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Protein

POU domain, class 4, transcription factor 3

Gene

Pou4f3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator (PubMed:8290353, PubMed:7935408). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:7935408). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (PubMed:8637595).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi274 – 333HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 3Imported
Alternative name(s):
Brain-specific homeobox/POU domain protein 3C
Short name:
Brain-3C
Short name:
Brn-3C
Brn-3.11 Publication
Gene namesi
Name:Pou4f3Imported
Synonyms:Brn-3.11 Publication, Brn-3cImported, Brn3cImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:102523 Pou4f3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutants are deaf and show deficits in balance and coordination that become severe at about P14 and exhibit hyperactivity by 5-6 weeks.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007431 – 338POU domain, class 4, transcription factor 3Add BLAST338

Proteomic databases

PaxDbiQ63955
PRIDEiQ63955

PTM databases

PhosphoSitePlusiQ63955

Expressioni

Tissue specificityi

Brain.

Developmental stagei

Expressed in developing spinal cord from E13 to postanal day 1, not expressed in adults (PubMed:8290353). Expressed by few neurons of dorsal root ganglion from, at least, E10.5 to E15.5 (PubMed:22326227).2 Publications

Gene expression databases

BgeeiENSMUSG00000024497 Expressed in 21 organ(s), highest expression level in retina
CleanExiMM_POU4F3
GenevisibleiQ63955 MM

Interactioni

Subunit structurei

Interacts with ISL1 (PubMed:24643061).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025374

Structurei

3D structure databases

ProteinModelPortaliQ63955
SMRiQ63955
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 256POU-specificPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi56 – 65POU-IV box10

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG1168 Eukaryota
ENOG410XPNX LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000116305
HOVERGENiHBG031829
InParanoidiQ63955
KOiK09366
OMAiDVTYHTM
OrthoDBiEOG091G0WBK
TreeFamiTF316413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR032961 POU4F3
IPR000327 POU_dom
PANTHERiPTHR11636:SF43 PTHR11636:SF43, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q63955-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD
60 70 80 90 100
ESLLARAEAL AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP
110 120 130 140 150
AALTSHPHHA VHQGLEGDLL EHISPTLSVS GLGAPEHSVM PAQIHPHHLG
160 170 180 190 200
AMGHLHQAMG MSHPHAVAPH SAMPACLSDV ESDPRELEAF AERFKQRRIK
210 220 230 240 250
LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN MIALKPVLQA
260 270 280 290 300
WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS
310 320 330
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH
Length:338
Mass (Da):37,016
Last modified:July 27, 2011 - v2
Checksum:i4B7C78BD788FB944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 9QP → HR in AAB30579 (PubMed:8162704).Curated2
Sequence conflicti55A → E no nucleotide entry (PubMed:8248179).Curated1
Sequence conflicti158A → P no nucleotide entry (PubMed:8248179).Curated1
Sequence conflicti210A → S no nucleotide entry (PubMed:8248179).Curated1
Sequence conflicti338H → D in AAB30579 (PubMed:8162704).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69352 Genomic DNA Translation: AAB30579.1
CH466528 Genomic DNA Translation: EDL10035.1
BC145941 mRNA Translation: AAI45942.1
CCDSiCCDS29212.1
PIRiB49642
RefSeqiNP_620395.2, NM_138945.2
UniGeneiMm.488204

Genome annotation databases

EnsembliENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497
GeneIDi18998
KEGGimmu:18998
UCSCiuc008etv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69352 Genomic DNA Translation: AAB30579.1
CH466528 Genomic DNA Translation: EDL10035.1
BC145941 mRNA Translation: AAI45942.1
CCDSiCCDS29212.1
PIRiB49642
RefSeqiNP_620395.2, NM_138945.2
UniGeneiMm.488204

3D structure databases

ProteinModelPortaliQ63955
SMRiQ63955
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025374

PTM databases

PhosphoSitePlusiQ63955

Proteomic databases

PaxDbiQ63955
PRIDEiQ63955

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497
GeneIDi18998
KEGGimmu:18998
UCSCiuc008etv.2 mouse

Organism-specific databases

CTDi5459
MGIiMGI:102523 Pou4f3

Phylogenomic databases

eggNOGiKOG1168 Eukaryota
ENOG410XPNX LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000116305
HOVERGENiHBG031829
InParanoidiQ63955
KOiK09366
OMAiDVTYHTM
OrthoDBiEOG091G0WBK
TreeFamiTF316413

Miscellaneous databases

PROiPR:Q63955
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024497 Expressed in 21 organ(s), highest expression level in retina
CleanExiMM_POU4F3
GenevisibleiQ63955 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR032961 POU4F3
IPR000327 POU_dom
PANTHERiPTHR11636:SF43 PTHR11636:SF43, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPO4F3_MOUSE
AccessioniPrimary (citable) accession number: Q63955
Secondary accession number(s): A6H6N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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