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Protein

Oligodendrocyte-myelin glycoprotein

Gene

Omg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Caution

Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).Curated

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte-myelin glycoprotein
Gene namesi
Name:Omg
Synonyms:Omgp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106586 Omg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000002189025 – 417Oligodendrocyte-myelin glycoproteinAdd BLAST393
PropeptideiPRO_0000021891418 – 440Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi417GPI-anchor amidated serineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated in its Ser/Thr-rich repeat domain.Curated

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ63912
PaxDbiQ63912
PeptideAtlasiQ63912
PRIDEiQ63912

PTM databases

PhosphoSitePlusiQ63912

Expressioni

Tissue specificityi

Oligodendrocytes and myelin of the central nervous system.

Gene expression databases

CleanExiMM_OMG

Interactioni

Subunit structurei

Binds to RTN4R.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63912, 2 interactors
MINTiQ63912
STRINGi10090.ENSMUSP00000132918

Structurei

3D structure databases

ProteinModelPortaliQ63912
SMRiQ63912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 55LRRNTAdd BLAST31
Repeati56 – 78LRR 1Add BLAST23
Repeati79 – 100LRR 2Add BLAST22
Repeati101 – 121LRR 3Add BLAST21
Repeati124 – 145LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Repeati169 – 189LRR 6Add BLAST21
Repeati192 – 213LRR 7Add BLAST22
Repeati216 – 239LRR 8Add BLAST24
Repeati229 – 270Ser/Thr-richAdd BLAST42
Repeati271 – 292Ser/Thr-richAdd BLAST22
Repeati293 – 335Ser/Thr-richAdd BLAST43
Repeati336 – 377Ser/Thr-richAdd BLAST42
Repeati378 – 416Ser/Thr-richAdd BLAST39

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000115267
HOVERGENiHBG007868
InParanoidiQ63912
KOiK16666
PhylomeDBiQ63912

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEYQILKMSS CLFILLFLTP GILCICPLQC TCTERHRHVD CSGRNLTTLP
60 70 80 90 100
PGLQENIIHL NLSYNHFTDL HNQLTPYTNL RTLDISNNRL ESLPAQLPRS
110 120 130 140 150
LWNMSAANNN IKLLDKSDTA YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV
160 170 180 190 200
LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT QILPGTLINL TNLTHLYLHN
210 220 230 240 250
NKFTFIPEQS FDQLLQLQEI TLHNNRWSCD HKQNITYLLK WVMETKAHVI
260 270 280 290 300
GTPCSKQVSS LKEQSMYPTP PGFTSSLFTM SEMQTVDTIN SLSMVTQPKV
310 320 330 340 350
TKTPKQYRGK ETTFGVTLSK DTTFSSTDRA VVAYPEDTPT EMTNSHEAAA
360 370 380 390 400
ATLTIHLQDG MSSNASLTSA TKSPPSPVTL SIARGMPNNF SEMPRQSTTL
410 420 430 440
NLRREETTAN GNTRPPSAAS AWKVNASLLL MLNAVVMLAG
Length:440
Mass (Da):49,284
Last modified:November 1, 1997 - v1
Checksum:i2F23047A41FC458A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XA53G3XA53_MOUSE
Oligodendrocyte-myelin glycoprotein
Omg mCG_19069
443Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67043 Genomic DNA Translation: AAB28991.2
BC024757 mRNA Translation: AAH24757.1
PIRiA47530
RefSeqiNP_062282.2, NM_019409.2
UniGeneiMm.93335

Genome annotation databases

GeneIDi18377
KEGGimmu:18377

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67043 Genomic DNA Translation: AAB28991.2
BC024757 mRNA Translation: AAH24757.1
PIRiA47530
RefSeqiNP_062282.2, NM_019409.2
UniGeneiMm.93335

3D structure databases

ProteinModelPortaliQ63912
SMRiQ63912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63912, 2 interactors
MINTiQ63912
STRINGi10090.ENSMUSP00000132918

PTM databases

PhosphoSitePlusiQ63912

Proteomic databases

MaxQBiQ63912
PaxDbiQ63912
PeptideAtlasiQ63912
PRIDEiQ63912

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18377
KEGGimmu:18377

Organism-specific databases

CTDi4974
MGIiMGI:106586 Omg

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000115267
HOVERGENiHBG007868
InParanoidiQ63912
KOiK16666
PhylomeDBiQ63912

Miscellaneous databases

PROiPR:Q63912
SOURCEiSearch...

Gene expression databases

CleanExiMM_OMG

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOMGP_MOUSE
AccessioniPrimary (citable) accession number: Q63912
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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