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Protein

Proteasome activator complex subunit 2

Gene

Psme2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-202424 Downstream TCR signaling
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562 Regulation of ornithine decarboxylase (ODC)
R-RNO-382556 ABC-family proteins mediated transport
R-RNO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870 Asymmetric localization of PCP proteins
R-RNO-4641257 Degradation of AXIN
R-RNO-4641258 Degradation of DVL
R-RNO-5358346 Hedgehog ligand biogenesis
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684 Hedgehog 'on' state
R-RNO-5658442 Regulation of RAS by GAPs
R-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-5689603 UCH proteinases
R-RNO-5689880 Ub-specific processing proteases
R-RNO-68827 CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949 Orc1 removal from chromatin
R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69229 Ubiquitin-dependent degradation of Cyclin D1
R-RNO-69481 G2/M Checkpoints
R-RNO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902 Regulation of RUNX2 expression and activity
R-RNO-8941858 Regulation of RUNX3 expression and activity
R-RNO-8948751 Regulation of PTEN stability and activity
R-RNO-9020702 Interleukin-1 signaling
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 2
Alternative name(s):
11S regulator complex subunit beta
Short name:
REG-beta
Activator of multicatalytic protease subunit 2
Proteasome activator 28 subunit beta
Short name:
PA28b
Short name:
PA28beta
Gene namesi
Name:Psme2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi3430 Psme2

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001617882 – 238Proteasome activator complex subunit 2Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ63798

PTM databases

iPTMnetiQ63798
PhosphoSitePlusiQ63798

Expressioni

Inductioni

By interferon gamma.

Gene expression databases

BgeeiENSRNOG00000019246
GenevisibleiQ63798 RN

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ63798
SMRiQ63798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

GeneTreeiENSGT00510000046374
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ63798
KOiK06697
OMAiDIRGFYA
OrthoDBiEOG091G0IU2
PhylomeDBiQ63798
TreeFamiTF106236

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPCGVRLS GEARKQVDAF RQNLFQEAED FLCTFLPRKI ISLSQLLQED
60 70 80 90 100
SLNVADLSSL RAPLDIPIPD PPPKDDEMET EQEKKEVPKC GFLPGNEKLL
110 120 130 140 150
ALLALVKPEV WTLKEKCILV ITWIQHLIPK IEDGNDFGVA IQEKVLERVN
160 170 180 190 200
AVKTKVEAFQ TAISKYFSER GDAVAKASKD THVMDYRALV HERDEAAYGA
210 220 230
LRAMVLDLRA FYAELHHIIS SNLEKIVNPK GEEKPSMY
Length:238
Mass (Da):26,857
Last modified:January 23, 2007 - v3
Checksum:iAFA0F013CECE1CD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45250 mRNA Translation: BAA08207.1
BC058486 mRNA Translation: AAH58486.1
BC097331 mRNA Translation: AAH97331.1
RefSeqiNP_058953.1, NM_017257.2
UniGeneiRn.127779

Genome annotation databases

EnsembliENSRNOT00000026279; ENSRNOP00000026279; ENSRNOG00000019246
GeneIDi29614
KEGGirno:29614
UCSCiRGD:3430 rat

Similar proteinsi

Entry informationi

Entry nameiPSME2_RAT
AccessioniPrimary (citable) accession number: Q63798
Secondary accession number(s): Q4QR96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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