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Protein

Hypoxia up-regulated protein 1

Gene

Hyou1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to hypoxia Source: GO_Central
  • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
  • response to hypoxia Source: RGD

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia up-regulated protein 1
Alternative name(s):
150 kDa oxygen-regulated protein
Short name:
ORP-150
Gene namesi
Name:Hyou1
Synonyms:Orp150
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621146 Hyou1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 322 PublicationsAdd BLAST32
ChainiPRO_000001353933 – 999Hypoxia up-regulated protein 1Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineCombined sources1
Modified residuei567PhosphoserineBy similarity1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi830N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi862N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi869N-linked (GlcNAc...) asparagineCombined sources1
Modified residuei883N6-acetyllysineBy similarity1
Glycosylationi922N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63617
PRIDEiQ63617

2D gel databases

World-2DPAGEi0004:Q63617

PTM databases

iPTMnetiQ63617
PhosphoSitePlusiQ63617
UniCarbKBiQ63617

Expressioni

Tissue specificityi

Selectively expressed by cultured astrocytes but not endothelial cells, microglia or neurons.

Inductioni

By oxygen deprivation.

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Protein-protein interaction databases

BioGridi251367, 4 interactors
IntActiQ63617, 3 interactors
STRINGi10116.ENSRNOP00000039172

Structurei

3D structure databases

ProteinModelPortaliQ63617
SMRiQ63617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi996 – 999Prevents secretion from ERSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi603 – 606Poly-Glu4

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
HOGENOMiHOG000007865
HOVERGENiHBG106402
InParanoidiQ63617
KOiK09486
PhylomeDBiQ63617

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63617-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATVRRQRP RRLLCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV
60 70 80 90 100
KPGVPMEIVL NKESRRKTPV TVTLKENERF LGDSAAGMAI KNPKATLRYF
110 120 130 140 150
QHLLGKQADN PHVALYRSRF PEHELNVDPQ RQTVRFQISP QLQFSPEEVL
160 170 180 190 200
GMVLNYSRSL AEDFAEQPIK DAVITVPAFF NQAERRAVLQ AARMAGLKVL
210 220 230 240 250
QLINDNTATA LSYGVFRRKD INSTAQNIMF YDMGSGSTVC TIVTYQTVKT
260 270 280 290 300
KEAGTQPQLQ IRGVGFDRTL GGLEMELRLR EHLAKLFNEQ RKGQKAKDVR
310 320 330 340 350
ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE
360 370 380 390 400
LCADLFDRVP GPVQQALQSA EMSLDQIEQV ILVGGPTRVP KVQEVLLKPV
410 420 430 440 450
GKEELGKNIN ADEAAAMGAV YQAAALSKAF KVKPFVVRDA VIYPILVEFT
460 470 480 490 500
REVEEEPGLR SLKHNKRVLF SRMGPYPQRK VITFNRYSHD FNFHINYGDL
510 520 530 540 550
GFLGPEDLRV FGSQNLTTVK LKGVGESFKK YPDYESKGIK AHFNLDESGV
560 570 580 590 600
LSLDRVESVF ETLVEDSPEE ESTLTKLGNT ISSLFGGGTS SDAKENGTDA
610 620 630 640 650
VQEEEESPAE GSKDEPAEQG ELKEEAEAPM EDTSQPPPSE PKGDAAREGE
660 670 680 690 700
TPDEKESGDK SEAQKPNEKG QAGPEGVPPA PEEEKKQKPA RKQKMVEEIG
710 720 730 740 750
VELAVLDLPD LPEDELAHSV QKLEDLTLRD LEKQEREKAA NSLEAFIFET
760 770 780 790 800
QDKLYQPEYQ EVSTEEQREE ISGKLSATST WLEDEGFGAT TVMLKDKLAE
810 820 830 840 850
LRKLCQGLFF RVEERRKWPE RLSALDNLLN HSSIFLKGAR LIPEMDQIFT
860 870 880 890 900
DVEMTTLEKV INDTWTWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR
910 920 930 940 950
EVQYLLNKAK FTKPRPRPKD KNGTRTEPPL NASAGDQEEK VIPPTGQTEE
960 970 980 990
AKAILEPDKE GLGTEAADSE PLELGGPGAE SEQAEQTAGQ KRPLKNDEL
Length:999
Mass (Da):111,289
Last modified:November 1, 1996 - v1
Checksum:iF93D53169C5A5EBD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P136Q6P136_RAT
Hyou1 protein
Hyou1 rCG_58188
998Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41853 mRNA Translation: AAB05672.1
RefSeqiNP_620222.2, NM_138867.2
UniGeneiRn.10542

Genome annotation databases

GeneIDi192235
KEGGirno:192235
UCSCiRGD:621146 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41853 mRNA Translation: AAB05672.1
RefSeqiNP_620222.2, NM_138867.2
UniGeneiRn.10542

3D structure databases

ProteinModelPortaliQ63617
SMRiQ63617
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251367, 4 interactors
IntActiQ63617, 3 interactors
STRINGi10116.ENSRNOP00000039172

PTM databases

iPTMnetiQ63617
PhosphoSitePlusiQ63617
UniCarbKBiQ63617

2D gel databases

World-2DPAGEi0004:Q63617

Proteomic databases

PaxDbiQ63617
PRIDEiQ63617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192235
KEGGirno:192235
UCSCiRGD:621146 rat

Organism-specific databases

CTDi10525
RGDi621146 Hyou1

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
HOGENOMiHOG000007865
HOVERGENiHBG106402
InParanoidiQ63617
KOiK09486
PhylomeDBiQ63617

Miscellaneous databases

PROiPR:Q63617

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYOU1_RAT
AccessioniPrimary (citable) accession number: Q63617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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