UniProtKB - Q63604 (NTRK2_RAT)
BDNF/NT-3 growth factors receptor
Ntrk2
Functioni
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells.
4 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation2 PublicationsEC:2.7.10.1PROSITE-ProRule annotation2 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 571 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 675 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 543 – 551 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- brain-derived neurotrophic factor-activated receptor activity Source: UniProtKB
- brain-derived neurotrophic factor binding Source: UniProtKB
- neurotrophin binding Source: UniProtKB
- neurotrophin receptor activity Source: RGD
- protease binding Source: RGD
- protein homodimerization activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: Reactome
- receptor tyrosine kinase binding Source: RGD
- transmembrane receptor protein serine/threonine kinase activity Source: Reactome
- transmembrane receptor protein tyrosine kinase activity Source: RGD
GO - Biological processi
- aging Source: RGD
- brain-derived neurotrophic factor receptor signaling pathway Source: UniProtKB
- calcium-mediated signaling using intracellular calcium source Source: RGD
- cellular response to amino acid stimulus Source: RGD
- cellular response to brain-derived neurotrophic factor stimulus Source: RGD
- cellular response to nerve growth factor stimulus Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- central nervous system neuron development Source: UniProtKB
- cerebral cortex development Source: UniProtKB
- circadian rhythm Source: RGD
- feeding behavior Source: RGD
- glutamate secretion Source: RGD
- inflammatory response Source: RGD
- learning Source: UniProtKB
- long-term memory Source: RGD
- long-term synaptic potentiation Source: RGD
- mechanoreceptor differentiation Source: RGD
- myelination in peripheral nervous system Source: RGD
- negative regulation of amyloid-beta formation Source: RGD
- negative regulation of anoikis Source: RGD
- negative regulation of neuron apoptotic process Source: UniProtKB
- neuronal action potential propagation Source: RGD
- neuron differentiation Source: UniProtKB
- neuron migration Source: UniProtKB
- oligodendrocyte differentiation Source: RGD
- peripheral nervous system neuron development Source: RGD
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glucocorticoid receptor signaling pathway Source: MGI
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: RGD
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of synapse assembly Source: RGD
- positive regulation of synaptic transmission, glutamatergic Source: RGD
- protein autophosphorylation Source: UniProtKB
- regulation of dendrite development Source: RGD
- regulation of GTPase activity Source: UniProtKB
- regulation of MAPK cascade Source: UniProtKB
- regulation of metabolic process Source: RGD
- regulation of neurotransmitter secretion Source: RGD
- regulation of protein kinase B signaling Source: RGD
- response to auditory stimulus Source: RGD
- response to light stimulus Source: RGD
- retina development in camera-type eye Source: RGD
- retinal rod cell development Source: RGD
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- trans-synaptic signaling by BDNF, modulating synaptic transmission Source: RGD
- trans-synaptic signaling by neuropeptide, modulating synaptic transmission Source: RGD
- vasculogenesis Source: RGD
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Differentiation, Neurogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 5301 |
Reactomei | R-RNO-9026527, Activated NTRK2 signals through PLCG1 R-RNO-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-RNO-9032759, NTRK2 activates RAC1 |
Names & Taxonomyi
Protein namesi | Recommended name: BDNF/NT-3 growth factors receptor (EC:2.7.10.12 Publications)Alternative name(s): Neurotrophic tyrosine kinase receptor type 2 TrkB tyrosine kinase Short name: Trk-B |
Gene namesi | Name:Ntrk2 Synonyms:Trkb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3213, Ntrk2 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Single-pass type I membrane protein By similarity
- Early endosome membrane By similarity
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Other locations
- axon 1 Publication
- dendrite 1 Publication
- perinuclear region 1 Publication
- postsynaptic density By similarity
Note: Internalized to endosomes upon ligand-binding.By similarity
Cytosol
- cytosol Source: RGD
Endoplasmic reticulum
- rough endoplasmic reticulum Source: RGD
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: RGD
Golgi apparatus
- Golgi membrane Source: Reactome
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: RGD
Other locations
- axon Source: UniProtKB
- axon terminus Source: RGD
- cell surface Source: RGD
- cytoplasm Source: RGD
- dendrite Source: UniProtKB
- dendritic spine Source: SynGO
- excitatory synapse Source: RGD
- glutamatergic synapse Source: SynGO
- growth cone Source: RGD
- neuronal cell body Source: RGD
- perikaryon Source: RGD
- perinuclear region of cytoplasm Source: UniProtKB
- postsynapse Source: SynGO
- postsynaptic density Source: RGD
- presynaptic active zone Source: RGD
- receptor complex Source: RGD
- terminal bouton Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 429 | ExtracellularSequence analysisAdd BLAST | 398 | |
Transmembranei | 430 – 453 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 454 – 821 | CytoplasmicSequence analysisAdd BLAST | 368 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 515 | Y → F: Loss of interaction with SHC1. 1 Publication | 1 | |
Mutagenesisi | 571 | K → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 701 | Y → F: Loss of autophosphorylation and altered interaction with SHC1 and PLCG1; when associated with F-705 and F-706. 1 Publication | 1 | |
Mutagenesisi | 705 | Y → F: Loss of autophosphorylation; when associated with F-701 and F-706. 2 Publications | 1 | |
Mutagenesisi | 706 | Y → F: Loss of autophosphorylation; when associated with F-701 and F-705. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL1795111 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | By similarityAdd BLAST | 31 | |
ChainiPRO_0000016729 | 32 – 821 | BDNF/NT-3 growth factors receptorAdd BLAST | 790 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 38 | PROSITE-ProRule annotation | ||
Disulfide bondi | 36 ↔ 45 | PROSITE-ProRule annotation | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 152 ↔ 176 | PROSITE-ProRule annotation | ||
Disulfide bondi | 154 ↔ 194 | PROSITE-ProRule annotation | ||
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 218 ↔ 266 | PROSITE-ProRule annotation | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 302 ↔ 345 | PROSITE-ProRule annotation | ||
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 338 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 515 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 701 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 705 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 706 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 816 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q63604 |
PRIDEi | Q63604 |
PTM databases
GlyGeni | Q63604, 12 sites, 8 N-linked glycans (2 sites) |
iPTMneti | Q63604 |
PhosphoSitePlusi | Q63604 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000018839, Expressed in frontal cortex and 22 other tissues |
ExpressionAtlasi | Q63604, baseline and differential |
Genevisiblei | Q63604, RN |
Interactioni
Subunit structurei
Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (PubMed:8627351).
Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation.
Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation.
Interacts with SH2B1 and SH2B2.
Interacts with NGFR; may regulate the ligand specificity of the receptor.
Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (By similarity).
Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2.
Interacts with SQSTM1 and KIDINS220.
Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway.
Interacts with APPL1 (By similarity).
Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (PubMed:21775604).
Interacts with SORL1; this interaction facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling (By similarity).
By similarity10 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 515 | Interaction with SHC1 | 1 | |
Sitei | 705 | Interaction with SH2D1A | 1 | |
Sitei | 816 | Interaction with PLCG1By similarity | 1 |
Binary interactionsi
Q63604
With | #Exp. | IntAct |
---|---|---|
Cdk5 [Q03114] | 5 | EBI-7287667,EBI-2008531 |
Fnta [Q04631] | 4 | EBI-7287667,EBI-602447 |
Nr3c1 [P06536] | 2 | EBI-7287667,EBI-1187143 |
Pirb [Q8K4V6] from Mus musculus. | 3 | EBI-7287667,EBI-8602514 |
GO - Molecular functioni
- brain-derived neurotrophic factor binding Source: UniProtKB
- neurotrophin binding Source: UniProtKB
- protease binding Source: RGD
- protein homodimerization activity Source: UniProtKB
- receptor tyrosine kinase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247131, 16 interactors |
CORUMi | Q63604 |
DIPi | DIP-5717N |
IntActi | Q63604, 12 interactors |
MINTi | Q63604 |
STRINGi | 10116.ENSRNOP00000045635 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 61 | LRRNTAdd BLAST | 30 | |
Repeati | 92 – 113 | LRR 1Add BLAST | 22 | |
Repeati | 116 – 137 | LRR 2Add BLAST | 22 | |
Domaini | 148 – 196 | LRRCTAdd BLAST | 49 | |
Domaini | 197 – 282 | Ig-like C2-type 1Add BLAST | 86 | |
Domaini | 295 – 365 | Ig-like C2-type 2Add BLAST | 71 | |
Domaini | 537 – 806 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 270 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 454 – 465 | Interaction with MAPK8IP3/JIP31 PublicationAdd BLAST | 12 | |
Regioni | 474 – 497 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 474 – 495 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000155181 |
HOGENOMi | CLU_000288_74_1_1 |
InParanoidi | Q63604 |
OrthoDBi | 295510at2759 |
PhylomeDBi | Q63604 |
TreeFami | TF106465 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR000372, LRRNT IPR020777, NTRK IPR020455, NTRK2 IPR031635, NTRK_LRRCT IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR002011, Tyr_kinase_rcpt_2_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 1 hit PF16920, LRRCT_2, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR01939, NTKRECEPTOR PR01941, NTKRECEPTOR2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00239, RECEPTOR_TYR_KIN_II, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPWPRWHGP AMARLWGLCL LVLGFWRASL ACPMSCKCST TRIWCTEPSP
60 70 80 90 100
GIVAFPRLEP NSIDPENITE ILIANQKRLE IINEDDVEAY VGLKNLTIVD
110 120 130 140 150
SGLKFVAYKA FLKNGNLRHI NFTRNKLTSL SRRHFRHLDL SDLILTGNPF
160 170 180 190 200
TCSCDIMWLK TLQETKSSPD TQDLYCLNES SKNTPLANLQ IPNCGLPSAR
210 220 230 240 250
LAAPNLTVEE GKSVTISCSV GGDPLPTLYW DVGNLVSKHM NETSHTQGSL
260 270 280 290 300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
310 320 330 340 350
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN
360 370 380 390 400
PTHMNNGDYT LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW
410 420 430 440 450
TTPTDIGDTT NKSNEIPSTD VADQTNREHL SVYAVVVIAS VVGFCLLVML
460 470 480 490 500
LLLKLARHSK FGMKGPASVI SNDDDSASPL HHISNGSNTP SSSEGGPDAV
510 520 530 540 550
IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK RELGEGAFGK
560 570 580 590 600
VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV
610 620 630 640 650
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS
660 670 680 690 700
QMLHIAQQIA AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV
710 720 730 740 750
YSTDYYRVGG HTMLPIRWMP PESIMYRKFT TESDVWSLGV VLWEIFTYGK
760 770 780 790 800
QPWYQLSNNE VIECITQGRV LQRPRTCPQE VYELMLGCWQ REPHTRKNIK
810 820
NIHTLLQNLA KASPVYLDIL G
The sequence of this isoform differs from the canonical sequence as follows:
466-476: PASVISNDDDS → FVLFHKIPLDG
477-821: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
466-474: PASVISNDD → KQKCAYFAS
475-821: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K5X6 | A0A0G2K5X6_RAT | Tyrosine-protein kinase receptor | Ntrk2 | 837 | Annotation score: | ||
A0A8I5ZLZ3 | A0A8I5ZLZ3_RAT | BDNF/NT-3 growth factors receptor | Ntrk2 | 489 | Annotation score: | ||
A0A8I5ZVM2 | A0A8I5ZVM2_RAT | BDNF/NT-3 growth factors receptor | Ntrk2 | 466 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002910 | 466 – 476 | PASVISNDDDS → FVLFHKIPLDG in isoform T1. CuratedAdd BLAST | 11 | |
Alternative sequenceiVSP_002912 | 466 – 474 | PASVISNDD → KQKCAYFAS in isoform T2. Curated | 9 | |
Alternative sequenceiVSP_002913 | 475 – 821 | Missing in isoform T2. CuratedAdd BLAST | 347 | |
Alternative sequenceiVSP_002911 | 477 – 821 | Missing in isoform T1. CuratedAdd BLAST | 345 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55291 mRNA Translation: AAA42279.1 M55292 mRNA Translation: AAA42280.1 M55293 mRNA Translation: AAA42281.1 |
PIRi | A39667 B39667 C39667 |
RefSeqi | NP_001156640.1, NM_001163168.2 [Q63604-2] NP_036863.1, NM_012731.2 [Q63604-1] |
Genome annotation databases
Ensembli | ENSRNOT00000042145; ENSRNOP00000045635; ENSRNOG00000018839 [Q63604-1] ENSRNOT00000090914; ENSRNOP00000070128; ENSRNOG00000018839 [Q63604-2] |
GeneIDi | 25054 |
KEGGi | rno:25054 |
UCSCi | RGD:3213, rat [Q63604-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55291 mRNA Translation: AAA42279.1 M55292 mRNA Translation: AAA42280.1 M55293 mRNA Translation: AAA42281.1 |
PIRi | A39667 B39667 C39667 |
RefSeqi | NP_001156640.1, NM_001163168.2 [Q63604-2] NP_036863.1, NM_012731.2 [Q63604-1] |
3D structure databases
AlphaFoldDBi | Q63604 |
SMRi | Q63604 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247131, 16 interactors |
CORUMi | Q63604 |
DIPi | DIP-5717N |
IntActi | Q63604, 12 interactors |
MINTi | Q63604 |
STRINGi | 10116.ENSRNOP00000045635 |
Chemistry databases
ChEMBLi | CHEMBL1795111 |
PTM databases
GlyGeni | Q63604, 12 sites, 8 N-linked glycans (2 sites) |
iPTMneti | Q63604 |
PhosphoSitePlusi | Q63604 |
Proteomic databases
PaxDbi | Q63604 |
PRIDEi | Q63604 |
Genome annotation databases
Ensembli | ENSRNOT00000042145; ENSRNOP00000045635; ENSRNOG00000018839 [Q63604-1] ENSRNOT00000090914; ENSRNOP00000070128; ENSRNOG00000018839 [Q63604-2] |
GeneIDi | 25054 |
KEGGi | rno:25054 |
UCSCi | RGD:3213, rat [Q63604-1] |
Organism-specific databases
CTDi | 4915 |
RGDi | 3213, Ntrk2 |
Phylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000155181 |
HOGENOMi | CLU_000288_74_1_1 |
InParanoidi | Q63604 |
OrthoDBi | 295510at2759 |
PhylomeDBi | Q63604 |
TreeFami | TF106465 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 5301 |
Reactomei | R-RNO-9026527, Activated NTRK2 signals through PLCG1 R-RNO-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-RNO-9032759, NTRK2 activates RAC1 |
Miscellaneous databases
PROi | PR:Q63604 |
Gene expression databases
Bgeei | ENSRNOG00000018839, Expressed in frontal cortex and 22 other tissues |
ExpressionAtlasi | Q63604, baseline and differential |
Genevisiblei | Q63604, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR000372, LRRNT IPR020777, NTRK IPR020455, NTRK2 IPR031635, NTRK_LRRCT IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR002011, Tyr_kinase_rcpt_2_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 1 hit PF16920, LRRCT_2, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR01939, NTKRECEPTOR PR01941, NTKRECEPTOR2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00239, RECEPTOR_TYR_KIN_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NTRK2_RAT | |
Accessioni | Q63604Primary (citable) accession number: Q63604 Secondary accession number(s): Q63605, Q63606 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families