Ntrk2

Functionⁱ

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells.4 Publications

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Activity regulationⁱ

The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	571	ATPPROSITE-ProRule annotation		1
Active siteⁱ	675	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	543 – 551	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
brain-derived neurotrophic factor-activated receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1645620
- 8627351
brain-derived neurotrophic factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1645620
neurotrophin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1645620
neurotrophin receptor activity
Source: RGD
Inferred from direct assayⁱ
- 16477614
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8627351
protein tyrosine kinase activity Source: Reactome
receptor tyrosine kinase binding
Source: RGD
Inferred from physical interactionⁱ
- 16801538
transmembrane receptor protein serine/threonine kinase activity Source: Reactome
transmembrane receptor protein tyrosine kinase activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 17447135

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging
Source: RGD
Inferred from expression patternⁱ
- 21951697
brain-derived neurotrophic factor receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 1645620
- 8627351
cellular response to brain-derived neurotrophic factor stimulus
Source: RGD
Inferred from expression patternⁱ
- 21958434
cellular response to nerve growth factor stimulus
Source: RGD
Inferred from expression patternⁱ
- 21958434
cellular response to tumor necrosis factor
Source: RGD
Inferred from expression patternⁱ
- 21958434
central nervous system neuron development Source: UniProtKB
cerebral cortex development Source: UniProtKB
inflammatory response
Source: RGD
Inferred from expression patternⁱ
- 21958434
learning Source: UniProtKB
long-term memory
Source: RGD
Inferred from direct assayⁱ
- 21136519
negative regulation of neuron apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10985347
neuron differentiation Source: UniProtKB
neuron migration Source: UniProtKB
positive regulation of axonogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10985347
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 9582017
positive regulation of gene expression Source: UniProtKB
positive regulation of glucocorticoid receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 23878391
positive regulation of MAPK cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10985347
positive regulation of neuron projection development Source: UniProtKB
positive regulation of phosphatidylinositol 3-kinase signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10985347
positive regulation of synaptic transmission, glutamatergic
Source: RGD
Inferred from mutant phenotypeⁱ
- 16983663
protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 9582017
regulation of dendrite development
Source: RGD
Inferred from mutant phenotypeⁱ
- 15654844
regulation of GTPase activity Source: UniProtKB
regulation of MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 9582017
regulation of neurotransmitter secretion
Source: RGD
Inferred from direct assayⁱ
- 16477614
response to auditory stimulus
Source: RGD
Inferred from expression patternⁱ
- 21034795
response to light stimulus
Source: RGD
Inferred from expression patternⁱ
- 17640634

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process	Differentiation, Neurogenesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 5301
Reactomeⁱ	R-RNO-9026527 Activated NTRK2 signals through PLCG1 R-RNO-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BDNF/NT-3 growth factors receptor (EC:2.7.10.1) Alternative name(s): Neurotrophic tyrosine kinase receptor type 2 TrkB tyrosine kinase Short name: Trk-B
Gene namesⁱ	Name:Ntrk2 Synonyms:Trkb
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 17

Organism-specific databases

Rat genome database More...RGDⁱ	3213 Ntrk2

RGDⁱ

3213 Ntrk2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	32 – 429	ExtracellularSequence analysisAdd BLAST	398
Transmembraneⁱ	430 – 453	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	454 – 821	CytoplasmicSequence analysisAdd BLAST	368

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	515	Y → F: Loss of interaction with SHC1. 1 Publication	1
Mutagenesisⁱ	571	K → A: Loss of kinase activity. 1 Publication	1
Mutagenesisⁱ	701	Y → F: Loss of autophosphorylation and altered interaction with SHC1 and PLCG1; when associated with F-705 and F-706. 1 Publication	1
Mutagenesisⁱ	705	Y → F: Loss of autophosphorylation; when associated with F-701 and F-706. 2 Publications	1
Mutagenesisⁱ	706	Y → F: Loss of autophosphorylation; when associated with F-701 and F-705. 1 Publication	1

Chemistry databases

ChEMBLⁱ	CHEMBL1795111

ChEMBLⁱ

CHEMBL1795111

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	By similarityAdd BLAST		31
ChainⁱPRO_0000016729	32 – 821	BDNF/NT-3 growth factors receptorAdd BLAST		790

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	32 ↔ 38	PROSITE-ProRule annotation
Disulfide bondⁱ	36 ↔ 45	PROSITE-ProRule annotation
Glycosylationⁱ	67	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	95	N-linked (GlcNAc...) asparagineCombined sources	1
Glycosylationⁱ	121	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	152 ↔ 176	PROSITE-ProRule annotation
Disulfide bondⁱ	154 ↔ 194	PROSITE-ProRule annotation
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	205	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	218 ↔ 266	PROSITE-ProRule annotation
Glycosylationⁱ	241	N-linked (GlcNAc...) asparagineCombined sources	1
Glycosylationⁱ	254	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	280	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	302 ↔ 345	PROSITE-ProRule annotation
Glycosylationⁱ	325	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	338	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	411	N-linked (GlcNAc...) asparagineBy similarity	1
Modified residueⁱ	515	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	701	Phosphotyrosine; by autocatalysis1 Publication	1
Modified residueⁱ	705	Phosphotyrosine; by autocatalysis1 Publication	1
Modified residueⁱ	706	Phosphotyrosine; by autocatalysis1 Publication	1
Modified residueⁱ	816	Phosphotyrosine; by autocatalysis1 Publication	1

Post-translational modificationⁱ

Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Some isoforms are not phosphorylated.2 Publications

Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q63604
PRIDEⁱ	Q63604

PTM databases

iPTMnetⁱ	Q63604
PhosphoSitePlusⁱ	Q63604
UniCarbKBⁱ	Q63604

Expressionⁱ

Tissue specificityⁱ

Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons.

Gene expression databases

Bgeeⁱ	ENSRNOG00000018839 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasⁱ	Q63604 baseline and differential
Genevisibleⁱ	Q63604 RN

Interactionⁱ

Subunit structureⁱ

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220. Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway. Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (PubMed:21775604).By similarity9 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	515	Interaction with SHC1	1
Siteⁱ	705	Interaction with SH2D1A	1
Siteⁱ	816	Interaction with PLCG1By similarity	1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Cdk5	Q03114	5	EBI-7287667,EBI-2008531
Fnta	Q04631	4	EBI-7287667,EBI-602447
Nr3c1	P06536	2	EBI-7287667,EBI-1187143
Pirb	Q8K4V6	3	EBI-7287667,EBI-8602514	From Mus musculus.

GO - Molecular functionⁱ

brain-derived neurotrophic factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1645620
neurotrophin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1645620
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8627351
receptor tyrosine kinase binding
Source: RGD
Inferred from physical interactionⁱ
- 16801538

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247131, 8 interactors
CORUMⁱ	Q63604
Database of interacting proteins More...DIPⁱ	DIP-5717N
IntActⁱ	Q63604, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q63604
STRINGⁱ	10116.ENSRNOP00000045635

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63604
SMRⁱ	Q63604
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	32 – 61	LRRNTAdd BLAST	30
Repeatⁱ	92 – 113	LRR 1Add BLAST	22
Repeatⁱ	116 – 137	LRR 2Add BLAST	22
Domainⁱ	148 – 196	LRRCTAdd BLAST	49
Domainⁱ	197 – 282	Ig-like C2-type 1Add BLAST	86
Domainⁱ	295 – 365	Ig-like C2-type 2Add BLAST	71
Domainⁱ	537 – 806	Protein kinasePROSITE-ProRule annotationAdd BLAST	270

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	454 – 465	Interaction with MAPK8IP3/JIP31 PublicationAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1026 Eukaryota ENOG410YGKQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118818
HOGENOMⁱ	HOG000264255
HOVERGENⁱ	HBG056735
InParanoidⁱ	Q63604
KEGG Orthology (KO) More...KOⁱ	K04360
PhylomeDBⁱ	Q63604
TreeFamⁱ	TF106465

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR000372 LRRNT IPR031635 NTRK_C2 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR020455 Tyr_kin_neurotrophic_rcpt_2 IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR020777 Tyr_kinase_NGF_rcpt IPR002011 Tyr_kinase_rcpt_2_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679 I-set, 2 hits PF13855 LRR_8, 1 hit PF07714 Pkinase_Tyr, 1 hit PF16920 TPKR_C2, 1 hit
PRINTSⁱ	PR01939 NTKRECEPTOR PR01941 NTKRECEPTOR2 PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00408 IGc2, 1 hit SM00082 LRRCT, 1 hit SM00013 LRRNT, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform GP145-TrkB (identifier: Q63604-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPWPRWHGP AMARLWGLCL LVLGFWRASL ACPMSCKCST TRIWCTEPSP 
        60         70         80         90        100
GIVAFPRLEP NSIDPENITE ILIANQKRLE IINEDDVEAY VGLKNLTIVD 
       110        120        130        140        150
SGLKFVAYKA FLKNGNLRHI NFTRNKLTSL SRRHFRHLDL SDLILTGNPF 
       160        170        180        190        200
TCSCDIMWLK TLQETKSSPD TQDLYCLNES SKNTPLANLQ IPNCGLPSAR 
       210        220        230        240        250
LAAPNLTVEE GKSVTISCSV GGDPLPTLYW DVGNLVSKHM NETSHTQGSL 
       260        270        280        290        300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
       310        320        330        340        350
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN 
       360        370        380        390        400
PTHMNNGDYT LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW 
       410        420        430        440        450
TTPTDIGDTT NKSNEIPSTD VADQTNREHL SVYAVVVIAS VVGFCLLVML 
       460        470        480        490        500
LLLKLARHSK FGMKGPASVI SNDDDSASPL HHISNGSNTP SSSEGGPDAV 
       510        520        530        540        550
IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK RELGEGAFGK 
       560        570        580        590        600
VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV 
       610        620        630        640        650
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS 
       660        670        680        690        700
QMLHIAQQIA AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV 
       710        720        730        740        750
YSTDYYRVGG HTMLPIRWMP PESIMYRKFT TESDVWSLGV VLWEIFTYGK 
       760        770        780        790        800
QPWYQLSNNE VIECITQGRV LQRPRTCPQE VYELMLGCWQ REPHTRKNIK 
       810        820 
NIHTLLQNLA KASPVYLDIL G

Length:821

Mass (Da):92,186

Last modified:November 1, 1996 - v1

Checksum:ⁱ0DDACDA212CDAA0E

GO

Isoform T1 (identifier: Q63604-2) [UniParc]FASTA Add to basket

Also known as: GP95-TrkB

The sequence of this isoform differs from the canonical sequence as follows:
466-476: PASVISNDDDS → FVLFHKIPLDG
477-821: Missing.

« Hide

        10         20         30         40         50
MSPWPRWHGP AMARLWGLCL LVLGFWRASL ACPMSCKCST TRIWCTEPSP 
        60         70         80         90        100
GIVAFPRLEP NSIDPENITE ILIANQKRLE IINEDDVEAY VGLKNLTIVD 
       110        120        130        140        150
SGLKFVAYKA FLKNGNLRHI NFTRNKLTSL SRRHFRHLDL SDLILTGNPF 
       160        170        180        190        200
TCSCDIMWLK TLQETKSSPD TQDLYCLNES SKNTPLANLQ IPNCGLPSAR 
       210        220        230        240        250
LAAPNLTVEE GKSVTISCSV GGDPLPTLYW DVGNLVSKHM NETSHTQGSL 
       260        270        280        290        300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
       310        320        330        340        350
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN 
       360        370        380        390        400
PTHMNNGDYT LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW 
       410        420        430        440        450
TTPTDIGDTT NKSNEIPSTD VADQTNREHL SVYAVVVIAS VVGFCLLVML 
       460        470 
LLLKLARHSK FGMKGFVLFH KIPLDG

Note: Non-catalytic isoform.

Show »

Length:476

Mass (Da):53,212

Checksum:ⁱ79AFCD9CA0AB13A8

GO

Isoform T2 (identifier: Q63604-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
466-474: PASVISNDD → KQKCAYFAS
475-821: Missing.

« Hide

        10         20         30         40         50
MSPWPRWHGP AMARLWGLCL LVLGFWRASL ACPMSCKCST TRIWCTEPSP 
        60         70         80         90        100
GIVAFPRLEP NSIDPENITE ILIANQKRLE IINEDDVEAY VGLKNLTIVD 
       110        120        130        140        150
SGLKFVAYKA FLKNGNLRHI NFTRNKLTSL SRRHFRHLDL SDLILTGNPF 
       160        170        180        190        200
TCSCDIMWLK TLQETKSSPD TQDLYCLNES SKNTPLANLQ IPNCGLPSAR 
       210        220        230        240        250
LAAPNLTVEE GKSVTISCSV GGDPLPTLYW DVGNLVSKHM NETSHTQGSL 
       260        270        280        290        300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
       310        320        330        340        350
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN 
       360        370        380        390        400
PTHMNNGDYT LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW 
       410        420        430        440        450
TTPTDIGDTT NKSNEIPSTD VADQTNREHL SVYAVVVIAS VVGFCLLVML 
       460        470 
LLLKLARHSK FGMKGKQKCA YFAS

Note: Non-catalytic isoform.

Show »

Length:474

Mass (Da):52,971

Checksum:ⁱ2A6F19237F9F692A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2K5X6	A0A0G2K5X6_RAT		Tyrosine-protein kinase receptor Tyrosine-protein kinase receptor, EC 2.7.10.1	Ntrk2	837	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002910	466 – 476	PASVISNDDDS → FVLFHKIPLDG in isoform T1. CuratedAdd BLAST	11
Alternative sequenceⁱVSP_002912	466 – 474	PASVISNDD → KQKCAYFAS in isoform T2. Curated	9
Alternative sequenceⁱVSP_002913	475 – 821	Missing in isoform T2. CuratedAdd BLAST	347
Alternative sequenceⁱVSP_002911	477 – 821	Missing in isoform T1. CuratedAdd BLAST	345

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55291 mRNA Translation: AAA42279.1 M55292 mRNA Translation: AAA42280.1 M55293 mRNA Translation: AAA42281.1
PIRⁱ	A39667 B39667 C39667
NCBI Reference Sequences More...RefSeqⁱ	NP_001156640.1, NM_001163168.2 [Q63604-2] NP_036863.1, NM_012731.2 [Q63604-1]
UniGeneⁱ	Rn.11246

Genome annotation databases

Ensemblⁱ	ENSRNOT00000042145; ENSRNOP00000045635; ENSRNOG00000018839 [Q63604-1] ENSRNOT00000090914; ENSRNOP00000070128; ENSRNOG00000018839 [Q63604-2]
GeneIDⁱ	25054
KEGGⁱ	rno:25054
UCSC genome browser More...UCSCⁱ	RGD:3213 rat [Q63604-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q63604	BDNF/NT-3 growth factors receptor		MOUSE		821	UniRef90_P15209
Tyrosine-protein kinase receptor		RAT		837
Tyrosine-protein kinase receptor		MESAU		823
Tyrosine-protein kinase receptor		ICTTR		821
Tyrosine-protein kinase receptor		LOXAF		820
+45
Q63604-2	BDNF/NT-3 growth factors receptor isoform X2		MESAU		538	UniRef90_Q63604-2
BDNF/NT-3 growth factors receptor		MOUSE		492
Neurotrophic tyrosine kinase, receptor, type 2		MICOH		476
Isoform T2 of BDNF/NT-3 growth factors receptor		RAT		474
UPI000A310E30		MUSPA		552
+19
Q63604-3	Isoform T1 of BDNF/NT-3 growth factors receptor		RAT		476	UniRef90_Q63604-2
BDNF/NT-3 growth factors receptor isoform X2		MESAU		538
BDNF/NT-3 growth factors receptor		MOUSE		492
Neurotrophic tyrosine kinase, receptor, type 2		MICOH		476
UPI000A310E30		MUSPA		552
+19

Protein	Similar proteins		Species	Score	Length	Source
Q63604	BDNF/NT-3 growth factors receptor		MOUSE		821	UniRef50_P15209
Tyrosine-protein kinase receptor		RAT		837
Tyrosine-protein kinase receptor		MESAU		823
Tyrosine-protein kinase receptor		ICTTR		821
Tyrosine-protein kinase receptor		LOXAF		820
+199
Q63604-2	BDNF/NT-3 growth factors receptor isoform X2		MESAU		538	UniRef50_Q63604-2
BDNF/NT-3 growth factors receptor		MOUSE		492
Neurotrophic tyrosine kinase, receptor, type 2		MICOH		476
Isoform T2 of BDNF/NT-3 growth factors receptor		RAT		474
Uncharacterized protein		CAVPO		471
+57
Q63604-3	Isoform T1 of BDNF/NT-3 growth factors receptor		RAT		476	UniRef50_Q63604-2
BDNF/NT-3 growth factors receptor isoform X2		MESAU		538
BDNF/NT-3 growth factors receptor		MOUSE		492
Neurotrophic tyrosine kinase, receptor, type 2		MICOH		476
Uncharacterized protein		CAVPO		471
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55291 mRNA Translation: AAA42279.1 M55292 mRNA Translation: AAA42280.1 M55293 mRNA Translation: AAA42281.1
PIRⁱ	A39667 B39667 C39667
RefSeqⁱ	NP_001156640.1, NM_001163168.2 [Q63604-2] NP_036863.1, NM_012731.2 [Q63604-1]
UniGeneⁱ	Rn.11246

3D structure databases

ProteinModelPortalⁱ	Q63604
SMRⁱ	Q63604
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247131, 8 interactors
CORUMⁱ	Q63604
DIPⁱ	DIP-5717N
IntActⁱ	Q63604, 11 interactors
MINTⁱ	Q63604
STRINGⁱ	10116.ENSRNOP00000045635

Chemistry databases

ChEMBLⁱ	CHEMBL1795111

ChEMBLⁱ

CHEMBL1795111

PTM databases

iPTMnetⁱ	Q63604
PhosphoSitePlusⁱ	Q63604
UniCarbKBⁱ	Q63604

Proteomic databases

PaxDbⁱ	Q63604
PRIDEⁱ	Q63604

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000042145; ENSRNOP00000045635; ENSRNOG00000018839 [Q63604-1] ENSRNOT00000090914; ENSRNOP00000070128; ENSRNOG00000018839 [Q63604-2]
GeneIDⁱ	25054
KEGGⁱ	rno:25054
UCSCⁱ	RGD:3213 rat [Q63604-1]

Organism-specific databases

CTDⁱ	4915
RGDⁱ	3213 Ntrk2

Phylogenomic databases

eggNOGⁱ	KOG1026 Eukaryota ENOG410YGKQ LUCA
GeneTreeⁱ	ENSGT00760000118818
HOGENOMⁱ	HOG000264255
HOVERGENⁱ	HBG056735
InParanoidⁱ	Q63604
KOⁱ	K04360
PhylomeDBⁱ	Q63604
TreeFamⁱ	TF106465

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 5301
Reactomeⁱ	R-RNO-9026527 Activated NTRK2 signals through PLCG1 R-RNO-9028731 Activated NTRK2 signals through FRS2 and FRS3

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q63604

PROⁱ

PR:Q63604

Gene expression databases

Bgeeⁱ	ENSRNOG00000018839 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasⁱ	Q63604 baseline and differential
Genevisibleⁱ	Q63604 RN

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR000372 LRRNT IPR031635 NTRK_C2 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR020455 Tyr_kin_neurotrophic_rcpt_2 IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR020777 Tyr_kinase_NGF_rcpt IPR002011 Tyr_kinase_rcpt_2_CS
Pfamⁱ	View protein in Pfam PF07679 I-set, 2 hits PF13855 LRR_8, 1 hit PF07714 Pkinase_Tyr, 1 hit PF16920 TPKR_C2, 1 hit
PRINTSⁱ	PR01939 NTKRECEPTOR PR01941 NTKRECEPTOR2 PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00408 IGc2, 1 hit SM00082 LRRCT, 1 hit SM00013 LRRNT, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00239 RECEPTOR_TYR_KIN_II, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NTRK2_RAT
Accessionⁱ	Q63604Primary (citable) accession number: Q63604 Secondary accession number(s): Q63605, Q63606
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63604 (NTRK2_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

BDNF/NT-3 growth factors receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Endoplasmic reticulum

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ