Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 129 (22 Apr 2020)
Sequence version 2 (16 Apr 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Periaxin

Gene

Prx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periaxin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prx
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
619960 Prx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000585651 – 1383PeriaxinAdd BLAST1383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei971PhosphoserineBy similarity1
Modified residuei1020PhosphoserineCombined sources1
Modified residuei1271PhosphoserineBy similarity1
Modified residuei1275PhosphoserineBy similarity1
Modified residuei1277PhosphoserineBy similarity1
Modified residuei1285PhosphoserineBy similarity1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1361PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63425

PRoteomics IDEntifications database

More...
PRIDEi
Q63425

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63425

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63425

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in sciatic nerve and in trigeminal nerve Schwann cells (PubMed:11430802). Detected in myelinating Schwann cells in sciatic nerve (at protein level) (PubMed:8155317, PubMed:10671475).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

mRNA and protein levels peak in the sciatic nerve between posnatal days 8 and 20; thereafter they decline precipitously.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via PDZ domain) (PubMed:11430802).

Interacts with SCN10A.

Found in a complex with SCN10A (PubMed:12591166).

Interacts with DRP2 (PubMed:11430802).

Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity).

Identified in a complex with EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, VIM and spectrin (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q63425, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000024771

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63425

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 99PDZPROSITE-ProRule annotationAdd BLAST84
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati432 – 43615
Repeati440 – 44425
Repeati448 – 45235
Repeati456 – 46045
Repeati461 – 46555
Repeati466 – 47065
Repeati474 – 47875
Repeati482 – 48685
Repeati487 – 49195
Repeati492 – 496105
Repeati497 – 501115
Repeati502 – 506125
Repeati507 – 511135
Repeati515 – 519145
Repeati523 – 527155
Repeati531 – 535165
Repeati536 – 540175
Repeati544 – 548185
Repeati549 – 553195
Repeati554 – 558205
Repeati562 – 566215
Repeati567 – 571225
Repeati575 – 579235
Repeati580 – 584245
Repeati585 – 589255
Repeati593 – 597265
Repeati601 – 605275
Repeati606 – 610285
Repeati611 – 615295
Repeati619 – 623305
Repeati627 – 631315
Repeati632 – 636325
Repeati637 – 641335
Repeati645 – 649345
Repeati653 – 657355
Repeati658 – 662365
Repeati663 – 667375
Repeati671 – 675385
Repeati676 – 680395
Repeati684 – 688405
Repeati689 – 693415
Repeati694 – 698425
Repeati699 – 703435
Repeati705 – 709445
Repeati713 – 717455
Repeati718 – 722465

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni432 – 72246 X 5 AA approximate tandem repeats of [LVMGIE]-[PSM]-[EDKA]-[LIVMA]-[AQKHPRT]; that may have a tripeptide spacer of [ALKD]-[IPV]-[KPH]Add BLAST291

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi70 – 84Nuclear export signalBy similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 196Arg/Lys-rich (basic)Add BLAST79
Compositional biasi136 – 139Poly-Lys4
Compositional biasi208 – 211Poly-Ala4
Compositional biasi1036 – 1163Glu-rich (acidic)Add BLAST128

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains.Curated
The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal.1 Publication
The PDZ domain contains the signal for export from the nucleus (By similarity). The N-terminal region including the PDZ domain is required for the formation of Cajal bands on myelinated nerves (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the periaxin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II3A Eukaryota
ENOG410ZMDY LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63425

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63425

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q63425-1) [UniParc]FASTAAdd to basket
Also known as: L-periaxin

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEARSRSAEE LRRAELVEII VETEAQTGVS GFNVAGGGKE GIFVRELRED
60 70 80 90 100
SPAAKSLSLQ EGDQLLSARV FFENFKYEDA LRLLQCAEPY KVSFCLKRTV
110 120 130 140 150
PTGDLALRPG TVSGYEMKGP RAKVAKLNIQ SLSPVKKKKM VIGTLGTPAD
160 170 180 190 200
LAPVDVEFSF PKFSRLRRGL KADAVKGPVP AAPARRRLQL PRLRVREVAE
210 220 230 240 250
EAQVARMAAA APPSRKAKSE AEVATGAGFT APQIELVGPR LPSAEVGVPK
260 270 280 290 300
VSVPKGTPST EAASGFALHL PTLGLGAPAA PAVEPPTTGI QVPQVELPTL
310 320 330 340 350
PSLPTLPTLP CLDTQEGAAV VKVPTLDVAA PSVEVDLALP GAEVEAQGEV
360 370 380 390 400
PEVALKMPRL SFPRFGVRGK EATEAKVVKG SPEAKAKGPR LRMPTFGLSL
410 420 430 440 450
LESRPSGPEV AAESKLKLPT LKMPSFGISV AGPEVKAPKG PEVKLPKVPE
460 470 480 490 500
IKLPKAPEAA IPDVQLPEVQ LPKMSDMKLP KIPEMAVPDV HLPEVKLPKV
510 520 530 540 550
PEMKVPEMKL PKIPEMAVPD VHLPDIQLPK VPEMKLPDMK LPKVPEMAVP
560 570 580 590 600
DVHLPDIQLP KVPEMKLPDM KLPKVPEMAV PDVRIPEVQL PKVSEVKLPK
610 620 630 640 650
IPDMAVPDVR LPELQLPKMS EVKLPKIPDM AVPDVRLPEV QLPKVSELKL
660 670 680 690 700
PKVPEMTMPD IRLPEVQLPK VPDIKLPEIK LPKVPEMAVP DVPLPELQLP
710 720 730 740 750
KVPQVPDVHL PKVPEMKLPK VPEAQRKSAG AEQAEKTEFS FKLPKMTVPK
760 770 780 790 800
LGKVTKPGEA GIEVPDKLLI LPCLQPEVGT EVARVGVPSL SLPSVELDLP
810 820 830 840 850
GALGLEGQVQ EAVSGKVEKP EGPRVAVGTG EAGFRVPSVE IVNPQLPTVE
860 870 880 890 900
VKKEQLEMVE MKVKPTSKFS LPKFGLSGPK AVKAEVEGPG RATKLKVSKF
910 920 930 940 950
AISLPRARAG TDADAKGAGE AGLLPALDLS IPQLSLDAQL PSGKVEVAGA
960 970 980 990 1000
ESKPKGSRFA LPKFGAKGRD SEADVLVAGE AELEGKGWGW DGKVKMPKLK
1010 1020 1030 1040 1050
MPSFGLSRGK EAEIQDGRVS PGEKLEAIAG QLKIPEVELV TPGAQETEKV
1060 1070 1080 1090 1100
TSGVKPSGLQ VSTTRQVVAE GQEGAQRVSS LGISLPQVEL ASFGEAGPEI
1110 1120 1130 1140 1150
AAPSAEGTVG SRIQVPQVML ELPGTQVAGG DLLVGEGIFK MPTVTVPQLE
1160 1170 1180 1190 1200
LDVGLGHEAQ AGETAKSEGG LKLKLPTLGA GGKGEGAEAQ SPEAQHTFHI
1210 1220 1230 1240 1250
SLPDVELTSP VSSHAEYQVV EGDGDGGHKL KVRLPLFGLA RAKEGIETGE
1260 1270 1280 1290 1300
KVKSPKLRLP RVGFSQSESA SGEGSPSPEE EEEGSGEGAS GRRGRVRVRL
1310 1320 1330 1340 1350
PRVGLASPSK GSKGQEGDAA SKSPVGEKSP KFRFPRVSLS PKARSGSKDR
1360 1370 1380
EEGGFRVRLP SVGFSETAAP GSARIEGTQA AAI
Length:1,383
Mass (Da):146,400
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF6593BCFA23A437
GO
Isoform 2 (identifier: Q63425-2) [UniParc]FASTAAdd to basket
Also known as: S-periaxin

The sequence of this isoform differs from the canonical sequence as follows:
     128-147: NIQSLSPVKKKKMVIGTLGT → VRVLSPVPVQDSPSDAVAAP
     148-1383: Missing.

Show »
Length:147
Mass (Da):15,968
Checksum:i17A1489927A9B022
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8D2G3V8D2_RAT
Periaxin
Prx rCG_54650
1,383Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004368128 – 147NIQSL…GTLGT → VRVLSPVPVQDSPSDAVAAP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_004369148 – 1383Missing in isoform 2. 1 PublicationAdd BLAST1236

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z29649 mRNA Translation: CAA82757.2

Protein sequence database of the Protein Information Resource

More...
PIRi
I58157

NCBI Reference Sequences

More...
RefSeqi
NP_076466.2, NM_023976.2 [Q63425-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:78960

UCSC genome browser

More...
UCSCi
RGD:619960 rat [Q63425-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29649 mRNA Translation: CAA82757.2
PIRiI58157
RefSeqiNP_076466.2, NM_023976.2 [Q63425-1]

3D structure databases

SMRiQ63425
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ63425, 3 interactors
STRINGi10116.ENSRNOP00000024771

PTM databases

iPTMnetiQ63425
PhosphoSitePlusiQ63425

Proteomic databases

PaxDbiQ63425
PRIDEiQ63425

Genome annotation databases

GeneIDi78960
KEGGirno:78960
UCSCiRGD:619960 rat [Q63425-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57716
RGDi619960 Prx

Phylogenomic databases

eggNOGiENOG410II3A Eukaryota
ENOG410ZMDY LUCA
InParanoidiQ63425
PhylomeDBiQ63425

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q63425

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAX_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63425
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: April 22, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again