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Entry version 163 (29 Sep 2021)
Sequence version 2 (16 May 2006)
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Protein

Striated muscle-specific serine/threonine-protein kinase

Gene

Speg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 2 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1635ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1724Proton acceptorBy similarity1
Binding sitei2987ATPPROSITE-ProRule annotation1
Active sitei3077Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1612 – 1620ATPPROSITE-ProRule annotation9
Nucleotide bindingi2964 – 2972ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Striated muscle-specific serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
Aortic preferentially expressed protein 1
Short name:
APEG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Speg
Synonyms:Apeg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Rat genome database

More...
RGDi
2124, Speg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726681 – 3259Striated muscle-specific serine/threonine-protein kinaseAdd BLAST3259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33Omega-N-methylarginineBy similarity1
Modified residuei141PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei382PhosphoserineBy similarity1
Modified residuei385PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei453PhosphothreonineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei531PhosphoserineBy similarity1
Modified residuei554PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi994 ↔ 1046PROSITE-ProRule annotation
Modified residuei1133PhosphoserineBy similarity1
Modified residuei1177PhosphoserineCombined sources1
Modified residuei1993PhosphoserineBy similarity1
Modified residuei2004PhosphoserineCombined sources1
Modified residuei2019PhosphoserineCombined sources1
Modified residuei2020PhosphoserineCombined sources1
Modified residuei2042PhosphoserineCombined sources1
Modified residuei2060Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei2060Omega-N-methylarginine; alternateBy similarity1
Modified residuei2114PhosphoserineCombined sources1
Modified residuei2135PhosphoserineCombined sources1
Modified residuei2144Omega-N-methylarginineBy similarity1
Modified residuei2182PhosphoserineCombined sources1
Modified residuei2207PhosphoserineCombined sources1
Modified residuei2376PhosphoserineBy similarity1
Modified residuei2380PhosphothreonineBy similarity1
Modified residuei2410PhosphoserineCombined sources1
Modified residuei2414PhosphoserineCombined sources1
Modified residuei2438PhosphoserineCombined sources1
Modified residuei2439PhosphoserineCombined sources1
Modified residuei2444PhosphoserineBy similarity1
Modified residuei2448PhosphoserineCombined sources1
Modified residuei2521PhosphoserineBy similarity1
Modified residuei2524PhosphoserineBy similarity1
Modified residuei2559PhosphoserineCombined sources1
Disulfide bondi2605 ↔ 2657PROSITE-ProRule annotation
Modified residuei2771PhosphothreonineBy similarity1
Modified residuei2774PhosphoserineCombined sources1
Modified residuei2941PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be autophosphorylated.

Keywords - PTMi

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63638

PRoteomics IDEntifications database

More...
PRIDEi
Q63638

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q63638

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63638

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63638

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is highly expressed in differentiated arterial smooth muscle cells (ASMC) in the medial layer of the aorta. Weakly detected in brain and testis and to a lesser extent in organs rich in striated muscle or visceral smooth muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000019850, Expressed in brain and 22 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q63638, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTM1 (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q63638, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000026941

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 126Ig-like 1Add BLAST82
Domaini727 – 817Ig-like 2Add BLAST91
Domaini874 – 963Ig-like 3Add BLAST90
Domaini968 – 1056Ig-like 4Add BLAST89
Domaini1069 – 1157Ig-like 5Add BLAST89
Domaini1193 – 1283Ig-like 6Add BLAST91
Domaini1290 – 1387Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini1490 – 1578Ig-like 7Add BLAST89
Domaini1606 – 1859Protein kinase 1PROSITE-ProRule annotationAdd BLAST254
Domaini2583 – 2673Ig-like 8Add BLAST91
Domaini2680 – 2774Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini2859 – 2965Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST107
Domaini2958 – 3210Protein kinase 2PROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni155 – 185DisorderedSequence analysisAdd BLAST31
Regioni198 – 226DisorderedSequence analysisAdd BLAST29
Regioni278 – 716DisorderedSequence analysisAdd BLAST439
Regioni816 – 880DisorderedSequence analysisAdd BLAST65
Regioni1162 – 1185DisorderedSequence analysisAdd BLAST24
Regioni1367 – 1386DisorderedSequence analysisAdd BLAST20
Regioni1913 – 2244DisorderedSequence analysisAdd BLAST332
Regioni2336 – 2451DisorderedSequence analysisAdd BLAST116
Regioni2463 – 2562DisorderedSequence analysisAdd BLAST100
Regioni2771 – 2829DisorderedSequence analysisAdd BLAST59
Regioni2855 – 2957DisorderedSequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 185Polar residuesSequence analysisAdd BLAST27
Compositional biasi297 – 313Pro residuesSequence analysisAdd BLAST17
Compositional biasi329 – 349Polar residuesSequence analysisAdd BLAST21
Compositional biasi368 – 385Polar residuesSequence analysisAdd BLAST18
Compositional biasi406 – 422Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi464 – 492Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi500 – 521Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi590 – 604Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi666 – 688Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi816 – 833Polar residuesSequence analysisAdd BLAST18
Compositional biasi851 – 877Polar residuesSequence analysisAdd BLAST27
Compositional biasi2204 – 2232Pro residuesSequence analysisAdd BLAST29
Compositional biasi2353 – 2368Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2463 – 2481Polar residuesSequence analysisAdd BLAST19
Compositional biasi2507 – 2540Polar residuesSequence analysisAdd BLAST34
Compositional biasi2789 – 2807Pro residuesSequence analysisAdd BLAST19
Compositional biasi2808 – 2829Polar residuesSequence analysisAdd BLAST22
Compositional biasi2857 – 2905Polar residuesSequence analysisAdd BLAST49
Compositional biasi2909 – 2927Pro residuesSequence analysisAdd BLAST19
Compositional biasi2934 – 2954Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032, Eukaryota
KOG0613, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000381_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63638

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMITKEP

Database of Orthologous Groups

More...
OrthoDBi
7796at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63638

TreeFam database of animal gene trees

More...
TreeFami
TF331962

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR015726, Ser/Thr_kin_striated-sp
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR47633:SF3, PTHR47633:SF3, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 8 hits
PF00069, Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 9 hits
SM00408, IGc2, 8 hits
SM00220, S_TKc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 9 hits
SSF49265, SSF49265, 1 hit
SSF56112, SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 8 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00108, PROTEIN_KINASE_ST, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q63638-1) [UniParc]FASTAAdd to basket
Also known as: SPEG

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGA GAGAPVFLRP
60 70 80 90 100
LKNAAVCAGS DVRLRVVVSG TPEPSLSWFR DGQLLPTPVP EPSCLWLRNC
110 120 130 140 150
GAQDAGVYSC SAQNERGKAS CEAVLTVLEV RDSETAEDDI SDVPGTQRLE
160 170 180 190 200
LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE
210 220 230 240 250
AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL VGASWGSEDS
260 270 280 290 300
LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LRREEPDLQP QPASDALRPR
310 320 330 340 350
PALPPPSKSA LLPPPSPRVG KRALPGSSAQ PPATPTSPHR CTQEPSLPED
360 370 380 390 400
ITTTEEKRGK KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA
410 420 430 440 450
GSRILDKLQF FEERRRSLER SDSPPAPLRP WVPLRKARSL EQPKSEGGAA
460 470 480 490 500
WDTPGASQEE LRSPRGSVAE RRRLFQQKAA SLDERTRQRS ATSDLELRFA
510 520 530 540 550
QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL FSRPSIPKTS
560 570 580 590 600
RAVSPAATQP PPPSGAGKSG DETGRPRSRG PVGRTEPGEG PQQEIKRRDQ
610 620 630 640 650
FPLTRSRAIQ ECRSPVPPFT ADPPESRTKA PSARKREPPA QAVRFLPWAT
660 670 680 690 700
PGVEDSVLPQ TLEKNRAGPE AEKRLRRGPE EDGPWGAWDR RGTRSQGKGR
710 720 730 740 750
RARPTSPELE SSDDSYVSAG EEPLEAPVFE IPLQNMVVAP GADVLLKCII
760 770 780 790 800
TANPPPQVSW KKDGSVLHSE GRLLIRAEGE RHTLLLREAQ AADAGSYTAT
810 820 830 840 850
ATNELGQASC ASSLAVRPGA STSPFSSPIT SDEEYLSPPE EFPEPGETWS
860 870 880 890 900
RTPTMKPSPS QDRDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE
910 920 930 940 950
PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV
960 970 980 990 1000
NEYGARQCEA RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA
1010 1020 1030 1040 1050
DVEVDWLCRG RLLQPALLKC KMHFDGRKCK LLLTSVHEDD SGVYTCKLST
1060 1070 1080 1090 1100
VKDELTCSAR LTVRPSLAPL FTRLLEDVEV LEGRAARLDC KISGTPPPSV
1110 1120 1130 1140 1150
TWTHFGHPVN ESENLRLRQD GGLHSLHIAR VGSEDEGLYE VSATNTHGQA
1160 1170 1180 1190 1200
HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ
1210 1220 1230 1240 1250
DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL
1260 1270 1280 1290 1300
VFPAVGPQHA GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPQVVAVT
1310 1320 1330 1340 1350
GRMVTLSWNP PRSLDMAIDP DSLTYTVQHQ VLGSDQWTAL VTGLREPEWA
1360 1370 1380 1390 1400
ATGLKKGLHH IFRVLSSSGK SSSKPSAPSE PVQLLEHGPP LEEAPAVLDK
1410 1420 1430 1440 1450
QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEPRTG VYELSQPDDD
1460 1470 1480 1490 1500
QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SITLELAEAP RFESIMEDVE
1510 1520 1530 1540 1550
VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVVL
1560 1570 1580 1590 1600
SAGSQDGGVY TCTARNLAGE VSCKAELSVH SAQTAMEVEG VGEDEEHRGR
1610 1620 1630 1640 1650
RLSDYYDIHQ EIGRGAFSYL RRVVERSSGL EFAAKFIPSQ AKPKASARRE
1660 1670 1680 1690 1700
ARLLARLQHD CVLYFHEAFE RRRGLVIVTE LCTEELLERM ARKPTVCESE
1710 1720 1730 1740 1750
TRTYMRQVLE GIGYLHQSHV LHLDVKPENL LVWDGAGGEE QVRICDFGNA
1760 1770 1780 1790 1800
QELTPGEPQY CQFGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS
1810 1820 1830 1840 1850
PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA
1860 1870 1880 1890 1900
EETLEHPWFK TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE
1910 1920 1930 1940 1950
LLRAPPERVW VAMPRRQPPS GGLSSSSDSE EEELEELPSV PRPLQPEFSG
1960 1970 1980 1990 2000
SRVSLTDIPT EDEALGTPEA GAATPMDWQE QGRAPSKDQE APSPEALPSP
2010 2020 2030 2040 2050
GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA ASVELPQRRS
2060 2070 2080 2090 2100
PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL
2110 2120 2130 2140 2150
GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA
2160 2170 2180 2190 2200
GAPLEIPVAR LGARRLQESP SLSALSETQP PSPALPSAPK PSITKSPEPS
2210 2220 2230 2240 2250
AATSRDSPQP PAPQPVPEKI PEPKPEPVRA AKPAQPPLAL QMPAQSLTPY
2260 2270 2280 2290 2300
AQIMQSLQLS SPTLSPQVPP SEPKPHAAVF ARVASPPPGA SEKRVPSARI
2310 2320 2330 2340 2350
PPVLAEKVRV PTVPPRPGSS LSGSIENLES EAVFEAKFKR SRESPLSRGL
2360 2370 2380 2390 2400
RLLSRSRSEE RGPFRGAEDD GIYRPSPAGT PLELVRRPER SRSVQDLRVA
2410 2420 2430 2440 2450
GEPGLVRRLS LSLSQKLRRT PPGQRHPAWE SRSGDGESSE GGSSARGSPV
2460 2470 2480 2490 2500
LAVRRRLSST LERLSSRLQR SGSSEDSGGA SGRSTPLFGR LRRATSEGES
2510 2520 2530 2540 2550
LRRLGVPHNQ LASQTGATTP SAESLGSEAS GTSGSSAPGE SRSRHRWGLS
2560 2570 2580 2590 2600
RLRKDKGLSQ PNLSASVQED LGHQYVPSES DFPPVFHIKL KDQVLLEGEA
2610 2620 2630 2640 2650
ATLLCLPAAC PTPRISWMKD KQSLRSEPSV VIVSCKDGRQ LLSIPRASKR
2660 2670 2680 2690 2700
HAGLYECSAT NVLGSITSSC TVAVARTPGK LAPPEVPQTY CDTALVLWKP
2710 2720 2730 2740 2750
GDSRAPCTYT LERRVDGESV WHPVSSGIPD CYYNVTQLPV GVTVRFRVAC
2760 2770 2780 2790 2800
SNRAGQGPFS NPSEKVFIRG TQDSPAQSAA APRDAPVTSG PTRAPPPDSP
2810 2820 2830 2840 2850
TSLVPTPPLA PQVSQASTLS PSTSSMSANQ ALSSLKAVGP PPATPPRKHR
2860 2870 2880 2890 2900
GLLATQQAEP SPPSILVTPS EHKSFVPDTG TLTPTSSPQG VKPAPSSSSL
2910 2920 2930 2940 2950
YMVTSFVSAP PDPQPPAPEP PPEPTKVTVR SLSPAKEVVS SPTPESTTLR
2960 2970 2980 2990 3000
QGPPQKPYTF LEEKARGRFG VVRSCRENAT GRTFVAKIVP YAAEGKRRVL
3010 3020 3030 3040 3050
QEYEVLRTLH HERLMSLHEA YITPRYLVLI AESCGNRELL CGLSDRFRYS
3060 3070 3080 3090 3100
EDDVATYVVQ LLQGLDYLHG RHVLHLDIKP DNLLLAADNA LKIVDFGSAQ
3110 3120 3130 3140 3150
PYNPQALKPL GHRTGTLEFM APEMVRGDPI GSATDIWGAG VLTYIMLSGY
3160 3170 3180 3190 3200
SPFYEPDPQE TEARIVGGRF DAFQLYPNTS QSATLFLRKV LSVHPWSRPS
3210 3220 3230 3240 3250
LQDCLAHPWL QDAYLMKLRR QTLTFTTNRL KEFLGEQRRR RAEAATRHKV

LLRSYPGSP
Length:3,259
Mass (Da):354,166
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59915197FF5DADCC
GO
Isoform 2 (identifier: Q63638-2) [UniParc]FASTAAdd to basket
Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
     966-967: AH → GE
     968-3259: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:113
Mass (Da):12,668
Checksum:iB213C366A759A363
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0182691 – 854Missing in isoform 2. 1 PublicationAdd BLAST854
Alternative sequenceiVSP_018270966 – 967AH → GE in isoform 2. 1 Publication2
Alternative sequenceiVSP_018271968 – 3259Missing in isoform 2. 1 PublicationAdd BLAST2292

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03067996 Genomic DNA No translation available.
U57097 mRNA Translation: AAC52667.1

NCBI Reference Sequences

More...
RefSeqi
NP_001102272.1, NM_001108802.1 [Q63638-1]
NP_037037.1, NM_012905.2 [Q63638-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000026941; ENSRNOP00000026941; ENSRNOG00000019850 [Q63638-1]
ENSRNOT00000065076; ENSRNOP00000063082; ENSRNOG00000019850 [Q63638-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
363256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:363256

UCSC genome browser

More...
UCSCi
RGD:2124, rat [Q63638-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03067996 Genomic DNA No translation available.
U57097 mRNA Translation: AAC52667.1
RefSeqiNP_001102272.1, NM_001108802.1 [Q63638-1]
NP_037037.1, NM_012905.2 [Q63638-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ63638, 1 interactor
STRINGi10116.ENSRNOP00000026941

PTM databases

CarbonylDBiQ63638
iPTMnetiQ63638
PhosphoSitePlusiQ63638

Proteomic databases

PaxDbiQ63638
PRIDEiQ63638

Genome annotation databases

EnsembliENSRNOT00000026941; ENSRNOP00000026941; ENSRNOG00000019850 [Q63638-1]
ENSRNOT00000065076; ENSRNOP00000063082; ENSRNOG00000019850 [Q63638-2]
GeneIDi363256
KEGGirno:363256
UCSCiRGD:2124, rat [Q63638-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10290
RGDi2124, Speg

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG0613, Eukaryota
GeneTreeiENSGT00940000161126
HOGENOMiCLU_000381_0_0_1
InParanoidiQ63638
OMAiEMITKEP
OrthoDBi7796at2759
PhylomeDBiQ63638
TreeFamiTF331962

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q63638

Gene expression databases

BgeeiENSRNOG00000019850, Expressed in brain and 22 other tissues
GenevisibleiQ63638, RN

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR015726, Ser/Thr_kin_striated-sp
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR47633:SF3, PTHR47633:SF3, 3 hits
PfamiView protein in Pfam
PF07679, I-set, 8 hits
PF00069, Pkinase, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 9 hits
SM00408, IGc2, 8 hits
SM00220, S_TKc, 2 hits
SUPFAMiSSF48726, SSF48726, 9 hits
SSF49265, SSF49265, 1 hit
SSF56112, SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 8 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00108, PROTEIN_KINASE_ST, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEG_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63638
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: September 29, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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