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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

Coq7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Iron 1UniRule annotation1
Metal bindingi52Iron 1UniRule annotation1
Metal bindingi52Iron 2UniRule annotation1
Metal bindingi55Iron 1UniRule annotation1
Metal bindingi104Iron 2UniRule annotation1
Metal bindingi140Iron 1UniRule annotation1
Metal bindingi140Iron 2UniRule annotation1
Metal bindingi143Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • response to drug Source: RGD
  • ubiquinone biosynthetic process Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processUbiquinone biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Timing protein clk-1 homologUniRule annotation
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:Coq7UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2381 Coq7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000079253‹1 – 1795-demethoxyubiquinone hydroxylase, mitochondrialAdd BLAST›179

Proteomic databases

PaxDbiQ63619
PeptideAtlasiQ63619
PRIDEiQ63619

PTM databases

iPTMnetiQ63619
PhosphoSitePlusiQ63619

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ8B and COQ6. Interacts with COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022988

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 911Add BLAST82
Repeati92 – 1792Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 1792 X approximate tandem repeatsAdd BLAST170

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4061 Eukaryota
COG2941 LUCA
HOGENOMiHOG000184972
HOVERGENiHBG002214
InParanoidiQ63619
PhylomeDBiQ63619

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Fragment.

Q63619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDNINRAA VDRIIRVDHA GEYGANRIYA GQMAVLGRTS VGPVIQKMWD
60 70 80 90 100
QEKNHLKKFN ELMVAFRVRP TVLMPLWNVA GFALGAGTAL LGKEGGMACT
110 120 130 140 150
VAVEESIAHH YNNQIRMLME EDAEKYEELL QVIKQFRDEE LEHHDTGLEH
160 170
DAELAPAYTL LKRLIQAGCS AAIYLSERF
Length:179
Mass (Da):20,140
Last modified:July 15, 1998 - v3
Checksum:iDB671199542F7922
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473956 Genomic DNA Translation: EDM17705.1
U46149 mRNA Translation: AAB51656.1
PIRiT10806
UniGeneiRn.6981

Similar proteinsi

Entry informationi

Entry nameiCOQ7_RAT
AccessioniPrimary (citable) accession number: Q63619
Secondary accession number(s): O08887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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