UniProtKB - Q63563 (ABCC9_RAT)
ATP-binding cassette sub-family C member 9
Abcc9
Functioni
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 701 – 708 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1342 – 1349 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type transporter activity Source: InterPro
- ATPase-coupled cation transmembrane transporter activity Source: ARUK-UCL
- ATPase-coupled transmembrane transporter activity Source: RGD
- ATP binding Source: UniProtKB-KW
- heterocyclic compound binding Source: RGD
- identical protein binding Source: IntAct
- potassium channel regulator activity Source: BHF-UCL
- sulfonylurea receptor activity Source: BHF-UCL
- syntaxin binding Source: RGD
- transmembrane transporter binding Source: RGD
GO - Biological processi
- cardiac conduction Source: RGD
- cation transmembrane transport Source: ARUK-UCL
- defense response to virus Source: RGD
- inorganic cation transmembrane transport Source: ARUK-UCL
- potassium ion import across plasma membrane Source: BHF-UCL
- potassium ion transmembrane transport Source: RGD
- potassium ion transport Source: RGD
- response to ATP Source: ARUK-UCL
- response to xenobiotic stimulus Source: RGD
- substrate-dependent cell migration, cell contraction Source: RGD
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-1296025, ATP sensitive Potassium channels R-RNO-382556, ABC-family proteins mediated transport R-RNO-5578775, Ion homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family C member 9Alternative name(s): Sulfonylurea receptor 2 |
Gene namesi | Name:Abcc9 Synonyms:Sur2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3787, Abcc9 |
Subcellular locationi
Other locations
- Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
Mitochondrion
- mitochondrion Source: RGD
Plasma Membrane
- inward rectifying potassium channel Source: BHF-UCL
- plasma membrane Source: RGD
- T-tubule Source: RGD
Other locations
- acrosomal vesicle Source: RGD
- membrane Source: GO_Central
- sarcomere Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 52 – 72 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 73 – 93 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 94 – 101 | ExtracellularSequence analysis | 8 | |
Transmembranei | 102 – 122 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 123 – 132 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 133 – 153 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 154 – 167 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 168 – 188 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 189 – 301 | CytoplasmicSequence analysisAdd BLAST | 113 | |
Transmembranei | 302 – 322 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 323 – 347 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 348 – 368 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 369 – 420 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 421 – 441 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 442 – 452 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 453 – 473 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 474 – 528 | CytoplasmicSequence analysisAdd BLAST | 55 | |
Transmembranei | 529 – 549 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 550 – 568 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 569 – 589 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 590 – 986 | CytoplasmicSequence analysisAdd BLAST | 397 | |
Transmembranei | 987 – 1007 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1008 – 1030 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 1031 – 1051 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1052 – 1123 | CytoplasmicSequence analysisAdd BLAST | 72 | |
Transmembranei | 1124 – 1144 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1145 – 1241 | ExtracellularSequence analysisAdd BLAST | 97 | |
Transmembranei | 1242 – 1262 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1263 – 1545 | CytoplasmicSequence analysisAdd BLAST | 283 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093405 | 1 – 1545 | ATP-binding cassette sub-family C member 9Add BLAST | 1545 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 331 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinPTM databases
GlyGeni | Q63563, 3 sites |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with KCNJ11.
Binary interactionsi
Abcc9 - isoform SUR2B [Q63563-2]
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-8282518,EBI-8282518 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- syntaxin binding Source: RGD
- transmembrane transporter binding Source: RGD
Protein-protein interaction databases
ComplexPortali | CPX-181, Inward rectifying potassium channel complex, Kir6.2-SUR2A [Q63563-1] CPX-185, Inward rectifying potassium channel complex, Kir6.2-SUR2B [Q63563-2] |
IntActi | Q63563, 1 interactor |
MINTi | Q63563 |
STRINGi | 10116.ENSRNOP00000052402 |
Chemistry databases
BindingDBi | Q63563 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 297 – 594 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 298 | |
Domaini | 668 – 908 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 241 | |
Domaini | 990 – 1270 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 281 | |
Domaini | 1308 – 1542 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 940 – 963 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 946 – 962 | Acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
InParanoidi | Q63563 |
OrthoDBi | 138195at2759 |
PhylomeDBi | Q63563 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV
360 370 380 390 400
LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL
410 420 430 440 450
SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG
460 470 480 490 500
SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK
510 520 530 540 550
LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA
560 570 580 590 600
TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ
610 620 630 640 650
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD
660 670 680 690 700
NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV
710 720 730 740 750
GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY
760 770 780 790 800
AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE
810 820 830 840 850
IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG
860 870 880 890 900
ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV
910 920 930 940 950
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED
960 970 980 990 1000
EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK
1010 1020 1030 1040 1050
HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS
1060 1070 1080 1090 1100
LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID
1110 1120 1130 1140 1150
QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR
1160 1170 1180 1190 1200
VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT
1210 1220 1230 1240 1250
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY
1260 1270 1280 1290 1300
ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE
1310 1320 1330 1340 1350
HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS
1360 1370 1380 1390 1400
LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR
1410 1420 1430 1440 1450
FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR
1460 1470 1480 1490 1500
QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA
1510 1520 1530 1540
HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK
The sequence of this isoform differs from the canonical sequence as follows:
1504-1545: SSIMDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3ZZ00 | D3ZZ00_RAT | ATP-binding cassette sub-family C m... | Abcc9 | 1,278 | Annotation score: | ||
F1M9Q2 | F1M9Q2_RAT | ATP-binding cassette sub-family C m... | Abcc9 | 1,545 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000061 | 1504 – 1545 | SSIMD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 2 PublicationsAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D83598 mRNA Translation: BAA12020.1 AF087838 mRNA Translation: AAC36347.1 AF019628 mRNA Translation: AAC24758.1 |
PIRi | T42751 T46645 |
RefSeqi | NP_037172.2, NM_013040.2 [Q63563-2] |
Genome annotation databases
GeneIDi | 25560 |
KEGGi | rno:25560 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D83598 mRNA Translation: BAA12020.1 AF087838 mRNA Translation: AAC36347.1 AF019628 mRNA Translation: AAC24758.1 |
PIRi | T42751 T46645 |
RefSeqi | NP_037172.2, NM_013040.2 [Q63563-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7MIT | electron microscopy | 3.40 | E | 1-1541 | [»] | |
7MJO | electron microscopy | 4.00 | E/G | 1-1541 | [»] | |
7MJP | electron microscopy | 4.20 | E | 1-1541 | [»] | |
7MJQ | electron microscopy | 4.20 | E/G | 1-1541 | [»] | |
SMRi | Q63563 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-181, Inward rectifying potassium channel complex, Kir6.2-SUR2A [Q63563-1] CPX-185, Inward rectifying potassium channel complex, Kir6.2-SUR2B [Q63563-2] |
IntActi | Q63563, 1 interactor |
MINTi | Q63563 |
STRINGi | 10116.ENSRNOP00000052402 |
Chemistry databases
BindingDBi | Q63563 |
ChEMBLi | CHEMBL3244 |
PTM databases
GlyGeni | Q63563, 3 sites |
Protocols and materials databases
ABCDi | Q63563, 5 sequenced antibodies |
Genome annotation databases
GeneIDi | 25560 |
KEGGi | rno:25560 |
Organism-specific databases
CTDi | 10060 |
RGDi | 3787, Abcc9 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
InParanoidi | Q63563 |
OrthoDBi | 138195at2759 |
PhylomeDBi | Q63563 |
Enzyme and pathway databases
Reactomei | R-RNO-1296025, ATP sensitive Potassium channels R-RNO-382556, ABC-family proteins mediated transport R-RNO-5578775, Ion homeostasis |
Miscellaneous databases
PROi | PR:Q63563 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCC9_RAT | |
Accessioni | Q63563Primary (citable) accession number: Q63563 Secondary accession number(s): O89115 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families