UniProtKB - Q63302 (TFEC_RAT)
Transcription factor EC
Tfec
Functioni
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity).
Collaborates with MITF in target gene activation (By similarity).
Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity).
Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity).
Binds DNA in a homo- or heterodimeric form.
By similarity1 PublicationGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cellular response to heat Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor ECShort name: TFE-C Short name: rTFEC |
Gene namesi | Name:Tfec Synonyms:Tcfec |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3846, Tfec |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313568 | 1 – 317 | Transcription factor ECAdd BLAST | 317 |
Proteomic databases
PaxDbi | Q63302 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000061595, Expressed in adult mammalian kidney and 19 other tissues |
Genevisiblei | Q63302, RN |
Interactioni
Subunit structurei
Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF (By similarity).
Interacts with MITF (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008156 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 110 – 163 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 90 | Necessary for transcriptional transactivationBy similarityAdd BLAST | 90 | |
Regioni | 242 – 317 | Necessary for transcriptional transactivationBy similarityAdd BLAST | 76 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1318, Eukaryota |
GeneTreei | ENSGT00940000159404 |
HOGENOMi | CLU_031638_0_0_1 |
InParanoidi | Q63302 |
OMAi | ICPFGTD |
OrthoDBi | 1211990at2759 |
PhylomeDBi | Q63302 |
TreeFami | TF317174 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR021802, MiT/TFE_C IPR024101, TFEC |
PANTHERi | PTHR45776:SF1, PTHR45776:SF1, 2 hits |
Pfami | View protein in Pfam PF11851, DUF3371, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTLDHRLFSQ TLKRAQPLAA SCMPLAEHGP RSPDSDAGCA GNPFTNPLAL
60 70 80 90 100
GKEDGVVEWR LSGSILDVYS GEQGISPVNT GLMNASCPSI LPMKKEIAET
110 120 130 140 150
DTRALAKERQ KKDNHNLIER RRRYNINYRI KELGTLIPKS NDPDIRWNKG
160 170 180 190 200
TILKASVDYI KWLQKEQQRA RELEHRQKKL EHANRQLMLR IQELEIQARA
210 220 230 240 250
HGLPILASLG TADFGTHITK QQTHSEKNSV GCCQQLTPSQ GTSPEFYEQA
260 270 280 290 300
VAFSDPLSHF TDLSFSAALK EEQRLDGMLL SDTICPFGTD PLLSAISPAV
310
SKASSRSSLS SEDGDEL
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08812 mRNA Translation: AAA41523.1 Sequence problems. |
RefSeqi | NP_071774.1, NM_022379.1 |
Genome annotation databases
Ensembli | ENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595 |
GeneIDi | 26296 |
KEGGi | rno:26296 |
UCSCi | RGD:3846, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08812 mRNA Translation: AAA41523.1 Sequence problems. |
RefSeqi | NP_071774.1, NM_022379.1 |
3D structure databases
AlphaFoldDBi | Q63302 |
SMRi | Q63302 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008156 |
Proteomic databases
PaxDbi | Q63302 |
Genome annotation databases
Ensembli | ENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595 |
GeneIDi | 26296 |
KEGGi | rno:26296 |
UCSCi | RGD:3846, rat |
Organism-specific databases
CTDi | 22797 |
RGDi | 3846, Tfec |
Phylogenomic databases
eggNOGi | KOG1318, Eukaryota |
GeneTreei | ENSGT00940000159404 |
HOGENOMi | CLU_031638_0_0_1 |
InParanoidi | Q63302 |
OMAi | ICPFGTD |
OrthoDBi | 1211990at2759 |
PhylomeDBi | Q63302 |
TreeFami | TF317174 |
Miscellaneous databases
PROi | PR:Q63302 |
Gene expression databases
Bgeei | ENSRNOG00000061595, Expressed in adult mammalian kidney and 19 other tissues |
Genevisiblei | Q63302, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR021802, MiT/TFE_C IPR024101, TFEC |
PANTHERi | PTHR45776:SF1, PTHR45776:SF1, 2 hits |
Pfami | View protein in Pfam PF11851, DUF3371, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TFEC_RAT | |
Accessioni | Q63302Primary (citable) accession number: Q63302 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | May 25, 2022 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families