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UniProtKB - Q632I5 (MENE_BACCZ)
Protein
2-succinylbenzoate--CoA ligase
Gene
menE
Organism
Bacillus cereus (strain ZK / E33L)
Status
Functioni
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
UniRule annotationCatalytic activityi
- EC:6.2.1.26UniRule annotation
: 1,4-dihydroxy-2-naphthoate biosynthesis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.
Pathwayi: menaquinone biosynthesis
This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- o-succinylbenzoate-CoA ligase activity Source: UniProtKB-UniRule
GO - Biological processi
- menaquinone biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ligase |
Biological process | Menaquinone biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA01057;UER00166 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-succinylbenzoate--CoA ligaseUniRule annotation (EC:6.2.1.26UniRule annotation)Alternative name(s): o-succinylbenzoyl-CoA synthetaseUniRule annotation Short name: OSB-CoA synthetaseUniRule annotation |
Gene namesi | Name:menEUniRule annotation Ordered Locus Names:BCE33L4607 |
Organismi | Bacillus cereus (strain ZK / E33L) |
Taxonomic identifieri | 288681 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193157 | 1 – 482 | 2-succinylbenzoate--CoA ligaseAdd BLAST | 482 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
OMAi | WLMQRAF |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_00731, MenE, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR010192, MenE |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR01923, menE, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q632I5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMETMPNWLM QRAFLTPDRT AIEMEEEKVT FMQLHEKVVS VCEHLTHVGV
60 70 80 90 100
KRGQKVAVLM KNGMEMITVI HALSYVGAVA VLLNTRLSRE ELLWQMDDAE
110 120 130 140 150
VICLVTDQDF EAKDIPVYSF AEVMNGPKEE ASIQEEFSLK EAMTIIYTSG
160 170 180 190 200
TTGKPKGVIL TYGNHWASAV GSSFNLGLRD DDCWLACMPM FHVGGLSLLM
210 220 230 240 250
KNIMYGMRIL LVPKYDADFI HKALQTRGVT IISVVSKMLT DLLERLGEET
260 270 280 290 300
YPPSLRCMLL GGGPAPKPLL EACVEKRIPV YQTYGMTETS SQICTLSADY
310 320 330 340 350
MLMKVGSAGK PLFQCQLRIE KDGVVVPPFA EGEIVVKGPN VTGGYFNRED
360 370 380 390 400
ATRETIQNGW LHTGDLGYLD EEGFLYVLDR RSDLIISGGE NIYPAQIEEV
410 420 430 440 450
LLSHPMVAEA GVVGMTDDKW GQVPAAFVVK SGEITEEEIL HFCEEKLAKY
460 470 480
KVPKKAWFLE ELPRNASKKL LRRELRQLVE EM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000001 Genomic DNA Translation: AAU15666.1 |
Genome annotation databases
EnsemblBacteriai | AAU15666; AAU15666; BCE33L4607 |
KEGGi | bcz:BCE33L4607 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000001 Genomic DNA Translation: AAU15666.1 |
3D structure databases
AlphaFoldDBi | Q632I5 |
SMRi | Q632I5 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAU15666; AAU15666; BCE33L4607 |
KEGGi | bcz:BCE33L4607 |
Phylogenomic databases
OMAi | WLMQRAF |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA01057;UER00166 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_00731, MenE, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR010192, MenE |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR01923, menE, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MENE_BACCZ | |
Accessioni | Q632I5Primary (citable) accession number: Q632I5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | October 25, 2004 | |
Last modified: | May 25, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families