ	TF320538

Miscellaneous databases

ChiTaRSⁱ	Insm1 mouse
Protein Ontology More...PROⁱ	PR:Q63ZV0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000068154 Expressed in 186 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_INSM1
ExpressionAtlasⁱ	Q63ZV0 baseline and differential
Genevisibleⁱ	Q63ZV0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INSM1_MOUSE
Accessionⁱ	Q63ZV0Primary (citable) accession number: Q63ZV0 Secondary accession number(s): Q9Z113
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	October 25, 2004
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63ZV0 (INSM1_MOUSE)

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Insulinoma-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ