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Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

Pde1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. May play an essential role in the rapid termination of the odorant-induced cAMP signal.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Activity regulationi

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288Proton donorBy similarity1
Metal bindingi292Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi328Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi329Divalent metal cation 1By similarity1
Metal bindingi329Divalent metal cation 2By similarity1
Metal bindingi436Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  • response to calcium ion Source: MGI
  • sensory perception of smell Source: RGD
  • signal transduction Source: InterPro

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase
Biological processOlfaction, Sensory transduction
LigandcAMP, cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
Short name:
Cam-PDE 1C
Gene namesi
Name:Pde1c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68332 Pde1c

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987941 – 768Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CAdd BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63421
PRIDEiQ63421

PTM databases

iPTMnetiQ63421
PhosphoSitePlusiQ63421

Expressioni

Tissue specificityi

Enriched in olfactory sensory neurons.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017531

Chemistry databases

BindingDBiQ63421

Structurei

3D structure databases

ProteinModelPortaliQ63421
SMRiQ63421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 588PDEasePROSITE-ProRule annotationAdd BLAST378

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3688 Eukaryota
ENOG410XQDD LUCA
HOGENOMiHOG000231888
HOVERGENiHBG056120
InParanoidiQ63421
KOiK13755
PhylomeDBiQ63421

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013706 PDEase_N
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PF08499 PDEase_I_N, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q63421-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ
60 70 80 90 100
NCLWNSLIDG LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT
110 120 130 140 150
SFRLRSLVKQ LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL
160 170 180 190 200
SDIQSDAVPS EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV
210 220 230 240 250
ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY
260 270 280 290 300
ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV
310 320 330 340 350
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL
360 370 380 390 400
YNDRSVLENH HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT
410 420 430 440 450
DMSCHFQQIK AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW
460 470 480 490 500
TMSLLEEFFR QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT
510 520 530 540 550
VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSEG
560 570 580 590 600
SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR
610 620 630 640 650
LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK
660 670 680 690 700
NSKGDKAGEK QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA
710 720 730 740 750
PSTSSTSRLT LPVIKPPLRH FKRPAYASSS YAPSVPKKTD DHPVRYKMLD
760
QRIKIKKIQN ISHHWNKK
Length:768
Mass (Da):86,671
Last modified:November 1, 1997 - v1
Checksum:i8816C208A30DD55E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMX4F1LMX4_RAT
Phosphodiesterase
Pde1c
668Annotation score:
A0A0G2KAI1A0A0G2KAI1_RAT
Phosphodiesterase
Pde1c rCG_52512
633Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41045 mRNA Translation: AAB00868.1
PIRiT10796
RefSeqiNP_112340.1, NM_031078.2
UniGeneiRn.10289

Genome annotation databases

GeneIDi81742
KEGGirno:81742
UCSCiRGD:68332 rat

Similar proteinsi

Entry informationi

Entry nameiPDE1C_RAT
AccessioniPrimary (citable) accession number: Q63421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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