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Protein

Calcineurin subunit B type 2

Gene

Ppp3r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.By similarity

Miscellaneous

This protein has four functional calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421By similarityAdd BLAST12
Calcium bindingi63 – 742By similarityAdd BLAST12
Calcium bindingi100 – 1113By similarityAdd BLAST12
Calcium bindingi141 – 1524By similarityAdd BLAST12

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase activity Source: MGI
  • calcium ion binding Source: InterPro

GO - Biological processi

  • defense response Source: MGI
  • glycogen metabolic process Source: MGI
  • sperm displacement Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:Ppp3r2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107171 Ppp3r2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000735002 – 179Calcineurin subunit B type 2Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ63811
PaxDbiQ63811
PRIDEiQ63811

PTM databases

iPTMnetiQ63811
PhosphoSitePlusiQ63811

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000028310 Expressed in 15 organ(s), highest expression level in testis
ExpressionAtlasiQ63811 baseline and differential
GenevisibleiQ63811 MM

Interactioni

Subunit structurei

Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei118Interaction with PxVP motif in substrates of the catalytic subunitBy similarity1
Sitei122Interaction with PxVP motif in substrates of the catalytic subunitBy similarity1

Protein-protein interaction databases

ComplexPortaliCPX-1008 Calcineurin-Calmodulin complex, beta-R2 variant
CPX-1049 Calcineurin-Calmodulin complex, alpha-R2 variant
CPX-1051 Calcineurin-Calmodulin complex, gamma-R2 variant
CPX-1115 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant
CPX-1117 Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant
CPX-1119 Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant
STRINGi10090.ENSMUSP00000029991

Structurei

3D structure databases

ProteinModelPortaliQ63811
SMRiQ63811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 136Calcineurin A bindingBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133729
HOGENOMiHOG000233019
HOVERGENiHBG105307
InParanoidiQ63811
KOiK06268
OMAiFSIYDMD
OrthoDBiEOG091G0R0W
PhylomeDBiQ63811
TreeFamiTF105558

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNEASYQTE LCNHFDQEEI RRLGKSFRKL DLDKSGSLSI EEFMRLPELQ
60 70 80 90 100
QNPLVGRVID IFDTDGNGEV DFHEFIVGTS QFSVKGDEEQ KLRFAFRIYD
110 120 130 140 150
MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF
160 170
EEFSDVVKTM EIHKKLVVFV EHGQEDLKA
Length:179
Mass (Da):20,659
Last modified:January 23, 2007 - v3
Checksum:i941E8DFDC5708B57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43865 mRNA Translation: AAB23172.1
AK029998 mRNA Translation: BAC26725.1
CCDSiCCDS18179.1
PIRiJC1221
RefSeqiNP_001004025.1, NM_001004025.4
UniGeneiMm.46125

Genome annotation databases

EnsembliENSMUST00000029991; ENSMUSP00000029991; ENSMUSG00000028310
GeneIDi19059
KEGGimmu:19059
UCSCiuc008swd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43865 mRNA Translation: AAB23172.1
AK029998 mRNA Translation: BAC26725.1
CCDSiCCDS18179.1
PIRiJC1221
RefSeqiNP_001004025.1, NM_001004025.4
UniGeneiMm.46125

3D structure databases

ProteinModelPortaliQ63811
SMRiQ63811
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1008 Calcineurin-Calmodulin complex, beta-R2 variant
CPX-1049 Calcineurin-Calmodulin complex, alpha-R2 variant
CPX-1051 Calcineurin-Calmodulin complex, gamma-R2 variant
CPX-1115 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant
CPX-1117 Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant
CPX-1119 Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant
STRINGi10090.ENSMUSP00000029991

PTM databases

iPTMnetiQ63811
PhosphoSitePlusiQ63811

Proteomic databases

MaxQBiQ63811
PaxDbiQ63811
PRIDEiQ63811

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029991; ENSMUSP00000029991; ENSMUSG00000028310
GeneIDi19059
KEGGimmu:19059
UCSCiuc008swd.1 mouse

Organism-specific databases

CTDi5535
MGIiMGI:107171 Ppp3r2

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133729
HOGENOMiHOG000233019
HOVERGENiHBG105307
InParanoidiQ63811
KOiK06268
OMAiFSIYDMD
OrthoDBiEOG091G0R0W
PhylomeDBiQ63811
TreeFamiTF105558

Miscellaneous databases

PROiPR:Q63811
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028310 Expressed in 15 organ(s), highest expression level in testis
ExpressionAtlasiQ63811 baseline and differential
GenevisibleiQ63811 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCANB2_MOUSE
AccessioniPrimary (citable) accession number: Q63811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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