Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Upstream stimulatory factor 2

Gene

Usf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream stimulatory factor 2
Alternative name(s):
Major late transcription factor 2
Upstream transcription factor 2
Gene namesi
Name:Usf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620975 Usf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001275021 – 346Upstream stimulatory factor 2Add BLAST346

Proteomic databases

PaxDbiQ63665

PTM databases

iPTMnetiQ63665
PhosphoSitePlusiQ63665

Interactioni

Subunit structurei

Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028550

Structurei

3D structure databases

ProteinModelPortaliQ63665
SMRiQ63665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 290bHLHPROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni307 – 328Leucine-zipperAdd BLAST22

Phylogenomic databases

eggNOGiENOG410INSC Eukaryota
ENOG4111DV1 LUCA
HOGENOMiHOG000294174
HOVERGENiHBG004346
InParanoidiQ63665
KOiK09106
PhylomeDBiQ63665
TreeFamiTF323338

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR12565 PTHR12565, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: At least 2 isoforms are produced.

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q63665-1) [UniParc]FASTAAdd to basket
Also known as: USF2L, USF2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMLDPGLDP ASSATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA
60 70 80 90 100
IASVQQAAFG DHNIQYQFRT ESNGGQVTYR VVQVTDGQLD GQGDAAGAVS
110 120 130 140 150
VVSTAAFAGG QQAVTQVGVD GAAQRPGPAA ASVPTGPAAP FPLAVIQNPF
160 170 180 190 200
SNGGSPAAEA VSGEARFAYF PASSVGDTTA VSVQTTDQSL QAGGQFYVMM
210 220 230 240 250
TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT PRDERRRAQH NEVERRRRDK
260 270 280 290 300
INNWIVQLSK IIPDCHADNS KTGASKGGIL SKACDYIREL RQTNQRMQET
310 320 330 340
FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GESTRQ
Length:346
Mass (Da):36,954
Last modified:December 6, 2005 - v2
Checksum:iE9D216BC25F9447B
GO
Isoform 2 (identifier: Q63665-2) [UniParc]FASTAAdd to basket
Also known as: USF2delta1

The sequence of this isoform differs from the canonical sequence as follows:
     117-143: Missing.

Show »
Length:319
Mass (Da):34,500
Checksum:i5A5D8BC8007BB90F
GO
Isoform 3 (identifier: Q63665-3) [UniParc]FASTAAdd to basket
Also known as: USF2delta2, USF2B

The sequence of this isoform differs from the canonical sequence as follows:
     77-143: Missing.

Show »
Length:279
Mass (Da):30,595
Checksum:iD9474CE884D8A60B
GO
Isoform 4 (identifier: Q63665-4) [UniParc]FASTAAdd to basket
Also known as: USF2delta3

The sequence of this isoform differs from the canonical sequence as follows:
     21-27: SHDKGPE → RRGRPGG
     28-346: Missing.

Show »
Length:27
Mass (Da):2,613
Checksum:iB5C9C83F09C71D5A
GO
Isoform 5 (identifier: Q63665-5) [UniParc]FASTAAdd to basket
Also known as: USF2delta4

The sequence of this isoform differs from the canonical sequence as follows:
     21-22: SH → RL
     23-346: Missing.

Show »
Length:22
Mass (Da):2,145
Checksum:i243D5A861D66A6DA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K3J3A0A0G2K3J3_RAT
Upstream stimulatory factor 2
Usf2
339Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95A → T in CAA62338 (PubMed:8576131).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01654221 – 27SHDKGPE → RRGRPGG in isoform 4. 1 Publication7
Alternative sequenceiVSP_01654321 – 22SH → RL in isoform 5. 1 Publication2
Alternative sequenceiVSP_01654423 – 346Missing in isoform 5. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_01654528 – 346Missing in isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_01654677 – 143Missing in isoform 3. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_016547117 – 143Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035647 mRNA Translation: BAB19964.1
AB035648 mRNA Translation: BAB19965.1
AB035649 mRNA Translation: BAB19966.1
AB035650 mRNA Translation: BAB19967.1
AB035651 mRNA Translation: BAB19968.1
AB047556 mRNA Translation: BAB20993.1
X90823 mRNA Translation: CAA62338.1
RefSeqiNP_112401.1, NM_031139.1 [Q63665-1]
UniGeneiRn.44637

Genome annotation databases

GeneIDi81817
KEGGirno:81817
UCSCiRGD:620975 rat [Q63665-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035647 mRNA Translation: BAB19964.1
AB035648 mRNA Translation: BAB19965.1
AB035649 mRNA Translation: BAB19966.1
AB035650 mRNA Translation: BAB19967.1
AB035651 mRNA Translation: BAB19968.1
AB047556 mRNA Translation: BAB20993.1
X90823 mRNA Translation: CAA62338.1
RefSeqiNP_112401.1, NM_031139.1 [Q63665-1]
UniGeneiRn.44637

3D structure databases

ProteinModelPortaliQ63665
SMRiQ63665
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028550

PTM databases

iPTMnetiQ63665
PhosphoSitePlusiQ63665

Proteomic databases

PaxDbiQ63665

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81817
KEGGirno:81817
UCSCiRGD:620975 rat [Q63665-1]

Organism-specific databases

CTDi7392
RGDi620975 Usf2

Phylogenomic databases

eggNOGiENOG410INSC Eukaryota
ENOG4111DV1 LUCA
HOGENOMiHOG000294174
HOVERGENiHBG004346
InParanoidiQ63665
KOiK09106
PhylomeDBiQ63665
TreeFamiTF323338

Miscellaneous databases

PROiPR:Q63665

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR12565 PTHR12565, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSF2_RAT
AccessioniPrimary (citable) accession number: Q63665
Secondary accession number(s): Q76MJ1
, Q76MU2, Q9EQX1, Q9EQX2, Q9EQX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again