Mycn

Functionⁱ

Positively regulates the transcription of MYCNOS in neuroblastoma cells.By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: InterPro
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: N-myc proto-oncogene protein
Gene namesⁱ	Name:Mycn Synonyms:Nmyc, Nmyc1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	1584995 Mycn

RGDⁱ

1584995 Mycn

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127326	1 – 462	N-myc proto-oncogene proteinAdd BLAST		462

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	259	Phosphoserine; by CK2By similarity		1
Modified residueⁱ	261	Phosphoserine; by CK2By similarity		1

Post-translational modificationⁱ

Phosphorylated by GSK3-beta which may promote its degradation. Phosphorylated by AURKA.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q63379
PRIDEⁱ	Q63379

PTM databases

iPTMnetⁱ	Q63379
PhosphoSitePlusⁱ	Q63379

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN. Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN.By similarity

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000008643

STRINGⁱ

10116.ENSRNOP00000008643

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63379
SMRⁱ	Q63379
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	379 – 431	bHLHPROSITE-ProRule annotationAdd BLAST		53

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	19 – 47	Interaction with AURKABy similarityAdd BLAST	29
Regionⁱ	61 – 90	Interaction with AURKA and FBXW7By similarityAdd BLAST	30
Regionⁱ	431 – 452	Leucine-zipperAdd BLAST	22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	260 – 276	Asp/Glu-rich (acidic)Add BLAST		17

Phylogenomic databases

eggNOGⁱ	ENOG410IJ8V Eukaryota ENOG41105VW LUCA
HOGENOMⁱ	HOG000043075
HOVERGENⁱ	HBG000472
InParanoidⁱ	Q63379
KEGG Orthology (KO) More...KOⁱ	K09109
PhylomeDBⁱ	Q63379

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF01056 Myc_N, 1 hit
PIRSFⁱ	PIRSF001705 Myc_protein, 1 hit
PRINTSⁱ	PR00044 LEUZIPPRMYC
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q63379-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSCTASTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW 
        60         70         80         90        100
KKFELLPTPP LSPSRAFPEH SPEPSNWATE MLLPEADLWG NPAEEDAFGL 
       110        120        130        140        150
GGLGGLTPNP VILQDCMWSG FSAREKLERA VNEKLQHGHG PPGASSSCPA 
       160        170        180        190        200
PGVGASSSGG RALGGSASAG RTGATLPTDL SHPAAECVDP AVVFPFPVNK 
       210        220        230        240        250
RESASVPAAP TSAPATSAVV TSVSVPAVAP VAAPARGSGR PANSGEHKAL 
       260        270        280        290        300
STSGEDTLSD SDDEDDEEED EEEEIDVVTV EKRRSSSNNK AVTTFTITVR 
       310        320        330        340        350
PKTSALGLGR AQPGELILKR CVPIHQQHNY AAPSPYVESE DAPPQKKIKS 
       360        370        380        390        400
EASPRPLKSV VPPKAKSLSP RNSDSEDSER RRNHNILERQ RRNDLRSSFL 
       410        420        430        440        450
TLRDHVPELV KNEKAAKVVI LKKATEYVHA LQANEHQLLL EKEKLQARQQ 
       460 
QLLKKIEHAR TC

Length:462

Mass (Da):49,695

Last modified:November 1, 1996 - v1

Checksum:ⁱ493130B3E0CAAB16

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V6T6	G3V6T6_RAT		N-myc proto-oncogene protein N-myc proto-oncogene protein (V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (Avian) (Mapped))	Mycn Mycn_mapped, rCG_62224	462	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63281 Genomic DNA Translation: CAA44920.1
PIRⁱ	S20073
NCBI Reference Sequences More...RefSeqⁱ	NP_001013114.1, NM_001013096.1
UniGeneⁱ	Rn.81116

Genome annotation databases

GeneIDⁱ	298894
KEGGⁱ	rno:298894

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q63379	N-myc proto-oncogene protein		MOUSE		462	UniRef90_P03966
LOW QUALITY PROTEIN: N-myc proto-oncogene protein		MESAU		553
N-myc proto-oncogene protein		RAT		462
UPI000A30ED85		MUSPA		465
UPI00038C0FE2		MICOH		462
+7

Protein	Similar proteins		Species	Score	Length	Source
Q63379	N-myc proto-oncogene protein	)	HUMAN		464	UniRef50_P04198
N-myc proto-oncogene protein		MARMO		460
N-myc proto-oncogene protein		MOUSE		462
Uncharacterized protein		FELCA		467
N-myc proto-oncogene protein isoform X1		Florida manatee		465
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63281 Genomic DNA Translation: CAA44920.1
PIRⁱ	S20073
RefSeqⁱ	NP_001013114.1, NM_001013096.1
UniGeneⁱ	Rn.81116

3D structure databases

ProteinModelPortalⁱ	Q63379
SMRⁱ	Q63379
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000008643

STRINGⁱ

10116.ENSRNOP00000008643

PTM databases

iPTMnetⁱ	Q63379
PhosphoSitePlusⁱ	Q63379

Proteomic databases

PaxDbⁱ	Q63379
PRIDEⁱ	Q63379

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	298894
KEGGⁱ	rno:298894

Organism-specific databases

CTDⁱ	4613
RGDⁱ	1584995 Mycn

Phylogenomic databases

eggNOGⁱ	ENOG410IJ8V Eukaryota ENOG41105VW LUCA
HOGENOMⁱ	HOG000043075
HOVERGENⁱ	HBG000472
InParanoidⁱ	Q63379
KOⁱ	K09109
PhylomeDBⁱ	Q63379

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q63379

PROⁱ

PR:Q63379

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF01056 Myc_N, 1 hit
PIRSFⁱ	PIRSF001705 Myc_protein, 1 hit
PRINTSⁱ	PR00044 LEUZIPPRMYC
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYCN_RAT
Accessionⁱ	Q63379Primary (citable) accession number: Q63379
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63379 (MYCN_RAT)

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N-myc proto-oncogene protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ