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Entry version 117 (29 Sep 2021)
Sequence version 2 (03 Jul 2019)
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Protein

SR-related and CTD-associated factor 4

Gene

Scaf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SR-related and CTD-associated factor 4Curated
Alternative name(s):
CTD-binding SR-like protein RA4Curated
Splicing factor, arginine/serine-rich 15Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scaf4Imported
Synonyms:Sfrs15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...
RGDi
727896, Scaf4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819441 – 1200SR-related and CTD-associated factor 4Add BLAST1200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49N6-acetyllysineBy similarity1
Modified residuei154PhosphoserineBy similarity1
Modified residuei722PhosphoserineBy similarity1
Modified residuei1058PhosphoserineBy similarity1
Modified residuei1178PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q63627

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63627

PeptideAtlas

More...
PeptideAtlasi
Q63627

PRoteomics IDEntifications database

More...
PRIDEi
Q63627

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63627

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002104, Expressed in testis and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q63627, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A; via C-terminal heptapeptide repeat domain (CTD) phosphorylated at 'Ser-2' and 'Ser-5'.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63627

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 139CIDPROSITE-ProRule annotationAdd BLAST139
Domaini574 – 648RRMPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni140 – 172DisorderedSequence analysisAdd BLAST33
Regioni299 – 324DisorderedSequence analysisAdd BLAST26
Regioni346 – 566DisorderedSequence analysisAdd BLAST221
Regioni696 – 724DisorderedSequence analysisAdd BLAST29
Regioni834 – 875DisorderedSequence analysisAdd BLAST42
Regioni927 – 1200DisorderedSequence analysisAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 157Polar residuesSequence analysisAdd BLAST16
Compositional biasi365 – 465Pro residuesSequence analysisAdd BLAST101
Compositional biasi501 – 543Basic residuesSequence analysisAdd BLAST43
Compositional biasi544 – 562Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi927 – 962Pro residuesSequence analysisAdd BLAST36
Compositional biasi983 – 1044Polar residuesSequence analysisAdd BLAST62
Compositional biasi1045 – 1142Basic and acidic residuesSequence analysisAdd BLAST98
Compositional biasi1150 – 1164Polar residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0132, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005263_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63627

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSREKMT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63627

TreeFam database of animal gene trees

More...
TreeFami
TF324527

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12461, RRM_SCAF4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034369, SCAF4_RRM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818, CID, 1 hit
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00582, RPR, 1 hit
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464, SSF48464, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391, CID, 1 hit
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAVNAFNQE LFSLMDMKPP ISRAKMILIT KAAIKAIKLY KHVVQIVEKF
60 70 80 90 100
IKKCKPEYKV PGLYVIDSIV RQSRHQFGTD KDVFGPRFSK NITATFQYLY
110 120 130 140 150
LCPSEDKSKI VRVLNLWQKN GVFKIEIIQP LLDMAAGTSN AAPGAENVTN
160 170 180 190 200
NEGSPPPPVK VSSELPQAPT NSMPAVPQLP SSDAFAAVAQ LFQTTQGQQL
210 220 230 240 250
QQILQTFQQP PKPQSPALDS AVMAQVQAIT AQLKTAPTQP PEQKTAFDKK
260 270 280 290 300
LLDRFDYDDE PEAVEDSKKE DAVAVATTAL ATAAPPVPAA ATPAVAPAVP
310 320 330 340 350
ASSATSPPPP QAPFGYPGDG MQQPAYTQHQ NVDQFQPRMM ALQQDSMQHQ
360 370 380 390 400
VPLPPNGQMP GFGLLSAPPP FPPMPQPGMP QPGMPQPGMP QPGLSQPGLP
410 420 430 440 450
QPGMPQPGMP QPGMPQPGMP QPGLPQPGLP QPGMPQPGMP QPGMPQPGMP
460 470 480 490 500
QPGMPPTPPV QPTFQPTFQP QNEPHSQKPH QQEMEVEQPC VTEVKRHVPE
510 520 530 540 550
SRKSRSRSPK RRRSRSGSRS RRSRHRRSRS RSRDRRRHSP RSRSQERRDR
560 570 580 590 600
EKERERRQKG LPQIKSETAS VCSTTLWVGQ LDKRTTQQDV ASLLEEFGPI
610 620 630 640 650
ESINMIPPRG CAYIVMVHRQ DAYRALQKLS RGNYKVNQKS IKIAWALNKG
660 670 680 690 700
IKADFKQYWD VELGVTYIPW DKVKAEELES FCEGGMLDSD TLNPDWKGIP
710 720 730 740 750
KKPENEVAQN GGAEASHTEP VSPIPKPVPV PVPALPVPAP ITVPPPQVPP
760 770 780 790 800
HQPGPPVVGA LQPPAFTPPL GIPPPGFGPG VPPPPPPPPP FLRPGFNPMH
810 820 830 840 850
LPPGFLPPGP PPPITPPVSI PPPHTPPISI PNLVSGARGN AESADSAKMY
860 870 880 890 900
GSAGPPAAPT SLPTPPVTQP VSLLGTQGVA PGPVIGLQAP STGLLGARPG
910 920 930 940 950
LIPLQRPPGM PPPHLQRFPM MPPRPMPPHM MHRGPPPGPG GFAMPPPHGM
960 970 980 990 1000
KGPFPPHGPF VRPGGMPGLG GPGPGPGGSE DRDGRQQQPQ QQQQQQQQQQ
1010 1020 1030 1040 1050
QQQQQQQQQP PPQQSQTQQQ PAPSQQPAPA QQQPQQFRND NRQQFNSGRD
1060 1070 1080 1090 1100
QERFGRRSFG SRVENDRERY GSRSDERDNS NRERREWGRR SPERDRHRDL
1110 1120 1130 1140 1150
EERSRRSSGH RDRDRDSRDR ESRREKEESR GKEKHEVADR AGGNKAVEAP
1160 1170 1180 1190 1200
LSQVGNTDTV SELNKGEAMA TVVKPEESPA EATSSVEPEK DSGSAAEAPR
Length:1,200
Mass (Da):130,953
Last modified:July 3, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7593A48AEED1B4F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M994F1M994_RAT
SR-related and CTD-associated facto...
Scaf4
919Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189A → D in AAC52660 (PubMed:8692929).1
Sequence conflicti425P → A in AAC52660 (PubMed:8692929).1
Sequence conflicti430P → A in AAC52660 (PubMed:8692929).1
Sequence conflicti792 – 793LR → WG in AAC52660 (PubMed:8692929).2
Sequence conflicti897A → G in AAC52660 (PubMed:8692929).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07033613 Genomic DNA No translation available.
U49058 mRNA Translation: AAC52660.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T31425

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000047741; ENSRNOP00000047258; ENSRNOG00000002104

UCSC genome browser

More...
UCSCi
RGD:727896, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07033613 Genomic DNA No translation available.
U49058 mRNA Translation: AAC52660.1
PIRiT31425

3D structure databases

SMRiQ63627
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047258

PTM databases

iPTMnetiQ63627

Proteomic databases

jPOSTiQ63627
PaxDbiQ63627
PeptideAtlasiQ63627
PRIDEiQ63627

Genome annotation databases

EnsembliENSRNOT00000047741; ENSRNOP00000047258; ENSRNOG00000002104
UCSCiRGD:727896, rat

Organism-specific databases

RGDi727896, Scaf4

Phylogenomic databases

eggNOGiKOG0132, Eukaryota
GeneTreeiENSGT00530000063946
HOGENOMiCLU_005263_0_1_1
InParanoidiQ63627
OMAiDSREKMT
PhylomeDBiQ63627
TreeFamiTF324527

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q63627

Gene expression databases

BgeeiENSRNOG00000002104, Expressed in testis and 20 other tissues
ExpressionAtlasiQ63627, baseline and differential

Family and domain databases

CDDicd12461, RRM_SCAF4, 1 hit
Gene3Di1.25.40.90, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034369, SCAF4_RRM
PfamiView protein in Pfam
PF04818, CID, 1 hit
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00582, RPR, 1 hit
SM00360, RRM, 1 hit
SUPFAMiSSF48464, SSF48464, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391, CID, 1 hit
PS50102, RRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCAF4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63627
Secondary accession number(s): F1LSM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 3, 2019
Last modified: September 29, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
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