UniProtKB - Q63MX6 (Q63MX6_BURPS)
Protein
Submitted name:
Putative ATPase
Gene
BPSS0522
Organism
Burkholderia pseudomallei (strain K96243)
Status
Functioni
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.ARBA annotation
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | ChaperoneARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BPSE272560:G1G3Q-4151-MONOMER |
Names & Taxonomyi
Protein namesi | Submitted name: Putative ATPaseImported |
Gene namesi | Ordered Locus Names:BPSS0522Imported |
Organismi | Burkholderia pseudomallei (strain K96243)Imported |
Taxonomic identifieri | 272560 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › |
Proteomesi |
|
Interactioni
Subunit structurei
Homohexamer. The oligomerization is ATP-dependent.
ARBA annotationProtein-protein interaction databases
STRINGi | 272560.BPSS0522 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 223 – 368 | AAAInterPro annotationAdd BLAST | 146 | |
Domaini | 598 – 742 | AAAInterPro annotationAdd BLAST | 145 | |
Domaini | 769 – 859 | ClpB_D2-smallInterPro annotationAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 898 – 956 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 922 – 937 | PolyampholyteSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the ClpA/ClpB family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
eggNOGi | COG0542, Bacteria |
OMAi | STALIEW |
Family and domain databases
Gene3Di | 1.10.1780.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR017729, ATPase_T6SS_ClpV1 IPR019489, Clp_ATPase_C IPR036628, Clp_N_dom_sf IPR004176, Clp_R_dom IPR001270, ClpA/B IPR018368, ClpA/B_CS1 IPR041546, ClpA/ClpB_AAA_lid IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF07724, AAA_2, 1 hit PF17871, AAA_lid_9, 1 hit PF02861, Clp_N, 1 hit PF10431, ClpB_D2-small, 1 hit |
PRINTSi | PR00300, CLPPROTEASEA |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01086, ClpB_D2-small, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF81923, SSF81923, 1 hit |
TIGRFAMsi | TIGR03345, VI_ClpV1, 1 hit |
PROSITEi | View protein in PROSITE PS00870, CLPAB_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q63MX6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNRERIFNCL GRTTYAALVD ATALGRSRRH AFIDLDHWAL CLLQREQSDL
60 70 80 90 100
ARLFELFGSD AGEAKRRMEK ALDGFDVSGD SLRDISSSLE RSVGPAVIWS
110 120 130 140 150
QIAARAGKVR SGHLLLAWLD EDLTRRWLQQ RVPSGITSVA LDDVVKRYEA
160 170 180 190 200
LAAGWPEADE APAALDGAAL GAQAGEAGAD GTGDALAKWA TCVTEQAARG
210 220 230 240 250
ELDPVVGRDD ELRTVIDILS RRRQNNPILV GEAGVGKTAV VEALAQKIHA
260 270 280 290 300
GAVPPGLVGA QVWALDLARM QAGAGVRGEF EQRLKSLIDA VIASPAPIIL
310 320 330 340 350
FCDETHTLIG AGGAAGTGDA ANLIKPMLAR GQLRMVAATT WSEYKQYIEP
360 370 380 390 400
DAALVRRFQA VAVDEPSDDA AVDMLRTIAP RFAAHHGVRI VDSALRGAVE
410 420 430 440 450
LSRRYLPARQ LPDKAISLLD TACARVAMSQ SCAPAELERL QHQAFAIGQT
460 470 480 490 500
LDWRASDRRM GVRTPGDEAE LEGRQASLAQ QAATLETVVD AQRDEVRAWL
510 520 530 540 550
ARLNDATPQA ADGDGAAFAA RIGANRWVRP WVDEHVVSEV LAEWTGVPVA
560 570 580 590 600
QLAQDDAQRV VELEAALNAG IHGQTGAMRS IAQALQVSHS GLNDPRRPLG
610 620 630 640 650
VMLLAGPTGT GKSQAAAKLA ELLFGGERNL LQFNMNEFQE AHTVSTLKGA
660 670 680 690 700
PPGYVGYGKG GRLTEAVRKK PYSVLLLDEF DRAHPDIHEV FYQVFDQGWM
710 720 730 740 750
EDGEGRRISF RNCLILLTSN LGEAEIEAAC KADPRISQAK LDKLVGERLQ
760 770 780 790 800
GRFSPALLAR IQLVAFRTLD VDALTGIATQ ALDELGERLA QNDLQWRADE
810 820 830 840 850
GVASWIAHAV SQHPANGRAV RDLLRQHVMP AVARGVLAAR AEGRALKTVR
860 870 880 890 900
LAANEKLSLV FDEDAWELSG TDAASLGEQA QAVAMAREAE AVAAAVAARE
910 920 930 940 950
AHGAHGTNEA DGGGGAPHAA KADAHVDSDD ERPGGAPHPD ETASANAGTT
GEPSCV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571966 Genomic DNA Translation: CAH37979.1 |
RefSeqi | WP_004525547.1, NZ_CP009537.1 YP_110543.1, NC_006351.1 |
Genome annotation databases
EnsemblBacteriai | CAH37979; CAH37979; BPSS0522 |
KEGGi | bps:BPSS0522 |
PATRICi | fig|272560.51.peg.6682 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571966 Genomic DNA Translation: CAH37979.1 |
RefSeqi | WP_004525547.1, NZ_CP009537.1 YP_110543.1, NC_006351.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 272560.BPSS0522 |
Genome annotation databases
EnsemblBacteriai | CAH37979; CAH37979; BPSS0522 |
KEGGi | bps:BPSS0522 |
PATRICi | fig|272560.51.peg.6682 |
Phylogenomic databases
eggNOGi | COG0542, Bacteria |
OMAi | STALIEW |
Enzyme and pathway databases
BioCyci | BPSE272560:G1G3Q-4151-MONOMER |
Family and domain databases
Gene3Di | 1.10.1780.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR017729, ATPase_T6SS_ClpV1 IPR019489, Clp_ATPase_C IPR036628, Clp_N_dom_sf IPR004176, Clp_R_dom IPR001270, ClpA/B IPR018368, ClpA/B_CS1 IPR041546, ClpA/ClpB_AAA_lid IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF07724, AAA_2, 1 hit PF17871, AAA_lid_9, 1 hit PF02861, Clp_N, 1 hit PF10431, ClpB_D2-small, 1 hit |
PRINTSi | PR00300, CLPPROTEASEA |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01086, ClpB_D2-small, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF81923, SSF81923, 1 hit |
TIGRFAMsi | TIGR03345, VI_ClpV1, 1 hit |
PROSITEi | View protein in PROSITE PS00870, CLPAB_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q63MX6_BURPS | |
Accessioni | Q63MX6Primary (citable) accession number: Q63MX6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 25, 2004 |
Last sequence update: | October 25, 2004 | |
Last modified: | February 10, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |