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Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi701 – 708ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1342 – 1349ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • drug binding Source: RGD
  • identical protein binding Source: IntAct
  • potassium channel regulator activity Source: BHF-UCL
  • sulfonylurea receptor activity Source: BHF-UCL
  • syntaxin binding Source: RGD

GO - Biological processi

  • potassium ion import Source: BHF-UCL
  • potassium ion transmembrane transport Source: RGD
  • response to drug Source: RGD
  • substrate-dependent cell migration, cell contraction Source: RGD
  • transmembrane transport Source: GO_Central

Keywordsi

Molecular functionReceptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene namesi
Name:Abcc9
Synonyms:Sur2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3787 Abcc9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini52 – 72CytoplasmicSequence analysisAdd BLAST21
Transmembranei73 – 93Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini94 – 101ExtracellularSequence analysis8
Transmembranei102 – 122Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini123 – 132CytoplasmicSequence analysis10
Transmembranei133 – 153Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini154 – 167ExtracellularSequence analysisAdd BLAST14
Transmembranei168 – 188Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini189 – 301CytoplasmicSequence analysisAdd BLAST113
Transmembranei302 – 322Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini323 – 347ExtracellularSequence analysisAdd BLAST25
Transmembranei348 – 368Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini369 – 420CytoplasmicSequence analysisAdd BLAST52
Transmembranei421 – 441Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini442 – 452ExtracellularSequence analysisAdd BLAST11
Transmembranei453 – 473Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini474 – 528CytoplasmicSequence analysisAdd BLAST55
Transmembranei529 – 549Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini550 – 568ExtracellularSequence analysisAdd BLAST19
Transmembranei569 – 589Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini590 – 986CytoplasmicSequence analysisAdd BLAST397
Transmembranei987 – 1007Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1008 – 1030ExtracellularSequence analysisAdd BLAST23
Transmembranei1031 – 1051Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1052 – 1123CytoplasmicSequence analysisAdd BLAST72
Transmembranei1124 – 1144Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1145 – 1241ExtracellularSequence analysisAdd BLAST97
Transmembranei1242 – 1262Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1263 – 1545CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934051 – 1545ATP-binding cassette sub-family C member 9Add BLAST1545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ63563

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and ovary. Moderate levels are found in brain, tongue and pancreatic islets. Low levels are found in lung, testis and adrenal gland. Expressed at very low levels in stomach, colon, thyroid and pituitary.

Interactioni

Subunit structurei

Interacts with KCNJ11.

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnj11P706732EBI-8744493,EBI-9560239

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-181 Inward rectifying potassium channel complex, Kir6.2-SUR2A [Q63563-1]
CPX-185 Inward rectifying potassium channel complex, Kir6.2-SUR2B [Q63563-2]
IntActiQ63563, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ63563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini297 – 594ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST298
Domaini668 – 908ABC transporter 1PROSITE-ProRule annotationAdd BLAST241
Domaini990 – 1270ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST281
Domaini1308 – 1542ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000168680
HOVERGENiHBG101342
InParanoidiQ63563
KOiK05033
PhylomeDBiQ63563

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR001475 ABCC9
IPR027417 P-loop_NTPase
IPR000388 Sulphorea_rcpt
PANTHERiPTHR24223:SF173 PTHR24223:SF173, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PRINTSiPR01094 SULFNYLUR2
PR01092 SULFNYLUREAR
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform SUR2A (identifier: Q63563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV
360 370 380 390 400
LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL
410 420 430 440 450
SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG
460 470 480 490 500
SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK
510 520 530 540 550
LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA
560 570 580 590 600
TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ
610 620 630 640 650
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD
660 670 680 690 700
NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV
710 720 730 740 750
GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY
760 770 780 790 800
AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE
810 820 830 840 850
IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG
860 870 880 890 900
ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV
910 920 930 940 950
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED
960 970 980 990 1000
EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK
1010 1020 1030 1040 1050
HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS
1060 1070 1080 1090 1100
LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID
1110 1120 1130 1140 1150
QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR
1160 1170 1180 1190 1200
VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT
1210 1220 1230 1240 1250
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY
1260 1270 1280 1290 1300
ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE
1310 1320 1330 1340 1350
HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS
1360 1370 1380 1390 1400
LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR
1410 1420 1430 1440 1450
FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR
1460 1470 1480 1490 1500
QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA
1510 1520 1530 1540
HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK
Length:1,545
Mass (Da):174,118
Last modified:November 1, 1996 - v1
Checksum:i768DA1F58E9945E7
GO
Isoform SUR2B (identifier: Q63563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1504-1545: SSIMDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,545
Mass (Da):174,306
Checksum:i8666453CED33154D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M9Q2F1M9Q2_RAT
ATP-binding cassette sub-family C m...
Abcc9
1,545Annotation score:
D3ZZ00D3ZZ00_RAT
ATP-binding cassette sub-family C m...
Abcc9
1,278Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0000611504 – 1545SSIMD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 2 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83598 mRNA Translation: BAA12020.1
AF087838 mRNA Translation: AAC36347.1
AF019628 mRNA Translation: AAC24758.1
PIRiT42751
T46645
RefSeqiNP_037172.2, NM_013040.2 [Q63563-2]
UniGeneiRn.10528
Rn.164431

Genome annotation databases

GeneIDi25560
KEGGirno:25560

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83598 mRNA Translation: BAA12020.1
AF087838 mRNA Translation: AAC36347.1
AF019628 mRNA Translation: AAC24758.1
PIRiT42751
T46645
RefSeqiNP_037172.2, NM_013040.2 [Q63563-2]
UniGeneiRn.10528
Rn.164431

3D structure databases

ProteinModelPortaliQ63563
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-181 Inward rectifying potassium channel complex, Kir6.2-SUR2A [Q63563-1]
CPX-185 Inward rectifying potassium channel complex, Kir6.2-SUR2B [Q63563-2]
IntActiQ63563, 1 interactor

Chemistry databases

ChEMBLiCHEMBL3244

Proteomic databases

PRIDEiQ63563

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25560
KEGGirno:25560

Organism-specific databases

CTDi10060
RGDi3787 Abcc9

Phylogenomic databases

HOGENOMiHOG000168680
HOVERGENiHBG101342
InParanoidiQ63563
KOiK05033
PhylomeDBiQ63563

Miscellaneous databases

PROiPR:Q63563

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR001475 ABCC9
IPR027417 P-loop_NTPase
IPR000388 Sulphorea_rcpt
PANTHERiPTHR24223:SF173 PTHR24223:SF173, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PRINTSiPR01094 SULFNYLUR2
PR01092 SULFNYLUREAR
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiABCC9_RAT
AccessioniPrimary (citable) accession number: Q63563
Secondary accession number(s): O89115
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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