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Entry version 125 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

COMM domain-containing protein 3

Gene

Commd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695, Neutrophil degranulation
R-MMU-8951664, Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
COMM domain-containing protein 3
Alternative name(s):
Bmi-1 upstream gene protein
Short name:
Bup protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Commd3
Synonyms:Bup
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88218, Commd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000773901 – 195COMM domain-containing protein 3Add BLAST195

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q63829

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q63829

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q63829

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63829

PeptideAtlas

More...
PeptideAtlasi
Q63829

PRoteomics IDEntifications database

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PRIDEi
Q63829

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63829

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63829

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000051154, Expressed in undifferentiated genital tubercle and 260 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q63829, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain).

Interacts with NFKB1/p105.

Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
198407, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q63829, 1 interactor

Molecular INTeraction database

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MINTi
Q63829

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000049882

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q63829, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 193COMMPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R79J, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015971

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_118734_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63829

KEGG Orthology (KO)

More...
KOi
K22559

Identification of Orthologs from Complete Genome Data

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OMAi
VSFSCTM

Database of Orthologous Groups

More...
OrthoDBi
1508761at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63829

TreeFam database of animal gene trees

More...
TreeFami
TF329267

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017920, COMM
IPR037355, COMMD3

The PANTHER Classification System

More...
PANTHERi
PTHR31159, PTHR31159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07258, COMM_domain, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51269, COMM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q63829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSESVQRG IQTLADPGSF DSNAFALLLR AAFQSLLDAR ADEAALDHPY
60 70 80 90 100
LKQIDPVVLK HCHAAAATCI LEAGKHQVDK STLSTYLEDC KFDRERIELF
110 120 130 140 150
CTEYQNNKNS LETLLGSIGR SLPHITDVSW RLEYQIKTNQ LHKMYRPGYL
160 170 180 190
VTLNVENNDS QSYPEINFSC NMEQLQDLVG KLKDASKSLE RATQL
Length:195
Mass (Da):22,037
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F7A3ACB43699D6D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S54914 Unassigned DNA Translation: AAB25378.1
AK041634 mRNA Translation: BAC31015.1
AK145955 mRNA Translation: BAE26783.1
AK145999 mRNA Translation: BAE26820.1
AL928680 Genomic DNA No translation available.
BC048815 mRNA Translation: AAH48815.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15710.1

NCBI Reference Sequences

More...
RefSeqi
NP_680087.1, NM_147778.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061158; ENSMUSP00000049882; ENSMUSG00000051154
ENSMUST00000171845; ENSMUSP00000127385; ENSMUSG00000051154

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12238

UCSC genome browser

More...
UCSCi
uc008ilx.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54914 Unassigned DNA Translation: AAB25378.1
AK041634 mRNA Translation: BAC31015.1
AK145955 mRNA Translation: BAE26783.1
AK145999 mRNA Translation: BAE26820.1
AL928680 Genomic DNA No translation available.
BC048815 mRNA Translation: AAH48815.1
CCDSiCCDS15710.1
RefSeqiNP_680087.1, NM_147778.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi198407, 1 interactor
IntActiQ63829, 1 interactor
MINTiQ63829
STRINGi10090.ENSMUSP00000049882

PTM databases

iPTMnetiQ63829
PhosphoSitePlusiQ63829

Proteomic databases

EPDiQ63829
jPOSTiQ63829
MaxQBiQ63829
PaxDbiQ63829
PeptideAtlasiQ63829
PRIDEiQ63829

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25612, 82 antibodies

The DNASU plasmid repository

More...
DNASUi
12238

Genome annotation databases

EnsembliENSMUST00000061158; ENSMUSP00000049882; ENSMUSG00000051154
ENSMUST00000171845; ENSMUSP00000127385; ENSMUSG00000051154
GeneIDi12238
KEGGimmu:12238
UCSCiuc008ilx.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23412
MGIiMGI:88218, Commd3

Phylogenomic databases

eggNOGiENOG502R79J, Eukaryota
GeneTreeiENSGT00390000015971
HOGENOMiCLU_118734_0_0_1
InParanoidiQ63829
KOiK22559
OMAiVSFSCTM
OrthoDBi1508761at2759
PhylomeDBiQ63829
TreeFamiTF329267

Enzyme and pathway databases

ReactomeiR-MMU-6798695, Neutrophil degranulation
R-MMU-8951664, Neddylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
12238, 5 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Commd3, mouse

Protein Ontology

More...
PROi
PR:Q63829
RNActiQ63829, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000051154, Expressed in undifferentiated genital tubercle and 260 other tissues
GenevisibleiQ63829, MM

Family and domain databases

InterProiView protein in InterPro
IPR017920, COMM
IPR037355, COMMD3
PANTHERiPTHR31159, PTHR31159, 1 hit
PfamiView protein in Pfam
PF07258, COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269, COMM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOMD3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63829
Secondary accession number(s): A2ASR4, Q3UKI1, Q8C9P5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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