Tfec

Functionⁱ

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.By similarity1 Publication

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 8336698
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8336698

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to heat Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 8336698
regulation of transcription, DNA-templated
Source: RGD
Inferred from direct assayⁱ
- 8336698

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor EC Short name: TFE-C Short name: rTFEC
Gene namesⁱ	Name:Tfec Synonyms:Tcfec
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 4

Organism-specific databases

Rat genome database More...RGDⁱ	3846 Tfec

RGDⁱ

3846 Tfec

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313568	1 – 317	Transcription factor ECAdd BLAST		317

Proteomic databases

PaxDbⁱ	Q63302
PRIDEⁱ	Q63302

Expressionⁱ

Tissue specificityⁱ

Expressed in kidney, spleen, lung, liver, testis and muscle.1 Publication

Developmental stageⁱ

Expressed in embryo at 14 dpc and in skeletal muscle at 18 dpc.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000061595 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
Genevisibleⁱ	Q63302 RN

Interactionⁱ

Subunit structureⁱ

Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF (By similarity). Interacts with MITF (By similarity).By similarity

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000008156

STRINGⁱ

10116.ENSRNOP00000008156

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63302
SMRⁱ	Q63302
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	110 – 163	bHLHPROSITE-ProRule annotationAdd BLAST		54

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 90	Necessary for transcriptional transactivationBy similarityAdd BLAST		90
Regionⁱ	242 – 317	Necessary for transcriptional transactivationBy similarityAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG4110SME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004402
HOGENOMⁱ	HOG000231368
HOVERGENⁱ	HBG006768
InParanoidⁱ	Q63302
KEGG Orthology (KO) More...KOⁱ	K15591
OMAⁱ	CDQAMAF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QCO
PhylomeDBⁱ	Q63302
TreeFamⁱ	TF317174

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR024101 TFEC
PANTHERⁱ	PTHR12565 PTHR12565, 2 hits PTHR12565:SF106 PTHR12565:SF106, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q63302-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLDHRLFSQ TLKRAQPLAA SCMPLAEHGP RSPDSDAGCA GNPFTNPLAL 
        60         70         80         90        100
GKEDGVVEWR LSGSILDVYS GEQGISPVNT GLMNASCPSI LPMKKEIAET 
       110        120        130        140        150
DTRALAKERQ KKDNHNLIER RRRYNINYRI KELGTLIPKS NDPDIRWNKG 
       160        170        180        190        200
TILKASVDYI KWLQKEQQRA RELEHRQKKL EHANRQLMLR IQELEIQARA 
       210        220        230        240        250
HGLPILASLG TADFGTHITK QQTHSEKNSV GCCQQLTPSQ GTSPEFYEQA 
       260        270        280        290        300
VAFSDPLSHF TDLSFSAALK EEQRLDGMLL SDTICPFGTD PLLSAISPAV 
       310 
SKASSRSSLS SEDGDEL

Length:317

Mass (Da):35,175

Last modified:January 15, 2008 - v2

Checksum:ⁱA68AC4E7F245E3DB

GO

Sequence cautionⁱ

The sequence AAA41523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAA41523 differs from that shown. Reason: Erroneous termination at position 36. Translated as Asp.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L08812 mRNA Translation: AAA41523.1 Sequence problems.
NCBI Reference Sequences More...RefSeqⁱ	NP_071774.1, NM_022379.1
UniGeneⁱ	Rn.9659

Genome annotation databases

Ensemblⁱ	ENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595
GeneIDⁱ	26296
KEGGⁱ	rno:26296
UCSC genome browser More...UCSCⁱ	RGD:3846 rat

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q63302	Transcription factor EC		MOUSE		317	UniRef50_Q63302
Transcription factor EC		BOVIN		317
transcription factor EC-like isoform X2		Asian bonytongue		384
Transcription factor EC (Fragment)		rifleman		263
Transcription factor EC (Fragment)		TAUER		263
+202

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L08812 mRNA Translation: AAA41523.1 Sequence problems.
RefSeqⁱ	NP_071774.1, NM_022379.1
UniGeneⁱ	Rn.9659

3D structure databases

ProteinModelPortalⁱ	Q63302
SMRⁱ	Q63302
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000008156

STRINGⁱ

10116.ENSRNOP00000008156

Proteomic databases

PaxDbⁱ	Q63302
PRIDEⁱ	Q63302

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595
GeneIDⁱ	26296
KEGGⁱ	rno:26296
UCSCⁱ	RGD:3846 rat

Organism-specific databases

CTDⁱ	22797
RGDⁱ	3846 Tfec

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG4110SME LUCA
GeneTreeⁱ	ENSGT00390000004402
HOGENOMⁱ	HOG000231368
HOVERGENⁱ	HBG006768
InParanoidⁱ	Q63302
KOⁱ	K15591
OMAⁱ	CDQAMAF
OrthoDBⁱ	EOG091G0QCO
PhylomeDBⁱ	Q63302
TreeFamⁱ	TF317174

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q63302

PROⁱ

PR:Q63302

Gene expression databases

Bgeeⁱ	ENSRNOG00000061595 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
Genevisibleⁱ	Q63302 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR024101 TFEC
PANTHERⁱ	PTHR12565 PTHR12565, 2 hits PTHR12565:SF106 PTHR12565:SF106, 2 hits
Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFEC_RAT
Accessionⁱ	Q63302Primary (citable) accession number: Q63302
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 15, 2008
	Last modified:	November 7, 2018
	This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniProtKB - Q63302 (TFEC_RAT)

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Transcription factor EC

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ