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Entry version 105 (07 Oct 2020)
Sequence version 2 (06 Feb 2007)
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Protein

Mucin-4

Gene

Muc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248' (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-4
Short name:
MUC-4
Alternative name(s):
Ascites sialoglycoprotein
Short name:
ASGP
Pancreatic adenocarcinoma mucin
Pre-sialomucin complex
Short name:
pSMC
Sialomucin complex
Testis mucin
Cleaved into the following 2 chains:
Alternative name(s):
Ascites sialoglycoprotein 1
Short name:
ASGP-1
Alternative name(s):
Ascites sialoglycoprotein 2
Short name:
ASGP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc4
Synonyms:Smc
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
621331, Muc4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2173 – 2193HelicalSequence analysisAdd BLAST21
Transmembranei2301 – 2321HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027423031 – 2344Mucin-4Add BLAST2314
ChainiPRO_000027423131 – 1615Mucin-4 alpha chainAdd BLAST1585
ChainiPRO_00002742321616 – 2344Mucin-4 beta chainAdd BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi391O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi392O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi470O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi479O-linked (GalNAc...) serineSequence analysis1
Glycosylationi1644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1689N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1698N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1759N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1780N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1829N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1874N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1951N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1974N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1981N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2029N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2048N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2051 ↔ 2062By similarity
Disulfide bondi2056 ↔ 2074By similarity
Disulfide bondi2076 ↔ 2085By similarity
Glycosylationi2114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2259 ↔ 2270By similarity
Disulfide bondi2264 ↔ 2279By similarity
Disulfide bondi2281 ↔ 2294By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, mucin-4 alpha chain and mucin-4 beta chain.
Mucin-4 alpha subunit is highly O-glycosylated.1 Publication
Mucin-4 beta subunit is predominantly N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1616 – 1617Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q63661

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q63661, 27 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is developmentally regulated in the mammary gland, dramatically increases in the lactating gland compared with the virgin mammary gland, while decreasing again during mammary gland involution. Expressed in 13762 ascites cells. Overexpressed in some aggressive mammary tumors. Overexpression seems to block cell-cell and cell-matrix interactions to protect tumor cells from immune surveillance, and to promote metastasis.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.

3 Publications

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63661

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 2041Add BLAST124
Repeati205 – 2912Add BLAST87
Repeati292 – 4153Add BLAST124
Repeati416 – 5394Add BLAST124
Repeati540 – 6625Add BLAST123
Repeati663 – 7886Add BLAST126
Repeati789 – 10067Add BLAST218
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1332 – 1492NIDOPROSITE-ProRule annotationAdd BLAST161
Domaini1610 – 1844VWFDPROSITE-ProRule annotationAdd BLAST235
Domaini2047 – 2086EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini2256 – 2295EGF-like 2PROSITE-ProRule annotationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 1266Thr-richAdd BLAST1236
Compositional biasi259 – 268Poly-Thr10
Compositional biasi445 – 1203Ser-richAdd BLAST759
Compositional biasi477 – 484Poly-Ser8
Compositional biasi874 – 883Poly-Thr10

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63661

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR039898, Mucin_4
IPR003886, NIDO_dom
IPR001846, VWF_type-D

The PANTHER Classification System

More...
PANTHERi
PTHR13802:SF53, PTHR13802:SF53, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06119, NIDO, 1 hit
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 3 hits
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS50026, EGF_3, 2 hits
PS51220, NIDO, 1 hit
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGPHGVSWR VPWLCLSCLC SCLLLLPVNT STTSAPKTST ALPSSTNPSQ
60 70 80 90 100
MTSQVSNPTA SSYRMTKNTG QASPMVTSSS ITTLPQSQHT GSMKTTRNPQ
110 120 130 140 150
TTGTTEVTTT LSASSSDQVQ VETTSQTTLS PDTTTTSHAP RESSSPPSTS
160 170 180 190 200
VILTTTASTE GTSGDTGHTM AVTTQGSTPA TTEISVTPST QKMSPVSTFS
210 220 230 240 250
TSTQEITTLS QSQHTGGMKT TRNPQTTGTT EVTTTLSASS SDHPTSSPES
260 270 280 290 300
TPGNTAPRTT ETSTTTTTKV LMTSLQQKLP TGSTLGTSTQ ELTTLPQSQH
310 320 330 340 350
TGIMKTTSRT QTTTPTEVTT RTLSASSSDH RQAETSSQTT LSPDTTTTSH
360 370 380 390 400
APRESSPPST SVILTHGHRE GTSGDTGHTM AVTTQGSTPA TTEISVTPST
410 420 430 440 450
QKMSPVSTFS TSTQEITTLS QSQHTGGMKT TRNPQRTTPT EVTTSTLSAS
460 470 480 490 500
SSDQVQVETT SRATLSPDTT TTSHAPSVSS SSPSPPSTEG TSVDTGLTTA
510 520 530 540 550
VTTQDSTPAT TQGSLTSSSQ TLSTVSPLST STQETSTQEL TSSQSQHTGS
560 570 580 590 600
MKTTHNPQTT RNTEVTTTLS ASSSDQVQVE TTSQTTLSDA TTTSHAPRES
610 620 630 640 650
SSPPSTSDIL TTMASTEGTS GDTGHTMAVT TQGSTPATTE ISVTPSTQKM
660 670 680 690 700
SPVSTFSTST QEITTLSQSQ HTGGMKTTRN PQTTGTTEVT TTLSASSSDQ
710 720 730 740 750
VQAETSSQTT LSPDTTTTSH APRESSSPPS TSDMLTTTAS TEGTSGDTGH
760 770 780 790 800
TTAVTTQGSI PATTQLSTTF ASQKMSTVST PTTSSIQELS TLPQSQHTGS
810 820 830 840 850
MEISSRPQTT SVTSTLSSSP SGSTPVQTRS VTSSSDERTN PTSSGVSNTS
860 870 880 890 900
PATTEVLTPT SSPESTPGNT APRTTETSTT TTTKVLMTSL QQKLPTGSTL
910 920 930 940 950
GTSTPTEVTT TLSASSSDQV QVETTSQTTL SPDATTTSHA PRESSSPPST
960 970 980 990 1000
SVILTTMAST EGTSGDTGHT TAVTDQGSTP ATTEISVTPS TQKMSTVSTL
1010 1020 1030 1040 1050
VTSTQELTSS QSQRTGSMGT SSKPQATTPT EVTTSTLSSF SRGSLFSARN
1060 1070 1080 1090 1100
CCLQTKKPPL PAVVCLPDPS SVPSLMHSSK PQATTPTEVT TSTLSSFSRG
1110 1120 1130 1140 1150
STQTQTVSWE TSSSGKITAP STSSRRTPSV ATSDIFTTTD STSGNAGHTL
1160 1170 1180 1190 1200
LTGSHSVITS RVASTTLGRL STVAHRQSTQ RSSTHSQSYL TESMGASSTS
1210 1220 1230 1240 1250
ETSLLTEATT ETSLCLFTWT HCDRDLLSWT SSSGLTTKTD NDRSTALSAT
1260 1270 1280 1290 1300
SLTLPAPSTS TASRSTVPPA PLPPDQGISL FQIGFPLGSL CGIPSILQIT
1310 1320 1330 1340 1350
VRSFSPSQTT MSSPTPTHLK EASQEGSVCH SGHSGVMLIS LAPGEPYFRT
1360 1370 1380 1390 1400
TTSHFTMSST SLIRKVESLI NEFTSDWSFK PSDTEVTWVN VPAYPAQGRT
1410 1420 1430 1440 1450
LGANTYQAIL STDGSRSYAL FLYQSGGMRW DVTQGLYNRV LMGFSSGDGY
1460 1470 1480 1490 1500
FENSPLIFRP AVEKYRPDRF LTPNYGSGDS RSTGYTGRCG PTTGSSVCSG
1510 1520 1530 1540 1550
WKVSLSSPAG AGTRFPALAP GSRDFGSGSS TQVCGAGSYA ASLRAGRVLY
1560 1570 1580 1590 1600
VWHLGEFREG WRMHSPWQFD EDEGRHRTGL AAGTTSPLSA SSTSSGGPEL
1610 1620 1630 1640 1650
VVLGTRPPRP AWTFGDPHIT TLDNAKYTFN GLGYFLLVQA QDRNSSFLLE
1660 1670 1680 1690 1700
GRTAQTDSAN ATNFIAFAAQ YNTSSLKSPI TVQWFLEPND TIRVVHNNQT
1710 1720 1730 1740 1750
VAFNTSDTED LPVFNATGVL LIQNGSQVSA NFDGTVTISV IALSNILHAS
1760 1770 1780 1790 1800
SSLSEEYRNH TKGLLGVWND NPEDDFRMPN GSTIPSNTSE ETLFHYGMTS
1810 1820 1830 1840 1850
ETNGIGLLGV RTDPLPSEFT PIFLSQLWNK SGAGEDLISG CNEDAQCKFD
1860 1870 1880 1890 1900
ILATGNRDIG QSTNSILRTF RHVNGTLNQY PPPIHYSSKI QAYKGREQWP
1910 1920 1930 1940 1950
LRSPATLRMS YSASPTSAVA FELFENGSLH VDTNIPRRTY LEILARDVKT
1960 1970 1980 1990 2000
NLSSVLQPET VACFCSKEEQ CLYNETSKEG NSSTEVTSCK CDGNSFGRLC
2010 2020 2030 2040 2050
EHSKDLCTEP CFPNVDCIPG KGCQACPPNM TGDGRHCVAV EISEFCQNHS
2060 2070 2080 2090 2100
CPVNYCYNHG HCDISGPPDC QPTCTCAPAF TGNRCFLAGN NFTPIIYKEL
2110 2120 2130 2140 2150
PLRTITLSLR EDENASNADV NASVANVLEN LDMRAFLSNS LVELIRTSPG
2160 2170 2180 2190 2200
APVLGKPIHH WKVVSHFKYR PRGPLIHYLN NQLISAVMEA FLLQARQERR
2210 2220 2230 2240 2250
KRSGEARKNV RFFPISRADV QDGMALNLSM LDEYFTCDGY KGYHLVYSPQ
2260 2270 2280 2290 2300
DGVTCVSPCS EGYCHNGGQC KHLPDGPQCT CATFSIYTSW GERCEHLSVK
2310 2320 2330 2340
LGAFFGILFG ALGALLLLAI LACVVFHFCG CSMNKFSYPL DSEL
Length:2,344
Mass (Da):248,041
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0182776F4FDE997F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M7W8F1M7W8_RAT
Mucin-4
Muc4
2,239Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81I → L in AAA85519 (PubMed:8163496).Curated1
Sequence conflicti81I → L in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti92S → G in AAA85519 (PubMed:8163496).Curated1
Sequence conflicti92S → G in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti103 – 104GT → RN in AAA85519 (PubMed:8163496).Curated2
Sequence conflicti103 – 104GT → RN in AAA85521 (PubMed:8163496).Curated2
Sequence conflicti110T → A in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti126 – 127QT → RA in AAA85521 (PubMed:8163496).Curated2
Sequence conflicti128T → A in AAA85519 (PubMed:8163496).Curated1
Sequence conflicti133T → A in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti141 – 143RES → ER in AAA85519 (PubMed:8163496).Curated3
Sequence conflicti150 – 485Missing in AAA85519 (PubMed:8163496).CuratedAdd BLAST336
Sequence conflicti156T → M in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti170M → T in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti174T → V in AAA85521 (PubMed:8163496).Curated1
Sequence conflicti490G → V in AAA85519 (PubMed:8163496).Curated1
Sequence conflicti498T → K in AAA85519 (PubMed:8163496).Curated1
Sequence conflicti501 – 502VT → IS in AAA85519 (PubMed:8163496).Curated2
Sequence conflicti505D → G in AAA85519 (PubMed:8163496).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U06746 mRNA Translation: AAA85517.1
U06748 mRNA Translation: AAA85519.1
U06750 mRNA Translation: AAA85521.1
U06752 mRNA Translation: AAA85523.1
AF240632 Genomic DNA Translation: AAF86958.1

Protein sequence database of the Protein Information Resource

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PIRi
A43353
A53577

Genome annotation databases

UCSC genome browser

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UCSCi
RGD:621331, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06746 mRNA Translation: AAA85517.1
U06748 mRNA Translation: AAA85519.1
U06750 mRNA Translation: AAA85521.1
U06752 mRNA Translation: AAA85523.1
AF240632 Genomic DNA Translation: AAF86958.1
PIRiA43353
A53577

3D structure databases

SMRiQ63661
ModBaseiSearch...

PTM databases

GlyGeniQ63661, 27 sites

Proteomic databases

PRIDEiQ63661

Genome annotation databases

UCSCiRGD:621331, rat

Organism-specific databases

RGDi621331, Muc4

Phylogenomic databases

InParanoidiQ63661

Miscellaneous databases

Protein Ontology

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PROi
PR:Q63661

Family and domain databases

InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR039898, Mucin_4
IPR003886, NIDO_dom
IPR001846, VWF_type-D
PANTHERiPTHR13802:SF53, PTHR13802:SF53, 1 hit
PfamiView protein in Pfam
PF06119, NIDO, 1 hit
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 3 hits
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS50026, EGF_3, 2 hits
PS51220, NIDO, 1 hit
PS51233, VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63661
Secondary accession number(s): Q63655
, Q63657, Q63659, Q9JIC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 7, 2020
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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