Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (07 Apr 2021)
Sequence version 2 (08 Nov 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Bile acid-CoA:amino acid N-acyltransferase

Gene

Baat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12951368, PubMed:624713). More efficient at taurine conjugation of cholyl CoA than glycine conjugation (PubMed:12951368, PubMed:624713). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.0 mM for taurine toward choloyl-CoA1 Publication
  2. KM=4.4 mM for glycine toward choloyl-CoA1 Publication
  3. KM=20 µM for glycine toward choloyl-CoA1 Publication
  4. KM=10 µM for taurine toward choloyl-CoA1 Publication
  5. KM=15 µM for glycine toward deoxycholoyl-CoA1 Publication
  6. KM=13 µM for taurine toward deoxycholoyl-CoA1 Publication
  7. KM=13 µM for glycine toward chenodeoxycholoyl-CoA1 Publication
  8. KM=16 µM for taurine toward chenodeoxycholoyl-CoA1 Publication
  9. KM=12 µM for glycine toward lithocholoyl-CoA1 Publication
  10. KM=11 µM for taurine toward lithocholoyl-CoA1 Publication
  1. Vmax=8.69 µmol/min/mg enzyme for glycine toward choloyl-CoA1 Publication
  2. Vmax=4.09 µmol/min/mg enzyme for taurine toward choloyl-CoA1 Publication
  3. Vmax=7.34 µmol/min/mg enzyme for glycine toward deoxycholoyl-CoA1 Publication
  4. Vmax=3.10 µmol/min/mg enzyme for taurine toward deoxycholoyl-CoA1 Publication
  5. Vmax=5.20 µmol/min/mg enzyme for glycine toward chenodeoxycholoyl-CoA1 Publication
  6. Vmax=3.05 µmol/min/mg enzyme for taurine toward chenodeoxycholoyl-CoA1 Publication
  7. Vmax=5.26 µmol/min/mg enzyme for glycine toward lithocholoyl-CoA1 Publication
  8. Vmax=3.42 µmol/min/mg enzyme for taurine toward lithocholoyl-CoA1 Publication

pH dependencei

Optimum pH is 7.8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei235Charge relay systemBy similarity1
Active sitei328Charge relay systemBy similarity1
Active sitei362Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Hydrolase, Serine esterase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-14337

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-159418, Recycling of bile acids and salts
R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-9033241, Peroxisomal protein import

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q63276

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
ratno-BAAT, Acyl-CoA_Thioesterase

MEROPS protease database

More...
MEROPSi
S09.A50

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bile acid-CoA:amino acid N-acyltransferase (EC:2.3.1.652 Publications)
Short name:
BACAT
Short name:
BAT
Alternative name(s):
Bile acid-CoA thioesteraseBy similarity
Choloyl-CoA hydrolase (EC:3.1.2.27By similarity)
Glycine N-choloyltransferase
Kan-1
Long-chain fatty-acyl-CoA hydrolase (EC:3.1.2.2By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Baat
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
2190, Baat

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002021611 – 420Bile acid-CoA:amino acid N-acyltransferaseAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40N6-succinyllysineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei346N6-succinyllysineBy similarity1
Modified residuei350N6-succinyllysineBy similarity1
Modified residuei409N6-succinyllysineBy similarity1
Modified residuei418PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63276

PRoteomics IDEntifications database

More...
PRIDEi
Q63276

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q63276

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63276

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63276

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver (at protein level); found in hepatocytes, sinusoidal endothelial cells and Kupffer cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007395, Expressed in liver and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q63276, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009777

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63276

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ8Z, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222336

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029849_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63276

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTPFQVV

Database of Orthologous Groups

More...
OrthoDBi
1260385at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63276

TreeFam database of animal gene trees

More...
TreeFami
TF314911

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2240, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR016662, Acyl-CoA_thioEstase_long-chain
IPR014940, BAAT_C
IPR006862, Thio_Ohase/aa_AcTrfase
IPR042490, Thio_Ohase/BAAT_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08840, BAAT_C, 1 hit
PF04775, Bile_Hydr_Trans, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016521, Acyl-CoA_hydro, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q63276-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKLTAVPLS ALVDEPVHIR VTGLTPFQVV CLQASLKDDK GNLFNSQAFY
60 70 80 90 100
RASEVGEVDL ERDSSLGGDY MGVHPMGLFW SMKPEKLLTR LVKRDVMNRP
110 120 130 140 150
HKVHIKLCHP YFPVEGKVIS SSLDSLILER WYVAPGVTRI HVKEGRIRGA
160 170 180 190 200
LFLPPGEGPF PGVIDLFGGA GGLFEFRASL LASHGFATLA LAYWGYDDLP
210 220 230 240 250
SRLEKVDLEY FEEGVEFLLR HPKVLGPGVG ILSVCIGAEI GLSMAINLKQ
260 270 280 290 300
ITATVLINGP NFVSSNPHVY RGKVFQPTPC SEEFVTTNAL GLVEFYRTFE
310 320 330 340 350
ETADKDSKYC FPIEKAHGHF LFVVGEDDKN LNSKVHAKQA IAQLMKSGKK
360 370 380 390 400
NWTLLSYPGA GHLIEPPYSP LCSASRMPFV IPSINWGGEV IPHAAAQEHS
410 420
WKEIQKFLKQ HLNPGFNSQL
Length:420
Mass (Da):46,465
Last modified:November 8, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAACDB03726EB546F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133V → M in BAA07901 (PubMed:7575455).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D43964 mRNA Translation: BAA07901.1
BC088153 mRNA Translation: AAH88153.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59131

NCBI Reference Sequences

More...
RefSeqi
NP_058996.2, NM_017300.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000009777; ENSRNOP00000009777; ENSRNOG00000007395

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29725

UCSC genome browser

More...
UCSCi
RGD:2190, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43964 mRNA Translation: BAA07901.1
BC088153 mRNA Translation: AAH88153.1
PIRiS59131
RefSeqiNP_058996.2, NM_017300.2

3D structure databases

SMRiQ63276
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009777

Protein family/group databases

ESTHERiratno-BAAT, Acyl-CoA_Thioesterase
MEROPSiS09.A50

PTM databases

CarbonylDBiQ63276
iPTMnetiQ63276
PhosphoSitePlusiQ63276

Proteomic databases

PaxDbiQ63276
PRIDEiQ63276

Genome annotation databases

EnsembliENSRNOT00000009777; ENSRNOP00000009777; ENSRNOG00000007395
GeneIDi29725
KEGGirno:29725
UCSCiRGD:2190, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
570
RGDi2190, Baat

Phylogenomic databases

eggNOGiENOG502QQ8Z, Eukaryota
GeneTreeiENSGT01010000222336
HOGENOMiCLU_029849_4_0_1
InParanoidiQ63276
OMAiLTPFQVV
OrthoDBi1260385at2759
PhylomeDBiQ63276
TreeFamiTF314911

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14337
ReactomeiR-RNO-159418, Recycling of bile acids and salts
R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-9033241, Peroxisomal protein import
SABIO-RKiQ63276

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q63276

Gene expression databases

BgeeiENSRNOG00000007395, Expressed in liver and 20 other tissues
GenevisibleiQ63276, RN

Family and domain databases

Gene3Di2.60.40.2240, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR016662, Acyl-CoA_thioEstase_long-chain
IPR014940, BAAT_C
IPR006862, Thio_Ohase/aa_AcTrfase
IPR042490, Thio_Ohase/BAAT_N
PfamiView protein in Pfam
PF08840, BAAT_C, 1 hit
PF04775, Bile_Hydr_Trans, 1 hit
PIRSFiPIRSF016521, Acyl-CoA_hydro, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAAT_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63276
Secondary accession number(s): Q5M8A2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 7, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again