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Protein

Selenium-binding protein 2

Gene

Selenbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Selenium- and acetaminophen-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandSelenium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenium-binding protein 2
Alternative name(s):
56 kDa acetaminophen-binding protein
Short name:
AP56
Gene namesi
Name:Selenbp2
Synonyms:Lpsb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104859 Selenbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001746351 – 472Selenium-binding protein 2Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei467Phosphoserine1 Publication1

Post-translational modificationi

The N-terminus is blocked.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ63836
PaxDbiQ63836
PeptideAtlasiQ63836
PRIDEiQ63836

2D gel databases

REPRODUCTION-2DPAGEiQ63836

PTM databases

iPTMnetiQ63836
PhosphoSitePlusiQ63836
SwissPalmiQ63836

Expressioni

Tissue specificityi

Mainly expressed in liver.

Gene expression databases

CleanExiMM_SELENBP2

Interactioni

Protein-protein interaction databases

BioGridi203157, 1 interactor
IntActiQ63836, 6 interactors
MINTiQ63836
STRINGi10090.ENSMUSP00000088358

Structurei

3D structure databases

ProteinModelPortaliQ63836
SMRiQ63836
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenium-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG0918 Eukaryota
ENOG410XP4F LUCA
HOGENOMiHOG000263885
HOVERGENiHBG017779
InParanoidiQ63836
KOiK17285
PhylomeDBiQ63836
TreeFamiTF315241

Family and domain databases

InterProiView protein in InterPro
IPR008826 Se-bd
PANTHERiPTHR23300 PTHR23300, 1 hit
PfamiView protein in Pfam
PF05694 SBP56, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q63836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATKCTKCGP GYPTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD
60 70 80 90 100
PKSPQYSQVI HRLPMPYLKD ELHHSGWNTC SSCFGDSTKS RNKLILPGLI
110 120 130 140 150
SSRIYVVDVG SEPRAPKLHK VIEASEIQAK CNVSNTHTSH CLASGEVMVN
160 170 180 190 200
TLGDLQGNGK GSFVLLDGET FEVKGTWEKP GGASPMGYDF WYQPRHNVMV
210 220 230 240 250
STEWAAPNVF KDGFNPAHVE AGLYGSRIFV WDWQRHEIIQ TLQMTDGLIP
260 270 280 290 300
LEIRFLHDPS ATQGFVGCAL SSNIQRFYKN EEGTWSVEKV IQVPSKKVKG
310 320 330 340 350
WMLPEMPGLI TDILLSLDDR FLYFSNWLHG DIRQYDISNP QKPRLTGQIF
360 370 380 390 400
LGGSIVRGGS VQVLEDQELT CQPEPLVVKG KRIPGGPQMI QLSLDGKRLY
410 420 430 440 450
ATTSLYSDWD KQFYPDLIRE GSVMLQVDVD TVNGGLKLNP NFLVDFGKEP
460 470
LGPALAHELR YPGGDCSSDI WI
Length:472
Mass (Da):52,610
Last modified:May 29, 2007 - v2
Checksum:i923BEBCDC4657511
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J135A0A0R4J135_MOUSE
Selenium-binding protein 2
Selenbp2
472Annotation score:
G3UYY2G3UYY2_MOUSE
Selenium-binding protein 2
Selenbp2
410Annotation score:
G3UWK0G3UWK0_MOUSE
Selenium-binding protein 2
Selenbp2
128Annotation score:
G3UZT2G3UZT2_MOUSE
Selenium-binding protein 2
Selenbp2
134Annotation score:
G3UWX5G3UWX5_MOUSE
Selenium-binding protein 2
Selenbp2
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100I → M in AAB25841 (PubMed:8453708).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56599 mRNA Translation: AAB25841.2
BC024106 mRNA Translation: AAH24106.1
CCDSiCCDS38539.1
RefSeqiNP_062287.1, NM_019414.2
UniGeneiMm.225405

Genome annotation databases

GeneIDi20342
KEGGimmu:20342
UCSCiuc008qgx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56599 mRNA Translation: AAB25841.2
BC024106 mRNA Translation: AAH24106.1
CCDSiCCDS38539.1
RefSeqiNP_062287.1, NM_019414.2
UniGeneiMm.225405

3D structure databases

ProteinModelPortaliQ63836
SMRiQ63836
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203157, 1 interactor
IntActiQ63836, 6 interactors
MINTiQ63836
STRINGi10090.ENSMUSP00000088358

PTM databases

iPTMnetiQ63836
PhosphoSitePlusiQ63836
SwissPalmiQ63836

2D gel databases

REPRODUCTION-2DPAGEiQ63836

Proteomic databases

MaxQBiQ63836
PaxDbiQ63836
PeptideAtlasiQ63836
PRIDEiQ63836

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20342
KEGGimmu:20342
UCSCiuc008qgx.1 mouse

Organism-specific databases

CTDi20342
MGIiMGI:104859 Selenbp2

Phylogenomic databases

eggNOGiKOG0918 Eukaryota
ENOG410XP4F LUCA
HOGENOMiHOG000263885
HOVERGENiHBG017779
InParanoidiQ63836
KOiK17285
PhylomeDBiQ63836
TreeFamiTF315241

Miscellaneous databases

PROiPR:Q63836
SOURCEiSearch...

Gene expression databases

CleanExiMM_SELENBP2

Family and domain databases

InterProiView protein in InterPro
IPR008826 Se-bd
PANTHERiPTHR23300 PTHR23300, 1 hit
PfamiView protein in Pfam
PF05694 SBP56, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBP2_MOUSE
AccessioniPrimary (citable) accession number: Q63836
Secondary accession number(s): Q8R1T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 29, 2007
Last modified: October 10, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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