Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi389 – 396ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE272560:G1G3Q-1151-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:BPSL1118
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei292 – 312HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925721 – 596Lipid A export ATP-binding/permease protein MsbAAdd BLAST596

Proteomic databases

PRIDEiQ63VX7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272560.BPSL1118

Structurei

3D structure databases

ProteinModelPortaliQ63VX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 321ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini353 – 589ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK11085
OMAiAWGTYLV

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q63VX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKPTLSKP IGGQDASSPA VVMRRLWPYV KPLVWVLVAG VLAMAAVAAT
60 70 80 90 100
EAGIPALLKP LLDHGFGSKG DMTTKLYVPA AVVGLALARA IAQYASGYLL
110 120 130 140 150
QYVSNRILLD LRIQMFERMI HTGVSFFQRE TASTVINAVV FEVNQVLSVL
160 170 180 190 200
MGVTITLVRD SLTVVFLLGY LFYLNWRLTL IVAILLPCIG WLVGKINRRL
210 220 230 240 250
RRLNREHQTL TNQLAYIVEE TVGGYKVVKV HNGEPYEIGR FNELSRKLRG
260 270 280 290 300
YSMRMTVSGG LAQPLTQFLA SIALAVVLTI AVVQSANDQT TVGGFVAFVT
310 320 330 340 350
AMLLIISPLK HLMDVNQPLQ RGMTAAELIF GLIDEPREPE GGGKPLARAS
360 370 380 390 400
GAIEFSHVSF SYGMSRDGRQ TLDDVSFTVA PGEMVALAGP SGSGKTTLVN
410 420 430 440 450
LLPRFFDPSS GSVRVDGVAL PEYSLRDLRN QIAMVSQDVV LFNDTIAANV
460 470 480 490 500
AYGQAPERDR VEAALRAANL WETVTAMPDG IDTLVGDNGM RLSGGQRQRL
510 520 530 540 550
AIARAIYKDA PILILDEATS ALDSESERHV QAALETLMKG RTTLVIAHRL
560 570 580 590
STIERADRIL VLEGGKIVES GSHRELLEQG GLYAHLHRIQ FQQDAG
Length:596
Mass (Da):64,839
Last modified:October 25, 2004 - v1
Checksum:i14EFC6B399B2C0FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA Translation: CAH35111.1
RefSeqiWP_004186431.1, NZ_CP009538.1
YP_107739.1, NC_006350.1

Genome annotation databases

EnsemblBacteriaiCAH35111; CAH35111; BPSL1118
GeneIDi3091747
KEGGibps:BPSL1118
PATRICifig|272560.51.peg.430

Similar proteinsi

Entry informationi

Entry nameiMSBA_BURPS
AccessioniPrimary (citable) accession number: Q63VX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health