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Protein

Short-wave-sensitive opsin 1

Gene

Opn1sw

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Short-wave-sensitive opsin 1
Short name:
S opsin
Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name:
BOP
Short wavelength-sensitive cone opsin
Gene namesi
Name:Opn1sw
Synonyms:Bcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621033 Opn1sw

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularAdd BLAST31
Transmembranei32 – 56Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini57 – 68CytoplasmicAdd BLAST12
Transmembranei69 – 94Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini95 – 108ExtracellularAdd BLAST14
Transmembranei109 – 128Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini129 – 147CytoplasmicAdd BLAST19
Transmembranei148 – 171Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini172 – 197ExtracellularAdd BLAST26
Transmembranei198 – 225Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini226 – 247CytoplasmicAdd BLAST22
Transmembranei248 – 271Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini272 – 279Extracellular8
Transmembranei280 – 304Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini305 – 346CytoplasmicAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977671 – 346Short-wave-sensitive opsin 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
Modified residuei291N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63652
PRIDEiQ63652

PTM databases

PhosphoSitePlusiQ63652

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009278

Structurei

3D structure databases

ProteinModelPortaliQ63652
SMRiQ63652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiQ63652
KOiK04252
PhylomeDBiQ63652

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR001521 Opsin_blue
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00574 OPSINBLUE
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q63652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEDEFYLF QNISSVGPWD GPQYHIAPVW AFHLQAAFMG FVFFAGTPLN
60 70 80 90 100
ATVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF
110 120 130 140 150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YLVICKPFGN IRFNSKHALT
160 170 180 190 200
VVLITWTIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEHYTW
210 220 230 240 250
FLFIFCFIIP LSLICFSYFQ LLRTLRAVAA QQQESATTQK AEREVSHMVV
260 270 280 290 300
VMVGSFCLCY VPYAALAMYM VNNRNHGLYL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRA CILEMVCRKP MTDESDMSGS QKTEVSTVSS SKVGPH
Length:346
Mass (Da):39,062
Last modified:May 30, 2006 - v2
Checksum:i6DE181761AD4F296
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70I → V in AAC05294 (Ref. 2) Curated1
Sequence conflicti173F → L in AAC05294 (Ref. 2) Curated1
Sequence conflicti279Y → D in AAC05294 (Ref. 2) Curated1
Sequence conflicti329G → S in AAC05294 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63972 mRNA Translation: AAB05931.1
AF051163 mRNA Translation: AAC05294.1
RefSeqiNP_112277.1, NM_031015.1
UniGeneiRn.10549

Genome annotation databases

GeneIDi81644
KEGGirno:81644
UCSCiRGD:621033 rat

Similar proteinsi

Entry informationi

Entry nameiOPSB_RAT
AccessioniPrimary (citable) accession number: Q63652
Secondary accession number(s): O70363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2006
Last modified: July 5, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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