UniProtKB - Q63537 (SYN2_RAT)
Protein
Synapsin-2
Gene
Syn2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity
GO - Molecular functioni
- ATP binding Source: InterPro
- calcium-dependent protein binding Source: RGD
- cytoskeletal protein binding Source: RGD
- identical protein binding Source: RGD
GO - Biological processi
- calcium-ion regulated exocytosis Source: RGD
- neurotransmitter secretion Source: ParkinsonsUK-UCL
- regulation of neurotransmitter secretion Source: RGD
- synaptic vesicle clustering Source: RGD
- synaptic vesicle cycle Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-181429, Serotonin Neurotransmitter Release Cycle R-RNO-212676, Dopamine Neurotransmitter Release Cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Synapsin-2Alternative name(s): Synapsin II |
Gene namesi | Name:Syn2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3798, Syn2 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- extrinsic component of synaptic vesicle membrane Source: SynGO
- glutamatergic synapse Source: RGD
- postsynaptic density Source: RGD
- Schaffer collateral - CA1 synapse Source: RGD
- SNARE complex Source: RGD
- synapse Source: ParkinsonsUK-UCL
- synaptic vesicle Source: UniProtKB
- synaptic vesicle membrane Source: ParkinsonsUK-UCL
- terminal bouton Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cell junction, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183023 | 1 – 586 | Synapsin-2Add BLAST | 586 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | Phosphoserine; by PKA and CaMK11 Publication | 1 | |
Modified residuei | 422 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 426 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation at Ser-426 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity). Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles.By similarity1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q63537 |
PaxDbi | Q63537 |
PRIDEi | Q63537 |
2D gel databases
World-2DPAGEi | 0004:Q63537 |
PTM databases
iPTMneti | Q63537 |
PhosphoSitePlusi | Q63537 |
SwissPalmi | Q63537 |
Interactioni
Subunit structurei
Interacts with CAPON.
1 PublicationGO - Molecular functioni
- calcium-dependent protein binding Source: RGD
- cytoskeletal protein binding Source: RGD
- identical protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247859, 5 interactors |
IntActi | Q63537, 3 interactors |
MINTi | Q63537 |
STRINGi | 10116.ENSRNOP00000011292 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q63537 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q63537 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | AAdd BLAST | 29 | |
Regioni | 33 – 113 | B; linkerAdd BLAST | 81 | |
Regioni | 114 – 421 | C; actin-binding and synaptic-vesicle bindingAdd BLAST | 308 | |
Regioni | 422 – 458 | G; Pro-rich linkerAdd BLAST | 37 | |
Regioni | 459 – 537 | H; Pro/Ser-rich linkerAdd BLAST | 79 | |
Regioni | 538 – 586 | EAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 487 – 499 | Poly-SerAdd BLAST | 13 | |
Compositional biasi | 515 – 520 | Poly-Ser | 6 |
Domaini
The A region binds phospholipids with a preference for negatively charged species.
Sequence similaritiesi
Belongs to the synapsin family.Curated
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
InParanoidi | Q63537 |
OrthoDBi | 799740at2759 |
PhylomeDBi | Q63537 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028712, SYN2/3 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF20, PTHR10841:SF20, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform IIa (identifier: Q63537-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GTATASAATS
60 70 80 90 100
AASPGPERRP PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG
110 120 130 140 150
LVDAPAPSAA SRKAKVLLVV DEPHTDWAKC FRGKKILGDY DIKVEQAEFS
160 170 180 190 200
ELNLVAHADG TYAVDMQVLR NGTKVVRSFR PDFVLIRQHA FGMAENEDFR
210 220 230 240 250
HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL GGEKFPLIEQ
260 270 280 290 300
TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ
310 320 330 340 350
TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM
360 370 380 390 400
SDRYKLWVDA CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ
410 420 430 440 450
VEDRQLITDL VISKMNQLLS RTPALSPQRP LTTQQPQSGT LKEPDSSKTP
460 470 480 490 500
PQRPAPQGGP GQPQGMQPPG KVLPPRRLPS GPSLPPSSSS SSSSSSSSSA
510 520 530 540 550
PQRPGGPTST QVNASSSSNS LAEPQAPQAA PPQKPQPHPQ LNKSQSLTNA
560 570 580
FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD
Isoform IIb (identifier: Q63537-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
459-479: GPGQPQGMQPPGKVLPPRRLP → CLQYILNCNGIAVGPKQVQAS
480-586: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V733 | G3V733_RAT | Synapsin II, isoform CRA_a | Syn2 rCG_30147 | 586 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006322 | 459 – 479 | GPGQP…PRRLP → CLQYILNCNGIAVGPKQVQA S in isoform IIb. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_006323 | 480 – 586 | Missing in isoform IIb. 1 PublicationAdd BLAST | 107 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27925 mRNA Translation: AAA42100.1 M27926 mRNA Translation: AAA42101.1 |
PIRi | C30411 |
RefSeqi | NP_001029192.1, NM_001034020.1 [Q63537-1] NP_062032.1, NM_019159.1 [Q63537-2] |
Genome annotation databases
GeneIDi | 29179 |
KEGGi | rno:29179 |
UCSCi | RGD:3798, rat [Q63537-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27925 mRNA Translation: AAA42100.1 M27926 mRNA Translation: AAA42101.1 |
PIRi | C30411 |
RefSeqi | NP_001029192.1, NM_001034020.1 [Q63537-1] NP_062032.1, NM_019159.1 [Q63537-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I7L | X-ray | 2.35 | A/B | 113-421 | [»] | |
1I7N | X-ray | 1.90 | A/B | 113-421 | [»] | |
SMRi | Q63537 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 247859, 5 interactors |
IntActi | Q63537, 3 interactors |
MINTi | Q63537 |
STRINGi | 10116.ENSRNOP00000011292 |
PTM databases
iPTMneti | Q63537 |
PhosphoSitePlusi | Q63537 |
SwissPalmi | Q63537 |
2D gel databases
World-2DPAGEi | 0004:Q63537 |
Proteomic databases
jPOSTi | Q63537 |
PaxDbi | Q63537 |
PRIDEi | Q63537 |
Protocols and materials databases
ABCDi | Q63537, 1 sequenced antibody |
Genome annotation databases
GeneIDi | 29179 |
KEGGi | rno:29179 |
UCSCi | RGD:3798, rat [Q63537-1] |
Organism-specific databases
CTDi | 6854 |
RGDi | 3798, Syn2 |
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
InParanoidi | Q63537 |
OrthoDBi | 799740at2759 |
PhylomeDBi | Q63537 |
Enzyme and pathway databases
Reactomei | R-RNO-181429, Serotonin Neurotransmitter Release Cycle R-RNO-212676, Dopamine Neurotransmitter Release Cycle |
Miscellaneous databases
EvolutionaryTracei | Q63537 |
PROi | PR:Q63537 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028712, SYN2/3 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF20, PTHR10841:SF20, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYN2_RAT | |
Accessioni | Q63537Primary (citable) accession number: Q63537 Secondary accession number(s): Q9Z1H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families