UniProtKB - Q63862 (MYH11_RAT)
Protein
Myosin-11
Gene
Myh11
Organism
Rattus norvegicus (Rat)
Status
Functioni
Muscle contraction.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 41 | ATPBy similarity | 8 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- motor activity Source: RGD
- structural constituent of muscle Source: RGD
GO - Biological processi
- cardiac muscle fiber development Source: RGD
- elastic fiber assembly Source: RGD
- smooth muscle contraction Source: RGD
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-11Alternative name(s): Myosin heavy chain 11 Myosin heavy chain, smooth muscle isoform SMMHC |
Gene namesi | Name:Myh11Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3136, Myh11 |
Subcellular locationi
Other locations
- Melanosome By similarity
- myofibril
Note: Thick filaments of the myofibrils.
Cytoskeleton
- muscle myosin complex Source: RGD
- myosin complex Source: RGD
- stress fiber Source: RGD
Other locations
- brush border Source: RGD
- melanosome Source: UniProtKB-SubCell
- myofibril Source: UniProtKB-SubCell
- myosin filament Source: UniProtKB-KW
- smooth muscle contractile fiber Source: RGD
Keywords - Cellular componenti
Cytoplasm, Thick filamentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123428 | ‹1 – 1327 | Myosin-11Add BLAST | ›1327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1039 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1077 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1306 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1309 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1326 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q63862 |
PaxDbi | Q63862 |
PRIDEi | Q63862 |
PTM databases
iPTMneti | Q63862 |
Expressioni
Tissue specificityi
Both isoform 1 and isoform 2 are detected in small and large intestine, uterus, bladder, aorta, stomach, and at much lower levels in lung. All three isoforms are coexpressed in smooth muscle. Isoform 2 predominates in most of the smooth muscles tested, with the exception of intestine and urinary bladder, which show greater expression of isoform 1.2 Publications
Interactioni
Subunit structurei
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
CuratedGO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | Q63862, 1 interactor |
STRINGi | 10116.ENSRNOP00000043197 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | ‹1 – 646 | Myosin motorPROSITE-ProRule annotationAdd BLAST | ›646 | |
Domaini | 649 – 678 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 524 – 546 | Actin-bindingBy similarityAdd BLAST | 23 | |
Regioni | 625 – 639 | Actin-bindingBy similarityAdd BLAST | 15 | |
Regioni | 1290 – 1327 | C-terminalAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 707 – 1289 | Sequence analysisAdd BLAST | 583 |
Domaini
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.Curated
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
InParanoidi | Q63862 |
PhylomeDBi | Q63862 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit |
s (3+)i Sequence
Sequence statusi: Fragments.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q63862-1) [UniParc]FASTAAdd to basket
Also known as: SM1B1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
KKRHEMPPHI YAIADTAYRS MLQDREDQSI LCTGESGAGK TENTKKVIQY
60 70 80 90 100
LAVVASSHKG KKDSSITQGP SFAYGELEKQ LLQANPILEA FGNAKTVKND
110 120 130 140 150
NSSRFGKFIR INFDVTGYIV GANIETYLLE KSRAIRHARD ERTFHIFYYL
160 170 180 190 200
IAGAKEKMRN DLLLESFNSY TFLSNGFVPI PAAQDDEMFQ ETLEAMSIMG
210 220 230 240 250
FSEEEQLAIL KVVSSVLQLG NIVFKKERNT DQASMPDNTA AQKVCHLVGI
260 270 280 290 300
NVTDFTRAIL TPRIKVGRDV VQKAQTKEQA DFAIEALAKA TYERLFRWIL
310 320 330 340 350
SRVNKALDKT HRQGASFLGI LDIAGFEIFE VNSFEQLCIN YTNEKLQQLF
360 370 380 390 400
NHTMFILEQE EYQREGIEWN FIDFGLDLQP CIELIERPNN PPGVLALLDE
410 420 430 440 450
ECWFPKATDK SFVEKLCSEQ GNHPKFQKPK QLKDKTEFSI IHYAGKVDYN
460 470 480 490 500
ASAWLTKNMD PLNDNVTSLL NASSDKFVAD LWKDVDRIVG LDQMAKMTES
510 520 530 540 550
SLPSASKTKK GMFRTVGQLY KEQLGKLMTT LRNTTPNFVR CIIPNHEKRS
560 570 580 590 600
GKLDAFLVLE QLRCNGVLEG IRICRQGFPN RIVFQEFRQR YEILAANAIP
610 620 630 640 650
KGFMDGKQAC ILMIKALELD PNLYRIGQSK IFFRTGVLAH LEEERDLKIT
660 670 680 690 700
DVIMAFQAMC RGYLARKAFT KRQQQLTASK VIQRNCAAYL KLRNWQWWRL
710 720 730 740 750
FTKVKPLDEE MEAKQNLERH VSTLNIQLSD SKKKLQDLAS TIEVMEEGKK
760 770 780 790 800
RLQKEMEGLG QQYEEKAAAY DKLEKTKNRL QQELDDLVVD LDNQRQLVSN
810 820 830 840 850
LEKKQKKFDQ LLAEEKNISS KYADERDRAE AEAREKETKA LSLARALEEA
860 870 880 890 900
LEAKEELERT NKMLKAEMED LVSSKDDVGK NVHELEKSKR ALETQMEEMR
910 920 930 940 950
TQLEELEDEL QATEDAKLRL EVNMQALKGQ FERDLQARDE QNEEKRRQLQ
960 970 980 990 1000
RQLHEYETEL EDERKQRALA AAAKKKLEGD LKDLELQADS AVKGREEAIK
1010 1020 1030 1040 1050
QLRKLQAQMK DFQRELDDAR ASRDEIFATS KENEKKAKSL EAELMQLQED
1060 1070 1080 1090 1100
LAAAERARKQ ADLEKEELAE ELASSLSGRN TLQDEKRRLE ARIAQLEEEL
1110 1120 1130 1140 1150
EEEQGNMEAM SDRVRKATLQ AEQLSNELVT ERSAAQKNES ARQQLERQNK
1160 1170 1180 1190 1200
ELRSKLQEVE GAVKAKLKST VAALEAKIVQ LEEQIEQEAR EKQAATKLLK
1210 1220 1230 1240 1250
QKDKKLKEVL LQVEDERKMV EQYKEQAEKG NTKVKQLKRQ LEEAEEESQR
1260 1270 1280 1290 1300
INANRRKLQR ELDEATESNE AMGREVNALK SKLRRGNEAS FVPSRRAGGR
1310 1320
RVIENTDGSE EEMDARDSDF NGTKASE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K6S9 | A0A0G2K6S9_RAT | Myosin-11 | Myh11 | 1,979 | Annotation score: | ||
E9PTU4 | E9PTU4_RAT | Myosin-11 | Myh11 | 1,972 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Curated | 1 | |
Non-adjacent residuesi | 706 – 707 | Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050914 | 61 – 67 | Missing in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_050915 | 1285 – 1327 | RGNEA…TKASE → GPPPQETSQ in isoform 3. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY953023 mRNA Translation: AAX51987.1 S61948 mRNA Translation: AAB26775.1 X16261 mRNA Translation: CAA34347.1 X16262 mRNA Translation: CAA34348.1 |
PIRi | S07537 S10450 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY953023 mRNA Translation: AAX51987.1 S61948 mRNA Translation: AAB26775.1 X16261 mRNA Translation: CAA34347.1 X16262 mRNA Translation: CAA34348.1 |
PIRi | S07537 S10450 |
3D structure databases
SMRi | Q63862 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q63862, 1 interactor |
STRINGi | 10116.ENSRNOP00000043197 |
PTM databases
iPTMneti | Q63862 |
Proteomic databases
jPOSTi | Q63862 |
PaxDbi | Q63862 |
PRIDEi | Q63862 |
Organism-specific databases
RGDi | 3136, Myh11 |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
InParanoidi | Q63862 |
PhylomeDBi | Q63862 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH11_RAT | |
Accessioni | Q63862Primary (citable) accession number: Q63862 Secondary accession number(s): Q58GJ0 Q63861 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | November 8, 2005 | |
Last modified: | October 7, 2020 | |
This is version 126 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families