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Entry version 128 (25 May 2022)
Sequence version 1 (01 Nov 1996)
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Protein

Sodium channel protein

Gene

SCP6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotationARBA annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCP6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei130 – 153HelicalUniRule annotationAdd BLAST24
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 275HelicalUniRule annotationAdd BLAST20
Transmembranei388 – 415HelicalUniRule annotationAdd BLAST28
Transmembranei750 – 768HelicalUniRule annotationAdd BLAST19
Transmembranei780 – 798HelicalUniRule annotationAdd BLAST19
Transmembranei860 – 888HelicalUniRule annotationAdd BLAST29
Transmembranei947 – 973HelicalUniRule annotationAdd BLAST27
Transmembranei1195 – 1213HelicalUniRule annotationAdd BLAST19
Transmembranei1234 – 1253HelicalUniRule annotationAdd BLAST20
Transmembranei1265 – 1288HelicalUniRule annotationAdd BLAST24
Transmembranei1309 – 1337HelicalUniRule annotationAdd BLAST29
Transmembranei1434 – 1460HelicalUniRule annotationAdd BLAST27
Transmembranei1519 – 1537HelicalUniRule annotationAdd BLAST19
Transmembranei1549 – 1567HelicalUniRule annotationAdd BLAST19
Transmembranei1579 – 1599HelicalUniRule annotationAdd BLAST21
Transmembranei1636 – 1664HelicalUniRule annotationAdd BLAST29
Transmembranei1739 – 1762HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 422Ion_transInterPro annotationAdd BLAST290
Domaini547 – 661Na_trans_cytoplInterPro annotationAdd BLAST115
Domaini750 – 977Ion_transInterPro annotationAdd BLAST228
Domaini987 – 1188Na_trans_assocInterPro annotationAdd BLAST202
Domaini1193 – 1468Ion_transInterPro annotationAdd BLAST276
Domaini1518 – 1772Ion_transInterPro annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64DisorderedSequence analysisAdd BLAST64
Regioni447 – 520DisorderedSequence analysisAdd BLAST74
Regioni571 – 597DisorderedSequence analysisAdd BLAST27
Regioni1103 – 1144DisorderedSequence analysisAdd BLAST42
Regioni1921 – 1976DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 59Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi501 – 520Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi578 – 597Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1112 – 1127Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1946 – 1976Basic and acidic residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR008054, Na_channel_a8su
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF00612, IQ, 1 hit
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL
PR01667, NACHANNEL8

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q63541-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRSARLLAP PGPDSFKPFT PESLANIERR IAESKLKKPP KADGSHREDD
60 70 80 90 100
EDSKPKPNSD LEAGKSLPFI YGDIPQGLVA VPLEDFDPYY LTQKTFVVLN
110 120 130 140 150
RGKTLFRFSA TPALYILSPF NLIRRIAIKI LIHSVFSMII MCTILTNCVF
160 170 180 190 200
MTFSNPPEWS KNVEYTFTGI YTFESLVKII ARGFCIDGFT FLRDPWNWLD
210 220 230 240 250
FSVIMMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK TIVGALIQSV
260 270 280 290 300
KKLSDVMILT VFCLSVFALI GLQLFHGNLS KQCVVWPINF NESYLENGTR
310 320 330 340 350
GFDWEEYINN KTNFYMVPGM LEPLLCGNSS DAGQCEGFQC SKAGRNPNYG
360 370 380 390 400
YTSFDTFSWA FLALFRLMTQ DYWENLYQLT LRAAGKTYMI FFVLVIFVGS
410 420 430 440 450
FYPVNLILAV VAMAYEEQNQ ATLEEAEQKE AEFKAMLEQL KKQQEEAQAA
460 470 480 490 500
AMATSAGTVS EDAIEEEGED GVGSPRSSSE LSKLSSKSAK ERRNRRKKRK
510 520 530 540 550
QKELSEGEEK GDPEKVFKSE SEYGMRRKAF RLPDNRIGRK FSIMNQSLLS
560 570 580 590 600
IPGSPFLSRH NSKSSIFSFG DPSVRDPGSE NEFADDEHST VEESEGRRDS
610 620 630 640 650
LFIPIRARER RSSYSGYSGY SQCSRSSRIS PACAQREANS TVDCNGVVSL
660 670 680 690 700
IGPGSHIGRL LLRQRLRWKL RRKALDSFSF YGPTRLLRTE GQNQQHNERG
710 720 730 740 750
HKHASEELEE SQRKCPPCWY KFANTFLIWE CHPYWIKLKE IVNLIVMDPF
760 770 780 790 800
VDLAITICIV LNTLFMAMEH HPMTPQFEHV LAVGNLVFTG IFTAEMFLKL
810 820 830 840 850
IAMDPYYYFQ EGWNIFDGFI VSLSLMELSL ADVEGLSVLR SFRLLRVFKL
860 870 880 890 900
AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM QLFGKSYKEC
910 920 930 940 950
VCKINQECKL PRWHMNDFFH SFLIVFRVLC GEWIETMWDC MEVAGQAMCL
960 970 980 990 1000
IVFMMVMVIG NLVVLNLFLA LLLSSFSADN LAATDDDGEM NNLQISVIRI
1010 1020 1030 1040 1050
KKGVAWTKVK VHAFMQAHFK QREADEVKPL DELYEKKANC IANHTGVDIH
1060 1070 1080 1090 1100
RNGDFQKNGN GTTSGIGSSV EKYIIDEDHM SFINNPNLTV RVPIAVGESD
1110 1120 1130 1140 1150
FENLNTEDVS SESDPEGSKD KLDDTSSSEG STIDIKPEVE EVPVEQPEEY
1160 1170 1180 1190 1200
LDPDACFTEG CVQRFKCCQV NIEEGLGKSW WILRKTCFLI VEHNWFETFI
1210 1220 1230 1240 1250
IFMILLSSGA LAFEDIYIEQ RKTIRTILEY ADKVFTYIFI LEMLLKWTTY
1260 1270 1280 1290 1300
GFVKFFTNAW CWLDFLIVAV SLVSLIANAL GYSELGAIKS LRTLRALRPL
1310 1320 1330 1340 1350
RALSRFEGMR VVVNALVGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKYH
1360 1370 1380 1390 1400
YCFNETSEIR FEIDIVNNKT DCEKLMEGNS TEIRWKNVKI NFDNVGAGYL
1410 1420 1430 1440 1450
ALLQVATFKG WMDIMYAAVD SRKPDEQPDY EGNIYMYIYF VIFIIFGSFF
1460 1470 1480 1490 1500
TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI
1510 1520 1530 1540 1550
PRPLNKIQGI VFDFVTQQAF DIVIMMLICL NMVTMMVETD TQSKQMENIL
1560 1570 1580 1590 1600
YWINLVFVIF FTCECVLKMF ALRHYYFTIG WNIFDFVVVI LSIVGMFLAD
1610 1620 1630 1640 1650
IIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI
1660 1670 1680 1690 1700
GLLLFLVMFI FSIFGMSNFA YVKHEAGIDD MFNFETFGNS MICLFQITTS
1710 1720 1730 1740 1750
AGWDGLLLPI LNRPPDCSLD KEHPGSGFKG DCGNPSVGIF FFVSYIIISF
1760 1770 1780 1790 1800
LIVVNMCIAI ILENFSVATE ESADPLSEDD FETFYEIWEK FDPDATQFIE
1810 1820 1830 1840 1850
YCKLADFADA LEHPLRVPKP NTIELIAMDL PMVSGDRIHC LDILFAFTKA
1860 1870 1880 1890 1900
VLGDSGELDI LRQQMEERFV ASNPSKVSYE AYHTTLRRNE EEVSAVVLQR
1910 1920 1930 1940 1950
AYRGHLARRG FICRKMASNK LENGGTHRDK KESTPSTASL PSYDSVTKPD
1960 1970
KEKQQRAEEG RRERAKRQKE VRESKC
Length:1,976
Mass (Da):225,229
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6949327A47FA88A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L39018 mRNA Translation: AAC42059.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I56555

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39018 mRNA Translation: AAC42059.1
PIRiI56555

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR008054, Na_channel_a8su
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF00612, IQ, 1 hit
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL
PR01667, NACHANNEL8
SMARTiView protein in SMART
SM00015, IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ63541_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63541
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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