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Entry version 149 (08 May 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Neurexin-2

Gene

Nrxn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi335CalciumBy similarity1
Metal bindingi352Calcium; via carbonyl oxygenBy similarity1
Metal bindingi420Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurexin-2
Alternative name(s):
Neurexin II-alpha
Neurexin-2-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrxn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620211 Nrxn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 1639ExtracellularSequence analysisAdd BLAST1610
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1640 – 1660HelicalSequence analysisAdd BLAST21
Topological domaini1661 – 1715CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29By similarityAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001949630 – 1715Neurexin-2Add BLAST1686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi206 ↔ 219By similarity
Disulfide bondi213 ↔ 229By similarity
Disulfide bondi231 ↔ 241By similarity
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 486By similarity
Disulfide bondi657 ↔ 686By similarity
Disulfide bondi694 ↔ 705By similarity
Disulfide bondi699 ↔ 714By similarity
Disulfide bondi716 ↔ 726By similarity
Glycosylationi844N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1068 ↔ 1096By similarity
Disulfide bondi1103 ↔ 1114By similarity
Disulfide bondi1108 ↔ 1123By similarity
Disulfide bondi1125 ↔ 1135By similarity
Glycosylationi1239N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63374

PRoteomics IDEntifications database

More...
PRIDEi
Q63374

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63374

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63374

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain (neuronal synapse).

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The laminin G-like domain 1 binds to NXPH1 (PubMed:9856994).

Interacts with PATJ (PubMed:9647694).

Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Isoforms alpha 2C bind to alpha-dystroglycan (PubMed:11470830).

Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (By similarity).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
250509, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q63374, 6 interactors

Molecular INTeraction database

More...
MINTi
Q63374

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000063600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63374

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 206Laminin G-like 1PROSITE-ProRule annotationAdd BLAST177
Domaini202 – 242EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini289 – 486Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini493 – 686Laminin G-like 3PROSITE-ProRule annotationAdd BLAST194
Domaini690 – 727EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini732 – 907Laminin G-like 4PROSITE-ProRule annotationAdd BLAST176
Domaini921 – 1096Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1099 – 1136EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1140 – 1348Laminin G-like 6PROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1371 – 1374Poly-Thr4
Compositional biasi1377 – 1380Poly-Thr4
Compositional biasi1447 – 1450Poly-Pro4
Compositional biasi1647 – 1650Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3514 Eukaryota
ENOG410XNU6 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230481

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63374

KEGG Orthology (KO)

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KOi
K07377

Database of Orthologous Groups

More...
OrthoDBi
35129at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (18+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 18 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five major alternatively spliced sites, each of which may be spliced in up to three different ways. Additional isoforms may derive from a minor cytoplasmic splice site 6. Combinatorial splicing at each of these six sites may lead to the generation of at least 216 isoforms but for simplicity only individual splice events are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4, 5 and 6. Experimental confirmation may be lacking for some isoforms.2 Publications

This entry has 18 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1a (identifier: Q63374-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1A2A3A4A5A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEGEHPMEG
260 270 280 290 300
PAHLTLNSPV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGA GVGSHSSSQR
560 570 580 590 600
ADYFAMELLD GYLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGESEVL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGICREGWN RFVCDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR
810 820 830 840 850
VGCAPSAAGK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ
860 870 880 890 900
MAGAHTRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK
910 920 930 940 950
DGDITYCELN ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK
960 970 980 990 1000
TTAPDGLLLF NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN
1010 1020 1030 1040 1050
DNQWHNVVVS RDPGNVHTLK IDSRTVTQHS NGARNLDLKG ELYIGGLSKN
1060 1070 1080 1090 1100
MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD LIADALHRIG QVERGCDGPS
1110 1120 1130 1140 1150
TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL
1160 1170 1180 1190 1200
ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ
1210 1220 1230 1240 1250
GTVGVIFNVG TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN
1260 1270 1280 1290 1300
ERYPAGNFDN ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI
1310 1320 1330 1340 1350
GGRDQGRPFQ GQVSGLYYNG LKVLALAAES DPNVRTEGHL RLVGEGPSVL
1360 1370 1380 1390 1400
LSAETTATTL LADMATTIME TTTTMATTTT RRGRSPTMRD STTQNTDDLL
1410 1420 1430 1440 1450
VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP
1460 1470 1480 1490 1500
TFYPFLTGVG ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS
1510 1520 1530 1540 1550
GEVFDSSLPP TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP
1560 1570 1580 1590 1600
GVLLAPSAPA PNLPAGKMNH RDPLQPLLEN PPLGPGVPTA FEPRRPPPLR
1610 1620 1630 1640 1650
PGVTSVPGFP RLPTANPTGP GERGPPGAVE VIRESSSTTG MVVGIVAAAA
1660 1670 1680 1690 1700
LCILILLYAM YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV VKEKAPAAPK
1710
TPSKAKKNKD KEYYV
Length:1,715
Mass (Da):185,169
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4A7A4129F25736C
GO
Isoform 2a (identifier: Q63374-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B

The sequence of this isoform differs from the canonical sequence as follows:
     250-259: Missing.

Show »
Length:1,705
Mass (Da):184,181
Checksum:i42B136F20A8E312C
GO
Isoform 3a (identifier: Q63374-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C

The sequence of this isoform differs from the canonical sequence as follows:
     250-283: Missing.

Show »
Length:1,681
Mass (Da):181,902
Checksum:iB88CFBD700F47847
GO
Isoform 4a (identifier: Q63374-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     393-399: Missing.

Show »
Length:1,708
Mass (Da):184,301
Checksum:i29AE45D36BC8599E
GO
Isoform 5a (identifier: Q63374-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C

The sequence of this isoform differs from the canonical sequence as follows:
     385-399: Missing.

Show »
Length:1,700
Mass (Da):183,526
Checksum:i96BE9160C5D0B080
GO
Isoform 6a (identifier: Q63374-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     807-809: Missing.

Show »
Length:1,712
Mass (Da):184,970
Checksum:iC68A686D8C3E6DB7
GO
Isoform 7a (identifier: Q63374-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-3C

The sequence of this isoform differs from the canonical sequence as follows:
     797-806: DCLRVGCAPS → G

Show »
Length:1,706
Mass (Da):184,224
Checksum:iA77431B274065E98
GO
Isoform 8a (identifier: Q63374-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B

The sequence of this isoform differs from the canonical sequence as follows:
     1256-1285: Missing.

Show »
Length:1,685
Mass (Da):181,573
Checksum:i58831E7E2755CC55
GO
Isoform 9a (identifier: Q63374-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B

The sequence of this isoform differs from the canonical sequence as follows:
     1421-1614: Missing.

Show »
Length:1,521
Mass (Da):164,826
Checksum:i358B693C6F80FA7F
GO
Isoform 10a (identifier: Q63374-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-6

The sequence of this isoform differs from the canonical sequence as follows:
     1667-1715: DEGSYQVDQS...KKNKDKEYYV → CRKSPREEKL...RQMQIYIKNK

Show »
Length:1,728
Mass (Da):186,513
Checksum:iA0EC3826D24CDBB4
GO
Isoform 1b (identifier: Q63376-1) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:662
Mass (Da):70,547
GO
Isoform 2b (identifier: Q63376-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:644
Mass (Da):68,688
GO
Isoform 3b (identifier: Q63376-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:632
Mass (Da):66,950
GO
Isoform 4b (identifier: Q63376-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:614
Mass (Da):65,092
GO
Isoform 5b (identifier: Q63376-5) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A6
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:675
Mass (Da):71,891
GO
Isoform 6b (identifier: Q63376-6) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B6
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:657
Mass (Da):70,032
GO
Isoform 7b (identifier: Q63376-7) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A6
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:645
Mass (Da):68,294
GO
Isoform 8b (identifier: Q63376-8) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B6
The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:627
Mass (Da):66,436
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q63376NRX2B_RAT
Neurexin-2-beta
Nrxn2
662Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZAD6D3ZAD6_RAT
Neurexin-2
Nrxn2
1,715Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZTM0D3ZTM0_RAT
Neurexin-2
Nrxn2
1,642Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244G → E in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti244G → E in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti259P → E in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti259P → E in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti277D → N in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti277D → N in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti297F → S in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti297F → S in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti335D → N in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti335D → N in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti349V → I in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti349V → I in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti809G → A in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti809G → A in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti829V → L in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti829V → L in AAA41707 (PubMed:1621094).Curated1
Sequence conflicti987G → S in AAA41706 (PubMed:1621094).Curated1
Sequence conflicti987G → S in AAA41707 (PubMed:1621094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti434N → L1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003510250 – 283Missing in isoform 3a. CuratedAdd BLAST34
Alternative sequenceiVSP_003509250 – 259Missing in isoform 2a. Curated10
Alternative sequenceiVSP_003511385 – 399Missing in isoform 5a. CuratedAdd BLAST15
Alternative sequenceiVSP_003512393 – 399Missing in isoform 4a. Curated7
Alternative sequenceiVSP_003513797 – 806DCLRVGCAPS → G in isoform 7a. Curated10
Alternative sequenceiVSP_003514807 – 809Missing in isoform 6a. Curated3
Alternative sequenceiVSP_0035151256 – 1285Missing in isoform 8a. CuratedAdd BLAST30
Alternative sequenceiVSP_0035161421 – 1614Missing in isoform 9a. CuratedAdd BLAST194
Alternative sequenceiVSP_0035171667 – 1715DEGSY…KEYYV → CRKSPREEKLLPGSAQGLGL DLAKACCVCRCRATCIAGKP LEERGGGRGEGERQMQIYIK NK in isoform 10a. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M96376 mRNA Translation: AAA41706.1
M96376 mRNA Translation: AAA41707.1
AABR03000676 Genomic DNA No translation available.
AABR03002856 Genomic DNA No translation available.
AABR03004066 Genomic DNA No translation available.
AABR03004601 Genomic DNA No translation available.
AABR03004809 Genomic DNA No translation available.
AABR03005995 Genomic DNA No translation available.
AABR03006603 Genomic DNA No translation available.
AABR03006786 Genomic DNA No translation available.
AABR03008290 Genomic DNA No translation available.
AABR03009435 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
C40228

NCBI Reference Sequences

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RefSeqi
NP_446298.1, NM_053846.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
116595

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:116595

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96376 mRNA Translation: AAA41706.1
M96376 mRNA Translation: AAA41707.1
AABR03000676 Genomic DNA No translation available.
AABR03002856 Genomic DNA No translation available.
AABR03004066 Genomic DNA No translation available.
AABR03004601 Genomic DNA No translation available.
AABR03004809 Genomic DNA No translation available.
AABR03005995 Genomic DNA No translation available.
AABR03006603 Genomic DNA No translation available.
AABR03006786 Genomic DNA No translation available.
AABR03008290 Genomic DNA No translation available.
AABR03009435 Genomic DNA No translation available.
PIRiC40228
RefSeqiNP_446298.1, NM_053846.1

3D structure databases

SMRiQ63374
ModBaseiSearch...

Protein-protein interaction databases

BioGridi250509, 4 interactors
IntActiQ63374, 6 interactors
MINTiQ63374
STRINGi10116.ENSRNOP00000063600

PTM databases

iPTMnetiQ63374
PhosphoSitePlusiQ63374

Proteomic databases

PaxDbiQ63374
PRIDEiQ63374

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116595
KEGGirno:116595

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9379
RGDi620211 Nrxn2

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
HOGENOMiHOG000230481
InParanoidiQ63374
KOiK07377
OrthoDBi35129at2759

Enzyme and pathway databases

ReactomeiR-RNO-6794361 Neurexins and neuroligins

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRX2A_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63374
Secondary accession number(s): Q63375
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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