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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

Polr2k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).By similarity
Factor that activates expression from a metal response element of the mouse metallothionein-I gene.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi36ZincBy similarity1
Metal bindingi39ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 39C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
DNA-directed RNA polymerase II subunit K
Metallothionein-I gene transcription activator
RPB10alpha
Gene namesi
Name:Polr2k
Synonyms:Mt1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:102725 Polr2k

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597511 – 58DNA-directed RNA polymerases I, II, and III subunit RPABC4Add BLAST58

Proteomic databases

MaxQBiQ63871
PaxDbiQ63871
PRIDEiQ63871

PTM databases

PhosphoSitePlusiQ63871

Expressioni

Gene expression databases

BgeeiENSMUSG00000045996 Expressed in 27 organ(s), highest expression level in brown adipose tissue
CleanExiMM_POLR2K
ExpressionAtlasiQ63871 baseline and differential
GenevisibleiQ63871 MM

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051968

Structurei

3D structure databases

ProteinModelPortaliQ63871
SMRiQ63871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 39C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3507 Eukaryota
COG1996 LUCA
GeneTreeiENSGT00390000008918
HOVERGENiHBG054239
InParanoidiQ63871
OMAiAMVYICG
PhylomeDBiQ63871

Family and domain databases

InterProiView protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR039747 RPABC4
IPR029040 RPABC4/Spt4
PANTHERiPTHR12056 PTHR12056, 1 hit
PfamiView protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012151 PD012151, 1 hit
SMARTiView protein in SMART
SM00659 RPOLCX, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK

RLVVFDAR
Length:58
Mass (Da):6,974
Last modified:November 1, 1997 - v2
Checksum:iD69BB6B37416F036
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BFX0Q8BFX0_MOUSE
DNA-directed RNA polymerases I, II,...
Polr2k
99Annotation score:

Sequence cautioni

The sequence AAB27565 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63758 mRNA Translation: AAB27565.2 Different initiation.
BC028543 mRNA Translation: AAH28543.1
CCDSiCCDS56980.1
RefSeqiNP_075616.2, NM_023127.3
UniGeneiMm.27375

Genome annotation databases

EnsembliENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996
GeneIDi17749
KEGGimmu:17749
UCSCiuc007vml.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63758 mRNA Translation: AAB27565.2 Different initiation.
BC028543 mRNA Translation: AAH28543.1
CCDSiCCDS56980.1
RefSeqiNP_075616.2, NM_023127.3
UniGeneiMm.27375

3D structure databases

ProteinModelPortaliQ63871
SMRiQ63871
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051968

PTM databases

PhosphoSitePlusiQ63871

Proteomic databases

MaxQBiQ63871
PaxDbiQ63871
PRIDEiQ63871

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996
GeneIDi17749
KEGGimmu:17749
UCSCiuc007vml.2 mouse

Organism-specific databases

CTDi5440
MGIiMGI:102725 Polr2k

Phylogenomic databases

eggNOGiKOG3507 Eukaryota
COG1996 LUCA
GeneTreeiENSGT00390000008918
HOVERGENiHBG054239
InParanoidiQ63871
OMAiAMVYICG
PhylomeDBiQ63871

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

PROiPR:Q63871
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045996 Expressed in 27 organ(s), highest expression level in brown adipose tissue
CleanExiMM_POLR2K
ExpressionAtlasiQ63871 baseline and differential
GenevisibleiQ63871 MM

Family and domain databases

InterProiView protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR039747 RPABC4
IPR029040 RPABC4/Spt4
PANTHERiPTHR12056 PTHR12056, 1 hit
PfamiView protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012151 PD012151, 1 hit
SMARTiView protein in SMART
SM00659 RPOLCX, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPAB4_MOUSE
AccessioniPrimary (citable) accession number: Q63871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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