UniProtKB - Q63J85 (Q63J85_BURPS)
Protein
UDP-glucose 6-dehydrogenase
Gene
udg2
Organism
Burkholderia pseudomallei (strain K96243)
Status
Functioni
Catalytic activityi
- H2O + 2 NAD+ + UDP-α-D-glucose = 3 H+ + 2 NADH + UDP-α-D-glucuronateUniRule annotationARBA annotationEC:1.1.1.22UniRule annotationARBA annotation
: UDP-alpha-D-glucuronate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- UDP-glucose 6-dehydrogenase (udg2), UDP-glucose 6-dehydrogenase (udg)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 30 | NADUniRule annotation | 1 | |
Binding sitei | 35 | NADUniRule annotation | 1 | |
Binding sitei | 86 | NADUniRule annotation | 1 | |
Binding sitei | 121 | NAD; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 158 | NADUniRule annotation | 1 | |
Active sitei | 270 | NucleophileUniRule annotation | 1 | |
Binding sitei | 273 | NADUniRule annotation | 1 | |
Binding sitei | 338 | NADUniRule annotation | 1 |
GO - Molecular functioni
- NAD binding Source: InterPro
- UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- polysaccharide biosynthetic process Source: InterPro
- UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseUniRule annotationImportedARBA annotation |
Ligand | NADUniRule annotationARBA annotation |
Enzyme and pathway databases
BioCyci | BPSE272560:G1G3Q-5530-MONOMER |
UniPathwayi | UPA00038;UER00491 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-glucose 6-dehydrogenaseUniRule annotationARBA annotation (EC:1.1.1.22UniRule annotationARBA annotation) |
Gene namesi | Name:udg2Imported Ordered Locus Names:BPSS1833Imported |
Organismi | Burkholderia pseudomallei (strain K96243)Imported |
Taxonomic identifieri | 272560 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 324 – 436 | UDPG_MGDP_dh_CInterPro annotationAdd BLAST | 113 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1004, Bacteria |
OMAi | LCTEWDE |
Family and domain databases
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR017476, UDP-Glc/GDP-Man IPR014027, UDP-Glc/GDP-Man_DH_C IPR036220, UDP-Glc/GDP-Man_DH_C_sf IPR014026, UDP-Glc/GDP-Man_DH_dimer IPR001732, UDP-Glc/GDP-Man_DH_N IPR028357, UDPglc_DH_bac |
Pfami | View protein in Pfam PF00984, UDPG_MGDP_dh, 1 hit PF03720, UDPG_MGDP_dh_C, 1 hit PF03721, UDPG_MGDP_dh_N, 1 hit |
PIRSFi | PIRSF500134, UDPglc_DH_bac, 1 hit PIRSF000124, UDPglc_GDPman_dh, 1 hit |
SMARTi | View protein in SMART SM00984, UDPG_MGDP_dh_C, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit SSF52413, SSF52413, 1 hit |
TIGRFAMsi | TIGR03026, NDP-sugDHase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q63J85-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLTIIGSGY VGLVTGACLA DIGHDVFCLD VDSKKIDVLN NGGVPIHEPG
60 70 80 90 100
LGEIIARNRA AGRLQFSTDV EAAVAHGDVQ FIAVGTPPDE DGSADLQYVL
110 120 130 140 150
AAARNIGRHM NGFKVIVDKS TVPVGTAERV RAAVADELKA RGEDSMFSVV
160 170 180 190 200
SNPEFLKEGA AVEDFTRPDR IVIGCDDDVP GERARELMKK LYAPFNRNHE
210 220 230 240 250
RTLYMDVRSA EFTKYAANAM LATRISFMNE LANLAERFGA DIEAVRRGIG
260 270 280 290 300
SDPRIGYHFL YAGCGYGGSC FPKDVEALIR TAAEHGQALR VLQAVSAVND
310 320 330 340 350
EQKHVLARKV VARFGGDLTG RRFGVWGLAF KPNTDDMREA PSRALIAALL
360 370 380 390 400
SRGAHVVAYD PVAQDEARRV LAIDLGEYPD ALGRLAFADD EAQVAQDADA
410 420 430 440 450
LVIVTEWKAF KSPDFAALGK RWKTPVIFDG RNLYEPIAMR ELGIEYYPIG
460 470
RPGAAPRTAA GESDAARAAR AGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571966 Genomic DNA Translation: CAH39309.1 |
RefSeqi | WP_004539365.1, NZ_CP009537.1 YP_111837.1, NC_006351.1 |
Genome annotation databases
EnsemblBacteriai | CAH39309; CAH39309; BPSS1833 |
KEGGi | bps:BPSS1833 |
PATRICi | fig|272560.51.peg.5280 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571966 Genomic DNA Translation: CAH39309.1 |
RefSeqi | WP_004539365.1, NZ_CP009537.1 YP_111837.1, NC_006351.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 272560.BPSS1833 |
Genome annotation databases
EnsemblBacteriai | CAH39309; CAH39309; BPSS1833 |
KEGGi | bps:BPSS1833 |
PATRICi | fig|272560.51.peg.5280 |
Phylogenomic databases
eggNOGi | COG1004, Bacteria |
OMAi | LCTEWDE |
Enzyme and pathway databases
UniPathwayi | UPA00038;UER00491 |
BioCyci | BPSE272560:G1G3Q-5530-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR036291, NAD(P)-bd_dom_sf IPR017476, UDP-Glc/GDP-Man IPR014027, UDP-Glc/GDP-Man_DH_C IPR036220, UDP-Glc/GDP-Man_DH_C_sf IPR014026, UDP-Glc/GDP-Man_DH_dimer IPR001732, UDP-Glc/GDP-Man_DH_N IPR028357, UDPglc_DH_bac |
Pfami | View protein in Pfam PF00984, UDPG_MGDP_dh, 1 hit PF03720, UDPG_MGDP_dh_C, 1 hit PF03721, UDPG_MGDP_dh_N, 1 hit |
PIRSFi | PIRSF500134, UDPglc_DH_bac, 1 hit PIRSF000124, UDPglc_GDPman_dh, 1 hit |
SMARTi | View protein in SMART SM00984, UDPG_MGDP_dh_C, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit SSF52413, SSF52413, 1 hit |
TIGRFAMsi | TIGR03026, NDP-sugDHase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q63J85_BURPS | |
Accessioni | Q63J85Primary (citable) accession number: Q63J85 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 25, 2004 |
Last sequence update: | October 25, 2004 | |
Last modified: | December 2, 2020 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |