Glutamate receptor ionotropic, kainate 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• glutamate receptor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors."
    Paternain A.V., Herrera M.T., Nieto M.A., Lerma J.
    J Neurosci 20:196-205(2000) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression."
    Ren Z., Riley N.J., Garcia E.P., Sanders J.M., Swanson G.T., Marshall J.
    J Neurosci 23:6608-6616(2003) [PubMed] [Europe PMC] [Abstract]
• kainate selective glutamate receptor activity Source: RGDInferred from direct assayⁱ
  • "Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures."
    Smolders I., Bortolotto Z.A., Clarke V.R., Warre R., Khan G.M., O'Neill M.J., Ornstein P.L., Bleakman D., Ogden A., Weiss B., Stables J.P., Ho K.H., Ebinger G., Collingridge G.L., Lodge D., Michotte Y.
    Nat Neurosci 5:796-804(2002) [PubMed] [Europe PMC] [Abstract]
• ligand-gated ion channel activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "Pursuit auditory tracking of dichotically presented tonal amplitudes."
    Sussman H.M., MacNeilage P.F., Lumbley J.L.
    J Speech Hear Res 18:74-81(1975) [PubMed] [Europe PMC] [Abstract]
• SH3 domain binding Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Pursuit auditory tracking of dichotically presented tonal amplitudes."
    Sussman H.M., MacNeilage P.F., Lumbley J.L.
    J Speech Hear Res 18:74-81(1975) [PubMed] [Europe PMC] [Abstract]
• signaling receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: RGD

GO - Biological processⁱ

• cellular response to glucose stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells."
    Santiago A.R., Rosa S.C., Santos P.F., Cristovao A.J., Barber A.J., Ambrosio A.F.
    Invest Ophthalmol Vis Sci 47:4130-4137(2006) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: RGDInferred from direct assayⁱ
  • "Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures."
    Smolders I., Bortolotto Z.A., Clarke V.R., Warre R., Khan G.M., O'Neill M.J., Ornstein P.L., Bleakman D., Ogden A., Weiss B., Stables J.P., Ho K.H., Ebinger G., Collingridge G.L., Lodge D., Michotte Y.
    Nat Neurosci 5:796-804(2002) [PubMed] [Europe PMC] [Abstract]
• establishment of localization in cell Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression."
    Ren Z., Riley N.J., Garcia E.P., Sanders J.M., Swanson G.T., Marshall J.
    J Neurosci 23:6608-6616(2003) [PubMed] [Europe PMC] [Abstract]
• excitatory postsynaptic potential Source: RGD
• modulation of chemical synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury."
    Jiang H.X., Guan Q.H., Pei D.S., Zhang G.Y.
    J Neurosci Res 85:2960-2970(2007) [PubMed] [Europe PMC] [Abstract]
• protein retention in ER lumen Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression."
    Ren Z., Riley N.J., Garcia E.P., Sanders J.M., Swanson G.T., Marshall J.
    J Neurosci 23:6608-6616(2003) [PubMed] [Europe PMC] [Abstract]
• receptor clustering Source: UniProtKBInferred from direct assayⁱ
  • "SAP90 binds and clusters kainate receptors causing incomplete desensitization."
    Garcia E.P., Mehta S., Blair L.A., Wells D.G., Shang J., Fukushima T., Fallon J.R., Garner C.C., Marshall J.
    Neuron 21:727-739(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane potential Source: RGD
• regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: RGD
• synaptic transmission, glutamatergic Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: UniProtKBInferred from physical interactionⁱ
  • "Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression."
    Ren Z., Riley N.J., Garcia E.P., Sanders J.M., Swanson G.T., Marshall J.
    J Neurosci 23:6608-6616(2003) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "Pursuit auditory tracking of dichotically presented tonal amplitudes."
    Sussman H.M., MacNeilage P.F., Lumbley J.L.
    J Speech Hear Res 18:74-81(1975) [PubMed] [Europe PMC] [Abstract]
• SH3 domain binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Pursuit auditory tracking of dichotically presented tonal amplitudes."
    Sussman H.M., MacNeilage P.F., Lumbley J.L.
    J Speech Hear Res 18:74-81(1975) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ 
        60         70         80         90        100
INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP 
       110        120        130        140        150
ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS 
       160        170        180        190        200
RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT 
       210        220        230        240        250
PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY KYILTTMDFP 
       260        270        280        290        300
ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP 
       310        320        330        340        350
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL 
       360        370        380        390        400
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN 
       410        420        430        440        450
ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM 
       460        470        480        490        500
LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF 
       510        520        530        540        550
TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM 
       560        570        580        590        600
LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 
       610        620        630        640        650
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV 
       660        670        680        690        700
PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV 
       710        720        730        740        750
FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI 
       760        770        780        790        800
GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG 
       810        820        830        840        850
MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR 
       860        870        880        890        900
HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 
       910        920        930        940        950
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP 
       960        970 
RGLGTPAEAT SPPRPRPGPT GPRELTEHE                        

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families