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Protein

Teashirt homolog 3

Gene

TSHZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 238C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri386 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST19
DNA bindingi891 – 961Homeobox; atypicalPROSITE-ProRule annotationAdd BLAST71
Zinc fingeri976 – 998C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1041 – 1064C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 3
Alternative name(s):
Zinc finger protein 537
Gene namesi
Name:TSHZ3
Synonyms:KIAA1474, TSH3, ZNF537
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000121297.6
HGNCiHGNC:30700 TSHZ3
MIMi614119 gene
neXtProtiNX_Q63HK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Nucleus

Pathology & Biotechi

Involvement in diseasei

TSHZ3 haploinsufficiency due to proximal chromosome 19q13.11 deletions causes a neurodevelopmental disorder characterized by developmental delay, absent or delayed speech, intellectual disability, and autistic features. Some patients may have reanal tract abnormalities.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi953 – 955VKY → ATA: Does not inhibit interaction with APBB1. 1 Publication3

Organism-specific databases

DisGeNETi57616
OpenTargetsiENSG00000121297
PharmGKBiPA134887020

Polymorphism and mutation databases

BioMutaiTSHZ3
DMDMi85541971

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470661 – 1081Teashirt homolog 3Add BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei682PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ63HK5
MaxQBiQ63HK5
PaxDbiQ63HK5
PeptideAtlasiQ63HK5
PRIDEiQ63HK5
ProteomicsDBi65878

PTM databases

iPTMnetiQ63HK5
PhosphoSitePlusiQ63HK5

Expressioni

Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease (PubMed:18776146, PubMed:19343227). Expressed in the fetal neocortex (PubMed:27668656).3 Publications

Developmental stagei

Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of gestation.1 Publication

Gene expression databases

BgeeiENSG00000121297 Expressed in 168 organ(s), highest expression level in frontal cortex
CleanExiHS_TSHZ3
ExpressionAtlasiQ63HK5 baseline and differential
GenevisibleiQ63HK5 HS

Organism-specific databases

HPAiHPA008834

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi121663, 21 interactors
CORUMiQ63HK5
IntActiQ63HK5, 28 interactors
MINTiQ63HK5
STRINGi9606.ENSP00000240587

Structurei

Secondary structure

11081
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ63HK5
SMRiQ63HK5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63HK5

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili606 – 630Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 164Ser-richAdd BLAST23
Compositional biasi493 – 496Poly-Glu4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 238C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri386 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri976 – 998C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1041 – 1064C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFDT Eukaryota
ENOG410XQQR LUCA
GeneTreeiENSGT00390000014977
HOGENOMiHOG000231480
HOVERGENiHBG079626
InParanoidiQ63HK5
KOiK09236
OMAiPQRDGCK
OrthoDBiEOG091G01GX
PhylomeDBiQ63HK5
TreeFamiTF328447

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR026810 Tshz3
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF5 PTHR12487:SF5, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63HK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRKQQAPR RAAAYVSEEL KAAALVDEGL DPEEHTADGE PSAKYMCPEK
60 70 80 90 100
ELARACPSYQ NSPAAEFSCH EMDSESHISE TSDRMADFES GSIKNEEETK
110 120 130 140 150
EVTVPLEDTT VSDSLEQMKA VYNNFLSNSY WSNLNLNLHQ PSSEKNNGSS
160 170 180 190 200
SSSSSSSSSC GSGSFDWHQS AMAKTLQQVS QSRMLPEPSL FSTVQLYRQS
210 220 230 240 250
SKLYGSIFTG ASKFRCKDCS AAYDTLVELT VHMNETGHYR DDNHETDNNN
260 270 280 290 300
PKRWSKPRKR SLLEMEGKED AQKVLKCMYC GHSFESLQDL SVHMIKTKHY
310 320 330 340 350
QKVPLKEPVT PVAAKIIPAT RKKASLELEL PSSPDSTGGT PKATISDTND
360 370 380 390 400
ALQKNSNPYI TPNNRYGHQN GASYAWHFEA RKSQILKCME CGSSHDTLQE
410 420 430 440 450
LTAHMMVTGH FIKVTNSAMK KGKPIVETPV TPTITTLLDE KVQSVPLAAT
460 470 480 490 500
TFTSPSNTPA SISPKLNVEV KKEVDKEKAV TDEKPKQKDK PGEEEEKCDI
510 520 530 540 550
SSKYHYLTEN DLEESPKGGL DILKSLENTV TSAINKAQNG TPSWGGYPSI
560 570 580 590 600
HAAYQLPNMM KLSLGSSGKS TPLKPMFGNS EIVSPTKNQT LVSPPSSQTS
610 620 630 640 650
PMPKTNFHAM EELVKKVTEK VAKVEEKMKE PDGKLSPPKR ATPSPCSSEV
660 670 680 690 700
GEPIKMEASS DGGFRSQENS PSPPRDGCKD GSPLAEPVEN GKELVKPLAS
710 720 730 740 750
SLSGSTAIIT DHPPEQPFVN PLSALQSVMN IHLGKAAKPS LPALDPMSML
760 770 780 790 800
FKMSNSLAEK AAVATPPPLQ SKKADHLDRY FYHVNNDQPI DLTKGKSDKG
810 820 830 840 850
CSLGSVLLSP TSTAPATSSS TVTTAKTSAV VSFMSNSPLR ENALSDISDM
860 870 880 890 900
LKNLTESHTS KSSTPSSISE KSDIDGATLE EAEESTPAQK RKGRQSNWNP
910 920 930 940 950
QHLLILQAQF AASLRQTSEG KYIMSDLSPQ ERMHISRFTG LSMTTISHWL
960 970 980 990 1000
ANVKYQLRRT GGTKFLKNLD TGHPVFFCND CASQIRTPST YISHLESHLG
1010 1020 1030 1040 1050
FRLRDLSKLS TEQINSQIAQ TKSPSEKMVT SSPEEDLGTS YQCKLCNRTF
1060 1070 1080
ASKHAVKLHL SKTHGKSPED HLLYVSELEK Q
Length:1,081
Mass (Da):118,566
Last modified:January 10, 2006 - v2
Checksum:iB4E0A4347B04E74A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ78U3KQ78_HUMAN
Teashirt homolog 3
TSHZ3
33Annotation score:

Sequence cautioni

The sequence AAI27096 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI27097 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66739 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176L → V in AAI27096 (PubMed:15489334).Curated1
Sequence conflicti176L → V in AAI27097 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063635469E → G2 PublicationsCorresponds to variant dbSNP:rs143453460Ensembl.1
Natural variantiVAR_052708687P → L. Corresponds to variant dbSNP:rs4805664Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648745 mRNA Translation: CAH56184.1
AB040907 mRNA Translation: BAA95998.1
AL136805 mRNA Translation: CAB66739.1 Different initiation.
BC127095 mRNA Translation: AAI27096.1 Different initiation.
BC127096 mRNA Translation: AAI27097.1 Different initiation.
CCDSiCCDS12421.2
RefSeqiNP_065907.2, NM_020856.3
UniGeneiHs.278436

Genome annotation databases

EnsembliENST00000240587; ENSP00000240587; ENSG00000121297
GeneIDi57616
KEGGihsa:57616
UCSCiuc002nsy.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Life's first breath - Issue 122 of October 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648745 mRNA Translation: CAH56184.1
AB040907 mRNA Translation: BAA95998.1
AL136805 mRNA Translation: CAB66739.1 Different initiation.
BC127095 mRNA Translation: AAI27096.1 Different initiation.
BC127096 mRNA Translation: AAI27097.1 Different initiation.
CCDSiCCDS12421.2
RefSeqiNP_065907.2, NM_020856.3
UniGeneiHs.278436

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMINMR-A202-303[»]
ProteinModelPortaliQ63HK5
SMRiQ63HK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121663, 21 interactors
CORUMiQ63HK5
IntActiQ63HK5, 28 interactors
MINTiQ63HK5
STRINGi9606.ENSP00000240587

PTM databases

iPTMnetiQ63HK5
PhosphoSitePlusiQ63HK5

Polymorphism and mutation databases

BioMutaiTSHZ3
DMDMi85541971

Proteomic databases

EPDiQ63HK5
MaxQBiQ63HK5
PaxDbiQ63HK5
PeptideAtlasiQ63HK5
PRIDEiQ63HK5
ProteomicsDBi65878

Protocols and materials databases

DNASUi57616
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240587; ENSP00000240587; ENSG00000121297
GeneIDi57616
KEGGihsa:57616
UCSCiuc002nsy.5 human

Organism-specific databases

CTDi57616
DisGeNETi57616
EuPathDBiHostDB:ENSG00000121297.6
GeneCardsiTSHZ3
HGNCiHGNC:30700 TSHZ3
HPAiHPA008834
MIMi614119 gene
neXtProtiNX_Q63HK5
OpenTargetsiENSG00000121297
PharmGKBiPA134887020
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDT Eukaryota
ENOG410XQQR LUCA
GeneTreeiENSGT00390000014977
HOGENOMiHOG000231480
HOVERGENiHBG079626
InParanoidiQ63HK5
KOiK09236
OMAiPQRDGCK
OrthoDBiEOG091G01GX
PhylomeDBiQ63HK5
TreeFamiTF328447

Miscellaneous databases

ChiTaRSiTSHZ3 human
EvolutionaryTraceiQ63HK5
GeneWikiiTSHZ3
GenomeRNAii57616
PROiPR:Q63HK5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121297 Expressed in 168 organ(s), highest expression level in frontal cortex
CleanExiHS_TSHZ3
ExpressionAtlasiQ63HK5 baseline and differential
GenevisibleiQ63HK5 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR026810 Tshz3
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF5 PTHR12487:SF5, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTSH3_HUMAN
AccessioniPrimary (citable) accession number: Q63HK5
Secondary accession number(s): A1L0U7, Q9H0G6, Q9P254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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