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Protein

Transcription factor EC

Gene

Tfec

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor EC
Short name:
TFE-C
Short name:
rTFEC
Gene namesi
Name:Tfec
Synonyms:Tcfec
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3846 Tfec

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003135681 – 317Transcription factor ECAdd BLAST317

Proteomic databases

PaxDbiQ63302
PRIDEiQ63302

Expressioni

Tissue specificityi

Expressed in kidney, spleen, lung, liver, testis and muscle.1 Publication

Developmental stagei

Expressed in embryo at 14 dpc and in skeletal muscle at 18 dpc.1 Publication

Gene expression databases

BgeeiENSRNOG00000061595 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ63302 RN

Interactioni

Subunit structurei

Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF (By similarity). Interacts with MITF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008156

Structurei

3D structure databases

ProteinModelPortaliQ63302
SMRiQ63302
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 163bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 90Necessary for transcriptional transactivationBy similarityAdd BLAST90
Regioni242 – 317Necessary for transcriptional transactivationBy similarityAdd BLAST76

Sequence similaritiesi

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402
HOGENOMiHOG000231368
HOVERGENiHBG006768
InParanoidiQ63302
KOiK15591
OMAiCDQAMAF
OrthoDBiEOG091G0QCO
PhylomeDBiQ63302
TreeFamiTF317174

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR024101 TFEC
PANTHERiPTHR12565 PTHR12565, 2 hits
PTHR12565:SF106 PTHR12565:SF106, 2 hits
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q63302-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLDHRLFSQ TLKRAQPLAA SCMPLAEHGP RSPDSDAGCA GNPFTNPLAL
60 70 80 90 100
GKEDGVVEWR LSGSILDVYS GEQGISPVNT GLMNASCPSI LPMKKEIAET
110 120 130 140 150
DTRALAKERQ KKDNHNLIER RRRYNINYRI KELGTLIPKS NDPDIRWNKG
160 170 180 190 200
TILKASVDYI KWLQKEQQRA RELEHRQKKL EHANRQLMLR IQELEIQARA
210 220 230 240 250
HGLPILASLG TADFGTHITK QQTHSEKNSV GCCQQLTPSQ GTSPEFYEQA
260 270 280 290 300
VAFSDPLSHF TDLSFSAALK EEQRLDGMLL SDTICPFGTD PLLSAISPAV
310
SKASSRSSLS SEDGDEL
Length:317
Mass (Da):35,175
Last modified:January 15, 2008 - v2
Checksum:iA68AC4E7F245E3DB
GO

Sequence cautioni

The sequence AAA41523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA41523 differs from that shown. Reason: Erroneous termination at position 36. Translated as Asp.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08812 mRNA Translation: AAA41523.1 Sequence problems.
RefSeqiNP_071774.1, NM_022379.1
UniGeneiRn.9659

Genome annotation databases

EnsembliENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595
GeneIDi26296
KEGGirno:26296
UCSCiRGD:3846 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08812 mRNA Translation: AAA41523.1 Sequence problems.
RefSeqiNP_071774.1, NM_022379.1
UniGeneiRn.9659

3D structure databases

ProteinModelPortaliQ63302
SMRiQ63302
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008156

Proteomic databases

PaxDbiQ63302
PRIDEiQ63302

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595
GeneIDi26296
KEGGirno:26296
UCSCiRGD:3846 rat

Organism-specific databases

CTDi22797
RGDi3846 Tfec

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402
HOGENOMiHOG000231368
HOVERGENiHBG006768
InParanoidiQ63302
KOiK15591
OMAiCDQAMAF
OrthoDBiEOG091G0QCO
PhylomeDBiQ63302
TreeFamiTF317174

Miscellaneous databases

PROiPR:Q63302

Gene expression databases

BgeeiENSRNOG00000061595 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ63302 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR024101 TFEC
PANTHERiPTHR12565 PTHR12565, 2 hits
PTHR12565:SF106 PTHR12565:SF106, 2 hits
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTFEC_RAT
AccessioniPrimary (citable) accession number: Q63302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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