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Protein

Dedicator of cytokinesis protein 9

Gene

Dock9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation (By similarity).By similarity

Miscellaneous

'Zizim' means 'spike' in Hebrew.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 9
Alternative name(s):
Cdc42 guanine nucleotide exchange factor zizimin-1
Protein TRG
Gene namesi
Name:Dock9
Synonyms:Trg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi629617 Dock9

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000190001‹1 – 720Dedicator of cytokinesis protein 9Add BLAST›720

Proteomic databases

PRIDEiQ63603

Interactioni

Subunit structurei

Homodimer. Interacts preferentially with nucleotide-depleted CDC42 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63603, 1 interactor

Structurei

3D structure databases

SMRiQ63603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 638DHR-2PROSITE-ProRule annotationAdd BLAST453

Domaini

The DHR-2 domain is necessary and sufficient for the GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.Curated

Phylogenomic databases

HOGENOMiHOG000230910
HOVERGENiHBG051390
InParanoidiQ63603
PhylomeDBiQ63603

Family and domain databases

InterProiView protein in InterPro
IPR027357 DHR-2
IPR026791 DOCK
IPR026796 DOCK9
IPR010703 DOCK_C
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF77 PTHR23317:SF77, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PROSITEiView protein in PROSITE
PS51651 DHR_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q63603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KLSRGHSPLM KKVFDVYLCF LQKHQSEMAL KNVFTALRSL IYKFPSTFYE
60 70 80 90 100
GRADMCASLC YEVLKCCNSK LSSIRTEASQ LLYFLMRNNF DYTGKKSFVR
110 120 130 140 150
THLQVIISLS QLIADVVGIG GTRFQQSLSI INNCANSDRL IKHTSFSSDV
160 170 180 190 200
KDLTKRIRTV LMATAQMKEH ENDPEMLVDL QYSLAKSYAS TPELRKTWLD
210 220 230 240 250
SMARIHVKNG DLSEAAMCYV HVTALVAEYL TRKEADLALQ REPPVFPYSH
260 270 280 290 300
TSCQRKSRGG MFRQGCTAFR VITPNIDEEA SMMEDVGMQD VHFNEDVLME
310 320 330 340 350
LLEQCADGLW KAERLRAGLL TSINSSSPSM KSGGTLETTH LYDTLHRPYS
360 370 380 390 400
KVTEVITRAA GSWDLLPGGL FGQGFFEDED GKEYIYKEPK LTPLSEISQR
410 420 430 440 450
LLKLYSDKFG SENVKMIQDS GKVNPKDLDS KFAYIQVTHV TPFFDEKELQ
460 470 480 490 500
ERKTEFERCH NIRRFMFEMP FTQTGKRQGG VEEQCKRRTI LTAIHCFPYV
510 520 530 540 550
KKRIPVMYQH HTDLNPIEVA IDEMSKKVAE LHQLCSSAEV DMIKLQLKLQ
560 570 580 590 600
GSVSVQVNAG PLAYARAFLD DTNTKRYPDN KVKLLKEVFR QFVEACGQAL
610 620 630 640 650
AVNERLIKED QLEYQEEMKA NYREIRKELS DIIVPRICPG EDKRATKFPA
660 670 680 690 700
HLQRHQRDTN KHSGSRVDQF ILSCVTLPHE PHVGTCFVMC KLRTTFRANH
710 720
WFCQAQEEAM GNGREKEPGL
Length:720
Mass (Da):82,455
Last modified:July 3, 2003 - v2
Checksum:i650A4F4BD3DF816C
GO

Sequence cautioni

The sequence CAA48220 differs from that shown. Reason: Frameshift at position 719.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68101 mRNA Translation: CAA48220.1 Frameshift.
PIRiI60486
UniGeneiRn.10431

Entry informationi

Entry nameiDOCK9_RAT
AccessioniPrimary (citable) accession number: Q63603
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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