ATP-binding cassette sub-family C member 9

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity Source: RGDInferred from sequence orthologyⁱ
  • "Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity."
    Fatehi M., Carter C.R., Youssef N., Hunter B.E., Holt A., Light P.E.
    Biosci. Rep. 35:0-0(2015) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled cation transmembrane transporter activity Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel."
    Cooper P.E., McClenaghan C., Chen X., Stary-Weinzinger A., Nichols C.G.
    J. Biol. Chem. 292:17387-17398(2017) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: UniProtKB-KW
• drug binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A."
    Lopez-Alonso J.P., de Araujo E.D., Kanelis V.
    Biochemistry 51:9211-9222(2012) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles."
    Fotinou C., Aittoniemi J., de Wet H., Polidori A., Pucci B., Sansom M.S., Venien-Bryan C., Ashcroft F.M.
    FEBS J. 280:1051-1063(2013) [PubMed] [Europe PMC] [Abstract]
• ion channel binding Source: RGDInferred from sequence orthologyⁱ
  • "Ankyrin-B regulates Kir6.2 membrane expression and function in heart."
    Li J., Kline C.F., Hund T.J., Anderson M.E., Mohler P.J.
    J. Biol. Chem. 285:28723-28730(2010) [PubMed] [Europe PMC] [Abstract]
• potassium channel activity Source: RGDInferred from sequence orthologyⁱ
  • "ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene."
    Hu D., Barajas-Martinez H., Terzic A., Park S., Pfeiffer R., Burashnikov E., Wu Y., Borggrefe M., Veltmann C., Schimpf R., Cai J.J., Nam G.B., Deshmukh P., Scheinman M., Preminger M., Steinberg J., Lopez-Izquierdo A., Ponce-Balbuena D.

    , Wolpert C., Haissaguerre M., Sanchez-Chapula J.A., Antzelevitch C.
    Int. J. Cardiol. 171:431-442(2014) [PubMed] [Europe PMC] [Abstract]
  • "Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity."
    Fatehi M., Carter C.R., Youssef N., Hunter B.E., Holt A., Light P.E.
    Biosci. Rep. 35:0-0(2015) [PubMed] [Europe PMC] [Abstract]
• potassium channel regulator activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
    Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
    Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
• sulfonylurea receptor activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
    Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
    Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
• syntaxin binding Source: RGDInferred from physical interactionⁱ
  • "Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A."
    Kang Y., Leung Y.M., Manning-Fox J.E., Xia F., Xie H., Sheu L., Tsushima R.G., Light P.E., Gaisano H.Y.
    J. Biol. Chem. 279:47125-47131(2004) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cardiac conduction Source: RGDInferred from sequence orthologyⁱ
  • "ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene."
    Hu D., Barajas-Martinez H., Terzic A., Park S., Pfeiffer R., Burashnikov E., Wu Y., Borggrefe M., Veltmann C., Schimpf R., Cai J.J., Nam G.B., Deshmukh P., Scheinman M., Preminger M., Steinberg J., Lopez-Izquierdo A., Ponce-Balbuena D.

    , Wolpert C., Haissaguerre M., Sanchez-Chapula J.A., Antzelevitch C.
    Int. J. Cardiol. 171:431-442(2014) [PubMed] [Europe PMC] [Abstract]
• cation transmembrane transport Source: ARUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Differential mechanisms of Cantu syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel."
    Cooper P.E., Sala-Rabanal M., Lee S.J., Nichols C.G.
    J. Gen. Physiol. 146:527-540(2015) [PubMed] [Europe PMC] [Abstract]
• defense response to virus Source: RGDInferred from sequence orthologyⁱ
  • "ATP-sensitive potassium channels mediate survival during infection in mammals and insects."
    Croker B., Crozat K., Berger M., Xia Y., Sovath S., Schaffer L., Eleftherianos I., Imler J.L., Beutler B.
    Nat. Genet. 39:1453-1460(2007) [PubMed] [Europe PMC] [Abstract]
• inorganic cation transmembrane transport Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel."
    Cooper P.E., McClenaghan C., Chen X., Stary-Weinzinger A., Nichols C.G.
    J. Biol. Chem. 292:17387-17398(2017) [PubMed] [Europe PMC] [Abstract]
• potassium ion import across plasma membrane Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
    Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
    Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
• potassium ion transmembrane transport Source: RGDInferred from direct assayⁱ
  • "Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure."
    Dorschner H., Brekardin E., Uhde I., Schwanstecher C., Schwanstecher M.
    Mol. Pharmacol. 55:1060-1066(1999) [PubMed] [Europe PMC] [Abstract]
• potassium ion transport Source: RGDInferred from direct assayⁱ
  • "An amino acid triplet in the NH2 terminus of rat ROMK1 determines interaction with SUR2B."
    Dong K., Xu J., Vanoye C.G., Welch R., MacGregor G.G., Giebisch G., Hebert S.C.
    J. Biol. Chem. 276:44347-44353(2001) [PubMed] [Europe PMC] [Abstract]
• response to ATP Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Differential mechanisms of Cantu syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel."
    Cooper P.E., Sala-Rabanal M., Lee S.J., Nichols C.G.
    J. Gen. Physiol. 146:527-540(2015) [PubMed] [Europe PMC] [Abstract]
  • "Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel."
    Cooper P.E., McClenaghan C., Chen X., Stary-Weinzinger A., Nichols C.G.
    J. Biol. Chem. 292:17387-17398(2017) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats."
    Gao M., Xue H., Wang Y., Wang H.
    Life Sci. 77:2743-2751(2005) [PubMed] [Europe PMC] [Abstract]
• substrate-dependent cell migration, cell contraction Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channel."
    Szamosfalvi B., Cortes P., Alviani R., Asano K., Riser B.L., Zasuwa G., Yee J.
    Kidney Int. 61:1739-1749(2002) [PubMed] [Europe PMC] [Abstract]
• transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles."
    Fotinou C., Aittoniemi J., de Wet H., Polidori A., Pucci B., Sansom M.S., Venien-Bryan C., Ashcroft F.M.
    FEBS J. 280:1051-1063(2013) [PubMed] [Europe PMC] [Abstract]
• ion channel binding Source: RGDInferred from sequence orthologyⁱ
  • "Ankyrin-B regulates Kir6.2 membrane expression and function in heart."
    Li J., Kline C.F., Hund T.J., Anderson M.E., Mohler P.J.
    J. Biol. Chem. 285:28723-28730(2010) [PubMed] [Europe PMC] [Abstract]
• syntaxin binding Source: RGDInferred from physical interactionⁱ
  • "Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A."
    Kang Y., Leung Y.M., Manning-Fox J.E., Xia F., Xie H., Sheu L., Tsushima R.G., Light P.E., Gaisano H.Y.
    J. Biol. Chem. 279:47125-47131(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG 
        60         70         80         90        100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR 
       110        120        130        140        150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 
       160        170        180        190        200
KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 
       210        220        230        240        250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 
       260        270        280        290        300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 
       310        320        330        340        350
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV 
       360        370        380        390        400
LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL 
       410        420        430        440        450
SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG 
       460        470        480        490        500
SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK 
       510        520        530        540        550
LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA 
       560        570        580        590        600
TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ 
       610        620        630        640        650
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD 
       660        670        680        690        700
NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV 
       710        720        730        740        750
GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY 
       760        770        780        790        800
AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE 
       810        820        830        840        850
IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG 
       860        870        880        890        900
ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV 
       910        920        930        940        950
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED 
       960        970        980        990       1000
EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK 
      1010       1020       1030       1040       1050
HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS 
      1060       1070       1080       1090       1100
LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID 
      1110       1120       1130       1140       1150
QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR 
      1160       1170       1180       1190       1200
VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT 
      1210       1220       1230       1240       1250
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY 
      1260       1270       1280       1290       1300
ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE 
      1310       1320       1330       1340       1350
HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS 
      1360       1370       1380       1390       1400
LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR 
      1410       1420       1430       1440       1450
FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR 
      1460       1470       1480       1490       1500
QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA 
      1510       1520       1530       1540 
HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK      

        10         20         30         40         50
MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG 
        60         70         80         90        100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR 
       110        120        130        140        150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 
       160        170        180        190        200
KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 
       210        220        230        240        250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 
       260        270        280        290        300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 
       310        320        330        340        350
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV 
       360        370        380        390        400
LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL 
       410        420        430        440        450
SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG 
       460        470        480        490        500
SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK 
       510        520        530        540        550
LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA 
       560        570        580        590        600
TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ 
       610        620        630        640        650
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD 
       660        670        680        690        700
NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV 
       710        720        730        740        750
GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY 
       760        770        780        790        800
AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE 
       810        820        830        840        850
IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG 
       860        870        880        890        900
ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV 
       910        920        930        940        950
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED 
       960        970        980        990       1000
EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK 
      1010       1020       1030       1040       1050
HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS 
      1060       1070       1080       1090       1100
LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID 
      1110       1120       1130       1140       1150
QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR 
      1160       1170       1180       1190       1200
VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT 
      1210       1220       1230       1240       1250
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY 
      1260       1270       1280       1290       1300
ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE 
      1310       1320       1330       1340       1350
HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS 
      1360       1370       1380       1390       1400
LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR 
      1410       1420       1430       1440       1450
FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR 
      1460       1470       1480       1490       1500
QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA 
      1510       1520       1530       1540 
HRVHTILTAD LVIVMKRGNI LEYDTPESLL AQEDGVFASF VRADM      

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families